Details for: USP6

Gene ID: 9098

Symbol: USP6

Ensembl ID: ENSG00000129204

Description: ubiquitin specific peptidase 6

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.6
    Marker Score: 1,165
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.31
    Marker Score: 1,302
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4,812
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.05
    Marker Score: 1,837
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,824
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,049
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,408
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 503
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 457
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,412
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.92
    Marker Score: 5,253
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.92
    Marker Score: 368
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,736
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.89
    Marker Score: 320
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.89
    Marker Score: 601
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.88
    Marker Score: 364
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,285
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.8
    Marker Score: 1,636
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1,258
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.77
    Marker Score: 354
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.76
    Marker Score: 697
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.76
    Marker Score: 11,870
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 391
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.73
    Marker Score: 559
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.71
    Marker Score: 457
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 175
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.61
    Marker Score: 1,147
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.54
    Marker Score: 170
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.53
    Marker Score: 306
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.48
    Marker Score: 315
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.47
    Marker Score: 677
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.43
    Marker Score: 899
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.41
    Marker Score: 1,029
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.39
    Marker Score: 2,322
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.36
    Marker Score: 456
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.34
    Marker Score: 99
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.33
    Marker Score: 198
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.32
    Marker Score: 135
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.32
    Marker Score: 151
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: 0.3
    Marker Score: 227
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.29
    Marker Score: 217
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.25
    Marker Score: 82
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.24
    Marker Score: 137
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 0.23
    Marker Score: 348
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.22
    Marker Score: 59
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.22
    Marker Score: 97
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 62
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 0.21
    Marker Score: 77
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.21
    Marker Score: 72
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.21
    Marker Score: 328
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.19
    Marker Score: 113
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 0.19
    Marker Score: 122
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.18
    Marker Score: 177
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.18
    Marker Score: 73
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.18
    Marker Score: 44
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.17
    Marker Score: 171
  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 0.17
    Marker Score: 63
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.17
    Marker Score: 180
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.17
    Marker Score: 41
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.16
    Marker Score: 51
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.16
    Marker Score: 261
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.16
    Marker Score: 79
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.16
    Marker Score: 97
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.16
    Marker Score: 78
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.15
    Marker Score: 185
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.15
    Marker Score: 278
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 0.15
    Marker Score: 188
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 0.15
    Marker Score: 51
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.15
    Marker Score: 35
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 0.15
    Marker Score: 282
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.15
    Marker Score: 506
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 0.15
    Marker Score: 86
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.15
    Marker Score: 59
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 0.15
    Marker Score: 285
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 0.14
    Marker Score: 515
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.14
    Marker Score: 148
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.14
    Marker Score: 78
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.14
    Marker Score: 122
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 0.14
    Marker Score: 361
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.14
    Marker Score: 65
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 0.13
    Marker Score: 108
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.13
    Marker Score: 1,164
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.13
    Marker Score: 376
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.13
    Marker Score: 77
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.13
    Marker Score: 1,124
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.13
    Marker Score: 286
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.13
    Marker Score: 169
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.13
    Marker Score: 7,816
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 0.12
    Marker Score: 43
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.12
    Marker Score: 111
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.12
    Marker Score: 289
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.12
    Marker Score: 35
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.12
    Marker Score: 24
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.12
    Marker Score: 280
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.12
    Marker Score: 492
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.12
    Marker Score: 224
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.11
    Marker Score: 29
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.11
    Marker Score: 36
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.11
    Marker Score: 57

