USP14 | ENSG00000101557 | NCBI 9097

Details for: USP14

Gene ID: 9097

Symbol: USP14

Ensembl ID: ENSG00000101557

Description: ubiquitin specific peptidase 14

Associated with

Cytokine signaling in immune system
(R-HSA-1280215)
Deubiquitination
(R-HSA-5688426)
Immune system
(R-HSA-168256)
Innate immune system
(R-HSA-168249)
Interleukin-1 family signaling
(R-HSA-446652)
Interleukin-1 signaling
(R-HSA-9020702)
Metabolism of proteins
(R-HSA-392499)
Myd88 cascade initiated on plasma membrane
(R-HSA-975871)
Myd88 dependent cascade initiated on endosome
(R-HSA-975155)
Myd88-independent tlr4 cascade
(R-HSA-166166)
Myd88:mal(tirap) cascade initiated on plasma membrane
(R-HSA-166058)
Post-translational protein modification
(R-HSA-597592)
Regulation of nf-kappa b signaling
(R-HSA-9758274)
Signaling by interleukins
(R-HSA-449147)
Tak1-dependent ikk and nf-kappa-b activation
(R-HSA-445989)
Toll-like receptor cascades
(R-HSA-168898)
Toll like receptor 2 (tlr2) cascade
(R-HSA-181438)
Toll like receptor 3 (tlr3) cascade
(R-HSA-168164)
Toll like receptor 4 (tlr4) cascade
(R-HSA-166016)
Toll like receptor 5 (tlr5) cascade
(R-HSA-168176)
Toll like receptor 7/8 (tlr7/8) cascade
(R-HSA-168181)
Toll like receptor 9 (tlr9) cascade
(R-HSA-168138)
Toll like receptor 10 (tlr10) cascade
(R-HSA-168142)
Toll like receptor tlr1:tlr2 cascade
(R-HSA-168179)
Toll like receptor tlr6:tlr2 cascade
(R-HSA-168188)
Traf6 mediated induction of nfkb and map kinases upon tlr7/8 or 9 activation
(R-HSA-975138)
Trif(ticam1)-mediated tlr4 signaling
(R-HSA-937061)
Ub-specific processing proteases
(R-HSA-5689880)
Cell surface
(GO:0009986)
Chemical synaptic transmission
(GO:0007268)
Cysteine-type deubiquitinase activity
(GO:0004843)
Cysteine-type endopeptidase activity
(GO:0004197)
Cytoplasm
(GO:0005737)
Cytoplasmic vesicle
(GO:0031410)
Cytosol
(GO:0005829)
Deubiquitinase activity
(GO:0101005)
Endopeptidase inhibitor activity
(GO:0004866)
Extracellular exosome
(GO:0070062)
Innate immune response
(GO:0045087)
K63-linked deubiquitinase activity
(GO:0061578)
Negative regulation of erad pathway
(GO:1904293)
Negative regulation of ubiquitin-dependent protein catabolic process
(GO:2000059)
Plasma membrane
(GO:0005886)
Proteasome-mediated ubiquitin-dependent protein catabolic process
(GO:0043161)
Proteasome binding
(GO:0070628)
Proteasome complex
(GO:0000502)
Protein binding
(GO:0005515)
Protein deubiquitination
(GO:0016579)
Regulation of chemotaxis
(GO:0050920)
Regulation of proteasomal protein catabolic process
(GO:0061136)
Synapse
(GO:0045202)

Other Information

Proteins

Ubiquitin carboxyl-terminal hydrolase 14

Genular Protein ID: 2679276303

Symbol: UBP14_HUMAN

Name: Ubiquitin carboxyl-terminal hydrolase 14

UniProtKB Accession Codes:

P54578 B7Z4N8 J3QRZ5 Q53XY5

Database IDs:

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16177791

Title: DNA sequence and analysis of human chromosome 18.

PubMed ID: 16177791

DOI: 10.1038/nature03983

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14499622

Title: Yeast two-hybrid screens imply involvement of Fanconi anemia proteins in transcription regulation, cell signaling, oxidative metabolism, and cellular transport.

PubMed ID: 14499622

DOI: 10.1016/s0014-4827(03)00261-1

PubMed ID: 19367720

Title: Phosphorylation analysis of primary human T lymphocytes using sequential IMAC and titanium oxide enrichment.

PubMed ID: 19367720

DOI: 10.1021/pr800500r

PubMed ID: 18162577

Title: Relative structural and functional roles of multiple deubiquitylating proteins associated with mammalian 26S proteasome.

