Details for: BPY2

Gene ID: 9083

Symbol: BPY2

Ensembl ID: ENSG00000183753

Description: basic charge Y-linked 2

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: melanocyte (CL0000148)
    Fold Change: 1.74
    Marker Score: 704
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 1.59
    Marker Score: 663
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 1.21
    Marker Score: 638
  • Cell Name: mast cell (CL0000097)
    Fold Change: 1.21
    Marker Score: 700
  • Cell Name: pericyte (CL0000669)
    Fold Change: 1.19
    Marker Score: 697
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.16
    Marker Score: 7,689
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 1.08
    Marker Score: 714
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,334
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.96
    Marker Score: 1,566
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,413
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.93
    Marker Score: 707
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.92
    Marker Score: 5,276
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2,742
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.9
    Marker Score: 497
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,245
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.81
    Marker Score: 741
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.79
    Marker Score: 449
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 0.79
    Marker Score: 714
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.74
    Marker Score: 663
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.74
    Marker Score: 714
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.69
    Marker Score: 554
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.67
    Marker Score: 713
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 0.66
    Marker Score: 709
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.64
    Marker Score: 709
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.64
    Marker Score: 710
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.59
    Marker Score: 714
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.48
    Marker Score: 669
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.34
    Marker Score: 712
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.32
    Marker Score: 709
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.23
    Marker Score: 707
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.2
    Marker Score: 714
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 0.2
    Marker Score: 714
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.18
    Marker Score: 714
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.12
    Marker Score: 713
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 0.11
    Marker Score: 704
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 0.11
    Marker Score: 711
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.05
    Marker Score: 651
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.04
    Marker Score: 708
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 0.03
    Marker Score: 694
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.01
    Marker Score: 713
  • Cell Name: mural cell (CL0008034)
    Fold Change: 0.01
    Marker Score: 658

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** BPY2 is a gene located on the Y chromosome, which is notable for its unique characteristics. The gene is encoded by a single exon and has no known pseudogenes. Its expression is restricted to specific cell types, suggesting a specialized role in these cells. The gene's product, the Basic Charge Y-Linked 2 protein, is predicted to have a basic charge and a potential role in protein-protein interactions. **Pathways and Functions:** BPY2 is involved in several signaling pathways, including: 1. **Hect domain binding**: The gene is predicted to interact with HECT domain-containing proteins, which are involved in ubiquitination and protein degradation. 2. **Nucleus**: BPY2 is localized to the nucleus, suggesting a role in nuclear function and regulation. 3. **Protein binding**: The gene product is predicted to interact with other proteins, potentially regulating their activity or localization. 4. **Single fertilization**: BPY2 is expressed in cells involved in single fertilization, suggesting a role in early embryonic development. 5. **Spermatogenesis**: The gene is also expressed in spermatogenic cells, indicating a potential role in male fertility. The functional significance of BPY2 is unclear, but it may play a role in: 1. **Cell signaling**: BPY2 may act as a signaling molecule, regulating cellular processes such as proliferation, differentiation, and survival. 2. **Gene regulation**: The gene product may interact with transcription factors or other proteins to regulate gene expression. 3. **Cell migration**: BPY2 may be involved in cell migration, potentially regulating the movement of cells during development or immune responses. **Clinical Significance:** While the clinical significance of BPY2 is unclear, its expression in various cell types suggests potential roles in disease. For example: 1. **Cancer**: Aberrant expression of BPY2 may contribute to tumorigenesis, particularly in cells with high proliferative potential. 2. **Autoimmune diseases**: Dysregulation of BPY2 may contribute to autoimmune diseases, such as rheumatoid arthritis or lupus, where immune cells are involved. 3. **Neurological disorders**: BPY2 expression in neurons or glial cells may be involved in neurological disorders, such as Alzheimer's disease or Parkinson's disease. In conclusion, the Basic Charge Y-Linked 2 (BPY2) gene is a mysterious and enigmatic gene with a wide range of expression across various cell types. Further research is needed to elucidate its functional significance and clinical relevance.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.