Details for: DNAJA3

Gene ID: 9093

Symbol: DNAJA3

Ensembl ID: ENSG00000103423

Description: DnaJ heat shock protein family (Hsp40) member A3

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 168,137
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 1.15
    Marker Score: 920
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.13
    Marker Score: 1,743
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 1.12
    Marker Score: 1,605
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.1
    Marker Score: 11,340
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.06
    Marker Score: 4,172
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,703
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47,925
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.99
    Marker Score: 9,364
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.99
    Marker Score: 1,236
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.98
    Marker Score: 60,552
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,393
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.96
    Marker Score: 8,285
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2,396
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.94
    Marker Score: 8,851
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.94
    Marker Score: 704
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.93
    Marker Score: 631
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.92
    Marker Score: 475
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.92
    Marker Score: 33,949
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.91
    Marker Score: 5,216
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.91
    Marker Score: 431
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.9
    Marker Score: 2,700
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 0.89
    Marker Score: 19,883
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.88
    Marker Score: 367
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,293
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.87
    Marker Score: 963
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 0.86
    Marker Score: 3,061
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.85
    Marker Score: 306
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.82
    Marker Score: 932
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.81
    Marker Score: 869
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.78
    Marker Score: 3,024
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.78
    Marker Score: 389
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.78
    Marker Score: 379
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.78
    Marker Score: 717
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.78
    Marker Score: 312
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.78
    Marker Score: 1,708
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,263
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.76
    Marker Score: 583
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.76
    Marker Score: 3,187
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.76
    Marker Score: 440
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.74
    Marker Score: 1,756
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.74
    Marker Score: 983
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.73
    Marker Score: 200
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.72
    Marker Score: 27,427
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 0.72
    Marker Score: 753
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.72
    Marker Score: 372
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.71
    Marker Score: 1,440
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.69
    Marker Score: 894
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.69
    Marker Score: 2,859
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.68
    Marker Score: 2,858
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.68
    Marker Score: 13,460
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.67
    Marker Score: 11,932
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.67
    Marker Score: 458
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.67
    Marker Score: 705
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.67
    Marker Score: 171
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.67
    Marker Score: 165
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.67
    Marker Score: 427
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.66
    Marker Score: 2,702
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.66
    Marker Score: 605
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 0.66
    Marker Score: 248
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.65
    Marker Score: 964
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.65
    Marker Score: 435
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 0.64
    Marker Score: 1,752
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.64
    Marker Score: 224
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.64
    Marker Score: 9,602
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.64
    Marker Score: 183
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.63
    Marker Score: 396
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.63
    Marker Score: 4,061
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.63
    Marker Score: 664
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.63
    Marker Score: 183
  • Cell Name: Unknown (CL0002371)
    Fold Change: 0.62
    Marker Score: 663
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.62
    Marker Score: 2,527
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.62
    Marker Score: 251
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.61
    Marker Score: 135
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.61
    Marker Score: 1,656
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 0.61
    Marker Score: 147
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.6
    Marker Score: 399
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.6
    Marker Score: 4,621
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 0.6
    Marker Score: 1,884
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.6
    Marker Score: 1,244
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 0.59
    Marker Score: 7,973
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.59
    Marker Score: 432
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.59
    Marker Score: 1,588
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.59
    Marker Score: 586
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 0.59
    Marker Score: 125
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 0.59
    Marker Score: 408
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 0.59
    Marker Score: 2,886
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 0.59
    Marker Score: 2,532
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.58
    Marker Score: 308
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.58
    Marker Score: 390
  • Cell Name: fat cell (CL0000136)
    Fold Change: 0.58
    Marker Score: 326
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 0.58
    Marker Score: 284
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.57
    Marker Score: 137
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.57
    Marker Score: 615
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.57
    Marker Score: 151
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.57
    Marker Score: 332
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 0.57
    Marker Score: 617
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.57
    Marker Score: 506
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.57
    Marker Score: 1,679
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 0.57
    Marker Score: 4,212