PubMed ID: 18162577

DOI: 10.1091/mbc.e07-10-1040

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19135427

Title: USP14 inhibits ER-associated degradation via interaction with IRE1alpha.

PubMed ID: 19135427

DOI: 10.1016/j.bbrc.2008.12.182

PubMed ID: 19106094

Title: Deubiquitination of CXCR4 by USP14 is critical for both CXCL12-induced CXCR4 degradation and chemotaxis but not ERK activation.

PubMed ID: 19106094

DOI: 10.1074/jbc.m808507200

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 27666593

Title: TRIM14 inhibits cGAS degradation mediated by selective autophagy receptor p62 to promote innate immune responses.

PubMed ID: 27666593

DOI: 10.1016/j.molcel.2016.08.025

PubMed ID: 28396413

Title: Ubiquitinated proteins promote the association of proteasomes with the deubiquitinating enzyme Usp14 and the ubiquitin ligase Ube3c.

PubMed ID: 28396413

DOI: 10.1073/pnas.1701734114

PubMed ID: 35145029

Title: TRIM14 inhibits OPTN-mediated autophagic degradation of KDM4D to epigenetically regulate inflammation.

PubMed ID: 35145029

DOI: 10.1073/pnas.2113454119

PubMed ID: 16211010

Title: Structure and mechanisms of the proteasome-associated deubiquitinating enzyme USP14.

PubMed ID: 16211010

DOI: 10.1038/sj.emboj.7600832

Sequence Information:

Length: 494
Mass: 56069
Checksum: E6D4679A86E9DF00
Sequence:

MPLYSVTVKW GKEKFEGVEL NTDEPPMVFK AQLFALTGVQ PARQKVMVKG GTLKDDDWGN 
IKIKNGMTLL MMGSADALPE EPSAKTVFVE DMTEEQLASA MELPCGLTNL GNTCYMNATV 
QCIRSVPELK DALKRYAGAL RASGEMASAQ YITAALRDLF DSMDKTSSSI PPIILLQFLH 
MAFPQFAEKG EQGQYLQQDA NECWIQMMRV LQQKLEAIED DSVKETDSSS ASAATPSKKK 
SLIDQFFGVE FETTMKCTES EEEEVTKGKE NQLQLSCFIN QEVKYLFTGL KLRLQEEITK 
QSPTLQRNAL YIKSSKISRL PAYLTIQMVR FFYKEKESVN AKVLKDVKFP LMLDMYELCT 
PELQEKMVSF RSKFKDLEDK KVNQQPNTSD KKSSPQKEVK YEPFSFADDI GSNNCGYYDL 
QAVLTHQGRS SSSGHYVSWV KRKQDEWIKF DDDKVSIVTP EDILRLSGGG DWHIAYVLLY 
GPRRVEIMEE ESEQ

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: USP14

Associated with

Other Information

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

DNA sequence and analysis of human chromosome 18. PubMed ID: 16177791

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Yeast two-hybrid screens imply involvement of Fanconi anemia proteins in transcription regulation, cell signaling, oxidative metabolism, and cellular transport. PubMed ID: 14499622

Phosphorylation analysis of primary human T lymphocytes using sequential IMAC and titanium oxide enrichment. PubMed ID: 19367720

Relative structural and functional roles of multiple deubiquitylating proteins associated with mammalian 26S proteasome. PubMed ID: 18162577

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

USP14 inhibits ER-associated degradation via interaction with IRE1alpha. PubMed ID: 19135427

Deubiquitination of CXCR4 by USP14 is critical for both CXCL12-induced CXCR4 degradation and chemotaxis but not ERK activation. PubMed ID: 19106094

Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. PubMed ID: 19690332

Lysine acetylation targets protein complexes and co-regulates major cellular functions. PubMed ID: 19608861

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

Initial characterization of the human central proteome. PubMed ID: 21269460

System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. PubMed ID: 21406692

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

TRIM14 inhibits cGAS degradation mediated by selective autophagy receptor p62 to promote innate immune responses. PubMed ID: 27666593

Ubiquitinated proteins promote the association of proteasomes with the deubiquitinating enzyme Usp14 and the ubiquitin ligase Ube3c. PubMed ID: 28396413

TRIM14 inhibits OPTN-mediated autophagic degradation of KDM4D to epigenetically regulate inflammation. PubMed ID: 35145029

Structure and mechanisms of the proteasome-associated deubiquitinating enzyme USP14. PubMed ID: 16211010