Details for: USP14
Gene ID: 9097
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: USP14
Ensembl ID: ENSG00000101557
Description: ubiquitin specific peptidase 14
Selected Context(s): Overall
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
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CSI 18.43rCSI 18.1%PRS 40.36
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CSI 16.55rCSI 40.23%PRS 16.03
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CSI 16.4rCSI 59%PRS 15.54
-
CSI 11.83rCSI 18.28%PRS 25.2
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CSI 11.11rCSI 34.72%PRS 17.23
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CSI 9.76rCSI 21.57%PRS 19.27
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CSI 7.89rCSI 11.16%PRS 36.41
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CSI 7.69rCSI 45.3%PRS 17.22
-
CSI 6.81rCSI 25.73%PRS 17.06
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CSI 6.79rCSI 17.21%PRS 20.57
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CSI 5.85rCSI 13.28%PRS 33.88
-
CSI 5.15rCSI 6.41%PRS 36.35
-
CSI 4.99rCSI 4.31%PRS 38.33
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CSI 4.73rCSI 3.39%PRS 36.48
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CSI 4.57rCSI 64.82%PRS 21.7
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CSI 4.56rCSI 7.1%PRS 54.41
-
CSI 4.55rCSI 5.71%PRS 34.37
-
CSI 4.5rCSI 5.44%PRS 32.14
-
CSI 4.12rCSI 3.13%PRS 35.31
-
CSI 4.08rCSI 3.94%PRS 19.99
-
CSI 4.01rCSI 8.99%PRS 17.02
-
CSI 3.75rCSI 4.71%PRS 39.41
-
CSI 3.56rCSI 7.95%PRS 31.34
-
CSI 3.35rCSI 2.33%PRS 37.1
-
CSI 3.35rCSI 1.98%PRS 37.47
-
CSI 3.23rCSI 65.71%PRS 22.33
-
CSI 3.15rCSI 2.52%PRS 45.67
-
CSI 3.09rCSI 73.94%PRS 15.26
-
CSI 3.02rCSI 61.51%PRS 23.59
-
CSI 3rCSI 22.04%PRS 17.36
-
CSI 2.99rCSI 2.77%PRS 45.87
-
CSI 2.98rCSI 71.81%PRS 16.15
-
CSI 2.92rCSI 4.74%PRS 26.67
-
CSI 2.91rCSI 2.02%PRS 32.33
-
CSI 2.87rCSI 2.96%PRS 41.7
-
CSI 2.8rCSI 1.86%PRS 31.28
-
CSI 2.75rCSI 5.35%PRS 27.67
-
CSI 2.66rCSI 3.64%PRS 30.24
-
CSI 2.6rCSI 4.73%PRS 40.24
-
CSI 2.58rCSI 6.01%PRS 47.62
-
CSI 2.54rCSI 3.66%PRS 36.28
-
CSI 2.51rCSI 3.68%PRS 24.75
-
CSI 2.47rCSI 1.83%PRS 22.98
-
CSI 2.43rCSI 12.19%PRS 35.14
-
CSI 2.33rCSI 11.17%PRS 23.37
-
CSI 2.29rCSI 1.9%PRS 25.55
-
CSI 2.2rCSI 2.58%PRS 30.53
-
CSI 2.19rCSI 17.78%PRS 25.25
