No CSI details found for gene ID: 9098
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 1460081987
Symbol: UBP6_HUMAN
Name: Ubiquitin carboxyl-terminal hydrolase 6
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 1565468
Title: A novel transcriptional unit of the tre oncogene widely expressed in human cancer cells.
PubMed ID: 1565468
PubMed ID: 12604796
Title: The Tre2 (USP6) oncogene is a hominoid-specific gene.
PubMed ID: 12604796
PubMed ID: 19077034
Title: Identification and characterization of a novel Tre-2/Bub2/Cdc16 (TBC) protein that possesses Rab3A-GAP activity.
PubMed ID: 19077034
PubMed ID: 16625196
Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.
PubMed ID: 16625196
DOI: 10.1038/nature04689
PubMed ID: 8247125
Title: The yeast DOA4 gene encodes a deubiquitinating enzyme related to a product of the human tre-2 oncogene.
PubMed ID: 8247125
DOI: 10.1038/366313a0
PubMed ID: 14521938
Title: Expression in a RabGAP yeast mutant of two human homologues, one of which is an oncogene.
PubMed ID: 14521938
PubMed ID: 12612085
Title: The TRE17 oncogene encodes a component of a novel effector pathway for Rho GTPases Cdc42 and Rac1 and stimulates actin remodeling.
PubMed ID: 12612085
PubMed ID: 15026324
Title: USP6 (Tre2) fusion oncogenes in aneurysmal bone cyst.
PubMed ID: 15026324
PubMed ID: 15509780
Title: The TBC (Tre-2/Bub2/Cdc16) domain protein TRE17 regulates plasma membrane-endosomal trafficking through activation of Arf6.
PubMed ID: 15509780
PubMed ID: 16127172
Title: Calcium/calmodulin regulates ubiquitination of the ubiquitin-specific protease TRE17/USP6.
PubMed ID: 16127172
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 20418905
Title: TRE17/USP6 oncogene translocated in aneurysmal bone cyst induces matrix metalloproteinase production via activation of NF-kappaB.
PubMed ID: 20418905
DOI: 10.1038/onc.2010.116
Sequence Information:
- Length: 1406
- Mass: 158658
- Checksum: D3A6822CEB441DB3
- Sequence:
MDMVENADSL QAQERKDILM KYDKGHRAGL PEDKGPEPVG INSSIDRFGI LHETELPPVT AREAKKIRRE MTRTSKWMEM LGEWETYKHS SKLIDRVYKG IPMNIRGPVW SVLLNIQEIK LKNPGRYQIM KERGKRSSEH IHHIDLDVRT TLRNHVFFRD RYGAKQRELF YILLAYSEYN PEVGYCRDLS HITALFLLYL PEEDAFWALV QLLASERHSL PGFHSPNGGT VQGLQDQQEH VVPKSQPKTM WHQDKEGLCG QCASLGCLLR NLIDGISLGL TLRLWDVYLV EGEQVLMPIT SIALKVQQKR LMKTSRCGLW ARLRNQFFDT WAMNDDTVLK HLRASTKKLT RKQGDLPPPA KREQGSLAPR PVPASRGGKT LCKGYRQAPP GPPAQFQRPI CSASPPWASR FSTPCPGGAV REDTYPVGTQ GVPSLALAQG GPQGSWRFLE WKSMPRLPTD LDIGGPWFPH YDFEWSCWVR AISQEDQLAT