USP2 | ENSG00000036672 | NCBI 9099

Details for: USP2

Gene ID: 9099

Symbol: USP2

Ensembl ID: ENSG00000036672

Description: ubiquitin specific peptidase 2

Associated with

Death receptor signaling
(R-HSA-73887)
Deubiquitination
(R-HSA-5688426)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Metabolism of proteins
(R-HSA-392499)
Post-translational protein modification
(R-HSA-597592)
Regulation of tnfr1 signaling
(R-HSA-5357905)
Regulation of tp53 activity
(R-HSA-5633007)
Regulation of tp53 degradation
(R-HSA-6804757)
Regulation of tp53 expression and degradation
(R-HSA-6806003)
Rna polymerase ii transcription
(R-HSA-73857)
Signal transduction
(R-HSA-162582)
Tnfr1-induced nf-kappa-b signaling pathway
(R-HSA-5357956)
Tnfr1-induced proapoptotic signaling
(R-HSA-5357786)
Tnf signaling
(R-HSA-75893)
Transcriptional regulation by tp53
(R-HSA-3700989)
Ub-specific processing proteases
(R-HSA-5689880)
Cell cycle
(GO:0007049)
Centrosome
(GO:0005813)
Circadian behavior
(GO:0048512)
Circadian regulation of gene expression
(GO:0032922)
Cyclin binding
(GO:0030332)
Cysteine-type deubiquitinase activity
(GO:0004843)
Cysteine-type endopeptidase activity
(GO:0004197)
Cytoplasm
(GO:0005737)
Entrainment of circadian clock by photoperiod
(GO:0043153)
Identical protein binding
(GO:0042802)
Locomotor rhythm
(GO:0045475)
Membrane
(GO:0016020)
Metal ion binding
(GO:0046872)
Muscle organ development
(GO:0007517)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Nucleoplasm
(GO:0005654)
Perinuclear region of cytoplasm
(GO:0048471)
Positive regulation of mitotic cell cycle
(GO:0045931)
Protein binding
(GO:0005515)
Protein deubiquitination
(GO:0016579)
Protein stabilization
(GO:0050821)
Proteolysis
(GO:0006508)
Regulation of signal transduction by p53 class mediator
(GO:1901796)
Ubiquitin protein ligase binding
(GO:0031625)

Other Information

Proteins

Ubiquitin carboxyl-terminal hydrolase 2

Genular Protein ID: 3096477453

Symbol: UBP2_HUMAN

Name: Ubiquitin carboxyl-terminal hydrolase 2

UniProtKB Accession Codes:

O75604 B0YJB8 E9PPM2 Q8IUM2 Q8IW04 Q96MB9 Q9BQ21

Database IDs:

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17290220

Title: The deubiquitinating enzyme USP2a regulates the p53 pathway by targeting Mdm2.

PubMed ID: 17290220

DOI: 10.1038/sj.emboj.7601567

PubMed ID: 19917254

Title: Suppression of cancer cell growth by promoting cyclin D1 degradation.

PubMed ID: 19917254

DOI: 10.1016/j.molcel.2009.10.018

PubMed ID: 19838211

Title: MdmX is a substrate for the deubiquitinating enzyme USP2a.

PubMed ID: 19838211

DOI: 10.1038/onc.2009.330

PubMed ID: 20403044

Title: Expression of USP2-69 in mesangial cells in vivo and in vitro.

PubMed ID: 20403044

DOI: 10.1111/j.1440-1827.2010.02496.x

PubMed ID: 22024150

Title: Deubiquitylating enzyme USP2 counteracts Nedd4-2-mediated downregulation of KCNQ1 potassium channels.

PubMed ID: 22024150

DOI: 10.1016/j.hrthm.2011.10.026

PubMed ID: 16905103

Title: Structural basis of ubiquitin recognition by the deubiquitinating protease USP2.

PubMed ID: 16905103

DOI: 10.1016/j.str.2006.06.012

Sequence Information:

Length: 605
Mass: 68072
Checksum: AFF4DA9344D21812
Sequence:

MSQLSSTLKR YTESARYTDA HYAKSGYGAY TPSSYGANLA ASLLEKEKLG FKPVPTSSFL 
TRPRTYGPSS LLDYDRGRPL LRPDITGGGK RAESQTRGTE RPLGSGLSGG SGFPYGVTNN 
CLSYLPINAY DQGVTLTQKL DSQSDLARDF SSLRTSDSYR IDPRNLGRSP MLARTRKELC 
TLQGLYQTAS CPEYLVDYLE NYGRKGSASQ VPSQAPPSRV PEIISPTYRP IGRYTLWETG 
KGQAPGPSRS SSPGRDGMNS KSAQGLAGLR NLGNTCFMNS ILQCLSNTRE LRDYCLQRLY 
MRDLHHGSNA HTALVEEFAK LIQTIWTSSP NDVVSPSEFK TQIQRYAPRF VGYNQQDAQE 
FLRFLLDGLH NEVNRVTLRP KSNPENLDHL PDDEKGRQMW RKYLEREDSR IGDLFVGQLK 
SSLTCTDCGY CSTVFDPFWD LSLPIAKRGY PEVTLMDCMR LFTKEDVLDG DEKPTCCRCR 
GRKRCIKKFS IQRFPKILVL HLKRFSESRI RTSKLTTFVN FPLRDLDLRE FASENTNHAV 
YNLYAVSNHS GTTMGGHYTA YCRSPGTGEW HTFNDSSVTP MSSSQVRTSD AYLLFYELAS 
PPSRM

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: USP2

Associated with

Other Information

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

Human chromosome 11 DNA sequence and analysis including novel gene identification. PubMed ID: 16554811

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

The deubiquitinating enzyme USP2a regulates the p53 pathway by targeting Mdm2. PubMed ID: 17290220

Suppression of cancer cell growth by promoting cyclin D1 degradation. PubMed ID: 19917254

MdmX is a substrate for the deubiquitinating enzyme USP2a. PubMed ID: 19838211

Expression of USP2-69 in mesangial cells in vivo and in vitro. PubMed ID: 20403044

Deubiquitylating enzyme USP2 counteracts Nedd4-2-mediated downregulation of KCNQ1 potassium channels. PubMed ID: 22024150

Structural basis of ubiquitin recognition by the deubiquitinating protease USP2. PubMed ID: 16905103