ACVR1B | ENSG00000135503 | NCBI 91

Details for: ACVR1B

Gene ID: 91

Symbol: ACVR1B

Ensembl ID: ENSG00000135503

Description: activin A receptor type 1B

Associated with

Developmental biology
(R-HSA-1266738)
Regulation of signaling by nodal
(R-HSA-1433617)
Signaling by activin
(R-HSA-1502540)
Signaling by nodal
(R-HSA-1181150)
Signaling by tgfb family members
(R-HSA-9006936)
Activin binding
(GO:0048185)
Activin receptor activity
(GO:0017002)
Activin receptor activity, type i
(GO:0016361)
Activin receptor complex
(GO:0048179)
Activin receptor signaling pathway
(GO:0032924)
Atp binding
(GO:0005524)
Cell surface
(GO:0009986)
Cellular response to growth factor stimulus
(GO:0071363)
Cytosol
(GO:0005829)
Extrinsic apoptotic signaling pathway
(GO:0097191)
G1/s transition of mitotic cell cycle
(GO:0000082)
Growth factor binding
(GO:0019838)
Hair follicle development
(GO:0001942)
I-smad binding
(GO:0070411)
Inhibin binding
(GO:0034711)
In utero embryonic development
(GO:0001701)
Metal ion binding
(GO:0046872)
Negative regulation of cell growth
(GO:0030308)
Negative regulation of gene expression
(GO:0010629)
Nervous system development
(GO:0007399)
Nodal signaling pathway
(GO:0038092)
Peptidyl-threonine phosphorylation
(GO:0018107)
Plasma membrane
(GO:0005886)
Positive regulation of activin receptor signaling pathway
(GO:0032927)
Positive regulation of erythrocyte differentiation
(GO:0045648)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of trophoblast cell migration
(GO:1901165)
Protein autophosphorylation
(GO:0046777)
Protein binding
(GO:0005515)
Protein phosphorylation
(GO:0006468)
Protein serine/threonine kinase activity
(GO:0004674)
Receptor complex
(GO:0043235)
Regulation of dna-templated transcription
(GO:0006355)
Signal transduction
(GO:0007165)
Smad binding
(GO:0046332)
Transmembrane receptor protein serine/threonine kinase activity
(GO:0004675)
Transmembrane receptor protein serine/threonine kinase signaling pathway
(GO:0007178)
Ubiquitin protein ligase binding
(GO:0031625)

Other Information

Proteins

Activin receptor type-1B

Genular Protein ID: 2057999171

Symbol: ACV1B_HUMAN

Name: Activin receptor type-1B

UniProtKB Accession Codes:

P36896 B7Z5L8 B7Z5W5 Q15479 Q15480 Q15481 Q15482

Database IDs:

Citations:

PubMed ID: 8397373

Title: Activin receptor-like kinases: a novel subclass of cell-surface receptors with predicted serine/threonine kinase activity.

PubMed ID: 8397373

PubMed ID: 8196624

Title: Type I receptors specify growth-inhibitory and transcriptional responses to transforming growth factor beta and activin.

PubMed ID: 8196624

DOI: 10.1128/mcb.14.6.3810-3821.1994

PubMed ID: 8058741

Title: Genomic structure and cloned cDNAs predict that four variants in the kinase domain of serine/threonine kinase receptors arise by alternative splicing and poly(A) addition.

PubMed ID: 8058741

DOI: 10.1073/pnas.91.17.7957

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8622651

Title: Activation of signalling by the activin receptor complex.

PubMed ID: 8622651

DOI: 10.1128/mcb.16.3.1066

PubMed ID: 9032295

Title: Activin and inhibin have antagonistic effects on ligand-dependent heteromerization of the type I and type II activin receptors and human erythroid differentiation.

PubMed ID: 9032295

DOI: 10.1128/mcb.17.3.1682

PubMed ID: 9892009

Title: Roles of pathway-specific and inhibitory Smads in activin receptor signaling.

PubMed ID: 9892009

DOI: 10.1210/mend.13.1.0218

PubMed ID: 11266516

Title: Modulation of activin signal transduction by inhibin B and inhibin-binding protein (INhBP).

PubMed ID: 11266516

DOI: 10.1210/mend.15.4.0616

PubMed ID: 12023024

Title: Phosphorylation regulation of the interaction between Smad7 and activin type I receptor.

PubMed ID: 12023024

DOI: 10.1016/s0014-5793(02)02718-7

PubMed ID: 12364468

Title: Overexpression of wild-type activin receptor alk4-1 restores activin antiproliferative effects in human pituitary tumor cells.

PubMed ID: 12364468

DOI: 10.1210/jc.2002-020527

PubMed ID: 11909953

Title: Cripto-1 activates nodal- and ALK4-dependent and -independent signaling pathways in mammary epithelial Cells.

PubMed ID: 11909953

DOI: 10.1128/mcb.22.8.2586-2597.2002

PubMed ID: 12112843

Title: Identification of the phosphotyrosine proteome from thrombin activated platelets.

PubMed ID: 12112843

DOI: 10.1002/1615-9861(200206)2:6<642::aid-prot642>3.0.co;2-i

PubMed ID: 12639945

Title: Activin signaling through type IB activin receptor stimulates aromatase activity in the ovarian granulosa cell-like human granulosa (KGN) cells.

PubMed ID: 12639945

DOI: 10.1210/en.2002-220978

PubMed ID: 12665502

Title: Identification of a functional binding site for activin on the type I receptor ALK4.

