Details for: PKMYT1

Gene ID: 9088

Symbol: PKMYT1

Ensembl ID: ENSG00000127564

Description: protein kinase, membrane associated tyrosine/threonine 1

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 2.83
    Marker Score: 4,058
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 1.94
    Marker Score: 1,734
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 1.65
    Marker Score: 1,292
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 1.6
    Marker Score: 1,001
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 1.57
    Marker Score: 2,256
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 1.56
    Marker Score: 3,224
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 1.18
    Marker Score: 884
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 1.16
    Marker Score: 3,159
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251,803
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1
    Marker Score: 2,968
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,822
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,046
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 1
    Marker Score: 1,326
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.98
    Marker Score: 15,363
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,408
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 504
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.97
    Marker Score: 659
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 458
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,412
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.95
    Marker Score: 1,924
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.93
    Marker Score: 679
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,736
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.91
    Marker Score: 5,179
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.9
    Marker Score: 1,126
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 323
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.89
    Marker Score: 1,686
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,285
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.81
    Marker Score: 429
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.79
    Marker Score: 249
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1,255
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 393
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.76
    Marker Score: 303
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.75
    Marker Score: 684
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.74
    Marker Score: 565
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 176
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.68
    Marker Score: 2,858
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 0.68
    Marker Score: 709
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.67
    Marker Score: 217
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.65
    Marker Score: 659
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 0.64
    Marker Score: 603
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.63
    Marker Score: 378
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.58
    Marker Score: 980
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.57
    Marker Score: 362
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.54
    Marker Score: 169
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: 0.53
    Marker Score: 380
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.52
    Marker Score: 247
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.51
    Marker Score: 213
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.51
    Marker Score: 391
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 0.51
    Marker Score: 248
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.5
    Marker Score: 483
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.47
    Marker Score: 236
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 0.45
    Marker Score: 221
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.45
    Marker Score: 1,052
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.44
    Marker Score: 126
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 0.41
    Marker Score: 436
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.41
    Marker Score: 108
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.41
    Marker Score: 1,596
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.4
    Marker Score: 99
  • Cell Name: pre-conventional dendritic cell (CL0002010)
    Fold Change: 0.36
    Marker Score: 106
  • Cell Name: erythroid lineage cell (CL0000764)
    Fold Change: 0.36
    Marker Score: 177
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.35
    Marker Score: 91
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.35
    Marker Score: 125
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.35
    Marker Score: 823
  • Cell Name: late pro-B cell (CL0002048)
    Fold Change: 0.34
    Marker Score: 407
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 0.34
    Marker Score: 216
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 0.34
    Marker Score: 196
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.34
    Marker Score: 711
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.33
    Marker Score: 147
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.32
    Marker Score: 343
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.32
    Marker Score: 101
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.32
    Marker Score: 200
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: 0.31
    Marker Score: 204
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.3
    Marker Score: 140
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 0.29
    Marker Score: 277
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.28
    Marker Score: 663
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.28
    Marker Score: 766
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.28
    Marker Score: 191
  • Cell Name: group 3 innate lymphoid cell (CL0001071)
    Fold Change: 0.27
    Marker Score: 114
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.26
    Marker Score: 102
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.26
    Marker Score: 109
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.26
    Marker Score: 177
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.26
    Marker Score: 125
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.25
    Marker Score: 256
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.25
    Marker Score: 101
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.25
    Marker Score: 263
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.25
    Marker Score: 166
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.25
    Marker Score: 299
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.24
    Marker Score: 89
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.24
    Marker Score: 979
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.23
    Marker Score: 84
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 0.23
    Marker Score: 73
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 64
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.22
    Marker Score: 159
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 0.22
    Marker Score: 2,948
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 0.22
    Marker Score: 77
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.22
    Marker Score: 131
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 0.22
    Marker Score: 55
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 74
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.22
    Marker Score: 119

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** PKMYT1 is a membrane-associated tyrosine/threonine kinase that belongs to the cyclin-dependent kinase (CDK) inhibitor family. It is characterized by its ability to phosphorylate and inhibit the activity of CDKs, particularly Cdc2, which is a key regulator of the cell cycle. PKMYT1's specific substrate specificity and localization to the Golgi apparatus and endoplasmic reticulum membrane make it an unique enzyme with distinct characteristics. **Pathways and Functions** PKMYT1 is involved in several key pathways, including: 1. **Cell Cycle Regulation**: PKMYT1 regulates the G2/M transition by phosphorylating and inhibiting Cdc2, a key CDK that drives the cell cycle forward. 2. **DNA Replication**: PKMYT1 plays a role in DNA replication by regulating the activity of CDKs involved in the replication process. 3. **Mitotic Nuclear Division**: PKMYT1 is involved in the regulation of mitotic nuclear division by phosphorylating and inhibiting Cdc2, which is essential for the proper segregation of chromosomes. 4. **Cyclin-Dependent Kinase Regulation**: PKMYT1 regulates the activity of CDKs, including Cdc2, which is a key regulator of the cell cycle. **Clinical Significance** Dysregulation of PKMYT1 has been implicated in various diseases, including: 1. **Cancer**: Overexpression of PKMYT1 has been observed in certain types of cancer, including breast cancer and leukemia, where it may contribute to tumorigenesis. 2. **Neurological Disorders**: PKMYT1 has been implicated in the pathogenesis of neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease, where it may contribute to neuronal dysfunction. 3. **Immune System Disorders**: PKMYT1 has been shown to play a role in the regulation of immune cell function, and its dysregulation may contribute to immune system disorders, such as autoimmune diseases. In conclusion, PKMYT1 is an essential enzyme that plays a critical role in various cellular processes, including cell cycle regulation, DNA replication, and mitotic nuclear division. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into the functions and clinical significance of PKMYT1.

