Details for: USP2

Gene ID: 9099

Symbol: USP2

Ensembl ID: ENSG00000036672

Description: ubiquitin specific peptidase 2

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 2.29
    Marker Score: 683
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.98
    Marker Score: 8,283
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.64
    Marker Score: 3,875
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.58
    Marker Score: 2,986
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 1.54
    Marker Score: 4,115
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 169,113
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 1.46
    Marker Score: 3,648
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 1.44
    Marker Score: 32,125
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 1.43
    Marker Score: 575
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 1.39
    Marker Score: 439
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 1.32
    Marker Score: 3,778
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.29
    Marker Score: 20,255
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 1.19
    Marker Score: 349
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 1.12
    Marker Score: 1,191
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 1.11
    Marker Score: 1,180
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.1
    Marker Score: 1,700
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 1.07
    Marker Score: 559
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 1.06
    Marker Score: 2,336
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 1.04
    Marker Score: 9,076
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,808
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,033
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 1
    Marker Score: 3,426
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.99
    Marker Score: 9,360
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,407
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 504
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.97
    Marker Score: 241
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 458
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,411
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.94
    Marker Score: 294
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,736
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.91
    Marker Score: 5,186
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 323
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.88
    Marker Score: 420
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.88
    Marker Score: 1,531
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.87
    Marker Score: 3,099
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,283
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 0.87
    Marker Score: 3,081
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 0.83
    Marker Score: 1,576
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.83
    Marker Score: 266
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.8
    Marker Score: 614
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.79
    Marker Score: 1,608
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1,257
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 393
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.76
    Marker Score: 3,173
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.75
    Marker Score: 301
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.74
    Marker Score: 679
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.71
    Marker Score: 6,141
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.71
    Marker Score: 6,706
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.69
    Marker Score: 42,597
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.69
    Marker Score: 25,488
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 177
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.67
    Marker Score: 2,797
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.67
    Marker Score: 907
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.62
    Marker Score: 568
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.57
    Marker Score: 316
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.56
    Marker Score: 484
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.56
    Marker Score: 144
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 441
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.55
    Marker Score: 352
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.55
    Marker Score: 249
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.53
    Marker Score: 244
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.53
    Marker Score: 446
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.53
    Marker Score: 253
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.53
    Marker Score: 261
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.53
    Marker Score: 755
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.5
    Marker Score: 223
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.5
    Marker Score: 127
  • Cell Name: PP cell (CL0000696)
    Fold Change: 0.5
    Marker Score: 112
  • Cell Name: bronchial smooth muscle cell (CL0002598)
    Fold Change: 0.5
    Marker Score: 140
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.49
    Marker Score: 496
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.49
    Marker Score: 484
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.49
    Marker Score: 18,454
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.48
    Marker Score: 7,212
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 0.48
    Marker Score: 458
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.48
    Marker Score: 2,282
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 0.47
    Marker Score: 150
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: 0.46
    Marker Score: 353
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.46
    Marker Score: 550
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 0.45
    Marker Score: 428
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.45
    Marker Score: 1,270
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.44
    Marker Score: 264
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.44
    Marker Score: 456
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.43
    Marker Score: 189
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 0.43
    Marker Score: 1,363
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.43
    Marker Score: 426
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 0.42
    Marker Score: 582
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.41
    Marker Score: 273
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 0.41
    Marker Score: 135
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.41
    Marker Score: 138
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 0.41
    Marker Score: 1,157
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.4
    Marker Score: 8,627
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.4
    Marker Score: 988
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.4
    Marker Score: 3,069
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.4
    Marker Score: 115
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.39
    Marker Score: 382
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.39
    Marker Score: 2,287
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 0.39
    Marker Score: 594
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 0.38
    Marker Score: 328
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.38
    Marker Score: 224
  • Cell Name: enterocyte of epithelium proper of ileum (CL1000342)
    Fold Change: 0.38
    Marker Score: 109

