Details for: CD1A

Gene ID: 909

Symbol: CD1A

Ensembl ID: ENSG00000158477

Description: CD1a molecule

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.8196
    Cell Significance Index: 12.6800
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 0.4251
    Cell Significance Index: -0.9300
  • Cell Name: helper T cell (CL0000912)
    Fold Change: 0.2189
    Cell Significance Index: 3.1100
  • Cell Name: adipocyte (CL0000136)
    Fold Change: 0.0042
    Cell Significance Index: 0.0600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0001
    Cell Significance Index: -0.0700
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0003
    Cell Significance Index: -0.0100
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0013
    Cell Significance Index: -0.0500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0104
    Cell Significance Index: -19.5600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0125
    Cell Significance Index: -7.9400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0135
    Cell Significance Index: -1.5900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0207
    Cell Significance Index: -38.1600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0226
    Cell Significance Index: -17.1000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0251
    Cell Significance Index: -11.3700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0280
    Cell Significance Index: -38.0900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0322
    Cell Significance Index: -17.5800
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.0323
    Cell Significance Index: -0.3200
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0395
    Cell Significance Index: -0.4800
  • Cell Name: monocyte-derived dendritic cell (CL0011031)
    Fold Change: -0.0396
    Cell Significance Index: -0.6800
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0401
    Cell Significance Index: -0.4200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0418
    Cell Significance Index: -4.7900
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0510
    Cell Significance Index: -1.2700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0564
    Cell Significance Index: -1.5800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0696
    Cell Significance Index: -20.0300
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: -0.0727
    Cell Significance Index: -0.7200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0747
    Cell Significance Index: -7.6300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0789
    Cell Significance Index: -3.7100
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.0810
    Cell Significance Index: -0.6800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0843
    Cell Significance Index: -16.7200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.1046
    Cell Significance Index: -20.9900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1113
    Cell Significance Index: -5.1900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1304
    Cell Significance Index: -8.4200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.1313
    Cell Significance Index: -18.0300
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.1384
    Cell Significance Index: -1.5700
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.1812
    Cell Significance Index: -2.2900
  • Cell Name: basal-myoepithelial cell of mammary gland (CL0002324)
    Fold Change: -0.2166
    Cell Significance Index: -1.6000
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.2664
    Cell Significance Index: -5.2000
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: -0.3195
    Cell Significance Index: -3.7100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.3241
    Cell Significance Index: -8.6700
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.3323
    Cell Significance Index: -9.7600
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.3500
    Cell Significance Index: -4.7200
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.3535
    Cell Significance Index: -9.0300
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.4361
    Cell Significance Index: -5.9800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.4502
    Cell Significance Index: -12.0200
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.4591
    Cell Significance Index: -8.4900
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.4595
    Cell Significance Index: -11.1300
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.4698
    Cell Significance Index: -11.9700
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.4704
    Cell Significance Index: -10.3000
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: -0.4904
    Cell Significance Index: -1.1100
  • Cell Name: lung interstitial macrophage (CL4033043)
    Fold Change: -0.5418
    Cell Significance Index: -5.2200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.5933
    Cell Significance Index: -19.4300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.6029
    Cell Significance Index: -16.1600
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.6096
    Cell Significance Index: -10.4200
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.6162
    Cell Significance Index: -9.9800
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: -0.6244
    Cell Significance Index: -7.9000
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.6326
    Cell Significance Index: -7.8300
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.6392
    Cell Significance Index: -9.2800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.6397
    Cell Significance Index: -22.4100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.6606
    Cell Significance Index: -21.0400
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.6662
    Cell Significance Index: -13.0300
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.7208
    Cell Significance Index: -26.4600
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.7561
    Cell Significance Index: -8.7700
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.7571
    Cell Significance Index: -10.3000
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.7595
    Cell Significance Index: -8.7400
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.7622
    Cell Significance Index: -9.1400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.7713