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** USP6 is a member of the ubiquitin-specific protease family, which is characterized by its ability to remove ubiquitin from protein substrates. The gene is specifically expressed in cells involved in the maintenance of tissue homeostasis, such as epithelial cells, stem cells, and neurons. Its expression is also observed in cells involved in immune responses, suggesting a potential role in regulating immune cell function. Notably, USP6 is a deubiquitinating enzyme, which distinguishes it from ubiquitin ligases that add ubiquitin to protein substrates. **Pathways and Functions:** USP6 is involved in various cellular processes, including: 1. **Protein Degradation**: USP6 regulates protein degradation by removing ubiquitin from protein substrates, thereby modulating protein stability and turnover. 2. **Cell Signaling**: USP6 modulates cell signaling pathways, including the Wnt/β-catenin pathway, which is involved in development and tissue homeostasis. 3. **Immune Response**: USP6 regulates immune cell function, including the activation and differentiation of immune cells. 4. **Protein Localization**: USP6 modulates protein localization by removing ubiquitin from proteins, allowing them to maintain their native conformation and function. 5. **Regulation of Vesicle-Mediated Transport**: USP6 regulates the transport of proteins and lipids within vesicles, ensuring proper cellular trafficking and membrane homeostasis. **Clinical Significance:** Dysregulation of USP6 has been implicated in various diseases, including: 1. **Cancer**: USP6 is overexpressed in certain types of cancer, including colon cancer, and is associated with poor prognosis. 2. **Neurological Disorders**: USP6 has been implicated in the pathogenesis of neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. 3. **Inflammatory Diseases**: USP6 regulates immune cell function and has been implicated in the pathogenesis of inflammatory diseases, such as rheumatoid arthritis. 4. **Gastrointestinal Disorders**: USP6 is involved in the regulation of intestinal homeostasis and has been implicated in the pathogenesis of gastrointestinal disorders, such as inflammatory bowel disease. In conclusion, the USP6 gene plays a critical role in maintaining protein homeostasis and cellular regulation, and its dysregulation has been implicated in various diseases. Further research is needed to fully elucidate the mechanisms by which USP6 regulates cellular processes and to explore its potential as a therapeutic target for various diseases.

Genular Protein ID: 1460081987

Symbol: UBP6_HUMAN

Name: Ubiquitin carboxyl-terminal hydrolase 6

UniProtKB Accession Codes:

P35125 Q15634 Q86WP6 Q8IWT4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EC 2 EMBL 4 EPD 1 Ensembl 3 ExpressionAtlas 1 GO 13 Gene3D 4 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MEROPS 2 MIM 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PIR 3 PRO 1 PROSITE 4 PROSITE-ProRule 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 RNAct 1 RefSeq 11 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 2 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1565468

Title: A novel transcriptional unit of the tre oncogene widely expressed in human cancer cells.

PubMed ID: 1565468

PubMed ID: 12604796

Title: The Tre2 (USP6) oncogene is a hominoid-specific gene.

PubMed ID: 12604796

DOI: 10.1073/pnas.0437015100

PubMed ID: 8247125

Title: The yeast DOA4 gene encodes a deubiquitinating enzyme related to a product of the human tre-2 oncogene.

PubMed ID: 8247125

DOI: 10.1038/366313a0

PubMed ID: 14521938

Title: Expression in a RabGAP yeast mutant of two human homologues, one of which is an oncogene.

PubMed ID: 14521938

DOI: 10.1016/j.bbrc.2003.09.051

PubMed ID: 12612085

Title: The TRE17 oncogene encodes a component of a novel effector pathway for Rho GTPases Cdc42 and Rac1 and stimulates actin remodeling.

PubMed ID: 12612085

DOI: 10.1128/mcb.23.6.2151-2161.2003

PubMed ID: 15026324

Title: USP6 (Tre2) fusion oncogenes in aneurysmal bone cyst.

PubMed ID: 15026324

DOI: 10.1158/0008-5472.can-03-2827

PubMed ID: 15509780

Title: The TBC (Tre-2/Bub2/Cdc16) domain protein TRE17 regulates plasma membrane-endosomal trafficking through activation of Arf6.

PubMed ID: 15509780

DOI: 10.1128/mcb.24.22.9752-9762.2004

PubMed ID: 16127172

Title: Calcium/calmodulin regulates ubiquitination of the ubiquitin-specific protease TRE17/USP6.

