Details for: UNC119

Gene ID: 9094

Symbol: UNC119

Ensembl ID: ENSG00000109103

Description: unc-119 lipid binding chaperone

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 4.15
    Marker Score: 11,828
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: 3.29
    Marker Score: 2,000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 2.76
    Marker Score: 823
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 2.71
    Marker Score: 1,915
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 2.15
    Marker Score: 1,719
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 2.08
    Marker Score: 1,085
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 1.89
    Marker Score: 3,843
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 1.75
    Marker Score: 512
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 1.59
    Marker Score: 3,096
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.52
    Marker Score: 5,619
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.43
    Marker Score: 1,733
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 1.37
    Marker Score: 1,713
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.31
    Marker Score: 8,363
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 1.28
    Marker Score: 16,948
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 1.27
    Marker Score: 1,199
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 1.21
    Marker Score: 2,110
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 1.19
    Marker Score: 2,966
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 1.17
    Marker Score: 1,415
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 1.16
    Marker Score: 2,452
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: 1.16
    Marker Score: 1,391
  • Cell Name: Unknown (CL0002371)
    Fold Change: 1.14
    Marker Score: 1,215
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.12
    Marker Score: 62,836
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 1.11
    Marker Score: 2,310
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 1.06
    Marker Score: 639
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 1.04
    Marker Score: 4,348
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 1.03
    Marker Score: 1,752
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,697
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47,920
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.99
    Marker Score: 6,423
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 0.99
    Marker Score: 4,092
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.98
    Marker Score: 983
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,390
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.97
    Marker Score: 671
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 0.97
    Marker Score: 988
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 0.97
    Marker Score: 2,338
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 0.96
    Marker Score: 339
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2,393
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.93
    Marker Score: 621
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.93
    Marker Score: 511
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.93
    Marker Score: 478
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.93
    Marker Score: 1,431
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.92
    Marker Score: 435
  • Cell Name: B-1b B cell (CL0000821)
    Fold Change: 0.92
    Marker Score: 211
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.91
    Marker Score: 9,115
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 0.9
    Marker Score: 849
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.9
    Marker Score: 2,698
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.9
    Marker Score: 2,110
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.89
    Marker Score: 257
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.89
    Marker Score: 5,062
  • Cell Name: mature B cell (CL0000785)
    Fold Change: 0.89
    Marker Score: 650
  • Cell Name: immature B cell (CL0000816)
    Fold Change: 0.88
    Marker Score: 586
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 0.88
    Marker Score: 305
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.87
    Marker Score: 8,842
  • Cell Name: centrocyte (CL0009111)
    Fold Change: 0.87
    Marker Score: 207
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,271
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 0.87
    Marker Score: 11,663
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.86
    Marker Score: 308
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.85
    Marker Score: 1,402
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.85
    Marker Score: 199
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.83
    Marker Score: 28,909
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.83
    Marker Score: 875
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 0.82
    Marker Score: 458
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 0.82
    Marker Score: 478
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.81
    Marker Score: 2,397
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 0.81
    Marker Score: 611
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.79
    Marker Score: 383
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.79
    Marker Score: 394
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 0.79
    Marker Score: 317
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.79
    Marker Score: 315
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.79
    Marker Score: 600
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,265
  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 0.78
    Marker Score: 1,632
  • Cell Name: epithelial cell of glomerular capsule (CL1000450)
    Fold Change: 0.76
    Marker Score: 195
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 0.75
    Marker Score: 742
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.74
    Marker Score: 1,089
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.73
    Marker Score: 734
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.73
    Marker Score: 1,047
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.73
    Marker Score: 483
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.72
    Marker Score: 374
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.72
    Marker Score: 778
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.72
    Marker Score: 867
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.71
    Marker Score: 457
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.71
    Marker Score: 652
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.71
    Marker Score: 143
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 0.71
    Marker Score: 5,252
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.7
    Marker Score: 1,916
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 0.7
    Marker Score: 243
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 0.7
    Marker Score: 621
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.69
    Marker Score: 2,725
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.69
    Marker Score: 2,891
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.69
    Marker Score: 583
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.68
    Marker Score: 760
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.68
    Marker Score: 271
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.67
    Marker Score: 614
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 0.67
    Marker Score: 226
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.67
    Marker Score: 172
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 0.67
    Marker Score: 230
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.66
    Marker Score: 276
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.65
    Marker Score: 351
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 0.65
    Marker Score: 1,904

