Details for: TBX19

Gene ID: 9095

Symbol: TBX19

Ensembl ID: ENSG00000143178

Description: T-box transcription factor 19

Associated with

  • Anatomical structure morphogenesis
    (GO:0009653)
  • Cell fate specification
    (GO:0001708)
  • Chromatin
    (GO:0000785)
  • Dna-binding transcription activator activity, rna polymerase ii-specific
    (GO:0001228)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Heart morphogenesis
    (GO:0003007)
  • Mesoderm formation
    (GO:0001707)
  • Nucleus
    (GO:0005634)
  • Pituitary gland development
    (GO:0021983)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Protein binding
    (GO:0005515)
  • Regulation of cell differentiation
    (GO:0045595)
  • Regulation of cell population proliferation
    (GO:0042127)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Sequence-specific double-stranded dna binding
    (GO:1990837)

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: 1.99
    Marker Score: 5,700
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,821
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,046
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,408
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.97
    Marker Score: 502
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.96
    Marker Score: 455
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,412
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.92
    Marker Score: 5,228
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.92
    Marker Score: 367
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,736
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.89
    Marker Score: 602
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.89
    Marker Score: 319
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,284
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.81
    Marker Score: 1,638
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.79
    Marker Score: 476
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1,256
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.76
    Marker Score: 693
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.75
    Marker Score: 390
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.73
    Marker Score: 557
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.68
    Marker Score: 2,858
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 173
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.64
    Marker Score: 10,027
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.56
    Marker Score: 3,377
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 443
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.52
    Marker Score: 334
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.45
    Marker Score: 501
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 0.42
    Marker Score: 233
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.39
    Marker Score: 231
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.38
    Marker Score: 724
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.38
    Marker Score: 179
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.37
    Marker Score: 246
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.33
    Marker Score: 3,375
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.32
    Marker Score: 132
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.31
    Marker Score: 124
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.29
    Marker Score: 93
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.27
    Marker Score: 119
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.26
    Marker Score: 172
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.26
    Marker Score: 639
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.26
    Marker Score: 235
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 0.25
    Marker Score: 225
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.24
    Marker Score: 325
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 0.23
    Marker Score: 161
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.23
    Marker Score: 58
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.23
    Marker Score: 72
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.23
    Marker Score: 113
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 62
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.21
    Marker Score: 63
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.21
    Marker Score: 72
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.21
    Marker Score: 56
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 0.2
    Marker Score: 53
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.2
    Marker Score: 195
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.2
    Marker Score: 88
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.2
    Marker Score: 554
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.2
    Marker Score: 1,863
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2
    Marker Score: 142
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.19
    Marker Score: 72
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.19
    Marker Score: 790
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.19
    Marker Score: 65
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.19
    Marker Score: 6,326
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.19
    Marker Score: 2,976
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.18
    Marker Score: 106
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.18
    Marker Score: 106
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.18
    Marker Score: 208
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.18
    Marker Score: 190
  • Cell Name: B-2 B cell (CL0000822)
    Fold Change: 0.17
    Marker Score: 215
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 0.17
    Marker Score: 139
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.17
    Marker Score: 174
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: 0.17
    Marker Score: 511
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.17
    Marker Score: 148
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.17
    Marker Score: 62
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.17
    Marker Score: 205
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 0.16
    Marker Score: 57
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 0.16
    Marker Score: 59
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.16
    Marker Score: 82
  • Cell Name: gut endothelial cell (CL0000131)
    Fold Change: 0.16
    Marker Score: 58
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.16
    Marker Score: 161
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.16
    Marker Score: 142
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 0.16
    Marker Score: 195
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.16
    Marker Score: 64
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.16
    Marker Score: 176
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 0.15
    Marker Score: 147
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 0.15
    Marker Score: 256
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.15
    Marker Score: 70
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.15
    Marker Score: 333
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.15
    Marker Score: 3,187
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.15
    Marker Score: 37
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.15
    Marker Score: 101
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.15
    Marker Score: 270
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.15
    Marker Score: 177
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.15
    Marker Score: 196
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.14
    Marker Score: 108
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.14
    Marker Score: 60
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.14
    Marker Score: 271
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.14
    Marker Score: 245
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.14
    Marker Score: 27
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.13
    Marker Score: 84
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 0.13
    Marker Score: 192
  • Cell Name: promonocyte (CL0000559)
    Fold Change: 0.13
    Marker Score: 85
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.13
    Marker Score: 462
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.13
    Marker Score: 184