CWQAEHCGEV HNKDMSWPEE MSFTANSSKI DRQKVPTEKG ATGLSNLGNT CFMNSSIQCV SNTQPLTQYF ISGRHLYELN RTNPIGMKGH MAKCYGDLVQ ELWSGTQKSV APLKLRRTIA KYAPKFDGFQ QQDSQELLAF LLDGLHEDLN RVHEKPYVEL KDSDGRPDWE VAAEAWDNHL RRNRSIIVDL FHGQLRSQVK CKTCGHISVR FDPFNFLSLP LPMDSYMDLE ITVIKLDGTT PVRYGLRLNM DEKYTGLKKQ LRDLCGLNSE QILLAEVHDS NIKNFPQDNQ KVQLSVSGFL CAFEIPVPSS PISASSPTQI DFSSSPSTNG MFTLTTNGDL PKPIFIPNGM PNTVVPCGTE KNFTNGMVNG HMPSLPDSPF TGYIIAVHRK MMRTELYFLS PQENRPSLFG MPLIVPCTVH TRKKDLYDAV WIQVSWLARP LPPQEASIHA QDRDNCMGYQ YPFTLRVVQK DGNSCAWCPQ YRFCRGCKID CGEDRAFIGN AYIAVDWHPT ALHLRYQTSQ ERVVDKHESV EQSRRAQAEP INLDSCLRAF TSEEELGESE MYYCSKCKTH CLATKKLDLW RLPPFLIIHL KRFQFVNDQW IKSQKIVRFL RESFDPSAFL VPRDPALCQH KPLTPQGDEL SKPRILAREV KKVDAQSSAG KEDMLLSKSP SSLSANISSS PKGSPSSSRK SGTSCPSSKN SSPNSSPRTL GRSKGRLRLP QIGSKNKPSS SKKNLDASKE NGAGQICELA DALSRGHMRG GSQPELVTPQ DHEVALANGF LYEHEACGNG CGDGYSNGQL GNHSEEDSTD DQREDTHIKP IYNLYAISCH SGILSGGHYI TYAKNPNCKW YCYNDSSCEE LHPDEIDTDS AYILFYEQQG IDYAQFLPKI DGKKMADTSS TDEDSESDYE KYSMLQ
Details Unavailable
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{
"geneID": 9098,
"tax": {
"id": 9606,
"name": [
{
"name": "Homo sapiens Linnaeus 1758"
},
{
"name": "Homo sapiens",
"type": 0
},
{
"name": "human",
"type": 4
}
]
},
"accession": {
"gene": [
"AC012146.25"
]
},
"genePos": {
"start": 5116032,
"end": 5174991
},
"orientation": false,
"symbol": "USP6",
"created": {
"$date": {
"$numberLong": "1738333349794"
}
},
"crossReference": {
"enseGeneID": "ENSG00000129204",
"enseRnaID": [
"ENST00000574788.6"
],
"enseProtID": [
"ENSP00000460380.1"
]
},
"chrom": {
"pos": "17",
"type": 1,
"loc": "17p13.2"
},
"desc": "ubiquitin specific peptidase 6",
"geneType": 5,
"ontology": [
{
"id": "GO:0003676",
"term": "nucleic acid binding",
"pubMed": [
1565468
],
"cat": 0
},
{
"id": "GO:0004197",
"term": "cysteine-type endopeptidase activity",
"pubMed": [
9827704
],
"cat": 0
},
{
"id": "GO:0004843",
"term": "cysteine-type deubiquitinase activity",
"cat": 0
},
{
"id": "GO:0004843",
"term": "cysteine-type deubiquitinase activity",
"pubMed": [
16127172
],
"cat": 0
},
{
"id": "GO:0005515",
"term": "protein binding",
"pubMed": [
12612085,
15509780,
16127172,
16555005
],
"cat": 0
},
{
"id": "GO:0005516",
"term": "calmodulin binding",
"cat": 0
},
{
"id": "GO:0006508",
"term": "proteolysis",
"cat": 1
},
{
"id": "GO:0016579",
"term": "protein deubiquitination",
"pubMed": [
16127172
],
"cat": 1
},
{
"id": "GO:0036211",
"term": "protein modification process",
"pubMed": [
9827704
