Details for: ACVR1B

Gene ID: 91

Symbol: ACVR1B

Ensembl ID: ENSG00000135503

Description: activin A receptor type 1B

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.58
    Marker Score: 97291
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.58
    Marker Score: 13567
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.57
    Marker Score: 6386
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.43
    Marker Score: 13592
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.42
    Marker Score: 2193
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 1.4
    Marker Score: 3761.5
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 1.39
    Marker Score: 1277
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.38
    Marker Score: 50829
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 1.36
    Marker Score: 1048
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 1.35
    Marker Score: 1369
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.33
    Marker Score: 50528
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.31
    Marker Score: 5070
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.31
    Marker Score: 10018
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.3
    Marker Score: 3056
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.3
    Marker Score: 13390
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.29
    Marker Score: 2247
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.28
    Marker Score: 1416
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 1.27
    Marker Score: 1348
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.27
    Marker Score: 1315
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 1.26
    Marker Score: 3171
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.25
    Marker Score: 11784
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.18
    Marker Score: 23436
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.14
    Marker Score: 2317
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 1.12
    Marker Score: 5190
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.1
    Marker Score: 16382
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 1.05
    Marker Score: 2019
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 1.02
    Marker Score: 4218
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 1.02
    Marker Score: 1429
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 1.01
    Marker Score: 1087
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71758
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47983
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.96
    Marker Score: 493
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.95
    Marker Score: 448
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2406
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.93
    Marker Score: 1315
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.93
    Marker Score: 1505
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.92
    Marker Score: 14367
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 0.91
    Marker Score: 473
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.91
    Marker Score: 961
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2723
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.9
    Marker Score: 30488.5
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 0.9
    Marker Score: 3873
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 0.89
    Marker Score: 509
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.88
    Marker Score: 2014
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.88
    Marker Score: 316
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.88
    Marker Score: 1100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5295
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.87
    Marker Score: 4971
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.84
    Marker Score: 198
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.84
    Marker Score: 441
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.84
    Marker Score: 262
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.84
    Marker Score: 382
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.84
    Marker Score: 269
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.83
    Marker Score: 720
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.82
    Marker Score: 7103
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.82
    Marker Score: 5250
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 0.81
    Marker Score: 775
  • Cell Name: fat cell (CL0000136)
    Fold Change: 0.81
    Marker Score: 454
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.81
    Marker Score: 552
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.81
    Marker Score: 932
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.8
    Marker Score: 1033
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.8
    Marker Score: 609
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.78
    Marker Score: 226
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.78
    Marker Score: 313
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.77
    Marker Score: 322
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.77
    Marker Score: 1617
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.75
    Marker Score: 853
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.75
    Marker Score: 3158
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.75
    Marker Score: 445
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.74
    Marker Score: 385
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 0.74
    Marker Score: 2316
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 0.72
    Marker Score: 3894
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.72
    Marker Score: 511
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.72
    Marker Score: 351
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.72
    Marker Score: 145
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 0.71
    Marker Score: 1184
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.71
    Marker Score: 4275
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.71
    Marker Score: 455
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.71
    Marker Score: 424
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.7
    Marker Score: 3771
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.7
    Marker Score: 637
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.7
    Marker Score: 2390
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 0.69
    Marker Score: 478
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.69
    Marker Score: 686
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.68
    Marker Score: 1503
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 0.68
    Marker Score: 5078
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 0.68
    Marker Score: 297
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.68
    Marker Score: 23059
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 0.68
    Marker Score: 3553
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 173
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 0.67
    Marker Score: 2261
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.66
    Marker Score: 385
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.66
    Marker Score: 2751.5
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.66
    Marker Score: 2328
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.65
    Marker Score: 1147
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.64
    Marker Score: 3088
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.64
    Marker Score: 1307
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.64
    Marker Score: 372
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.63
    Marker Score: 244

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Other Information

**Key characteristics:** - The ACVR1B gene is located on chromosome 17q21.1. - It is a single copy gene, with a size of approximately 28.5 kb. - The protein encoded by ACVR1B is a transmembrane protein with a molecular weight of approximately 160 kDa. - It is a member of the activin receptor superfamily, which is characterized by the presence of a conserved cysteine-rich domain. **Pathways and functions:** - The ACVR1B protein is a key regulator of the MAPK signaling pathway. - It is also involved in the regulation of cell growth, differentiation, and apoptosis. - It is expressed in a variety of cell types, including neurons, astrocytes, and endothelial cells. - In neurons, ACVR1B is expressed in L2/3-6 intratelencephalic projecting glutamatergic neurons, which are implicated in a variety of brain functions, including learning and memory. **Clinical significance:** - Mutations in the ACVR1B gene have been linked to a number of human diseases, including autism, schizophrenia, and developmental disorders. - The role of ACVR1B in human health is an active area of research. **Other important facts:** - ACVR1B is a highly conserved gene, with a similar gene found in mammals, birds, and fish. - It is a member of the Activin receptor superfamily, which is characterized by the presence of a conserved cysteine-rich domain. - The crystal structure of the ACVR1B protein has been determined, and it has been shown to be a ligand for the cytokine TGF-beta.

Genular Protein ID: 2057999171

Symbol: ACV1B_HUMAN

Name: Activin receptor type-1B

UniProtKB Accession Codes:

P36896 B7Z5L8 B7Z5W5 Q15479 Q15480 Q15481 Q15482

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 1 CTD 1 ChEBI 14 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 2 DrugCentral 1 EC 3 EMBL 13 EPD 1 Ensembl 5 ExpressionAtlas 1 GO 35 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 2 PIR 3 PRO 1 PROSITE 4 PROSITE-ProRule 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 5 RNAct 1 Reactome 3 RefSeq 3 Rhea 6 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8397373

Title: Activin receptor-like kinases: a novel subclass of cell-surface receptors with predicted serine/threonine kinase activity.

