Details for: UNC119

Gene ID: 9094

Symbol: UNC119

Ensembl ID: ENSG00000109103

Description: unc-119 lipid binding chaperone

Associated with

Other Information

Genular Protein ID: 1399735832

Symbol: U119A_HUMAN

Name: Protein unc-119 homolog A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 8576185

Title: Cloning of the cDNA for a novel photoreceptor protein.

PubMed ID: 8576185

DOI: 10.1074/jbc.271.3.1797

PubMed ID: 9761287

Title: Mammalian orthologs of C. elegans unc-119 highly expressed in photoreceptors.

PubMed ID: 9761287

PubMed ID: 10329014

Title: Characterization of the gene for HRG4 (UNC119), a novel photoreceptor synaptic protein homologous to unc-119.

PubMed ID: 10329014

DOI: 10.1006/geno.1999.5791

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 21697133

Title: Full-length transcriptome analysis of human retina-derived cell lines ARPE-19 and Y79 using the vector-capping method.

PubMed ID: 21697133

DOI: 10.1167/iovs.11-7479

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11303027

Title: ADP-ribosylation factors (ARFs) and ARF-like 1 (ARL1) have both specific and shared effectors: characterizing ARL1-binding proteins.

PubMed ID: 11303027

DOI: 10.1074/jbc.m102359200

PubMed ID: 12496276

Title: Identification of UNC119 as a novel activator of SRC-type tyrosine kinases.

PubMed ID: 12496276

DOI: 10.1074/jbc.m208261200

PubMed ID: 14757743

Title: Unc119, a novel activator of Lck/Fyn, is essential for T cell activation.

PubMed ID: 14757743

DOI: 10.1084/jem.20030589

PubMed ID: 18588884

Title: Specificity of Arl2/Arl3 signaling is mediated by a ternary Arl3-effector-GAP complex.

PubMed ID: 18588884

DOI: 10.1016/j.febslet.2008.05.053

PubMed ID: 19381274

Title: Unc119 protects from Shigella infection by inhibiting the Abl family kinases.

PubMed ID: 19381274

DOI: 10.1371/journal.pone.0005211

PubMed ID: 22085962

Title: An ARL3-UNC119-RP2 GTPase cycle targets myristoylated NPHP3 to the primary cilium.

PubMed ID: 22085962

DOI: 10.1101/gad.173443.111

PubMed ID: 23535298

Title: UNC119a bridges the transmission of Fyn signals to Rab11, leading to the completion of cytokinesis.

PubMed ID: 23535298

DOI: 10.4161/cc.24404

PubMed ID: 30945270

Title: Whole-exome sequencing identified ARL2 as a novel candidate gene for MRCS (microcornea, rod-cone dystrophy, cataract, and posterior staphyloma) syndrome.

PubMed ID: 30945270

DOI: 10.1111/cge.13541

PubMed ID: 31696965

Title: Cul3-Klhl18 ubiquitin ligase modulates rod transducin translocation during light-dark adaptation.

PubMed ID: 31696965

DOI: 10.15252/embj.2018101409

PubMed ID: 21642972

Title: UNC119 is required for G protein trafficking in sensory neurons.

PubMed ID: 21642972

DOI: 10.1038/nn.2835

PubMed ID: 22960633

Title: Structural basis for Arl3-specific release of myristoylated ciliary cargo from UNC119.

PubMed ID: 22960633

DOI: 10.1038/emboj.2012.257

PubMed ID: 11006213

Title: HRG4 (UNC119) mutation found in cone-rod dystrophy causes retinal degeneration in a transgenic model.

PubMed ID: 11006213

PubMed ID: 22184408

Title: A mutation in the human Uncoordinated 119 gene impairs TCR signaling and is associated with CD4 lymphopenia.

PubMed ID: 22184408

DOI: 10.1182/blood-2011-04-350686

PubMed ID: 35947183

Title: Clinical-genetic findings in a group of subjects with macular dystrophies due to mutations in rare inherited retinopathy genes.

PubMed ID: 35947183

DOI: 10.1007/s00417-022-05786-4

Sequence Information:

  • Length: 240
  • Mass: 26962
  • Checksum: 22FD19C3518A4446
  • Sequence:
  • MKVKKGGGGA GTATESAPGP SGQSVAPIPQ PPAESESGSE SEPDAGPGPR PGPLQRKQPI 
    GPEDVLGLQR ITGDYLCSPE ENIYKIDFVR FKIRDMDSGT VLFEIKKPPV SERLPINRRD 
    LDPNAGRFVR YQFTPAFLRL RQVGATVEFT VGDKPVNNFR MIERHYFRNQ LLKSFDFHFG 
    FCIPSSKNTC EHIYDFPPLS EELISEMIRH PYETQSDSFY FVDDRLVMHN KADYSYSGTP

Genular Protein ID: 2662131016

Symbol: K7EN86_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

Sequence Information:

  • Length: 145
  • Mass: 17081
  • Checksum: 4B3DE6DECB9D7793
  • Sequence:
  • MDSGTVLFEI KKPPVSERLP INRRDLDPNA GRFVRYQFTP AFLRLRQVGA TVEFTVGDKP 
    VNNFRMIERH YFRNQLLKSF DFHFGFCIPS SKNTCEHIYD FPPLSEELIS EMIRHPYETQ 
    SDSFYFVDDR LVMHNKADYS YSGTP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.