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TBX19 is a transcription factor, a type of protein that regulates gene expression by binding to specific DNA sequences. Its T-box domain confers the ability to interact with other transcription factors and DNA-binding proteins, modulating chromatin structure and transcriptional activity. The presence of RNA polymerase II-specific motifs and the ability to regulate transcription by RNA polymerase II indicate that TBX19 plays a critical role in the regulation of gene expression. Moreover, its involvement in various developmental processes, including heart morphogenesis, mesoderm formation, and pituitary gland development, underscores its importance in embryonic development. **Pathways and Functions:** TBX19's involvement in developmental processes can be attributed to its participation in several key signaling pathways: 1. **Anatomical structure morphogenesis**: TBX19 regulates the formation and patterning of tissues during embryonic development, including the heart and mesoderm. 2. **Cell fate specification**: By interacting with other transcription factors, TBX19 determines the fate of cells, influencing their differentiation and proliferation. 3. **Chromatin regulation**: TBX19 modulates chromatin structure, influencing gene expression and transcriptional activity. 4. **DNA-binding transcription activator activity**: TBX19 acts as a transcriptional activator, enhancing the expression of target genes. **Clinical Significance:** TBX19's dysregulation has been implicated in various diseases and disorders, including: 1. **Cancer**: Aberrant expression of TBX19 has been observed in certain types of cancer, including colon and pituitary tumors. 2. **Developmental disorders**: Mutations in TBX19 have been linked to developmental abnormalities, such as heart defects and pituitary gland malformations. 3. **Neurological disorders**: TBX19 has been implicated in the pathogenesis of neurological disorders, including schizophrenia and autism spectrum disorder. In conclusion, TBX19 is a critical regulator of developmental processes, tissue homeostasis, and disease prevention. Further research into the mechanisms of TBX19's action and its role in various diseases will shed light on the intricate relationships between this transcription factor and human health.

Genular Protein ID: 1320959104

Symbol: TBX19_HUMAN

Name: T-box factor, pituitary

UniProtKB Accession Codes:

O60806 Q52M53

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 1 ExpressionAtlas 1 GO 14 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 2 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PRINTS 2 PRO 1 PROSITE 3 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 9888994

Title: Identification, mapping and phylogenomic analysis of four new human members of the T-box gene family: EOMES, TBX6, TBX18, and TBX19.

PubMed ID: 9888994

DOI: 10.1006/geno.1998.5632

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11290323

Title: A pituitary cell-restricted T-box factor, Tpit, activates POMC transcription in cooperation with Pitx homeoproteins.

PubMed ID: 11290323

DOI: 10.1016/s0092-8674(01)00282-3

Sequence Information:

  • Length: 448
  • Mass: 48238
  • Checksum: B7B1DFF14B8B53C5
  • Sequence:
    • MAMSELGTRK PSDGTVSHLL NVVESELQAG REKGDPTEKQ LQIILEDAPL WQRFKEVTNE 
MIVTKNGRRM FPVLKISVTG LDPNAMYSLL LDFVPTDSHR WKYVNGEWVP AGKPEVSSHS 
CVYIHPDSPN FGAHWMKAPI SFSKVKLTNK LNGGGQIMLN SLHKYEPQVH IVRVGSAHRM 
VTNCSFPETQ FIAVTAYQNE EITALKIKYN PFAKAFLDAK ERNHLRDVPE AISESQHVTY 
SHLGGWIFSN PDGVCTAGNS NYQYAAPLPL PAPHTHHGCE HYSGLRGHRQ APYPSAYMHR 
NHSPSVNLIE SSSNNLQVFS GPDSWTSLSS TPHASILSVP HTNGPINPGP SPYPCLWTIS 
NGAGGPSGPG PEVHASTPGA FLLGNPAVTS PPSVLSTQAP TSAGVEVLGE PSLTSIAVST 
WTAVASHPFA GWGGPGAGGH HSPSSLDG

Genular Protein ID: 338290663

Symbol: B3KRD9_HUMAN

Name: N/A

UniProtKB Accession Codes:

B3KRD9

Database IDs:

ARBA 5 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 EMBL 2 GO 4 Gene3D 1 Genevisible 1 GenomeRNAi 1 InterPro 6 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 2 PROSITE 3 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 RefSeq 1 SMART 1 SUPFAM 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

Sequence Information:

  • Length: 316
  • Mass: 33598
  • Checksum: 2F652B3F57B6621E
  • Sequence:
    • MFPVLKISVT GLDPNAMYSL LLDFVPTDSH RWKYVNGEWV PAGKPEVSSH SCVYIHPDSP 
NFGAHWMKAP ISFSKVKLTN KLNGGGQIML NSLHKYEPQV HIVRVGSAHR MVTNCSFPET 
QFIAVTAYQN EEITALKIKY NPFAKAFLDA KERNHLRDVP EAISESQHVT YSHLNLIESS 
SNNLQVFSGP DSWTSLSSTP HASILSVPHT NGPINPGPSP YPCLWTISNG AGGPSGPGPE 
VHASTPGAFL LGNPAVTSPP SVLSTQAPTS AGVEVLGEPS LTSIAVSTWT AVASHPFAGW 
GGPGAGGHHS PSSLDG

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.