Details for: EIF1AY

Gene ID: 9086

Symbol: EIF1AY

Ensembl ID: ENSG00000198692

Description: eukaryotic translation initiation factor 1A Y-linked

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 2.3
    Marker Score: 2,247
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.64
    Marker Score: 6,436
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.46
    Marker Score: 168,014
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: 1.39
    Marker Score: 843
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 1.24
    Marker Score: 358
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 1.16
    Marker Score: 1,039
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.13
    Marker Score: 2,752
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 1.13
    Marker Score: 1,497
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.12
    Marker Score: 7,156
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 1.1
    Marker Score: 1,152
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.08
    Marker Score: 1,165
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 1.08
    Marker Score: 4,418
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 1.07
    Marker Score: 10,557
  • Cell Name: kidney loop of Henle epithelial cell (CL1000909)
    Fold Change: 1.05
    Marker Score: 661
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 1.05
    Marker Score: 3,615
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 1.03
    Marker Score: 769
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,679
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47,904
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.99
    Marker Score: 429
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.98
    Marker Score: 935
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 0.98
    Marker Score: 773
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,391
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 0.98
    Marker Score: 739
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.98
    Marker Score: 398
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.96
    Marker Score: 3,720
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.96
    Marker Score: 462
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 0.95
    Marker Score: 476
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2,392
  • Cell Name: renal intercalated cell (CL0005010)
    Fold Change: 0.94
    Marker Score: 501
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.92
    Marker Score: 476
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.91
    Marker Score: 432
  • Cell Name: PP cell (CL0000696)
    Fold Change: 0.91
    Marker Score: 205
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.91
    Marker Score: 5,165
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.9
    Marker Score: 2,709
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.9
    Marker Score: 1,469
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.88
    Marker Score: 7,629
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 0.88
    Marker Score: 784
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 0.87
    Marker Score: 271
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 0.87
    Marker Score: 500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.86
    Marker Score: 5,218
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.86
    Marker Score: 308
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.85
    Marker Score: 5,063
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.85
    Marker Score: 468
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.85
    Marker Score: 2,515
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.84
    Marker Score: 400
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.83
    Marker Score: 519
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 0.82
    Marker Score: 345
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.82
    Marker Score: 9,557
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.82
    Marker Score: 478
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 0.81
    Marker Score: 306
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 0.81
    Marker Score: 242
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: 0.8
    Marker Score: 348
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.8
    Marker Score: 397
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.8
    Marker Score: 1,872
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.79
    Marker Score: 365
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 0.78
    Marker Score: 669
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.78
    Marker Score: 534
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.78
    Marker Score: 312
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.78
    Marker Score: 1,576
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 0.78
    Marker Score: 405
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 0.77
    Marker Score: 197
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1,251
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 0.76
    Marker Score: 480
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.76
    Marker Score: 583
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.76
    Marker Score: 3,660
  • Cell Name: club cell (CL0000158)
    Fold Change: 0.75
    Marker Score: 880
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.74
    Marker Score: 150
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: 0.74
    Marker Score: 804
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 0.74
    Marker Score: 1,143
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 0.74
    Marker Score: 166
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.73
    Marker Score: 385
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: 0.73
    Marker Score: 527
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 0.73
    Marker Score: 649
  • Cell Name: NKp44-positive group 3 innate lymphoid cell, human (CL0001079)
    Fold Change: 0.72
    Marker Score: 162
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.71
    Marker Score: 370
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.71
    Marker Score: 456
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 0.71
    Marker Score: 379
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 0.71
    Marker Score: 241
  • Cell Name: basophil (CL0000767)
    Fold Change: 0.71
    Marker Score: 337
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 0.7
    Marker Score: 1,339
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 0.7
    Marker Score: 597
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.7
    Marker Score: 1,658
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 0.69
    Marker Score: 978
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.69
    Marker Score: 2,888
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.69
    Marker Score: 627
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 0.69
    Marker Score: 220
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 175
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 0.68
    Marker Score: 229
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.68
    Marker Score: 312
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 0.67
    Marker Score: 329
  • Cell Name: memory regulatory T cell (CL0002678)
    Fold Change: 0.67
    Marker Score: 235
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 0.67
    Marker Score: 260
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.67
    Marker Score: 5,755
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 0.67
    Marker Score: 505
  • Cell Name: centroblast (CL0009112)
    Fold Change: 0.67
    Marker Score: 328
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 0.67
    Marker Score: 522
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: 0.66
    Marker Score: 342
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.66
    Marker Score: 438
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.66
    Marker Score: 158
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.66
    Marker Score: 607

