CD1A | ENSG00000158477 | NCBI 909

Details for: CD1A

Gene ID: 909

Symbol: CD1A

Ensembl ID: ENSG00000158477

Description: CD1a molecule

Associated with

Adaptive immune system
(R-HSA-1280218)
Immune system
(R-HSA-168256)
Immunoregulatory interactions between a lymphoid and a non-lymphoid cell
(R-HSA-198933)
Adaptive immune response
(GO:0002250)
Antigen processing and presentation, endogenous lipid antigen via mhc class ib
(GO:0048006)
Antigen processing and presentation, exogenous lipid antigen via mhc class ib
(GO:0048007)
Endogenous lipid antigen binding
(GO:0030883)
Endosome membrane
(GO:0010008)
Exogenous lipid antigen binding
(GO:0030884)
External side of plasma membrane
(GO:0009897)
Extracellular space
(GO:0005615)
Immune response
(GO:0006955)
Lipopeptide binding
(GO:0071723)
Membrane raft
(GO:0045121)
Plasma membrane
(GO:0005886)
Positive regulation of t cell mediated cytotoxicity
(GO:0001916)
Protein binding
(GO:0005515)

Other Information

Proteins

T-cell surface glycoprotein CD1a

Genular Protein ID: 171542717

Symbol: CD1A_HUMAN

Name: T-cell surface glycoprotein CD1a

UniProtKB Accession Codes:

P06126 D3DVD7 Q13962 Q5TDJ8 Q9UMM4 Q9Y5M5

Database IDs:

Citations:

PubMed ID: 2701945

Title: Expression of cDNA clones encoding the thymocyte antigens CD1a, b, c demonstrates a hierarchy of exclusion in fibroblasts.

PubMed ID: 2701945

PubMed ID: 2447586

Title: Structure and expression of the human thymocyte antigens CD1a, CD1b, and CD1c.

PubMed ID: 2447586

DOI: 10.1073/pnas.84.24.9189

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 10488738

Title: Polymorphism of human CD1 genes.

PubMed ID: 10488738

DOI: 10.1034/j.1399-0039.1999.540202.x

PubMed ID: 2784820

Title: Molecular cloning of CD1a (T6), a human epidermal dendritic cell marker related to class I MHC molecules.

PubMed ID: 2784820

DOI: 10.1111/1523-1747.ep12712175

PubMed ID: 3093894

Title: A novel family of human major histocompatibility complex-related genes not mapping to chromosome 6.

PubMed ID: 3093894

DOI: 10.1038/323540a0

PubMed ID: 3097645

Title: Isolation of CD1 genes: a family of major histocompatibility complex-related differentiation antigens.

PubMed ID: 3097645

DOI: 10.1073/pnas.83.23.9154

PubMed ID: 11231314

Title: CD1a molecules traffic through the early recycling endosomal pathway in human Langerhans cells.

PubMed ID: 11231314

DOI: 10.1046/j.1523-1747.2001.01264.x

PubMed ID: 16272286

Title: CD1a-, b-, and c-restricted TCRs recognize both self and foreign antigens.

PubMed ID: 16272286

DOI: 10.4049/jimmunol.175.10.6344

PubMed ID: 18178838

Title: Regulation of CD1a surface expression and antigen presentation by invariant chain and lipid rafts.

PubMed ID: 18178838

DOI: 10.4049/jimmunol.180.2.980

PubMed ID: 12833155

Title: Crystal structure of CD1a in complex with a sulfatide self antigen at a resolution of 2.15 A.

PubMed ID: 12833155

DOI: 10.1038/ni948

PubMed ID: 15723809

Title: Molecular mechanism of lipopeptide presentation by CD1a.

PubMed ID: 15723809

DOI: 10.1016/j.immuni.2004.12.009

PubMed ID: 25642819

Title: alphabeta T cell antigen receptor recognition of CD1a presenting self lipid ligands.

PubMed ID: 25642819

DOI: 10.1038/ni.3098

PubMed ID: 11600221

Title: Structural characterization of two CD1A allelic variants.

PubMed ID: 11600221

DOI: 10.1016/s0198-8859(01)00314-7

Sequence Information:

Length: 327
Mass: 37077
Checksum: C575C3C538F0AA29
Sequence:

MLFLLLPLLA VLPGDGNADG LKEPLSFHVT WIASFYNHSW KQNLVSGWLS DLQTHTWDSN 
SSTIVFLCPW SRGNFSNEEW KELETLFRIR TIRSFEGIRR YAHELQFEYP FEIQVTGGCE 
LHSGKVSGSF LQLAYQGSDF VSFQNNSWLP YPVAGNMAKH FCKVLNQNQH ENDITHNLLS 
DTCPRFILGL LDAGKAHLQR QVKPEAWLSH GPSPGPGHLQ LVCHVSGFYP KPVWVMWMRG 
EQEQQGTQRG DILPSADGTW YLRATLEVAA GEAADLSCRV KHSSLEGQDI VLYWEHHSSV 
GFIILAVIVP LLLLIGLALW FRKRCFC

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: CD1A

Associated with

Other Information

Expression of cDNA clones encoding the thymocyte antigens CD1a, b, c demonstrates a hierarchy of exclusion in fibroblasts. PubMed ID: 2701945

Structure and expression of the human thymocyte antigens CD1a, CD1b, and CD1c. PubMed ID: 2447586

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence and biological annotation of human chromosome 1. PubMed ID: 16710414

Polymorphism of human CD1 genes. PubMed ID: 10488738

Molecular cloning of CD1a (T6), a human epidermal dendritic cell marker related to class I MHC molecules. PubMed ID: 2784820

A novel family of human major histocompatibility complex-related genes not mapping to chromosome 6. PubMed ID: 3093894

Isolation of CD1 genes: a family of major histocompatibility complex-related differentiation antigens. PubMed ID: 3097645

CD1a molecules traffic through the early recycling endosomal pathway in human Langerhans cells. PubMed ID: 11231314

CD1a-, b-, and c-restricted TCRs recognize both self and foreign antigens. PubMed ID: 16272286

Regulation of CD1a surface expression and antigen presentation by invariant chain and lipid rafts. PubMed ID: 18178838

Crystal structure of CD1a in complex with a sulfatide self antigen at a resolution of 2.15 A. PubMed ID: 12833155

Molecular mechanism of lipopeptide presentation by CD1a. PubMed ID: 15723809

alphabeta T cell antigen receptor recognition of CD1a presenting self lipid ligands. PubMed ID: 25642819

Structural characterization of two CD1A allelic variants. PubMed ID: 11600221