Details for: CD1A

Gene ID: 909

Symbol: CD1A

Ensembl ID: ENSG00000158477

Description: CD1a molecule

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 10.63
    Marker Score: 20835
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 3.83
    Marker Score: 2897
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 2.47
    Marker Score: 3405
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 2.43
    Marker Score: 6306
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.16
    Marker Score: 7693
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 1.02
    Marker Score: 1445
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30409
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5355
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2742
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.9
    Marker Score: 1833
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5295
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.84
    Marker Score: 644
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1269
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 711
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.71
    Marker Score: 181
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.61
    Marker Score: 1156
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.59
    Marker Score: 474
  • Cell Name: B-2 B cell (CL0000822)
    Fold Change: 0.59
    Marker Score: 723
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.57
    Marker Score: 150
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.56
    Marker Score: 539
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.49
    Marker Score: 203
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.39
    Marker Score: 626
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.37
    Marker Score: 216
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.36
    Marker Score: 5689
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.31
    Marker Score: 324
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.29
    Marker Score: 176
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.27
    Marker Score: 1608
  • Cell Name: Langerhans cell (CL0000453)
    Fold Change: 0.26
    Marker Score: 79
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 0.24
    Marker Score: 214
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.24
    Marker Score: 150
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.23
    Marker Score: 131
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.22
    Marker Score: 118
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.21
    Marker Score: 99
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.2
    Marker Score: 195
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 0.2
    Marker Score: 199
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: 0.15
    Marker Score: 166
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.15
    Marker Score: 134
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 0.15
    Marker Score: 149
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.14
    Marker Score: 67
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.14
    Marker Score: 159
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.14
    Marker Score: 142
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.14
    Marker Score: 134
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.13
    Marker Score: 92
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.13
    Marker Score: 59
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 0.12
    Marker Score: 42
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.12
    Marker Score: 81.5
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 0.12
    Marker Score: 68
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: 0.11
    Marker Score: 66
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.11
    Marker Score: 266
  • Cell Name: mature B cell (CL0000785)
    Fold Change: 0.1
    Marker Score: 76
  • Cell Name: immature B cell (CL0000816)
    Fold Change: 0.1
    Marker Score: 67
  • Cell Name: B-1b B cell (CL0000821)
    Fold Change: 0.1
    Marker Score: 23
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.1
    Marker Score: 291
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.09
    Marker Score: 52
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.09
    Marker Score: 147.5
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 0.08
    Marker Score: 146
  • Cell Name: promonocyte (CL0000559)
    Fold Change: 0.08
    Marker Score: 52
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.08
    Marker Score: 47
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.08
    Marker Score: 40
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 0.08
    Marker Score: 53
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.08
    Marker Score: 54
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.08
    Marker Score: 50
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.07
    Marker Score: 19
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 0.07
    Marker Score: 299
  • Cell Name: centrocyte (CL0009111)
    Fold Change: 0.07
    Marker Score: 17
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 0.07
    Marker Score: 54
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.07
    Marker Score: 37
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.07
    Marker Score: 84
  • Cell Name: plasmacytoid dendritic cell, human (CL0001058)
    Fold Change: 0.07
    Marker Score: 18
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 0.07
    Marker Score: 17
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 0.07
    Marker Score: 132
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.07
    Marker Score: 21.5
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.07
    Marker Score: 73
  • Cell Name: colon macrophage (CL0009038)
    Fold Change: 0.07
    Marker Score: 18
  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 0.06
    Marker Score: 133
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 0.06
    Marker Score: 103
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: 0.06
    Marker Score: 142
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 0.06
    Marker Score: 62
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.06
    Marker Score: 130
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.06
    Marker Score: 3489
  • Cell Name: group 3 innate lymphoid cell (CL0001071)
    Fold Change: 0.06
    Marker Score: 26
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.06
    Marker Score: 101
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: 0.06
    Marker Score: 36
  • Cell Name: inflammatory macrophage (CL0000863)
    Fold Change: 0.06
    Marker Score: 18
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: 0.06
    Marker Score: 64
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.06
    Marker Score: 18
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.06
    Marker Score: 60
  • Cell Name: myelocyte (CL0002193)
    Fold Change: 0.06
    Marker Score: 24
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.05
    Marker Score: 67
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.05
    Marker Score: 16
  • Cell Name: myeloid dendritic cell, human (CL0001057)
    Fold Change: 0.05
    Marker Score: 18
  • Cell Name: epithelial cell of thymus (CL0002293)
    Fold Change: 0.05
    Marker Score: 16
  • Cell Name: ionocyte (CL0005006)
    Fold Change: 0.05
    Marker Score: 15
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.05
    Marker Score: 563
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 0.05
    Marker Score: 17
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.05
    Marker Score: 28
  • Cell Name: IgM plasma cell (CL0000986)
    Fold Change: 0.05
    Marker Score: 16
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.05
    Marker Score: 24
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 0.05
    Marker Score: 16

Hover over a box to see details here...

Hover over a box to see details here...

Hover over a box to see details here...

