Details for: CCT6A

Gene ID: 908

Symbol: CCT6A

Ensembl ID: ENSG00000146731

Description: chaperonin containing TCP1 subunit 6A

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 367.5137
    Cell Significance Index: -57.1700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 237.2623
    Cell Significance Index: -60.1800
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 191.6142
    Cell Significance Index: -78.9400
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 169.9558
    Cell Significance Index: -80.2400
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 148.6629
    Cell Significance Index: -76.4700
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 119.8619
    Cell Significance Index: -80.4300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 61.2715
    Cell Significance Index: -75.5500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 23.7508
    Cell Significance Index: -63.6300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 20.2734
    Cell Significance Index: -80.0000
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 15.9631
    Cell Significance Index: -49.0300
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 10.8974
    Cell Significance Index: -23.8500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 4.8229
    Cell Significance Index: 333.5300
  • Cell Name: germ cell (CL0000586)
    Fold Change: 4.6658
    Cell Significance Index: 35.2300
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 3.5837
    Cell Significance Index: 38.9600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 2.3157
    Cell Significance Index: 80.4700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 2.0202
    Cell Significance Index: 42.2900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.9228
    Cell Significance Index: 50.5600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.8156
    Cell Significance Index: 991.5200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.7814
    Cell Significance Index: 219.0400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.7800
    Cell Significance Index: 48.4500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.6286
    Cell Significance Index: 293.5900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 1.5912
    Cell Significance Index: 74.7900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.5515
    Cell Significance Index: 213.0700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 1.5515
    Cell Significance Index: 109.7300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.4019
    Cell Significance Index: 90.4500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 1.3946
    Cell Significance Index: 616.5700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.3436
    Cell Significance Index: 158.4600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.2829
    Cell Significance Index: 208.6500
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 1.2394
    Cell Significance Index: 14.0800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.0557
    Cell Significance Index: 28.1900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.0170
    Cell Significance Index: 131.3900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.9767
    Cell Significance Index: 193.8300
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.7960
    Cell Significance Index: 7.3300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.6963
    Cell Significance Index: 36.1700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.6760
    Cell Significance Index: 31.5200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.5690
    Cell Significance Index: 114.1500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.5568
    Cell Significance Index: 41.5000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.5318
    Cell Significance Index: 90.8000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.5317
    Cell Significance Index: 11.5200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5294
    Cell Significance Index: 478.0400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.5260
    Cell Significance Index: 14.7000
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.4605
    Cell Significance Index: 13.5300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.4335
    Cell Significance Index: 55.5700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.3393
    Cell Significance Index: 15.3800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2562
    Cell Significance Index: 48.7600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.2518
    Cell Significance Index: 174.1700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1977
    Cell Significance Index: 70.9000
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.1766
    Cell Significance Index: 4.0800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.1729
    Cell Significance Index: 10.9000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1466
    Cell Significance Index: 14.5000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.0802
    Cell Significance Index: 4.2100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0771
    Cell Significance Index: 2.7100
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.0576
    Cell Significance Index: 0.4600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0275
    Cell Significance Index: 20.8000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0113
    Cell Significance Index: 8.2700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0119
    Cell Significance Index: -0.3400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0149
    Cell Significance Index: -28.0800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0188
    Cell Significance Index: -34.6800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0217
    Cell Significance Index: -33.3900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0290
    Cell Significance Index: -21.4800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0421
    Cell Significance Index: -0.7100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0421
    Cell Significance Index: -4.3000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0483
    Cell Significance Index: -65.6900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0581
    Cell Significance Index: -36.2800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0582
    Cell Significance Index: -36.9600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0814
    Cell Significance Index: -2.3500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0855
    Cell Significance Index: -48.2400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1276
    Cell Significance Index: -57.9300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1528
    Cell Significance Index: -32.1800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.2200
    Cell Significance Index: -63.3000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2456
    Cell Significance Index: -13.7800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.3152
    Cell Significance Index: -36.1100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.3256
    Cell Significance Index: -6.9400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.3457
    Cell Significance Index: -40.2900
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.3492
    Cell Significance Index: -8.9200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.3610
    Cell Significance Index: -22.1900
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.3637
    Cell Significance Index: -4.6600
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.3666
    Cell Significance Index: -2.2200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.3733
    Cell Significance Index: -54.2700
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.3880
    Cell Significance Index: -44.2900
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.4062
    Cell Significance Index: -10.8700
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.4323
    Cell Significance Index: -7.6400
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.4745
    Cell Significance Index: -8.7700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.5267
    Cell Significance Index: -40.4200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.6419
    Cell Significance Index: -20.5600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.6787
    Cell Significance Index: -53.7500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.7108
    Cell Significance Index: -19.0500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.7395
    Cell Significance Index: -10.0900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.7487
    Cell Significance Index: -77.9600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.8490
    Cell Significance Index: -57.0900
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.9689
    Cell Significance Index: -11.5500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.9886
    Cell Significance Index: -60.6100
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -1.0067
    Cell Significance Index: -14.1200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -1.3002
    Cell Significance Index: -33.4200
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: -1.4011
    Cell Significance Index: -12.0400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -1.4505
    Cell Significance Index: -64.1600
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -1.5272
    Cell Significance Index: -21.7000
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -1.5523
    Cell Significance Index: -23.2600
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -1.5604
    Cell Significance Index: -26.7400
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -1.5726
    Cell Significance Index: -46.3200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** CCT6A is a member of the CCT complex, a group of molecular chaperones that assist in the folding of proteins during biosynthesis. The CCT complex is composed of seven subunits, with CCT6A being one of the six subunits. CCT6A is a 15-kDa protein that contains a WD40-repeat domain, a motif known for its involvement in protein-protein interactions. The CCT6A protein is highly conserved across species, suggesting its essential role in maintaining cellular function. **Pathways and Functions** CCT6A is involved in various cellular pathways, including: 1. **Chaperone-mediated protein folding**: CCT6A assists in the correct folding of proteins, ensuring their proper structure and function. 2. **Association of tric/cct with target proteins during biosynthesis**: CCT6A interacts with target proteins during their biosynthesis, facilitating their correct folding. 3. **Atp-dependent protein folding chaperone**: CCT6A is an ATP-dependent chaperone, requiring energy from ATP hydrolysis to facilitate protein folding. 4. **Cooperation of pdcl (phlp1) and tric/cct in g-protein beta folding**: CCT6A collaborates with other chaperones, such as pdcl (phlp1), to facilitate the folding of G-protein beta subunits. 5. **Cooperation of prefoldin and tric/cct in actin and tubulin folding**: CCT6A works in conjunction with prefoldin to assist in the folding of actin and tubulin, essential structural proteins. **Clinical Significance** Dysregulation of CCT6A has been implicated in various diseases, including: 1. **Muscular dystrophy**: CCT6A mutations have been associated with muscular dystrophy, highlighting the importance of CCT6A in maintaining muscle function. 2. **Neurodegenerative diseases**: CCT6A has been implicated in neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease, where protein misfolding plays a critical role. 3. **Cancer**: CCT6A expression has been altered in various types of cancer, suggesting its potential role in tumorigenesis and cancer progression. In conclusion, CCT6A is a critical gene involved in maintaining cellular homeostasis through its role in protein folding. Its dysregulation has been implicated in various diseases, highlighting the importance of CCT6A in human health and disease. Further research is needed to fully elucidate the mechanisms by which CCT6A regulates protein folding and its role in disease pathogenesis.

