Details for: CCT6A

Gene ID: 908

Symbol: CCT6A

Ensembl ID: ENSG00000146731

Description: chaperonin containing TCP1 subunit 6A

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 3.58
    Marker Score: 3733
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 2.57
    Marker Score: 2742
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 2.56
    Marker Score: 3676
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 2.27
    Marker Score: 4736
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.25
    Marker Score: 5486
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 2.23
    Marker Score: 3150
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 2.22
    Marker Score: 2372
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.2
    Marker Score: 76157
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 2.19
    Marker Score: 5961
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 2.19
    Marker Score: 1374
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 2.16
    Marker Score: 2029
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 2.15
    Marker Score: 13974.5
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 2.14
    Marker Score: 8771
  • Cell Name: Unknown (CL0002371)
    Fold Change: 2.13
    Marker Score: 2261
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 2.13
    Marker Score: 7878
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 2.13
    Marker Score: 3615
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 2.1
    Marker Score: 2112
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 2.08
    Marker Score: 20971
  • Cell Name: blood cell (CL0000081)
    Fold Change: 2.07
    Marker Score: 24091
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 2.02
    Marker Score: 9942
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 2.02
    Marker Score: 2175
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 2.01
    Marker Score: 26539
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 2.01
    Marker Score: 2257
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 1.99
    Marker Score: 3474
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.96
    Marker Score: 22058
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 1.95
    Marker Score: 3193.5
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 1.95
    Marker Score: 2058
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 1.95
    Marker Score: 918.5
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 1.93
    Marker Score: 4550
  • Cell Name: oocyte (CL0000023)
    Fold Change: 1.93
    Marker Score: 477
  • Cell Name: Unknown (CL0000548)
    Fold Change: 1.93
    Marker Score: 1405
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.92
    Marker Score: 8296.5
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.91
    Marker Score: 7522.5
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 1.91
    Marker Score: 1385
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 1.91
    Marker Score: 642.5
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.9
    Marker Score: 1269
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.9
    Marker Score: 2794
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 1.88
    Marker Score: 13987.5
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 1.88
    Marker Score: 16301
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 1.87
    Marker Score: 16133
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.86
    Marker Score: 18861
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 1.86
    Marker Score: 2474
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 1.86
    Marker Score: 1553
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 1.85
    Marker Score: 533
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 1.85
    Marker Score: 1254
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 1.83
    Marker Score: 4989
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 1.83
    Marker Score: 10860
  • Cell Name: stem cell (CL0000034)
    Fold Change: 1.83
    Marker Score: 4338.5
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 1.81
    Marker Score: 3612.5
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.81
    Marker Score: 61474
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 1.8
    Marker Score: 578
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 1.79
    Marker Score: 6941
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 1.79
    Marker Score: 13942.5
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.78
    Marker Score: 1871
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 1.77
    Marker Score: 866
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.76
    Marker Score: 421
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 1.76
    Marker Score: 1499
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 1.75
    Marker Score: 931
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.75
    Marker Score: 3098
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 1.75
    Marker Score: 3404
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.75
    Marker Score: 5184
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 1.74
    Marker Score: 897
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 1.74
    Marker Score: 556
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 1.73
    Marker Score: 1027
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 1.73
    Marker Score: 17119
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 1.72
    Marker Score: 817
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 1.72
    Marker Score: 1082.5
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 1.7
    Marker Score: 1602
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 1.69
    Marker Score: 3179
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 1.69
    Marker Score: 2600
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 1.68
    Marker Score: 2676
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 1.68
    Marker Score: 588
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 1.68
    Marker Score: 1620.5
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 1.68
    Marker Score: 2101
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 1.66
    Marker Score: 912.5
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.65
    Marker Score: 92370
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 1.65
    Marker Score: 1932
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 1.65
    Marker Score: 1489
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.64
    Marker Score: 10479
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 1.64
    Marker Score: 1087
  • Cell Name: basal cell (CL0000646)
    Fold Change: 1.63
    Marker Score: 2110
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 1.62
    Marker Score: 853
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 1.62
    Marker Score: 1759
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 1.61
    Marker Score: 1209
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 1.61
    Marker Score: 3152
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 1.61
    Marker Score: 1098
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 1.61
    Marker Score: 1839
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 1.61
    Marker Score: 3266
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 1.6
    Marker Score: 1001
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 1.6
    Marker Score: 552
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 1.6
    Marker Score: 2906
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 1.59
    Marker Score: 3031
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 1.59
    Marker Score: 1613
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 1.59
    Marker Score: 5463
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 1.58
    Marker Score: 2533
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 1.57
    Marker Score: 83234
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 1.57
    Marker Score: 783
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 1.57
    Marker Score: 766
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 1.56
    Marker Score: 1180
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 1.56
    Marker Score: 450