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** DNAJA3 exhibits several key characteristics that enable it to perform its functions: 1. **Mitochondrial localization**: DNAJA3 is primarily localized to the mitochondrial matrix, where it interacts with other mitochondrial proteins to regulate mitochondrial function. 2. **GTPase regulator activity**: DNAJA3 interacts with small GTPases, regulating their activity and modulating various cellular processes. 3. **Heat shock protein function**: As a member of the Hsp40 family, DNAJA3 assists in the proper folding of other proteins, protecting them from heat-induced stress and protein misfolding. 4. **Cell cycle regulation**: DNAJA3 is involved in the regulation of cell cycle progression, particularly in the negative regulation of cell population proliferation. 5. **Apoptosis regulation**: DNAJA3 also plays a role in the negative regulation of apoptotic processes, preventing excessive cell death. **Pathways and Functions** DNAJA3 is involved in several key cellular pathways, including: 1. **Mitochondrial DNA replication**: DNAJA3 regulates mitochondrial DNA replication, ensuring the proper maintenance of mitochondrial function. 2. **Cellular senescence**: DNAJA3 is involved in the regulation of cellular senescence, a process where cells become dormant in response to stress. 3. **Actin filament regulation**: DNAJA3 interacts with actin filaments, regulating their dynamics and cytoskeletal organization. 4. **Neurotransmitter release**: In neurons, DNAJA3 is involved in the regulation of neurotransmitter release, particularly in the clustering of acetylcholine-gated channels. 5. **Immune cell regulation**: DNAJA3 is expressed in immune cells, where it regulates T cell proliferation and apoptosis. **Clinical Significance** The dysregulation of DNAJA3 has been implicated in various diseases, including: 1. **Neurodegenerative disorders**: Mutations in DNAJA3 have been linked to neurodegenerative diseases, such as amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). 2. **Cancer**: DNAJA3 is often downregulated in cancer cells, suggesting its role in tumor suppression. 3. **Autoimmune diseases**: Alterations in DNAJA3 expression have been observed in autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis. 4. **Mitochondrial disorders**: DNAJA3 mutations can cause mitochondrial disorders, characterized by impaired energy metabolism and organ dysfunction. In summary, DNAJA3 is a multifunctional protein that plays a crucial role in maintaining cellular homeostasis, particularly in the regulation of mitochondrial function, protein folding, and apoptosis. Its dysregulation has been implicated in various diseases, highlighting the importance of understanding its mechanisms of action.

Genular Protein ID: 1701150643

Symbol: DNJA3_HUMAN

Name: DnaJ homolog subfamily A member 3, mitochondrial

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 9683573

Title: A novel human DnaJ protein, hTid-1, a homolog of the Drosophila tumor suppressor protein Tid56, can interact with the human papillomavirus type 16 E7 oncoprotein.

PubMed ID: 9683573

DOI: 10.1006/viro.1998.9220

PubMed ID: 11679576

Title: hTid-1, a human DnaJ protein, modulates the interferon signaling pathway.

PubMed ID: 11679576

DOI: 10.1074/jbc.m103683200

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15616553

Title: The sequence and analysis of duplication-rich human chromosome 16.

PubMed ID: 15616553

DOI: 10.1038/nature03187

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12097419

Title: Large scale identification of human hepatocellular carcinoma-associated antigens by autoantibodies.

PubMed ID: 12097419

DOI: 10.4049/jimmunol.169.2.1102

PubMed ID: 10411904

Title: TID1, a human homolog of the Drosophila tumor suppressor l(2)tid, encodes two mitochondrial modulators of apoptosis with opposing functions.

PubMed ID: 10411904

DOI: 10.1073/pnas.96.15.8499

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 23455924

Title: A Y2H-seq approach defines the human protein methyltransferase interactome.