Genular Protein ID: 3188908206

Symbol: PMYT1_HUMAN

Name: Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase

UniProtKB Accession Codes:

Q99640 B3KUN8 B4DXD4 D3DUA4 F8W164 I3L1V2 O14731 Q7LE24 Q8TCM9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 4 CDD 1 CPTAC 1 CTD 1 ChEBI 14 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 DrugCentral 1 EC 3 ELM 1 EMBL 11 EPD 1 Ensembl 5 EvolutionaryTrace 1 ExpressionAtlas 1 GO 23 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 16 PDBsum 13 PIRSF 1 PRO 1 PROSITE 3 PROSITE-ProRule 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 Pumba 1 RNAct 1 Reactome 3 RefSeq 7 Rhea 6 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9268380

Title: Human Myt1 is a cell cycle-regulated kinase that inhibits Cdc2 but not Cdk2 activity.

PubMed ID: 9268380

DOI: 10.1074/jbc.272.35.22300

PubMed ID: 9001210

Title: The human Myt1 kinase preferentially phosphorylates Cdc2 on threonine 14 and localizes to the endoplasmic reticulum and Golgi complex.

PubMed ID: 9001210

DOI: 10.1128/mcb.17.2.571

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15616553

Title: The sequence and analysis of duplication-rich human chromosome 16.

PubMed ID: 15616553

DOI: 10.1038/nature03187

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 9499405

Title: The essential mitotic peptidyl-prolyl isomerase Pin1 binds and regulates mitosis-specific phosphoproteins.

PubMed ID: 9499405

DOI: 10.1101/gad.12.5.706

PubMed ID: 10504341

Title: The C-terminal domain of the Cdc2 inhibitory kinase Myt1 interacts with Cdc2 complexes and is required for inhibition of G(2)/M progression.

PubMed ID: 10504341

DOI: 10.1242/jcs.112.19.3361

PubMed ID: 10373560

Title: Overproduction of human Myt1 kinase induces a G2 cell cycle delay by interfering with the intracellular trafficking of Cdc2-cyclin B1 complexes.

PubMed ID: 10373560

DOI: 10.1128/mcb.19.7.5113

PubMed ID: 12738781

Title: Identification of a consensus motif for Plk (Polo-like kinase) phosphorylation reveals Myt1 as a Plk1 substrate.

PubMed ID: 12738781

DOI: 10.1074/jbc.c300126200

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

Sequence Information:

  • Length: 499
  • Mass: 54521
  • Checksum: 4DF28A5965265567
  • Sequence:
    • MLERPPALAM PMPTEGTPPP LSGTPIPVPA YFRHAEPGFS LKRPRGLSRS LPPPPPAKGS 
IPISRLFPPR TPGWHQLQPR RVSFRGEASE TLQSPGYDPS RPESFFQQSF QRLSRLGHGS 
YGEVFKVRSK EDGRLYAVKR SMSPFRGPKD RARKLAEVGS HEKVGQHPCC VRLEQAWEEG 
GILYLQTELC GPSLQQHCEA WGASLPEAQV WGYLRDTLLA LAHLHSQGLV HLDVKPANIF 
LGPRGRCKLG DFGLLVELGT AGAGEVQEGD PRYMAPELLQ GSYGTAADVF SLGLTILEVA 
CNMELPHGGE GWQQLRQGYL PPEFTAGLSS ELRSVLVMML EPDPKLRATA EALLALPVLR 
QPRAWGVLWC MAAEALSRGW ALWQALLALL CWLWHGLAHP ASWLQPLGPP ATPPGSPPCS 
LLLDSSLSSN WDDDSLGPSL SPEAVLARTV GSTSTPRSRC TPRDALDLSD INSEPPRGSF 
PSFEPRNLLS LFEDTLDPT

Genular Protein ID: 3280063731

Symbol: Q0IJ49_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q0IJ49

Database IDs:

ARBA 7 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 11 ChiTaRS 1 DNASU 1 EC 2 EMBL 4 GO 2 Gene3D 1 GenomeRNAi 1 IntAct 1 InterPro 4 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 4 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 1 RefSeq 1 Rhea 6 RuleBase 1 SAM 1 SMART 1 SMR 1 SUPFAM 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 485
  • Mass: 52906
  • Checksum: 968435E411F7B10A
  • Sequence:
    • MLERPPALAM PMPTEGTPPP LSGTPIPVPA YFRHAEPGFS LKRPRGLSRS LPPPPPAKGS 
IPISRLFPPR TPGWHQLQPR RVSFRGEASE TLQSPGYDPS RPESFFQQSF QRLSRLGHGS 
YGEVFKVRSK EDGRLYAVKR SMSPFRGPKD RARKLAEVGS HEKVGQHPCC VRLEQAWEEG 
GILYLQTELC GPSLQQHCEA WGASLPEAQV WGYLRDTLLA LAHLHSQGLV HLDVKPANIF 
LGPRGRCKLG DFGLLVELGT AGAGEVQEGD PRYMAPELLQ GSYGTAADVF SLGLTILEVA 
CNMELPHGGE GWQQLRQGYL PPEFTAGLSS ELRSVLVMML EPDPKLRATA EALLALPVLR 
QPRAWGVLWC MAAEALSRGW ALWQALLALL CWLWHGLAHP ASWLQPLGPP ATPPGSPPCS 
LLLDSSLSSN WDDDSLGPSL SPEAVLARTV GSTSTPRSRC TPRDALDLSD INSEPPRGSF 
PSFEP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.