PubMed ID: 12665502

DOI: 10.1074/jbc.m302015200

PubMed ID: 16720724

Title: FKBP12 functions as an adaptor of the Smad7-Smurf1 complex on activin type I receptor.

PubMed ID: 16720724

DOI: 10.1677/jme.1.01966

PubMed ID: 18039968

Title: Ttrap is an essential modulator of Smad3-dependent Nodal signaling during zebrafish gastrulation and left-right axis determination.

PubMed ID: 18039968

DOI: 10.1242/dev.000026

PubMed ID: 20226172

Title: Activin A induces neuronal differentiation and survival via ALK4 in a SMAD-independent manner in a subpopulation of human neuroblastomas.

PubMed ID: 20226172

DOI: 10.1016/j.bbrc.2010.03.039

PubMed ID: 20596523

Title: Development and validation of a method for profiling post-translational modification activities using protein microarrays.

PubMed ID: 20596523

DOI: 10.1371/journal.pone.0011332

PubMed ID: 21791611

Title: TSC-22 promotes transforming growth factor beta-mediated cardiac myofibroblast differentiation by antagonizing Smad7 activity.

PubMed ID: 21791611

DOI: 10.1128/mcb.05448-11

PubMed ID: 21377836

Title: Activation of the activin A-ALK-Smad pathway in systemic sclerosis.

PubMed ID: 21377836

DOI: 10.1016/j.jaut.2010.09.004

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

Sequence Information:

Length: 505
Mass: 56807
Checksum: 40A6C65CAA4C7573
Sequence:

MAESAGASSF FPLVVLLLAG SGGSGPRGVQ ALLCACTSCL QANYTCETDG ACMVSIFNLD 
GMEHHVRTCI PKVELVPAGK PFYCLSSEDL RNTHCCYTDY CNRIDLRVPS GHLKEPEHPS 
MWGPVELVGI IAGPVFLLFL IIIIVFLVIN YHQRVYHNRQ RLDMEDPSCE MCLSKDKTLQ 
DLVYDLSTSG SGSGLPLFVQ RTVARTIVLQ EIIGKGRFGE VWRGRWRGGD VAVKIFSSRE 
ERSWFREAEI YQTVMLRHEN ILGFIAADNK DNGTWTQLWL VSDYHEHGSL FDYLNRYTVT 
IEGMIKLALS AASGLAHLHM EIVGTQGKPG IAHRDLKSKN ILVKKNGMCA IADLGLAVRH 
DAVTDTIDIA PNQRVGTKRY MAPEVLDETI NMKHFDSFKC ADIYALGLVY WEIARRCNSG 
GVHEEYQLPY YDLVPSDPSI EEMRKVVCDQ KLRPNIPNWW QSYEALRVMG KMMRECWYAN 
GAARLTALRI KKTLSQLSVQ EDVKI

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: ACVR1B

Associated with

Other Information

Activin receptor-like kinases: a novel subclass of cell-surface receptors with predicted serine/threonine kinase activity. PubMed ID: 8397373

Type I receptors specify growth-inhibitory and transcriptional responses to transforming growth factor beta and activin. PubMed ID: 8196624

Genomic structure and cloned cDNAs predict that four variants in the kinase domain of serine/threonine kinase receptors arise by alternative splicing and poly(A) addition. PubMed ID: 8058741

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The finished DNA sequence of human chromosome 12. PubMed ID: 16541075

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Activation of signalling by the activin receptor complex. PubMed ID: 8622651

Activin and inhibin have antagonistic effects on ligand-dependent heteromerization of the type I and type II activin receptors and human erythroid differentiation. PubMed ID: 9032295

Roles of pathway-specific and inhibitory Smads in activin receptor signaling. PubMed ID: 9892009

Modulation of activin signal transduction by inhibin B and inhibin-binding protein (INhBP). PubMed ID: 11266516

Phosphorylation regulation of the interaction between Smad7 and activin type I receptor. PubMed ID: 12023024

Overexpression of wild-type activin receptor alk4-1 restores activin antiproliferative effects in human pituitary tumor cells. PubMed ID: 12364468

Cripto-1 activates nodal- and ALK4-dependent and -independent signaling pathways in mammary epithelial Cells. PubMed ID: 11909953

Identification of the phosphotyrosine proteome from thrombin activated platelets. PubMed ID: 12112843

Activin signaling through type IB activin receptor stimulates aromatase activity in the ovarian granulosa cell-like human granulosa (KGN) cells. PubMed ID: 12639945

Identification of a functional binding site for activin on the type I receptor ALK4. PubMed ID: 12665502

FKBP12 functions as an adaptor of the Smad7-Smurf1 complex on activin type I receptor. PubMed ID: 16720724

Ttrap is an essential modulator of Smad3-dependent Nodal signaling during zebrafish gastrulation and left-right axis determination. PubMed ID: 18039968

Activin A induces neuronal differentiation and survival via ALK4 in a SMAD-independent manner in a subpopulation of human neuroblastomas. PubMed ID: 20226172

Development and validation of a method for profiling post-translational modification activities using protein microarrays. PubMed ID: 20596523

TSC-22 promotes transforming growth factor beta-mediated cardiac myofibroblast differentiation by antagonizing Smad7 activity. PubMed ID: 21791611

Activation of the activin A-ALK-Smad pathway in systemic sclerosis. PubMed ID: 21377836

Patterns of somatic mutation in human cancer genomes. PubMed ID: 17344846