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Lipid Binding Chaperone:** UNC119 acts as a lipid binding chaperone, ensuring the proper folding and transport of lipids within cells. 2. **Endocytosis Regulation:** UNC119 negatively regulates caveolin-mediated and clathrin-dependent endocytosis, which is critical for maintaining cellular homeostasis. 3. **Cellular Localization:** UNC119 is highly expressed in cells of the nervous system, immune cells, and epithelial cells, suggesting its involvement in multiple physiological and pathological processes. 4. **Protein Binding:** UNC119 interacts with various proteins, including protein tyrosine kinases, caveolins, and clathrins, to regulate lipid binding and endocytosis. **Pathways and Functions:** 1. **Centrosome and Mitotic Cytokinesis:** UNC119 regulates centrosome formation and mitotic cytokinesis, ensuring proper cell division and maintaining cellular homeostasis. 2. **Chemical Synaptic Transmission:** UNC119 modulates chemical synaptic transmission, which is critical for neuronal communication and learning. 3. **Cytosol and Lipid Binding:** UNC119 facilitates lipid binding and transport within the cytosol, which is essential for maintaining cellular homeostasis. 4. **Negative Regulation of Endocytosis:** UNC119 negatively regulates caveolin-mediated and clathrin-dependent endocytosis, which is critical for maintaining cellular homeostasis. **Clinical Significance:** 1. **Neurological Disorders:** UNC119 dysregulation has been implicated in various neurological disorders, including Alzheimer's disease, Parkinson's disease, and retinitis pigmentosa. 2. **Immunological Disorders:** UNC119 dysregulation is also associated with immunological disorders, such as autoimmune diseases and allergic responses. 3. **Cancer:** UNC119 dysregulation has been implicated in cancer development and progression, particularly in epithelial cells. 4. **Visual Perception:** UNC119 plays a critical role in visual perception, particularly in retinal rod cells and photoreceptor cells. In conclusion, the UNC119 gene is a critical regulator of lipid binding and cellular processes, with implications for various physiological and pathological processes. Further research is necessary to fully understand the mechanisms by which UNC119 regulates cellular homeostasis and to explore its potential as a therapeutic target for various diseases.

Genular Protein ID: 1399735832

Symbol: U119A_HUMAN

Name: Protein unc-119 homolog A

UniProtKB Accession Codes:

Q13432 A8K8G4 F1T095 O95126

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChEBI 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 10 EPD 1 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 17 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 5 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PDB 9 PDBsum 7 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 RefSeq 3 SAM 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8576185

Title: Cloning of the cDNA for a novel photoreceptor protein.

PubMed ID: 8576185

DOI: 10.1074/jbc.271.3.1797

PubMed ID: 9761287

Title: Mammalian orthologs of C. elegans unc-119 highly expressed in photoreceptors.

PubMed ID: 9761287

PubMed ID: 10329014

Title: Characterization of the gene for HRG4 (UNC119), a novel photoreceptor synaptic protein homologous to unc-119.

PubMed ID: 10329014

DOI: 10.1006/geno.1999.5791

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 21697133

Title: Full-length transcriptome analysis of human retina-derived cell lines ARPE-19 and Y79 using the vector-capping method.

PubMed ID: 21697133

DOI: 10.1167/iovs.11-7479

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11303027

Title: ADP-ribosylation factors (ARFs) and ARF-like 1 (ARL1) have both specific and shared effectors: characterizing ARL1-binding proteins.

PubMed ID: 11303027

DOI: 10.1074/jbc.m102359200

PubMed ID: 12496276

Title: Identification of UNC119 as a novel activator of SRC-type tyrosine kinases.

PubMed ID: 12496276

DOI: 10.1074/jbc.m208261200

PubMed ID: 14757743

Title: Unc119, a novel activator of Lck/Fyn, is essential for T cell activation.