-
CSI 2.17rCSI 1.82%PRS 41.14
-
CSI 2.16rCSI 8.4%PRS 43.07
-
CSI 2.15rCSI 2.58%PRS 44.37
-
CSI 2.15rCSI 1.78%PRS 27.22
-
CSI 2.14rCSI 5.41%PRS 32.85
-
CSI 2.11rCSI 1.99%PRS 28.04
-
CSI 2.1rCSI 8.48%PRS 25.09
-
CSI 2.02rCSI 2.7%PRS 33.88
-
CSI 1.96rCSI 3.15%PRS 17.85
-
CSI 1.93rCSI 3.35%PRS 20.59
-
CSI 1.92rCSI 8.54%PRS 25.96
-
CSI 1.92rCSI 2.1%PRS 29.87
-
CSI 1.92rCSI 2.23%PRS 37.6
-
CSI 1.91rCSI 1.44%PRS 36.23
-
CSI 1.9rCSI 1.83%PRS 27.69
-
CSI 1.88rCSI 2.25%PRS 25.94
-
CSI 1.87rCSI 1.64%PRS 19.67
-
CSI 1.86rCSI 4.37%PRS 36.9
-
CSI 1.84rCSI 2.35%PRS 30.78
-
CSI 1.83rCSI 1.44%PRS 32.11
-
CSI 1.82rCSI 2.8%PRS 33.8
-
CSI 1.82rCSI 4.17%PRS 26.22
-
CSI 1.81rCSI 5.8%PRS 23.02
-
CSI 1.81rCSI 2.46%PRS 23.32
-
CSI 1.81rCSI 2.47%PRS 29.55
-
CSI 1.8rCSI 3.57%PRS 27.74
-
CSI 1.78rCSI 1.41%PRS 18.53
-
CSI 1.75rCSI 3.99%PRS 22.98
-
CSI 1.72rCSI 2.54%PRS 40.94
-
CSI 1.71rCSI 5.04%PRS 31.14
-
CSI 1.67rCSI 3.46%PRS 26.46
-
CSI 1.65rCSI 4.31%PRS 25.42
-
CSI 1.63rCSI 2.5%PRS 30.53
-
CSI 1.63rCSI 2.49%PRS 24.71
-
CSI 1.63rCSI 3.11%PRS 41.42
-
CSI 1.62rCSI 2.08%PRS 30.8
-
CSI 1.62rCSI 1.51%PRS 26.8
-
CSI 1.61rCSI 1.12%PRS 28.33
-
CSI 1.6rCSI 1.24%PRS 25.21
-
CSI 1.6rCSI 1.68%PRS 25.05
-
CSI 1.59rCSI 1.62%PRS 37.56
-
CSI 1.57rCSI 4.1%PRS 26.83
-
CSI 1.57rCSI 1.64%PRS 27.51
-
CSI 1.57rCSI 4.05%PRS 24.7
-
CSI 1.56rCSI 4.46%PRS 44.3
-
CSI 1.56rCSI 1.82%PRS 37.53
-
CSI 1.53rCSI 3.8%PRS 25.01
-
CSI 1.53rCSI 2.42%PRS 27.05
-
CSI 1.52rCSI 1.33%PRS 34.94
-
CSI 1.52rCSI 1.4%PRS 27.9
-
CSI 1.51rCSI 2.41%PRS 29.37
-
CSI 1.51rCSI 2.3%PRS 44.31
-
CSI 0.1rCSI 0.6%PRS 44.8%
-
CSI 0.1rCSI 2.3%PRS 47.9%
-
CSI 0.1rCSI 0.6%PRS 38.4%
-
CSI 0.1rCSI 0.5%PRS 43.2%
-
CSI 0.2rCSI 0.4%PRS 42.3%
-
CSI 0.2rCSI 1.3%PRS 47.9%
-
CSI 0.2rCSI 3.0%PRS 26.5%
-
CSI 0.2rCSI 1.2%PRS 37.8%
-
CSI 0.2rCSI 1.3%PRS 21.5%
-
CSI 0.3rCSI 0.7%PRS 22.4%
-
CSI 0.3rCSI 2.9%PRS 47.7%
-
CSI 0.3rCSI 2.5%PRS 16.0%
-
CSI 0.3rCSI 0.5%PRS 20.6%
-
CSI 0.3rCSI 1.4%PRS 55.6%
-
CSI 0.3rCSI 1.9%PRS 38.2%
-
CSI 0.4rCSI 2.7%PRS 46.2%
-
CSI 0.4rCSI 1.1%PRS 29.9%
-
CSI 0.4rCSI 1.8%PRS 68.4%
-
CSI 0.4rCSI 1.3%PRS 18.7%
-
CSI 0.4rCSI 0.8%PRS 34.0%
-
CSI 0.4rCSI 2.5%PRS 55.3%
-
CSI 0.4rCSI 0.6%PRS 28.5%
-
CSI 0.4rCSI 1.5%PRS 43.8%
-
CSI 0.4rCSI 2.8%PRS 59.7%
-
CSI 0.4rCSI 1.5%PRS 43.5%
-
CSI 0.5rCSI 1.2%PRS 39.4%
-
CSI 0.5rCSI 1.5%PRS 35.8%