],
"cat": 1
},
{
"id": "GO:0060627",
"term": "regulation of vesicle-mediated transport",
"pubMed": [
15509780
],
"cat": 1
},
{
"id": "GO:0099149",
"term": "regulation of postsynaptic neurotransmitter receptor internalization",
"pubMed": [
31841517
],
"cat": 1
},
{
"id": "GO:0005737",
"term": "cytoplasm",
"pubMed": [
12612085
],
"cat": 2
},
{
"id": "GO:0005764",
"term": "lysosome",
"pubMed": [
9827704
],
"cat": 2
},
{
"id": "GO:0005794",
"term": "Golgi apparatus",
"cat": 2
},
{
"id": "GO:0005886",
"term": "plasma membrane",
"pubMed": [
12612085
],
"cat": 2
},
{
"id": "GO:0055037",
"term": "recycling endosome",
"pubMed": [
15509780
],
"cat": 2
},
{
"id": "GO:0098978",
"term": "glutamatergic synapse",
"pubMed": [
31841517
],
"cat": 2
},
{
"id": "GO:0099092",
"term": "postsynaptic density, intracellular component",
"pubMed": [
31841517
],
"cat": 2
}
],
"geneRelations": [
{
"type": 8,
"similarGenes": [
"162632"
]
}
],
"protein": [
{
"symbol": "UBP6_HUMAN",
"name": "Ubiquitin carboxyl-terminal hydrolase 6",
"accession": [
"P35125",
"B9A6N0",
"Q15634",
"Q86WP6",
"Q8IWT4"
],
"databaseIDs": {
"NCBI Taxonomy": [
"9606"
],
"EC": [
"3.4.19.12",
"3.4.19.12"
],
"EMBL": [
"X63546",
"X63547",
"AY143550",
"AY163314",
"AB449915",
"AC012146",
"CH471108"
],
"CCDS": [
"CCDS11069.2"
],
"PIR": [
"S57867",
"S57868",
"S57874"
],
"RefSeq": [
"NP_001291213.1",
"NP_004496.2",
"XP_011522352.1",
"XP_011522353.1",
"XP_011522354.1",
"XP_011522355.1",
"XP_011522356.1",
"XP_011522357.1",
"XP_011522358.1",
"XP_011522361.1",
"XP_016880779.1"
],
"AlphaFoldDB": [
"P35125"
],
"SMR": [
"P35125"
],
"BioGRID": [
"114552"
],
"IntAct": [
"P35125"
],
"STRING": [
"9606.ENSP00000460380"
],
"BindingDB": [
"P35125"
],
"ChEMBL": [
"CHEMBL4630817"
],
"MEROPS": [
"C19.009",
"C19.044"
],
"iPTMnet": [
"P35125"
],
"PhosphoSitePlus": [
"P35125"
],
"BioMuta": [
"USP6"
],
"DMDM": [
"50403738"
],
"jPOST": [
"P35125"
],
"MassIVE": [
"P35125"
],
"PaxDb": [
"9606-ENSP00000460380"
],
"PeptideAtlas": [
"P35125"
],
"ProteomicsDB": [
"54980",
"54981",
"54982"
],
"Antibodypedia": [
"11505"
],
"DNASU": [
"9098"
],
"Ensembl": [
"ENST00000250066.6",
"ENST00000572949.5",
"ENST00000574788.6"
],
"KEGG": [
"hsa:9098"
],
"MANE-Select": [
"ENST00000574788.6"
],
"UCSC": [
"uc002gau.2"
],
"AGR": [
"HGNC:12629"
],
"CTD": [
"9098"
],
"DisGeNET": [
"9098"
],
"GeneCards": [
"USP6"
],
"HGNC": [
"HGNC:12629"
],
"HPA": [
"ENSG00000129204"
],
"MalaCards": [
"USP6"
],
"MIM": [
"604334"
],
"neXtProt": [
"NX_P35125"
],
"OpenTargets": [