    Cell Significance Index: -20.2800
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: -0.7772
    Cell Significance Index: -8.0500
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.8022
    Cell Significance Index: -8.3200
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.8073
    Cell Significance Index: -8.6800
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.8182
    Cell Significance Index: -9.6600
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: -0.8300
    Cell Significance Index: -7.0700
  • Cell Name: CD141-positive myeloid dendritic cell (CL0002394)
    Fold Change: -0.8527
    Cell Significance Index: -9.2200
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: -0.8528
    Cell Significance Index: -5.3400
  • Cell Name: kidney interstitial alternatively activated macrophage (CL1000695)
    Fold Change: -0.8559
    Cell Significance Index: -8.7500
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.8568
    Cell Significance Index: -21.4000
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: -0.8608
    Cell Significance Index: -8.9200
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.8795
    Cell Significance Index: -11.3800
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.8838
    Cell Significance Index: -5.3400
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: -0.8842
    Cell Significance Index: -8.8300
  • Cell Name: podocyte (CL0000653)
    Fold Change: -0.8857
    Cell Significance Index: -10.1600
  • Cell Name: plasmacytoid dendritic cell, human (CL0001058)
    Fold Change: -0.8911
    Cell Significance Index: -8.7900
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.8947
    Cell Significance Index: -8.4000
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: -0.8948
    Cell Significance Index: -8.1600
  • Cell Name: platelet (CL0000233)
    Fold Change: -0.8962
    Cell Significance Index: -9.2200
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: -0.8971
    Cell Significance Index: -9.2800
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.8981
    Cell Significance Index: -15.1100
  • Cell Name: granule cell (CL0000120)
    Fold Change: -0.9038
    Cell Significance Index: -10.2900
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: -0.9105
    Cell Significance Index: -10.3400
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.9124
    Cell Significance Index: -22.7600
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.9287
    Cell Significance Index: -11.9300
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: -0.9305
    Cell Significance Index: -10.3300
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.9344
    Cell Significance Index: -15.7400
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.9424
    Cell Significance Index: -9.5200
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.9470
    Cell Significance Index: -11.1900
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.9578
    Cell Significance Index: -13.9600
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.9585
    Cell Significance Index: -16.2800
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.9607
    Cell Significance Index: -10.6400
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -0.9620
    Cell Significance Index: -11.4200
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.9715
    Cell Significance Index: -20.9900
  • Cell Name: erythroblast (CL0000765)
    Fold Change: -0.9758
    Cell Significance Index: -11.6400
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.9779
    Cell Significance Index: -19.5000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** CD1A is a type I transmembrane glycoprotein that belongs to the CD1 family, which is characterized by their ability to present lipid antigens to T cells. CD1A is primarily expressed on the surface of myeloid dendritic cells (DCs), which are professional APCs that play a crucial role in initiating immune responses. CD1A is also found on thymocytes, alpha-beta T cells, and other immune cells, where it serves as a co-receptor for T cell activation. The CD1A molecule is composed of two extracellular domains and a transmembrane domain, which are linked by a single intracellular domain. **Pathways and Functions:** CD1A plays a crucial role in the presentation of lipid antigens to T cells through the major histocompatibility complex class I (MHC I) pathway. This process involves the binding of lipid antigens to CD1A, which then presents them to CD1-restricted T cells, such as alpha-beta T cells. CD1A also interacts with other molecules, including MHC I and CD4, to facilitate T cell activation and cytokine production. The CD1A molecule has been shown to bind to a variety of lipid antigens, including natural lipid antigens, such as sphingolipids and cholesterol, as well as synthetic lipid antigens, such as lipopeptides. The binding of lipid antigens to CD1A triggers a signaling cascade that activates T cells and promotes an immune response. **Clinical Significance:** CD1A has been implicated in various immune-related disorders, including multiple sclerosis, type 1 diabetes, and autoimmune hepatitis. In these conditions, CD1A is thought to play a role in the presentation of lipid antigens to autoreactive T cells, leading to the activation of immune responses against self-antigens. Furthermore, CD1A has been shown to be involved in the pathogenesis of infectious diseases, such as tuberculosis and leishmaniasis, where it plays a role in the presentation of lipid antigens to T cells and the activation of immune responses against pathogens. In addition, CD1A has been explored as a potential target for immunotherapy in cancer, where it is thought to play a role in the presentation of lipid antigens to T cells and the activation of immune responses against tumor cells. **Conclusion:** In conclusion, CD1A is a critical molecule that plays a key role in the presentation of lipid antigens to T cells and the activation of immune responses. Its dysregulation has been implicated in various immune-related disorders, and it has potential as a target for immunotherapy in cancer. Further research is needed to fully understand the mechanisms of CD1A and its role in the immune system, but its importance in the context of immune responses is clear.