PubMed ID: 23455924

DOI: 10.1038/nmeth.2397

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

Sequence Information:

  • Length: 480
  • Mass: 52489
  • Checksum: 5A57B9020992CF59
  • Sequence:
  • MAARCSTRWL LVVVGTPRLP AISGRGARPP REGVVGAWLS RKLSVPAFAS SLTSCGPRAL 
    LTLRPGVSLT GTKHNPFICT ASFHTSAPLA KEDYYQILGV PRNASQKEIK KAYYQLAKKY 
    HPDTNKDDPK AKEKFSQLAE AYEVLSDEVK RKQYDAYGSA GFDPGASGSQ HSYWKGGPTV 
    DPEELFRKIF GEFSSSSFGD FQTVFDQPQE YFMELTFNQA AKGVNKEFTV NIMDTCERCN 
    GKGNEPGTKV QHCHYCGGSG METINTGPFV MRSTCRRCGG RGSIIISPCV VCRGAGQAKQ 
    KKRVMIPVPA GVEDGQTVRM PVGKREIFIT FRVQKSPVFR RDGADIHSDL FISIAQALLG 
    GTARAQGLYE TINVTIPPGT QTDQKIRMGG KGIPRINSYG YGDHYIHIKI RVPKRLTSRQ 
    QSLILSYAED ETDVEGTVNG VTLTSSGGST MDSSAGSKAR REAGEDEEGF LSKLKKMFTS

Genular Protein ID: 2944926533

Symbol: B3KM81_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

Sequence Information:

  • Length: 453
  • Mass: 49583
  • Checksum: DEE8850F767165CC
  • Sequence:
  • MAARCSTRWL LVVVGTPRLP AISGRGARPP REGVVGAWLS RKLSVPAFAS SLTSCGPRAL 
    LTLRPGVSLT GTKHNPFICT ASFHTSAPLA KEDYYQILGV PQNASQKEIK KAYYQLAKKY 
    HPDTNKDDPK AKEKFSQLAE AYEVLSDEVK RKQYDAYGSA GFDPGASGSQ HSYWKGGPTV 
    DPEELFRKIF GEFSSSSFGD FQTVFDQPQE YFMELTFNQA AKGVNKEFTV NIMDTCERCN 
    GKGNEPGTKV QHCHYCGGSG METINTGPFV MRSTCRRCGG RGSIIISPCV VCRGAGQAKQ 
    KKRVMIPVPA GVEDGQTVRM PVGKREIFIT FRVQKSPVFR RDGADIHSDL FISIAQALLG 
    GTARAQGLYE TINVTIPPGT QTDQKIRMGG KGIPRINSYG YGDHYIHIKI RVPKRLTSRQ 
    QSLILSYAED ETDVEGTVNG VTLTSSGKRS TGN

Genular Protein ID: 1784436229

Symbol: Q59E88_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 478
  • Mass: 52286
  • Checksum: F79D9A5FC3B18DD9
  • Sequence:
  • ARCSTRWLLV VVGTPRLPAI SGRGARPPRE GVVGAWLSRK LSVPAFASSL TSCGPRALLT 
    LRPGVSLTGT KHNPFICTAS FHTSAPLAKE DYYQILGVPR NASQKEIKKA YYQLAKKYHP 
    DTNKDDPKAK EKFSQLAEAY EVLSDEVKRK QYDAYGSAGF DPGASGSQHS YWKGGPTVDP 
    EELFRKIFGE FSSSSFGDFQ TVFDQPQEYF MELTFNQAAK GVNKEFTVNI MDTCERCNGK 
    GNEPGTKVQH CHYCGGSGME TINTGPFVMR STCRRCGGRG SIIISPCVVC RGAGQAKQKK 
    RVMIPVPAGV EDGQTVRMPV GKREIFITFR VQKSPVFRRD GADIHSDLFI SIAQALLGGT 
    ARAQGLYETI NVTIPPGTQT DQKIRMGGKG IPRINSYGYG DHYIHIKIRV PKRLTSRQQS 
    LILSYAEDET DVEGTVNGVT LTSSGGSTMD SSAGSKARRE AGEDEEGFLS KLKKMFTS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.