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Deubiquitinating enzyme**: USP2 is a cysteine-type deubiquitinating enzyme that removes ubiquitin from lysine residues, thereby regulating protein activity and stability. 2. **Regulation of protein stability and activity**: USP2 plays a crucial role in regulating the stability and activity of various proteins involved in cell cycle progression, apoptosis, and immune response. 3. **Cell cycle regulation**: USP2 is involved in regulating the cell cycle, particularly in the progression from G1 to S phase. 4. **Apoptosis regulation**: USP2 can regulate apoptosis by modulating the activity of pro-apoptotic proteins. 5. **Immune response regulation**: USP2 is involved in regulating the immune response by modulating the activity of immune-related proteins. **Pathways and Functions:** 1. **Cell cycle regulation**: USP2 regulates the cell cycle by removing ubiquitin from proteins involved in cell cycle progression, such as cyclins and cyclin-dependent kinases. 2. **Apoptosis regulation**: USP2 regulates apoptosis by removing ubiquitin from pro-apoptotic proteins, thereby preventing their activation. 3. **Immune response regulation**: USP2 regulates the immune response by modulating the activity of immune-related proteins, such as tumor necrosis factor receptors (TNFRs) and p53. 4. **Protein stabilization**: USP2 can stabilize proteins by removing ubiquitin, thereby preventing their degradation. 5. **Signal transduction regulation**: USP2 regulates signal transduction pathways by modulating the activity of proteins involved in these pathways. **Clinical Significance:** 1. **Cancer**: USP2 has been implicated in cancer development and progression, as it can regulate the activity of proteins involved in cell cycle progression and apoptosis. 2. **Neurodegenerative diseases**: USP2 has been implicated in neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease, as it can regulate the activity of proteins involved in protein degradation and aggregation. 3. **Immune disorders**: USP2 has been implicated in immune disorders, such as rheumatoid arthritis and lupus, as it can regulate the activity of immune-related proteins. 4. **Regenerative medicine**: USP2 has been identified as a potential therapeutic target for regenerative medicine, as it can regulate the activity of proteins involved in tissue repair and regeneration. In conclusion, the USP2 gene is a multifaceted gene involved in regulating protein stability, activity, and degradation. Its dysregulation has been implicated in various diseases, including cancer, neurodegenerative diseases, and immune disorders. Further research is needed to fully understand the mechanisms of USP2 and its role in human diseases.

Genular Protein ID: 3096477453

Symbol: UBP2_HUMAN

Name: Ubiquitin carboxyl-terminal hydrolase 2

UniProtKB Accession Codes:

O75604 B0YJB8 E9PPM2 Q8IUM2 Q8IW04 Q96MB9 Q9BQ21

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 1 CORUM 1 CTD 1 ChEBI 4 ChEMBL 1 ChiTaRS 1 DIP 1 DNASU 1 DisGeNET 1 EC 2 EMBL 13 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 23 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MEROPS 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 MoonDB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 14 PDBsum 8 PRO 1 PROSITE 3 PROSITE-ProRule 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 5 RNAct 1 Reactome 5 RefSeq 5 SAM 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17290220

Title: The deubiquitinating enzyme USP2a regulates the p53 pathway by targeting Mdm2.

PubMed ID: 17290220

DOI: 10.1038/sj.emboj.7601567

PubMed ID: 19917254

Title: Suppression of cancer cell growth by promoting cyclin D1 degradation.

PubMed ID: 19917254

DOI: 10.1016/j.molcel.2009.10.018

PubMed ID: 19838211

Title: MdmX is a substrate for the deubiquitinating enzyme USP2a.

PubMed ID: 19838211

DOI: 10.1038/onc.2009.330

PubMed ID: 20403044

Title: Expression of USP2-69 in mesangial cells in vivo and in vitro.

PubMed ID: 20403044

DOI: 10.1111/j.1440-1827.2010.02496.x

PubMed ID: 22024150

Title: Deubiquitylating enzyme USP2 counteracts Nedd4-2-mediated downregulation of KCNQ1 potassium channels.

PubMed ID: 22024150

DOI: 10.1016/j.hrthm.2011.10.026

PubMed ID: 16905103

Title: Structural basis of ubiquitin recognition by the deubiquitinating protease USP2.

PubMed ID: 16905103

DOI: 10.1016/j.str.2006.06.012

Sequence Information:

  • Length: 605
  • Mass: 68072
  • Checksum: AFF4DA9344D21812
  • Sequence:
    • MSQLSSTLKR YTESARYTDA HYAKSGYGAY TPSSYGANLA ASLLEKEKLG FKPVPTSSFL 
TRPRTYGPSS LLDYDRGRPL LRPDITGGGK RAESQTRGTE RPLGSGLSGG SGFPYGVTNN 
CLSYLPINAY DQGVTLTQKL DSQSDLARDF SSLRTSDSYR IDPRNLGRSP MLARTRKELC 
TLQGLYQTAS CPEYLVDYLE NYGRKGSASQ VPSQAPPSRV PEIISPTYRP IGRYTLWETG 
KGQAPGPSRS SSPGRDGMNS KSAQGLAGLR NLGNTCFMNS ILQCLSNTRE LRDYCLQRLY 
MRDLHHGSNA HTALVEEFAK LIQTIWTSSP NDVVSPSEFK TQIQRYAPRF VGYNQQDAQE 
FLRFLLDGLH NEVNRVTLRP KSNPENLDHL PDDEKGRQMW RKYLEREDSR IGDLFVGQLK 
SSLTCTDCGY CSTVFDPFWD LSLPIAKRGY PEVTLMDCMR LFTKEDVLDG DEKPTCCRCR 
GRKRCIKKFS IQRFPKILVL HLKRFSESRI RTSKLTTFVN FPLRDLDLRE FASENTNHAV 
YNLYAVSNHS GTTMGGHYTA YCRSPGTGEW HTFNDSSVTP MSSSQVRTSD AYLLFYELAS 
PPSRM

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.