Genular Protein ID: 171542717

Symbol: CD1A_HUMAN

Name: T-cell surface glycoprotein CD1a

UniProtKB Accession Codes:

P06126 D3DVD7 Q13962 Q5TDJ8 Q9UMM4 Q9Y5M5

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 3 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EMBL 15 Ensembl 1 EvolutionaryTrace 1 GO 13 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 15 PDBsum 15 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 2 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2701945

Title: Expression of cDNA clones encoding the thymocyte antigens CD1a, b, c demonstrates a hierarchy of exclusion in fibroblasts.

PubMed ID: 2701945

PubMed ID: 2447586

Title: Structure and expression of the human thymocyte antigens CD1a, CD1b, and CD1c.

PubMed ID: 2447586

DOI: 10.1073/pnas.84.24.9189

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 10488738

Title: Polymorphism of human CD1 genes.

PubMed ID: 10488738

DOI: 10.1034/j.1399-0039.1999.540202.x

PubMed ID: 2784820

Title: Molecular cloning of CD1a (T6), a human epidermal dendritic cell marker related to class I MHC molecules.

PubMed ID: 2784820

DOI: 10.1111/1523-1747.ep12712175

PubMed ID: 3093894

Title: A novel family of human major histocompatibility complex-related genes not mapping to chromosome 6.

PubMed ID: 3093894

DOI: 10.1038/323540a0

PubMed ID: 3097645

Title: Isolation of CD1 genes: a family of major histocompatibility complex-related differentiation antigens.

PubMed ID: 3097645

DOI: 10.1073/pnas.83.23.9154

PubMed ID: 11231314

Title: CD1a molecules traffic through the early recycling endosomal pathway in human Langerhans cells.

PubMed ID: 11231314

DOI: 10.1046/j.1523-1747.2001.01264.x

PubMed ID: 16272286

Title: CD1a-, b-, and c-restricted TCRs recognize both self and foreign antigens.

PubMed ID: 16272286

DOI: 10.4049/jimmunol.175.10.6344

PubMed ID: 18178838

Title: Regulation of CD1a surface expression and antigen presentation by invariant chain and lipid rafts.

PubMed ID: 18178838

DOI: 10.4049/jimmunol.180.2.980

PubMed ID: 12833155

Title: Crystal structure of CD1a in complex with a sulfatide self antigen at a resolution of 2.15 A.

PubMed ID: 12833155

DOI: 10.1038/ni948

PubMed ID: 15723809

Title: Molecular mechanism of lipopeptide presentation by CD1a.

PubMed ID: 15723809

DOI: 10.1016/j.immuni.2004.12.009

PubMed ID: 25642819

Title: alphabeta T cell antigen receptor recognition of CD1a presenting self lipid ligands.

PubMed ID: 25642819

DOI: 10.1038/ni.3098

PubMed ID: 11600221

Title: Structural characterization of two CD1A allelic variants.

PubMed ID: 11600221

DOI: 10.1016/s0198-8859(01)00314-7

Sequence Information:

  • Length: 327
  • Mass: 37077
  • Checksum: C575C3C538F0AA29
  • Sequence:
    • MLFLLLPLLA VLPGDGNADG LKEPLSFHVT WIASFYNHSW KQNLVSGWLS DLQTHTWDSN 
SSTIVFLCPW SRGNFSNEEW KELETLFRIR TIRSFEGIRR YAHELQFEYP FEIQVTGGCE 
LHSGKVSGSF LQLAYQGSDF VSFQNNSWLP YPVAGNMAKH FCKVLNQNQH ENDITHNLLS 
DTCPRFILGL LDAGKAHLQR QVKPEAWLSH GPSPGPGHLQ LVCHVSGFYP KPVWVMWMRG 
EQEQQGTQRG DILPSADGTW YLRATLEVAA GEAADLSCRV KHSSLEGQDI VLYWEHHSSV 
GFIILAVIVP LLLLIGLALW FRKRCFC

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.