Details for: USP14

Gene ID: 9097

Symbol: USP14

Ensembl ID: ENSG00000101557

Description: ubiquitin specific peptidase 14

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 1.76
    Marker Score: 4,313
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 1.75
    Marker Score: 3,852
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.73
    Marker Score: 17,864
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.68
    Marker Score: 103,291
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.62
    Marker Score: 15,351
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.6
    Marker Score: 13,776
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.59
    Marker Score: 58,647
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.59
    Marker Score: 6,244
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.58
    Marker Score: 14,818
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.57
    Marker Score: 6,573
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.56
    Marker Score: 59,432
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.56
    Marker Score: 1,641
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 1.54
    Marker Score: 1,044
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.53
    Marker Score: 30,514
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.49
    Marker Score: 5,768
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.48
    Marker Score: 6,030
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.46
    Marker Score: 2,250
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 1.45
    Marker Score: 6,020
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.45
    Marker Score: 11,079
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 1.45
    Marker Score: 504
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 1.44
    Marker Score: 605
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.41
    Marker Score: 21,084
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 1.4
    Marker Score: 2,018
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.4
    Marker Score: 2,067
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 1.38
    Marker Score: 1,734
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 1.38
    Marker Score: 805
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 1.35
    Marker Score: 1,795
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 1.34
    Marker Score: 3,217
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 1.32
    Marker Score: 1,409
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.32
    Marker Score: 4,884
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 1.32
    Marker Score: 416
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.31
    Marker Score: 27,906
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.31
    Marker Score: 45,219
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 1.29
    Marker Score: 6,350
  • Cell Name: basal cell (CL0000646)
    Fold Change: 1.29
    Marker Score: 1,664
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 1.29
    Marker Score: 804
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 1.27
    Marker Score: 1,342
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.27
    Marker Score: 1,401
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 1.26
    Marker Score: 22,439
  • Cell Name: neural cell (CL0002319)
    Fold Change: 1.26
    Marker Score: 609
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 1.24
    Marker Score: 930
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 1.23
    Marker Score: 2,568
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.22
    Marker Score: 1,409
  • Cell Name: Unknown (CL0002371)
    Fold Change: 1.21
    Marker Score: 1,288
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 1.21
    Marker Score: 1,459
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 1.2
    Marker Score: 1,209
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 1.19
    Marker Score: 695
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 1.19
    Marker Score: 814
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 1.19
    Marker Score: 2,018
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.19
    Marker Score: 2,703
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 1.19
    Marker Score: 691
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 1.18
    Marker Score: 346
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 1.18
    Marker Score: 574
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 1.18
    Marker Score: 322
  • Cell Name: Unknown (CL0000548)
    Fold Change: 1.17
    Marker Score: 856
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.17
    Marker Score: 280
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.17
    Marker Score: 1,263
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 1.17
    Marker Score: 1,417
  • Cell Name: oocyte (CL0000023)
    Fold Change: 1.16
    Marker Score: 288
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 1.15
    Marker Score: 29,471
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 1.15
    Marker Score: 3,117
  • Cell Name: podocyte (CL0000653)
    Fold Change: 1.14
    Marker Score: 422
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 1.14
    Marker Score: 1,046
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.13
    Marker Score: 38,601
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 1.13
    Marker Score: 459
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 1.13
    Marker Score: 767
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 1.12
    Marker Score: 324
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.12
    Marker Score: 11,255
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 1.12
    Marker Score: 588
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 1.11
    Marker Score: 454
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 1.11
    Marker Score: 1,200
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 1.11
    Marker Score: 3,027
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 1.11
    Marker Score: 1,491
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 1.11
    Marker Score: 955
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 1.1
    Marker Score: 242
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 1.09
    Marker Score: 944
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 1.09
    Marker Score: 1,092
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 1.08
    Marker Score: 312
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 1.08
    Marker Score: 844
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 1.07
    Marker Score: 1,205
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.07
    Marker Score: 6,843
  • Cell Name: pre-B-I cell (CL0000956)
    Fold Change: 1.07
    Marker Score: 273
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 1.07
    Marker Score: 370
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 1.06
    Marker Score: 6,454
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.06
    Marker Score: 707
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 1.06
    Marker Score: 4,891
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 1.05
    Marker Score: 259
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.05
    Marker Score: 11,807
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.04
    Marker Score: 2,549
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 1.04
    Marker Score: 331
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 1.04
    Marker Score: 1,475
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 1.04
    Marker Score: 2,790
  • Cell Name: blood cell (CL0000081)
    Fold Change: 1.04
    Marker Score: 12,038
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 1.03
    Marker Score: 34,941
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 1.03
    Marker Score: 1,125
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 1.03
    Marker Score: 238
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 1.03
    Marker Score: 652
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 1.03
    Marker Score: 728
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 1.03
    Marker Score: 8,879
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 1.03
    Marker Score: 538