"ENSG00000129204"
],
"Orphanet": [
"477742"
],
"PharmGKB": [
"PA37254"
],
"VEuPathDB": [
"HostDB:ENSG00000129204"
],
"eggNOG": [
"KOG1102",
"KOG1870"
],
"GeneTree": [
"ENSGT00940000155797"
],
"HOGENOM": [
"CLU_005123_0_0_1"
],
"InParanoid": [
"P35125"
],
"OrthoDB": [
"4687814at2759"
],
"PhylomeDB": [
"P35125"
],
"TreeFam": [
"TF324190"
],
"PathwayCommons": [
"P35125"
],
"SignaLink": [
"P35125"
],
"SIGNOR": [
"P35125"
],
"BioGRID-ORCS": [
"9098"
],
"ChiTaRS": [
"USP6"
],
"GeneWiki": [
"USP6"
],
"GenomeRNAi": [
"9098"
],
"Pharos": [
"P35125"
],
"PRO": [
"PR:P35125"
],
"Proteomes": [
"UP000005640"
],
"RNAct": [
"P35125"
],
"Bgee": [
"ENSG00000129204"
],
"ExpressionAtlas": [
"P35125"
],
"GO": [
"GO:0005737",
"GO:0098978",
"GO:0005794",
"GO:0005764",
"GO:0005886",
"GO:0099092",
"GO:0055037",
"GO:0005516",
"GO:0004843",
"GO:0004197",
"GO:0003676",
"GO:0016579",
"GO:0036211",
"GO:0006508",
"GO:0099149",
"GO:0060627"
],
"Gene3D": [
"3.90.70.10",
"1.10.8.270",
"1.10.10.750",
"1.10.472.80"
],
"InterPro": [
"IPR038765",
"IPR001394",
"IPR000195",
"IPR035969",
"IPR050185",
"IPR018200",
"IPR028889"
],
"PANTHER": [
"PTHR21646",
"PTHR21646:SF96"
],
"Pfam": [
"PF00566",
"PF00443"
],
"SMART": [
"SM00164"
],
"SUPFAM": [
"SSF54001",
"SSF47923"
],
"PROSITE": [
"PS50086",
"PS00972",
"PS00973",
"PS50235"
]
},
"citations": [
{
"title": "A novel transcriptional unit of the tre oncogene widely expressed in human cancer cells.",
"pubmedID": "1565468"
},
{
"title": "The Tre2 (USP6) oncogene is a hominoid-specific gene.",
"pubmedID": "12604796",
"doi": "10.1073\/pnas.0437015100"
},
{
"title": "Identification and characterization of a novel Tre-2\/Bub2\/Cdc16 (TBC) protein that possesses Rab3A-GAP activity.",
"pubmedID": "19077034",
"doi": "10.1111\/j.1365-2443.2008.01251.x"
},
{
"title": "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.",
"pubmedID": "16625196",
"doi": "10.1038\/nature04689"
},
{
"title": "The yeast DOA4 gene encodes a deubiquitinating enzyme related to a product of the human tre-2 oncogene.",
"pubmedID": "8247125",
"doi": "10.1038\/366313a0"
},
{
"title": "Expression in a RabGAP yeast mutant of two human homologues, one of which is an oncogene.",
"pubmedID": "14521938",
"doi": "10.1016\/j.bbrc.2003.09.051"
},
{
"title": "The TRE17 oncogene encodes a component of a novel effector pathway for Rho GTPases Cdc42 and Rac1 and stimulates actin remodeling.",
"pubmedID": "12612085",
"doi": "10.1128\/mcb.23.6.2151-2161.2003"
},
{
"title": "USP6 (Tre2) fusion oncogenes in aneurysmal bone cyst.",
