Details for: TMSB4Y

Gene ID: 9087

Symbol: TMSB4Y

Ensembl ID: ENSG00000154620

Description: thymosin beta 4 Y-linked

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 2.06
    Marker Score: 7,974
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 1.34
    Marker Score: 1,918
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 1
    Marker Score: 1,048
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,825
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,050
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,408
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.97
    Marker Score: 502
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.96
    Marker Score: 455
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,412
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5,325
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.92
    Marker Score: 368
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,740
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.89
    Marker Score: 319
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,285
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.8
    Marker Score: 540
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,261
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.75
    Marker Score: 390
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.75
    Marker Score: 682
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 174
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.68
    Marker Score: 518
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.66
    Marker Score: 2,754
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.48
    Marker Score: 307
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.45
    Marker Score: 271
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: 0.35
    Marker Score: 233
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.23
    Marker Score: 287
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.23
    Marker Score: 377
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 0.22
    Marker Score: 83
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 62
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.21
    Marker Score: 89
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.21
    Marker Score: 141
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.21
    Marker Score: 71
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.2
    Marker Score: 196
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.19
    Marker Score: 166
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.19
    Marker Score: 186
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.19
    Marker Score: 392
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 0.19
    Marker Score: 47
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.19
    Marker Score: 78
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.18
    Marker Score: 103
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 0.18
    Marker Score: 53
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 0.18
    Marker Score: 54
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.17
    Marker Score: 677
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.17
    Marker Score: 718
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.17
    Marker Score: 54
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.17
    Marker Score: 76
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.17
    Marker Score: 41
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.16
    Marker Score: 47
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 0.16
    Marker Score: 85
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.16
    Marker Score: 555
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: 0.16
    Marker Score: 97
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.16
    Marker Score: 379
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.16
    Marker Score: 336
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.15
    Marker Score: 40
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.14
    Marker Score: 262
  • Cell Name: epithelial cell of glomerular capsule (CL1000450)
    Fold Change: 0.14
    Marker Score: 36
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.14
    Marker Score: 74
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.14
    Marker Score: 145
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.14
    Marker Score: 171
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 0.13
    Marker Score: 94
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 0.13
    Marker Score: 64
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.13
    Marker Score: 87
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 0.13
    Marker Score: 330
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.12
    Marker Score: 43
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.12
    Marker Score: 132
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.12
    Marker Score: 126
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 0.12
    Marker Score: 189
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.12
    Marker Score: 143
  • Cell Name: gut endothelial cell (CL0000131)
    Fold Change: 0.12
    Marker Score: 43
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.12
    Marker Score: 35
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.12
    Marker Score: 24
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.12
    Marker Score: 701
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.12
    Marker Score: 276
  • Cell Name: platelet (CL0000233)
    Fold Change: 0.12
    Marker Score: 53
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.11
    Marker Score: 115
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 0.11
    Marker Score: 38
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: 0.11
    Marker Score: 99
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.11
    Marker Score: 121
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.11
    Marker Score: 741
  • Cell Name: NKp44-positive group 3 innate lymphoid cell, human (CL0001079)
    Fold Change: 0.11
    Marker Score: 25
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: 0.11
    Marker Score: 85
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.11
    Marker Score: 75
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.11
    Marker Score: 104
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.11
    Marker Score: 399
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 0.11
    Marker Score: 86
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 0.11
    Marker Score: 24
  • Cell Name: paneth cell (CL0000510)
    Fold Change: 0.11
    Marker Score: 74
  • Cell Name: centrocyte (CL0009111)
    Fold Change: 0.11
    Marker Score: 25
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.1
    Marker Score: 167
  • Cell Name: B-1b B cell (CL0000821)
    Fold Change: 0.1
    Marker Score: 24
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 0.1
    Marker Score: 2,662
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.1
    Marker Score: 93
  • Cell Name: kidney loop of Henle epithelial cell (CL1000909)
    Fold Change: 0.1
    Marker Score: 65
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.1
    Marker Score: 57
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.1
    Marker Score: 291
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.1
    Marker Score: 59
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.1
    Marker Score: 161
  • Cell Name: type I enteroendocrine cell (CL0002277)
    Fold Change: 0.1
    Marker Score: 25
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.1
    Marker Score: 39
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.1
    Marker Score: 46
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 0.1
    Marker Score: 78

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** The TMSB4Y gene exhibits several distinct characteristics that set it apart from other genes. Its location on the Y chromosome suggests a potential role in X-linked disorders, although its expression patterns and functions suggest a more complex and multifaceted role. The gene's involvement in regulating actin polymerization and depolymerization, as well as sequestering actin monomers, underscores its significance in maintaining cellular structure and function. Furthermore, its expression in various cell types, including those in the nervous system and intestinal epithelium, highlights its potential role in tissue development and maintenance. **Pathways and Functions:** The TMSB4Y gene is implicated in several key cellular processes, including: 1. **Actin filament organization**: TMSB4Y regulates the assembly and disassembly of actin filaments, which are essential for maintaining cellular structure and function. 2. **Cytoskeleton dynamics**: The gene's involvement in regulating actin polymerization and depolymerization highlights its role in maintaining cytoskeletal homeostasis. 3. **Cell migration**: TMSB4Y's expression in thymocytes and intestinal epithelial cells suggests a role in regulating cell migration and tissue architecture. 4. **Protein binding**: The gene's ability to bind proteins involved in actin regulation and cell migration underscores its importance in these processes. **Clinical Significance:** The TMSB4Y gene's involvement in regulating cellular processes has significant implications for human health. Abnormal expression or function of this gene may contribute to various diseases, including: 1. **Neurological disorders**: Dysregulation of TMSB4Y's role in actin filament organization and cytoskeleton dynamics may contribute to neurological disorders, such as neurodegenerative diseases. 2. **Intestinal disorders**: Alterations in TMSB4Y's expression in intestinal epithelial cells may contribute to intestinal disorders, such as inflammatory bowel disease. 3. **Cancer**: TMSB4Y's role in regulating cell migration and cytoskeleton dynamics may also contribute to cancer development and progression. In conclusion, the thymosin beta 4 Y-linked gene (TMSB4Y) is a complex gene with multiple roles in regulating cellular processes. Further research is needed to fully elucidate its functions and implications in human health, but its significance in maintaining cellular homeostasis and tissue architecture is clear.

Genular Protein ID: 4172981316

Symbol: TYB4Y_HUMAN

Name: Thymosin beta-4, Y-chromosomal

UniProtKB Accession Codes:

O14604 Q0VDA2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 1 GO 9 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIRSF 1 PRO 1 PROSITE 1 PathwayCommons 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RefSeq 1 SAM 1 SMART 1 SMR 1 STRING 1 SignaLink 1 UCSC 1 VEuPathDB 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9381176

Title: Functional coherence of the human Y chromosome.

PubMed ID: 9381176

DOI: 10.1126/science.278.5338.675

PubMed ID: 12815422

Title: The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes.

PubMed ID: 12815422

DOI: 10.1038/nature01722

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 44
  • Mass: 5013
  • Checksum: 7B336158483A9BE2
  • Sequence:
    • MSDKPGMAEI EKFDKSKLKK TETQEKNPLS SKETIEQERQ AGES

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.