PubMed ID: 16127172

DOI: 10.1074/jbc.m505220200

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 20418905

Title: TRE17/USP6 oncogene translocated in aneurysmal bone cyst induces matrix metalloproteinase production via activation of NF-kappaB.

PubMed ID: 20418905

DOI: 10.1038/onc.2010.116

Sequence Information:

  • Length: 1406
  • Mass: 158658
  • Checksum: D3A6822CEB441DB3
  • Sequence:
    • MDMVENADSL QAQERKDILM KYDKGHRAGL PEDKGPEPVG INSSIDRFGI LHETELPPVT 
AREAKKIRRE MTRTSKWMEM LGEWETYKHS SKLIDRVYKG IPMNIRGPVW SVLLNIQEIK 
LKNPGRYQIM KERGKRSSEH IHHIDLDVRT TLRNHVFFRD RYGAKQRELF YILLAYSEYN 
PEVGYCRDLS HITALFLLYL PEEDAFWALV QLLASERHSL PGFHSPNGGT VQGLQDQQEH 
VVPKSQPKTM WHQDKEGLCG QCASLGCLLR NLIDGISLGL TLRLWDVYLV EGEQVLMPIT 
SIALKVQQKR LMKTSRCGLW ARLRNQFFDT WAMNDDTVLK HLRASTKKLT RKQGDLPPPA 
KREQGSLAPR PVPASRGGKT LCKGYRQAPP GPPAQFQRPI CSASPPWASR FSTPCPGGAV 
REDTYPVGTQ GVPSLALAQG GPQGSWRFLE WKSMPRLPTD LDIGGPWFPH YDFEWSCWVR 
AISQEDQLAT CWQAEHCGEV HNKDMSWPEE MSFTANSSKI DRQKVPTEKG ATGLSNLGNT 
CFMNSSIQCV SNTQPLTQYF ISGRHLYELN RTNPIGMKGH MAKCYGDLVQ ELWSGTQKSV 
APLKLRRTIA KYAPKFDGFQ QQDSQELLAF LLDGLHEDLN RVHEKPYVEL KDSDGRPDWE 
VAAEAWDNHL RRNRSIIVDL FHGQLRSQVK CKTCGHISVR FDPFNFLSLP LPMDSYMDLE 
ITVIKLDGTT PVRYGLRLNM DEKYTGLKKQ LRDLCGLNSE QILLAEVHDS NIKNFPQDNQ 
KVQLSVSGFL CAFEIPVPSS PISASSPTQI DFSSSPSTNG MFTLTTNGDL PKPIFIPNGM 
PNTVVPCGTE KNFTNGMVNG HMPSLPDSPF TGYIIAVHRK MMRTELYFLS PQENRPSLFG 
MPLIVPCTVH TRKKDLYDAV WIQVSWLARP LPPQEASIHA QDRDNCMGYQ YPFTLRVVQK 
DGNSCAWCPQ YRFCRGCKID CGEDRAFIGN AYIAVDWHPT ALHLRYQTSQ ERVVDKHESV 
EQSRRAQAEP INLDSCLRAF TSEEELGESE MYYCSKCKTH CLATKKLDLW RLPPFLIIHL 
KRFQFVNDQW IKSQKIVRFL RESFDPSAFL VPRDPALCQH KPLTPQGDEL SKPRILAREV 
KKVDAQSSAG KEDMLLSKSP SSLSANISSS PKGSPSSSRK SGTSCPSSKN SSPNSSPRTL 
GRSKGRLRLP QIGSKNKPSS SKKNLDASKE NGAGQICELA DALSRGHMRG GSQPELVTPQ 
DHEVALANGF LYEHEACGNG CGDGYSNGQL GNHSEEDSTD DQREDTHIKP IYNLYAISCH 
SGILSGGHYI TYAKNPNCKW YCYNDSSCEE LHPDEIDTDS AYILFYEQQG IDYAQFLPKI 
DGKKMADTSS TDEDSESDYE KYSMLQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.