"pubmedID": "15026324",
"doi": "10.1158\/0008-5472.can-03-2827"
},
{
"title": "The TBC (Tre-2\/Bub2\/Cdc16) domain protein TRE17 regulates plasma membrane-endosomal trafficking through activation of Arf6.",
"pubmedID": "15509780",
"doi": "10.1128\/mcb.24.22.9752-9762.2004"
},
{
"title": "Calcium\/calmodulin regulates ubiquitination of the ubiquitin-specific protease TRE17\/USP6.",
"pubmedID": "16127172",
"doi": "10.1074\/jbc.m505220200"
},
{
"title": "A quantitative atlas of mitotic phosphorylation.",
"pubmedID": "18669648",
"doi": "10.1073\/pnas.0805139105"
},
{
"title": "TRE17\/USP6 oncogene translocated in aneurysmal bone cyst induces matrix metalloproteinase production via activation of NF-kappaB.",
"pubmedID": "20418905",
"doi": "10.1038\/onc.2010.116"
}
],
"sequence": {
"length": 1406,
"mass": 158658,
"checksum": "D3A6822CEB441DB3",
"modified": {
"$date": {
"$numberLong": "1090195200000"
}
},
"version": 2,
"sequence": "MDMVENADSLQAQERKDILMKYDKGHRAGLPEDKGPEPVGINSSIDRFGILHETELPPVTAREAKKIRREMTRTSKWMEMLGEWETYKHSSKLIDRVYKGIPMNIRGPVWSVLLNIQEIKLKNPGRYQIMKERGKRSSEHIHHIDLDVRTTLRNHVFFRDRYGAKQRELFYILLAYSEYNPEVGYCRDLSHITALFLLYLPEEDAFWALVQLLASERHSLPGFHSPNGGTVQGLQDQQEHVVPKSQPKTMWHQDKEGLCGQCASLGCLLRNLIDGISLGLTLRLWDVYLVEGEQVLMPITSIALKVQQKRLMKTSRCGLWARLRNQFFDTWAMNDDTVLKHLRASTKKLTRKQGDLPPPAKREQGSLAPRPVPASRGGKTLCKGYRQAPPGPPAQFQRPICSASPPWASRFSTPCPGGAVREDTYPVGTQGVPSLALAQGGPQGSWRFLEWKSMPRLPTDLDIGGPWFPHYDFEWSCWVRAISQEDQLATCWQAEHCGEVHNKDMSWPEEMSFTANSSKIDRQKVPTEKGATGLSNLGNTCFMNSSIQCVSNTQPLTQYFISGRHLYELNRTNPIGMKGHMAKCYGDLVQELWSGTQKSVAPLKLRRTIAKYAPKFDGFQQQDSQELLAFLLDGLHEDLNRVHEKPYVELKDSDGRPDWEVAAEAWDNHLRRNRSIIVDLFHGQLRSQVKCKTCGHISVRFDPFNFLSLPLPMDSYMDLEITVIKLDGTTPVRYGLRLNMDEKYTGLKKQLRDLCGLNSEQILLAEVHDSNIKNFPQDNQKVQLSVSGFLCAFEIPVPSSPISASSPTQIDFSSSPSTNGMFTLTTNGDLPKPIFIPNGMPNTVVPCGTEKNFTNGMVNGHMPSLPDSPFTGYIIAVHRKMMRTELYFLSPQENRPSLFGMPLIVPCTVHTRKKDLYDAVWIQVSWLARPLPPQEASIHAQDRDNCMGYQYPFTLRVVQKDGNSCAWCPQYRFCRGCKIDCGEDRAFIGNAYIAVDWHPTALHLRYQTSQERVVDKHESVEQSRRAQAEPINLDSCLRAFTSEEELGESEMYYCSKCKTHCLATKKLDLWRLPPFLIIHLKRFQFVNDQWIKSQKIVRFLRESFDPSAFLVPRDPALCQHKPLTPQGDELSKPRILAREVKKVDAQSSAGKEDMLLSKSPSSLSANISSSPKGSPSSSRKSGTSCPSSKNSSPNSSPRTLGRSKGRLRLPQIGSKNKPSSSKKNLDASKENGAGQICELADALSRGHMRGGSQPELVTPQDHEVALANGFLYEHEACGNGCGDGYSNGQLGNHSEEDSTDDQREDTHIKPIYNLYAISCHSGILSGGHYITYAKNPNCKWYCYNDSSCEELHPDEIDTDSAYILFYEQQGIDYAQFLPKIDGKKMADTSSTDEDSESDYEKYSMLQ"
},
"existence": 0,
"relevance": 1,
"proteinID": 1460081987
}
],
"singleCellExpressions": {
"cellSignificanceIndex": []
}
}