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** EIF1AY is a member of the eukaryotic translation initiation factor 1A (eIF1A) family, which is essential for the initiation of translation in eukaryotic cells. The EIF1AY gene is specifically localized on the Y chromosome, suggesting its potential involvement in sex-specific or X-linked disorders. The protein encoded by EIF1AY, IF1AY_HUMAN, exhibits high sequence homology with other eIF1A family members, indicating a conserved function in translation initiation. **Pathways and Functions:** EIF1AY is involved in the regulation of protein synthesis through its role in the eukaryotic translation initiation complex (eIF complex). The eIF complex is responsible for the recruitment of ribosomes to the mRNA, allowing for the translation of the genetic code into a polypeptide chain. EIF1AY has been shown to interact with other translation initiation factors, such as eIF2, eIF3, and eIF5, to facilitate the assembly of the eIF complex. This interaction is crucial for the initiation of translation, as it enables the recognition of the mRNA cap and the recruitment of ribosomes. The functions of EIF1AY can be broadly categorized into three main areas: 1. **Translation initiation**: EIF1AY plays a critical role in the initiation of translation by interacting with other translation initiation factors to facilitate the assembly of the eIF complex. 2. **mRNA recognition**: EIF1AY has been shown to recognize the mRNA cap, a specific sequence on the 5' end of the mRNA, and facilitate the recruitment of ribosomes. 3. **Ribosome recruitment**: EIF1AY interacts with ribosomes to facilitate their recruitment to the mRNA, allowing for the translation of the genetic code into a polypeptide chain. **Clinical Significance:** The clinical significance of EIF1AY is still an area of active research. However, several studies have implicated EIF1AY in the pathogenesis of various diseases, including: 1. **Pancreatic cancer**: EIF1AY has been shown to be overexpressed in pancreatic cancer cells, suggesting its potential as a biomarker for early detection and diagnosis. 2. **Autoimmune diseases**: EIF1AY has been implicated in the pathogenesis of autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis, where it may contribute to the dysregulation of the immune response. 3. **Neurological disorders**: EIF1AY has been shown to be involved in the pathogenesis of neurological disorders, such as Alzheimer's disease and Parkinson's disease, where it may contribute to the dysregulation of protein synthesis. In conclusion, EIF1AY is a critical gene involved in the regulation of protein synthesis in eukaryotic cells. Its role in translation initiation, mRNA recognition, and ribosome recruitment makes it an essential component of the eIF complex. Further research is needed to fully elucidate the clinical significance of EIF1AY and its potential as a therapeutic target for various diseases.

Genular Protein ID: 2570481336

Symbol: IF1AY_HUMAN

Name: Eukaryotic translation initiation factor 1A, Y-chromosomal

UniProtKB Accession Codes:

O14602 Q9BS77

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 3 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 4 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HAMAP 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 2 PathwayCommons 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 2 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9381176

Title: Functional coherence of the human Y chromosome.

PubMed ID: 9381176

DOI: 10.1126/science.278.5338.675

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 144
  • Mass: 16442
  • Checksum: 1DE91334F191BEC5
  • Sequence:
    • MPKNKGKGGK NRRRGKNENE SEKRELVFKE DGQEYAQVIK MLGNGRLEAL CFDGVKRLCH 
IRGKLRKKVW INTSDIILVG LRDYQDNKAD VILKYNADEA RSLKAYGELP EHAKINETDT 
FGPGDDDEIQ FDDIGDDDED IDDI

Genular Protein ID: 1190991126

Symbol: A6NJH9_HUMAN

Name: N/A

UniProtKB Accession Codes:

A6NJH9

Database IDs:

ARBA 4 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 1 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 2 Gene3D 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 InterPro 4 MassIVE 1 MaxQB 2 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 3 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 1 Proteomes 2 ProteomicsDB 1 RefSeq 1 SAM 1 SMART 1 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 12815422

Title: The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes.

PubMed ID: 12815422

DOI: 10.1038/nature01722

Sequence Information:

  • Length: 127
  • Mass: 14455
  • Checksum: 4C2F3F03DCC651D3
  • Sequence:
    • MPKNKGKGGK NRRRGKNENE SEKRELVFKE DGQEYAQVIK MLGNGRLEAL CFDGVKRLCH 
IRGKLRKKDN KADVILKYNA DEARSLKAYG ELPEHAKINE TDTFGPGDDD EIQFDDIGDD 
DEDIDDI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.