Genular Protein ID: 225150841

Symbol: TCPZ_HUMAN

Name: T-complex protein 1 subunit zeta

UniProtKB Accession Codes:

P40227 A6NCD2 Q3KP28 Q75LP4 Q96S46

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CORUM 1 CPTAC 3 CTD 1 ChiTaRS 1 ComplexPortal 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 8 EMDB 50 Ensembl 2 ExpressionAtlas 1 GO 19 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 NCBIfam 2 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 49 PDBsum 49 PIR 1 PRIDE 1 PRINTS 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 REPRODUCTION-2DPAGE 2 RNAct 1 Reactome 6 RefSeq 2 SIGNOR 1 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8034610

Title: Tcp20, a subunit of the eukaryotic TRiC chaperonin from humans and yeast.

PubMed ID: 8034610

DOI: 10.1016/s0021-9258(17)32354-2

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1352881

Title: Isolation of a gene encoding a chaperonin-like protein by complementation of yeast amino acid transport mutants with human cDNA.

PubMed ID: 1352881

DOI: 10.1073/pnas.89.13.6060

PubMed ID: 12665801

Title: Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.

PubMed ID: 12665801

DOI: 10.1038/nbt810

PubMed ID: 14532270

Title: A product of the human gene adjacent to parkin is a component of Lewy bodies and suppresses Pael receptor-induced cell death.

PubMed ID: 14532270

DOI: 10.1074/jbc.m309655200

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 25467444

Title: Proteostatic control of telomerase function through TRiC-mediated folding of TCAB1.

PubMed ID: 25467444

DOI: 10.1016/j.cell.2014.10.059

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

Sequence Information:

  • Length: 531
  • Mass: 58024
  • Checksum: 43ABCF548CC82B81
  • Sequence:
    • MAAVKTLNPK AEVARAQAAL AVNISAARGL QDVLRTNLGP KGTMKMLVSG AGDIKLTKDG 
NVLLHEMQIQ HPTASLIAKV ATAQDDITGD GTTSNVLIIG ELLKQADLYI SEGLHPRIIT 
EGFEAAKEKA LQFLEEVKVS REMDRETLID VARTSLRTKV HAELADVLTE AVVDSILAIK 
KQDEPIDLFM IEIMEMKHKS ETDTSLIRGL VLDHGARHPD MKKRVEDAYI LTCNVSLEYE 
KTEVNSGFFY KSAEEREKLV KAERKFIEDR VKKIIELKRK VCGDSDKGFV VINQKGIDPF 
SLDALSKEGI VALRRAKRRN MERLTLACGG VALNSFDDLS PDCLGHAGLV YEYTLGEEKF 
TFIEKCNNPR SVTLLIKGPN KHTLTQIKDA VRDGLRAVKN AIDDGCVVPG AGAVEVAMAE 
ALIKHKPSVK GRAQLGVQAF ADALLIIPKV LAQNSGFDLQ ETLVKIQAEH SESGQLVGVD 
LNTGEPMVAA EVGVWDNYCV KKQLLHSCTV IATNILLVDE IMRAGMSSLK G

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.