PubMed ID: 8397373

PubMed ID: 8196624

Title: Type I receptors specify growth-inhibitory and transcriptional responses to transforming growth factor beta and activin.

PubMed ID: 8196624

DOI: 10.1128/mcb.14.6.3810-3821.1994

PubMed ID: 8058741

Title: Genomic structure and cloned cDNAs predict that four variants in the kinase domain of serine/threonine kinase receptors arise by alternative splicing and poly(A) addition.

PubMed ID: 8058741

DOI: 10.1073/pnas.91.17.7957

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8622651

Title: Activation of signalling by the activin receptor complex.

PubMed ID: 8622651

DOI: 10.1128/mcb.16.3.1066

PubMed ID: 9032295

Title: Activin and inhibin have antagonistic effects on ligand-dependent heteromerization of the type I and type II activin receptors and human erythroid differentiation.

PubMed ID: 9032295

DOI: 10.1128/mcb.17.3.1682

PubMed ID: 9892009

Title: Roles of pathway-specific and inhibitory Smads in activin receptor signaling.

PubMed ID: 9892009

DOI: 10.1210/mend.13.1.0218

PubMed ID: 11266516

Title: Modulation of activin signal transduction by inhibin B and inhibin-binding protein (INhBP).

PubMed ID: 11266516

DOI: 10.1210/mend.15.4.0616

PubMed ID: 12023024

Title: Phosphorylation regulation of the interaction between Smad7 and activin type I receptor.

PubMed ID: 12023024

DOI: 10.1016/s0014-5793(02)02718-7

PubMed ID: 12364468

Title: Overexpression of wild-type activin receptor alk4-1 restores activin antiproliferative effects in human pituitary tumor cells.

PubMed ID: 12364468

DOI: 10.1210/jc.2002-020527

PubMed ID: 11909953

Title: Cripto-1 activates nodal- and ALK4-dependent and -independent signaling pathways in mammary epithelial Cells.

PubMed ID: 11909953

DOI: 10.1128/mcb.22.8.2586-2597.2002

PubMed ID: 12112843

Title: Identification of the phosphotyrosine proteome from thrombin activated platelets.

PubMed ID: 12112843

DOI: 10.1002/1615-9861(200206)2:6<642::aid-prot642>3.0.co;2-i

PubMed ID: 12639945

Title: Activin signaling through type IB activin receptor stimulates aromatase activity in the ovarian granulosa cell-like human granulosa (KGN) cells.

PubMed ID: 12639945

DOI: 10.1210/en.2002-220978

PubMed ID: 12665502

Title: Identification of a functional binding site for activin on the type I receptor ALK4.

PubMed ID: 12665502

DOI: 10.1074/jbc.m302015200

PubMed ID: 16720724

Title: FKBP12 functions as an adaptor of the Smad7-Smurf1 complex on activin type I receptor.

PubMed ID: 16720724

DOI: 10.1677/jme.1.01966

PubMed ID: 18039968

Title: Ttrap is an essential modulator of Smad3-dependent Nodal signaling during zebrafish gastrulation and left-right axis determination.

PubMed ID: 18039968

DOI: 10.1242/dev.000026

PubMed ID: 20226172

Title: Activin A induces neuronal differentiation and survival via ALK4 in a SMAD-independent manner in a subpopulation of human neuroblastomas.

PubMed ID: 20226172

DOI: 10.1016/j.bbrc.2010.03.039

PubMed ID: 20596523

Title: Development and validation of a method for profiling post-translational modification activities using protein microarrays.

PubMed ID: 20596523

DOI: 10.1371/journal.pone.0011332

PubMed ID: 21791611

Title: TSC-22 promotes transforming growth factor beta-mediated cardiac myofibroblast differentiation by antagonizing Smad7 activity.

PubMed ID: 21791611

DOI: 10.1128/mcb.05448-11

PubMed ID: 21377836

Title: Activation of the activin A-ALK-Smad pathway in systemic sclerosis.

PubMed ID: 21377836

DOI: 10.1016/j.jaut.2010.09.004

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

Sequence Information:

  • Length: 505
  • Mass: 56807
  • Checksum: 40A6C65CAA4C7573
  • Sequence:
    • MAESAGASSF FPLVVLLLAG SGGSGPRGVQ ALLCACTSCL QANYTCETDG ACMVSIFNLD 
GMEHHVRTCI PKVELVPAGK PFYCLSSEDL RNTHCCYTDY CNRIDLRVPS GHLKEPEHPS 
MWGPVELVGI IAGPVFLLFL IIIIVFLVIN YHQRVYHNRQ RLDMEDPSCE MCLSKDKTLQ 
DLVYDLSTSG SGSGLPLFVQ RTVARTIVLQ EIIGKGRFGE VWRGRWRGGD VAVKIFSSRE 
ERSWFREAEI YQTVMLRHEN ILGFIAADNK DNGTWTQLWL VSDYHEHGSL FDYLNRYTVT 
IEGMIKLALS AASGLAHLHM EIVGTQGKPG IAHRDLKSKN ILVKKNGMCA IADLGLAVRH 
DAVTDTIDIA PNQRVGTKRY MAPEVLDETI NMKHFDSFKC ADIYALGLVY WEIARRCNSG 
GVHEEYQLPY YDLVPSDPSI EEMRKVVCDQ KLRPNIPNWW QSYEALRVMG KMMRECWYAN 
GAARLTALRI KKTLSQLSVQ EDVKI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.