PubMed ID: 14757743

DOI: 10.1084/jem.20030589

PubMed ID: 18588884

Title: Specificity of Arl2/Arl3 signaling is mediated by a ternary Arl3-effector-GAP complex.

PubMed ID: 18588884

DOI: 10.1016/j.febslet.2008.05.053

PubMed ID: 19381274

Title: Unc119 protects from Shigella infection by inhibiting the Abl family kinases.

PubMed ID: 19381274

DOI: 10.1371/journal.pone.0005211

PubMed ID: 22085962

Title: An ARL3-UNC119-RP2 GTPase cycle targets myristoylated NPHP3 to the primary cilium.

PubMed ID: 22085962

DOI: 10.1101/gad.173443.111

PubMed ID: 23535298

Title: UNC119a bridges the transmission of Fyn signals to Rab11, leading to the completion of cytokinesis.

PubMed ID: 23535298

DOI: 10.4161/cc.24404

PubMed ID: 30945270

Title: Whole-exome sequencing identified ARL2 as a novel candidate gene for MRCS (microcornea, rod-cone dystrophy, cataract, and posterior staphyloma) syndrome.

PubMed ID: 30945270

DOI: 10.1111/cge.13541

PubMed ID: 31696965

Title: Cul3-Klhl18 ubiquitin ligase modulates rod transducin translocation during light-dark adaptation.

PubMed ID: 31696965

DOI: 10.15252/embj.2018101409

PubMed ID: 21642972

Title: UNC119 is required for G protein trafficking in sensory neurons.

PubMed ID: 21642972

DOI: 10.1038/nn.2835

PubMed ID: 22960633

Title: Structural basis for Arl3-specific release of myristoylated ciliary cargo from UNC119.

PubMed ID: 22960633

DOI: 10.1038/emboj.2012.257

PubMed ID: 11006213

Title: HRG4 (UNC119) mutation found in cone-rod dystrophy causes retinal degeneration in a transgenic model.

PubMed ID: 11006213

PubMed ID: 22184408

Title: A mutation in the human Uncoordinated 119 gene impairs TCR signaling and is associated with CD4 lymphopenia.

PubMed ID: 22184408

DOI: 10.1182/blood-2011-04-350686

PubMed ID: 35947183

Title: Clinical-genetic findings in a group of subjects with macular dystrophies due to mutations in rare inherited retinopathy genes.

PubMed ID: 35947183

DOI: 10.1007/s00417-022-05786-4

Sequence Information:

  • Length: 240
  • Mass: 26962
  • Checksum: 22FD19C3518A4446
  • Sequence:
    • MKVKKGGGGA GTATESAPGP SGQSVAPIPQ PPAESESGSE SEPDAGPGPR PGPLQRKQPI 
GPEDVLGLQR ITGDYLCSPE ENIYKIDFVR FKIRDMDSGT VLFEIKKPPV SERLPINRRD 
LDPNAGRFVR YQFTPAFLRL RQVGATVEFT VGDKPVNNFR MIERHYFRNQ LLKSFDFHFG 
FCIPSSKNTC EHIYDFPPLS EELISEMIRH PYETQSDSFY FVDDRLVMHN KADYSYSGTP

Genular Protein ID: 2662131016

Symbol: K7EN86_HUMAN

Name: N/A

UniProtKB Accession Codes:

K7EN86 A0A024QZ13

Database IDs:

ARBA 10 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 3 EPD 1 Ensembl 2 Gene3D 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 InterPro 3 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 Pfam 2 Proteomes 2 RefSeq 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

Sequence Information:

  • Length: 145
  • Mass: 17081
  • Checksum: 4B3DE6DECB9D7793
  • Sequence:
    • MDSGTVLFEI KKPPVSERLP INRRDLDPNA GRFVRYQFTP AFLRLRQVGA TVEFTVGDKP 
VNNFRMIERH YFRNQLLKSF DFHFGFCIPS SKNTCEHIYD FPPLSEELIS EMIRHPYETQ 
SDSFYFVDDR LVMHNKADYS YSGTP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.