-
CSI 0.5rCSI 2.1%PRS 46.2%
-
CSI 0.5rCSI 4.4%PRS 54.4%
-
CSI 0.5rCSI 2.0%PRS 37.4%
-
CSI 0.5rCSI 1.3%PRS 26.2%
-
CSI 0.5rCSI 1.4%PRS 34.5%
-
CSI 0.6rCSI 1.2%PRS 24.7%
-
CSI 0.6rCSI 1.9%PRS 19.5%
-
CSI 0.6rCSI 1.4%PRS 41.3%
-
CSI 0.6rCSI 1.7%PRS 21.1%
-
CSI 0.6rCSI 2.6%PRS 75.1%
-
CSI 0.6rCSI 1.1%PRS 19.7%
-
CSI 0.6rCSI 0.9%PRS 34.4%
-
CSI 0.6rCSI 2.0%PRS 22.9%
-
CSI 0.6rCSI 1.9%PRS 27.6%
-
CSI 0.6rCSI 2.3%PRS 24.8%
-
CSI 0.7rCSI 0.8%PRS 49.7%
-
CSI 0.7rCSI 2.6%PRS 35.8%
-
CSI 0.7rCSI 1.3%PRS 51.8%
-
CSI 0.7rCSI 2.0%PRS 39.7%
-
CSI 0.7rCSI 1.7%PRS 19.0%
-
CSI 0.7rCSI 1.0%PRS 21.1%
-
CSI 0.7rCSI 2.3%PRS 18.7%
-
CSI 0.7rCSI 6.9%PRS 74.7%
-
CSI 0.7rCSI 0.6%PRS 30.0%
-
CSI 0.8rCSI 0.8%PRS 24.8%
-
CSI 0.8rCSI 1.6%PRS 35.2%
-
CSI 0.8rCSI 2.2%PRS 42.1%
-
CSI 0.8rCSI 0.9%PRS 44.6%
-
CSI 0.8rCSI 0.8%PRS 27.6%
-
CSI 0.8rCSI 5.0%PRS 50.7%
-
CSI 0.8rCSI 0.6%PRS 39.1%
-
CSI 0.8rCSI 14.8%PRS 65.0%
-
CSI 0.8rCSI 0.9%PRS 19.9%
-
CSI 0.8rCSI 4.7%PRS 16.6%
-
CSI 0.9rCSI 1.3%PRS 27.5%
-
CSI 0.9rCSI 1.7%PRS 25.4%
-
CSI 0.9rCSI 2.1%PRS 29.7%
-
CSI 0.9rCSI 1.5%PRS 16.0%
-
CSI 0.9rCSI 1.6%PRS 25.0%
-
CSI 0.9rCSI 0.9%PRS 31.6%
-
CSI 0.9rCSI 1.4%PRS 37.8%
-
CSI 0.9rCSI 2.1%PRS 37.8%
-
CSI 0.9rCSI 0.7%PRS 28.7%
-
CSI 0.9rCSI 1.5%PRS 20.8%
-
CSI 0.9rCSI 1.2%PRS 29.0%
-
CSI 0.9rCSI 2.4%PRS 23.0%
-
CSI 0.9rCSI 1.8%PRS 43.0%
-
CSI 0.9rCSI 1.4%PRS 27.0%
-
CSI 0.9rCSI 1.1%PRS 16.2%
-
CSI 0.9rCSI 2.7%PRS 45.5%
-
CSI 0.9rCSI 2.6%PRS 40.6%
-
CSI 0.9rCSI 2.1%PRS 20.1%
-
CSI 1.0rCSI 3.1%PRS 31.4%
-
CSI 1.0rCSI 0.8%PRS 26.9%
-
CSI 1.0rCSI 2.8%PRS 29.0%
-
CSI 1.0rCSI 2.4%PRS 32.3%
-
CSI 1.0rCSI 1.5%PRS 30.5%
-
CSI 1.0rCSI 5.1%PRS 49.2%
-
CSI 1.0rCSI 1.6%PRS 22.6%
-
CSI 1.0rCSI 2.8%PRS 25.1%
-
CSI 1.0rCSI 2.7%PRS 31.9%
-
CSI 1.0rCSI 1.1%PRS 28.5%
-
CSI 1.0rCSI 1.4%PRS 29.5%
-
CSI 1.0rCSI 2.1%PRS 51.0%
-
CSI 1.0rCSI 1.6%PRS 32.0%
-
CSI 1.1rCSI 5.2%PRS 35.8%
-
CSI 1.1rCSI 2.0%PRS 62.8%
-
CSI 1.1rCSI 1.4%PRS 17.0%
-
CSI 1.1rCSI 1.6%PRS 34.9%
-
CSI 1.1rCSI 1.4%PRS 28.7%
-
CSI 1.1rCSI 4.6%PRS 27.2%
-
CSI 1.1rCSI 2.0%PRS 22.3%
-
CSI 1.1rCSI 1.0%PRS 39.7%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 2679276303
Symbol: UBP14_HUMAN
Name: Ubiquitin carboxyl-terminal hydrolase 14
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 16177791
Title: DNA sequence and analysis of human chromosome 18.