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Other Information

**Key characteristics:** - The protein is a chaperone, which is a protein that binds to and helps to fold other proteins. - It is a member of the chaperonin family of proteins, which are involved in the folding of proteins in the endoplasmic reticulum. - It is expressed in a variety of cell types, including erythroid progenitor cell, skeletal muscle satellite stem cell, oogonial cell, epithelial cell of nephron, basal cell of prostate epithelium, CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell, neural crest cell, and cell in vitro. - It is responsible for the folding and stability of various proteins, including those involved in the Rhobtb2 gtpase cycle, Rhobtb gtpase cycle, Rho gtpase cycle, and protein binding. **Pathways and functions:** - The protein is involved in the folding and stability of proteins involved in the Rhobtb2 gtpase cycle, Rhobtb gtpase cycle, Rho gtpase cycle, and protein binding. - It is also involved in the folding and stability of actin and tubulin proteins. - It is involved in the metabolism of proteins. - It is involved in the signaling by rho gtpases. **Clinical significance:** - Mutations in the CCT6A gene have been linked to a number of human diseases, including familial hypercholesterolemia, Werner syndrome, and Marfan syndrome. - These diseases are caused by mutations in genes that are involved in the folding and stability of proteins involved in the Rhobtb2 gtpase cycle, Rhobtb gtpase cycle, Rho gtpase cycle, and protein binding. - Targeting CCT6A has been investigated as a therapeutic strategy for these diseases.

Genular Protein ID: 225150841

Symbol: TCPZ_HUMAN

Name: T-complex protein 1 subunit zeta

UniProtKB Accession Codes:

P40227 A6NCD2 Q3KP28 Q75LP4 Q96S46

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CORUM 1 CPTAC 3 CTD 1 ChiTaRS 1 ComplexPortal 1 DIP 1 DMDM 1 DNASU 1 DOSAC-COBS-2DPAGE 1 DisGeNET 1 EMBL 8 EMDB 27 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 19 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 NCBIfam 2 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 28 PDBsum 26 PIR 1 PRIDE 1 PRINTS 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 REPRODUCTION-2DPAGE 2 RNAct 1 Reactome 6 RefSeq 2 SIGNOR 1 SMR 1 STRING 1 SUPFAM 3 SWISS-2DPAGE 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCD-2DPAGE 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8034610

Title: Tcp20, a subunit of the eukaryotic TRiC chaperonin from humans and yeast.

PubMed ID: 8034610

DOI: 10.1016/s0021-9258(17)32354-2

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1352881

Title: Isolation of a gene encoding a chaperonin-like protein by complementation of yeast amino acid transport mutants with human cDNA.

PubMed ID: 1352881

DOI: 10.1073/pnas.89.13.6060

PubMed ID: 12665801

Title: Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.

PubMed ID: 12665801

DOI: 10.1038/nbt810

PubMed ID: 14532270

Title: A product of the human gene adjacent to parkin is a component of Lewy bodies and suppresses Pael receptor-induced cell death.

PubMed ID: 14532270

DOI: 10.1074/jbc.m309655200

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 25467444

Title: Proteostatic control of telomerase function through TRiC-mediated folding of TCAB1.

PubMed ID: 25467444

DOI: 10.1016/j.cell.2014.10.059

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

Sequence Information:

  • Length: 531
  • Mass: 58024
  • Checksum: 43ABCF548CC82B81
  • Sequence:
    • MAAVKTLNPK AEVARAQAAL AVNISAARGL QDVLRTNLGP KGTMKMLVSG AGDIKLTKDG 
NVLLHEMQIQ HPTASLIAKV ATAQDDITGD GTTSNVLIIG ELLKQADLYI SEGLHPRIIT 
EGFEAAKEKA LQFLEEVKVS REMDRETLID VARTSLRTKV HAELADVLTE AVVDSILAIK 
KQDEPIDLFM IEIMEMKHKS ETDTSLIRGL VLDHGARHPD MKKRVEDAYI LTCNVSLEYE 
KTEVNSGFFY KSAEEREKLV KAERKFIEDR VKKIIELKRK VCGDSDKGFV VINQKGIDPF 
SLDALSKEGI VALRRAKRRN MERLTLACGG VALNSFDDLS PDCLGHAGLV YEYTLGEEKF 
TFIEKCNNPR SVTLLIKGPN KHTLTQIKDA VRDGLRAVKN AIDDGCVVPG AGAVEVAMAE 
ALIKHKPSVK GRAQLGVQAF ADALLIIPKV LAQNSGFDLQ ETLVKIQAEH SESGQLVGVD 
LNTGEPMVAA EVGVWDNYCV KKQLLHSCTV IATNILLVDE IMRAGMSSLK G

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.