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Deubiquitinating activity**: USP14 is a cysteine-type deubiquitinase that specifically removes K63-linked ubiquitin chains from target proteins. 2. **Proteasome binding**: USP14 interacts with the 26S proteasome, a key component of the ubiquitin-proteasome system (UPS), to regulate protein degradation. 3. **Regulation of signaling pathways**: USP14 modulates the activity of various signaling pathways, including NF-κB, MAPK, and IL-1 signaling, by removing ubiquitin chains from key regulatory proteins. 4. **Immune system regulation**: USP14 plays a critical role in regulating immune responses, including cytokine signaling, Toll-like receptor (TLR) activation, and MyD88-dependent cascade initiation. 5. **Cell type-specific expression**: USP14 is highly expressed in epithelial cells, neurons, and immune cells, suggesting its importance in maintaining tissue homeostasis and responding to environmental stimuli. **Pathways and Functions:** 1. **Cell surface signaling**: USP14 regulates cell surface signaling by removing ubiquitin chains from key regulatory proteins, such as MyD88 and IRAK1, which are involved in TLR and IL-1 signaling. 2. **Cytokine signaling**: USP14 modulates cytokine signaling by removing ubiquitin chains from key regulatory proteins, such as IL-1R and TNFR, which are involved in inflammatory responses. 3. **Protein degradation**: USP14 regulates protein degradation by interacting with the 26S proteasome, which is responsible for the ubiquitin-dependent proteasome-mediated ubiquitin-dependent protein catabolic process. 4. **Immune system regulation**: USP14 plays a critical role in regulating immune responses, including the initiation of MyD88-dependent and MyD88-independent TLR cascades. 5. **Neurotransmission and synaptic plasticity**: USP14 regulates neurotransmission and synaptic plasticity by removing ubiquitin chains from key regulatory proteins, such as synaptotagmin and SNAP-25. **Clinical Significance:** 1. **Cancer**: USP14 has been implicated in cancer development and progression, as its dysregulation can lead to the accumulation of oncogenic proteins. 2. **Neurodegenerative diseases**: USP14 has been linked to neurodegenerative diseases, such as Alzheimer's and Parkinson's, as its dysregulation can lead to the accumulation of toxic proteins. 3. **Inflammatory disorders**: USP14 plays a critical role in regulating inflammatory responses, and its dysregulation can contribute to the development of inflammatory disorders, such as arthritis and asthma. 4. **Immune system disorders**: USP14 is essential for maintaining immune system homeostasis, and its dysregulation can contribute to the development of immune system disorders, such as autoimmune diseases and immunodeficiency disorders. In conclusion, USP14 is a critical regulator of various cellular processes, including protein degradation, signaling, and immune responses. Its dysregulation has been implicated in various diseases, including cancer, neurodegenerative diseases, inflammatory disorders, and immune system disorders. Further research is necessary to fully understand the functions and clinical significance of USP14.