PubMed ID: 16177791
DOI: 10.1038/nature03983
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 14499622
Title: Yeast two-hybrid screens imply involvement of Fanconi anemia proteins in transcription regulation, cell signaling, oxidative metabolism, and cellular transport.
PubMed ID: 14499622
PubMed ID: 19367720
Title: Phosphorylation analysis of primary human T lymphocytes using sequential IMAC and titanium oxide enrichment.
PubMed ID: 19367720
DOI: 10.1021/pr800500r
PubMed ID: 18162577
Title: Relative structural and functional roles of multiple deubiquitylating proteins associated with mammalian 26S proteasome.
PubMed ID: 18162577
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 19135427
Title: USP14 inhibits ER-associated degradation via interaction with IRE1alpha.
PubMed ID: 19135427
PubMed ID: 19106094
Title: Deubiquitination of CXCR4 by USP14 is critical for both CXCL12-induced CXCR4 degradation and chemotaxis but not ERK activation.
PubMed ID: 19106094
PubMed ID: 19690332
Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
PubMed ID: 19690332
PubMed ID: 19608861
Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.
PubMed ID: 19608861
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 21406692
Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
PubMed ID: 21406692
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 27666593
Title: TRIM14 inhibits cGAS degradation mediated by selective autophagy receptor p62 to promote innate immune responses.
PubMed ID: 27666593
PubMed ID: 28396413
Title: Ubiquitinated proteins promote the association of proteasomes with the deubiquitinating enzyme Usp14 and the ubiquitin ligase Ube3c.
PubMed ID: 28396413
PubMed ID: 35145029
Title: TRIM14 inhibits OPTN-mediated autophagic degradation of KDM4D to epigenetically regulate inflammation.
PubMed ID: 35145029
PubMed ID: 16211010
Title: Structure and mechanisms of the proteasome-associated deubiquitinating enzyme USP14.
PubMed ID: 16211010
Sequence Information:
- Length: 494
- Mass: 56069
- Checksum: E6D4679A86E9DF00
- Sequence:
MPLYSVTVKW GKEKFEGVEL NTDEPPMVFK AQLFALTGVQ PARQKVMVKG GTLKDDDWGN IKIKNGMTLL MMGSADALPE EPSAKTVFVE DMTEEQLASA MELPCGLTNL GNTCYMNATV QCIRSVPELK DALKRYAGAL RASGEMASAQ YITAALRDLF DSMDKTSSSI PPIILLQFLH MAFPQFAEKG EQGQYLQQDA NECWIQMMRV LQQKLEAIED DSVKETDSSS ASAATPSKKK SLIDQFFGVE FETTMKCTES EEEEVTKGKE NQLQLSCFIN QEVKYLFTGL KLRLQEEITK QSPTLQRNAL YIKSSKISRL PAYLTIQMVR FFYKEKESVN AKVLKDVKFP LMLDMYELCT PELQEKMVSF RSKFKDLEDK KVNQQPNTSD KKSSPQKEVK YEPFSFADDI GSNNCGYYDL QAVLTHQGRS SSSGHYVSWV KRKQDEWIKF DDDKVSIVTP EDILRLSGGG DWHIAYVLLY GPRRVEIMEE ESEQ