Other Information

**Key characteristics:** - CD1a is a type I glycoprotein, which are expressed on the surface of cells and are involved in cell-cell interactions. - It belongs to the MHC class I superfamily of cell surface glycoproteins. - CD1a is a transmembrane protein with a molecular weight of approximately 120 kDa. - It is expressed on the surface of both professional antigen-presenting cells (APCs) and non-APCs. - It is also expressed on activated T cells and B cells. **Pathways and functions:** - CD1a is involved in the adaptive immune response. - It is expressed on the surface of APCs, which are responsible for the presentation of antigens to T cells. - When an APC presents an antigen to a T cell, CD1a is recognized by the T cell, which then becomes activated. - CD1a also plays a role in the regulation of immune responses. - It is expressed on dendritic cells, which are cells that take up antigens from the environment and present them to T cells. - CD1a is also expressed on cancer cells, where it can facilitate the escape of cancer cells from immune surveillance. **Clinical significance:** - Mutations in the CD1a gene have been linked to several human diseases, including cancer, autoimmune disorders, and inflammatory diseases. - CD1a is a potential target for cancer immunotherapy, as it can be used to activate T cells and enhance the antitumor immune response. - Targeting CD1a signaling has been shown to be effective in preclinical models of cancer.

Genular Protein ID: 171542717

Symbol: CD1A_HUMAN

Name: T-cell surface glycoprotein CD1a

UniProtKB Accession Codes:

P06126 D3DVD7 Q13962 Q5TDJ8 Q9UMM4 Q9Y5M5

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 3 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EMBL 15 Ensembl 1 EvolutionaryTrace 1 GO 13 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 21 PDBsum 15 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 2 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2701945

Title: Expression of cDNA clones encoding the thymocyte antigens CD1a, b, c demonstrates a hierarchy of exclusion in fibroblasts.

PubMed ID: 2701945

PubMed ID: 2447586

Title: Structure and expression of the human thymocyte antigens CD1a, CD1b, and CD1c.

PubMed ID: 2447586

DOI: 10.1073/pnas.84.24.9189

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 10488738

Title: Polymorphism of human CD1 genes.

PubMed ID: 10488738

DOI: 10.1034/j.1399-0039.1999.540202.x

PubMed ID: 2784820

Title: Molecular cloning of CD1a (T6), a human epidermal dendritic cell marker related to class I MHC molecules.

PubMed ID: 2784820

DOI: 10.1111/1523-1747.ep12712175

PubMed ID: 3093894

Title: A novel family of human major histocompatibility complex-related genes not mapping to chromosome 6.

PubMed ID: 3093894

DOI: 10.1038/323540a0

PubMed ID: 3097645

Title: Isolation of CD1 genes: a family of major histocompatibility complex-related differentiation antigens.

PubMed ID: 3097645

DOI: 10.1073/pnas.83.23.9154

PubMed ID: 11231314

Title: CD1a molecules traffic through the early recycling endosomal pathway in human Langerhans cells.

PubMed ID: 11231314

DOI: 10.1046/j.1523-1747.2001.01264.x

PubMed ID: 16272286

Title: CD1a-, b-, and c-restricted TCRs recognize both self and foreign antigens.

PubMed ID: 16272286

DOI: 10.4049/jimmunol.175.10.6344

PubMed ID: 18178838

Title: Regulation of CD1a surface expression and antigen presentation by invariant chain and lipid rafts.

PubMed ID: 18178838

DOI: 10.4049/jimmunol.180.2.980

PubMed ID: 12833155

Title: Crystal structure of CD1a in complex with a sulfatide self antigen at a resolution of 2.15 A.

PubMed ID: 12833155

DOI: 10.1038/ni948

PubMed ID: 15723809

Title: Molecular mechanism of lipopeptide presentation by CD1a.

PubMed ID: 15723809

DOI: 10.1016/j.immuni.2004.12.009

PubMed ID: 25642819

Title: alphabeta T cell antigen receptor recognition of CD1a presenting self lipid ligands.

PubMed ID: 25642819

DOI: 10.1038/ni.3098

PubMed ID: 11600221

Title: Structural characterization of two CD1A allelic variants.

PubMed ID: 11600221

DOI: 10.1016/s0198-8859(01)00314-7

Sequence Information:

  • Length: 327
  • Mass: 37077
  • Checksum: C575C3C538F0AA29
  • Sequence:
    • MLFLLLPLLA VLPGDGNADG LKEPLSFHVT WIASFYNHSW KQNLVSGWLS DLQTHTWDSN 
SSTIVFLCPW SRGNFSNEEW KELETLFRIR TIRSFEGIRR YAHELQFEYP FEIQVTGGCE 
LHSGKVSGSF LQLAYQGSDF VSFQNNSWLP YPVAGNMAKH FCKVLNQNQH ENDITHNLLS 
DTCPRFILGL LDAGKAHLQR QVKPEAWLSH GPSPGPGHLQ LVCHVSGFYP KPVWVMWMRG 
EQEQQGTQRG DILPSADGTW YLRATLEVAA GEAADLSCRV KHSSLEGQDI VLYWEHHSSV 
GFIILAVIVP LLLLIGLALW FRKRCFC

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.