Genular Protein ID: 2679276303

Symbol: UBP14_HUMAN

Name: Ubiquitin carboxyl-terminal hydrolase 14

UniProtKB Accession Codes:

P54578 B7Z4N8 J3QRZ5 Q53XY5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 2 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EC 2 EMBL 6 EMDB 14 EPD 1 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 20 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 MANE-Select 1 MEROPS 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OGP 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 25 PDBsum 21 PIR 1 PRO 1 PROSITE 5 PROSITE-ProRule 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 2 RefSeq 2 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16177791

Title: DNA sequence and analysis of human chromosome 18.

PubMed ID: 16177791

DOI: 10.1038/nature03983

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14499622

Title: Yeast two-hybrid screens imply involvement of Fanconi anemia proteins in transcription regulation, cell signaling, oxidative metabolism, and cellular transport.

PubMed ID: 14499622

DOI: 10.1016/s0014-4827(03)00261-1

PubMed ID: 19367720

Title: Phosphorylation analysis of primary human T lymphocytes using sequential IMAC and titanium oxide enrichment.

PubMed ID: 19367720

DOI: 10.1021/pr800500r

PubMed ID: 18162577

Title: Relative structural and functional roles of multiple deubiquitylating proteins associated with mammalian 26S proteasome.

PubMed ID: 18162577

DOI: 10.1091/mbc.e07-10-1040

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19135427

Title: USP14 inhibits ER-associated degradation via interaction with IRE1alpha.

PubMed ID: 19135427

DOI: 10.1016/j.bbrc.2008.12.182

PubMed ID: 19106094

Title: Deubiquitination of CXCR4 by USP14 is critical for both CXCL12-induced CXCR4 degradation and chemotaxis but not ERK activation.

PubMed ID: 19106094

DOI: 10.1074/jbc.m808507200

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 27666593

Title: TRIM14 inhibits cGAS degradation mediated by selective autophagy receptor p62 to promote innate immune responses.

PubMed ID: 27666593

DOI: 10.1016/j.molcel.2016.08.025

PubMed ID: 28396413

Title: Ubiquitinated proteins promote the association of proteasomes with the deubiquitinating enzyme Usp14 and the ubiquitin ligase Ube3c.

PubMed ID: 28396413

DOI: 10.1073/pnas.1701734114

PubMed ID: 35145029

Title: TRIM14 inhibits OPTN-mediated autophagic degradation of KDM4D to epigenetically regulate inflammation.

PubMed ID: 35145029

DOI: 10.1073/pnas.2113454119

PubMed ID: 16211010

Title: Structure and mechanisms of the proteasome-associated deubiquitinating enzyme USP14.

PubMed ID: 16211010

DOI: 10.1038/sj.emboj.7600832

Sequence Information:

  • Length: 494
  • Mass: 56069
  • Checksum: E6D4679A86E9DF00
  • Sequence:
    • MPLYSVTVKW GKEKFEGVEL NTDEPPMVFK AQLFALTGVQ PARQKVMVKG GTLKDDDWGN 
IKIKNGMTLL MMGSADALPE EPSAKTVFVE DMTEEQLASA MELPCGLTNL GNTCYMNATV 
QCIRSVPELK DALKRYAGAL RASGEMASAQ YITAALRDLF DSMDKTSSSI PPIILLQFLH 
MAFPQFAEKG EQGQYLQQDA NECWIQMMRV LQQKLEAIED DSVKETDSSS ASAATPSKKK 
SLIDQFFGVE FETTMKCTES EEEEVTKGKE NQLQLSCFIN QEVKYLFTGL KLRLQEEITK 
QSPTLQRNAL YIKSSKISRL PAYLTIQMVR FFYKEKESVN AKVLKDVKFP LMLDMYELCT 
PELQEKMVSF RSKFKDLEDK KVNQQPNTSD KKSSPQKEVK YEPFSFADDI GSNNCGYYDL 
QAVLTHQGRS SSSGHYVSWV KRKQDEWIKF DDDKVSIVTP EDILRLSGGG DWHIAYVLLY 
GPRRVEIMEE ESEQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.