Details for: ACVR1B

Gene ID: 91

Symbol: ACVR1B

Ensembl ID: ENSG00000135503

Description: activin A receptor type 1B

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 180.7191
    Cell Significance Index: -28.1100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 109.1296
    Cell Significance Index: -27.6800
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 60.7046
    Cell Significance Index: -28.6600
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 42.7706
    Cell Significance Index: -28.7000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 22.8232
    Cell Significance Index: -28.1400
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 7.1363
    Cell Significance Index: -28.1600
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 5.9192
    Cell Significance Index: 97.5400
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 5.8257
    Cell Significance Index: -12.7500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 3.7145
    Cell Significance Index: 50.6800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.4846
    Cell Significance Index: 297.8000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.3817
    Cell Significance Index: 150.2900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.1839
    Cell Significance Index: 192.5500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.0574
    Cell Significance Index: 209.8500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.7539
    Cell Significance Index: 52.1400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.7168
    Cell Significance Index: 257.0900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.7096
    Cell Significance Index: 19.8300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.6887
    Cell Significance Index: 31.2200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.6370
    Cell Significance Index: 13.8000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.5966
    Cell Significance Index: 36.6700
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.4357
    Cell Significance Index: 9.5400
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.4065
    Cell Significance Index: 9.7500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3386
    Cell Significance Index: 305.7300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.3320
    Cell Significance Index: 146.8000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.3156
    Cell Significance Index: 17.7100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3027
    Cell Significance Index: 8.7200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2763
    Cell Significance Index: 49.8000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.2618
    Cell Significance Index: 13.6000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.2438
    Cell Significance Index: 29.9800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.2179
    Cell Significance Index: 15.4100
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.2156
    Cell Significance Index: 149.1200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.2150
    Cell Significance Index: 10.0200
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.2145
    Cell Significance Index: 2.6600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.2090
    Cell Significance Index: 7.9200
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.1917
    Cell Significance Index: 5.4700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.1871
    Cell Significance Index: 8.2800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1638
    Cell Significance Index: 27.9700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1610
    Cell Significance Index: 15.9300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1370
    Cell Significance Index: 74.8100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.1202
    Cell Significance Index: 6.3100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.1113
    Cell Significance Index: 2.3700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.1017
    Cell Significance Index: 6.8400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0965
    Cell Significance Index: 6.0800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0906
    Cell Significance Index: 17.2500
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.0712
    Cell Significance Index: 1.3900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0679
    Cell Significance Index: 5.2100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0581
    Cell Significance Index: 2.0400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0560
    Cell Significance Index: 0.9600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0233
    Cell Significance Index: 17.0900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0187
    Cell Significance Index: 35.2400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0100
    Cell Significance Index: 4.5300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0013
    Cell Significance Index: -1.9900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0031
    Cell Significance Index: -0.4200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0082
    Cell Significance Index: -5.2200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0092
    Cell Significance Index: -17.0200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0093
    Cell Significance Index: -5.7800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0131
    Cell Significance Index: -17.8200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0148
    Cell Significance Index: -11.0000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0155
    Cell Significance Index: -11.7600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0210
    Cell Significance Index: -11.8600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0286
    Cell Significance Index: -4.1600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0366
    Cell Significance Index: -1.0000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0486
    Cell Significance Index: -6.2300
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0501
    Cell Significance Index: -1.0400
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.0507
    Cell Significance Index: -0.7600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0589
    Cell Significance Index: -12.4000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0687
    Cell Significance Index: -1.9700
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0801
    Cell Significance Index: -1.3500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0803
    Cell Significance Index: -23.1100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0809
    Cell Significance Index: -8.2700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0928
    Cell Significance Index: -10.8200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1217
    Cell Significance Index: -13.9400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1334
    Cell Significance Index: -9.9400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.1364
    Cell Significance Index: -3.4100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1519
    Cell Significance Index: -19.6200
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.1893
    Cell Significance Index: -1.9600
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1974
    Cell Significance Index: -4.1900
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2195
    Cell Significance Index: -6.4700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.2273
    Cell Significance Index: -26.8100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2277
    Cell Significance Index: -23.7100
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.2398
    Cell Significance Index: -3.5400
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2424
    Cell Significance Index: -27.6700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2533
    Cell Significance Index: -11.9100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.3007
    Cell Significance Index: -19.4000
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: -0.3040
    Cell Significance Index: -2.7400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3081
    Cell Significance Index: -24.4000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.3157
    Cell Significance Index: -8.1200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3482
    Cell Significance Index: -11.4000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3954
    Cell Significance Index: -24.2400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.3968
    Cell Significance Index: -12.7100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.4179
    Cell Significance Index: -13.3100
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.4425
    Cell Significance Index: -7.1000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.4594
    Cell Significance Index: -23.9300
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.4832
    Cell Significance Index: -9.7000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.4875
    Cell Significance Index: -16.9400
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.5017
    Cell Significance Index: -9.9200
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -0.5164
    Cell Significance Index: -3.9800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.5341
    Cell Significance Index: -18.7100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.5951
    Cell Significance Index: -9.9600
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.6019
    Cell Significance Index: -7.1800
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.6301
    Cell Significance Index: -23.1300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** The ACVR1B gene exhibits several key characteristics that enable it to function effectively in the body: 1. **Receptor Structure**: The ACVR1B receptor is a transmembrane receptor protein serine/threonine kinase, consisting of an extracellular domain, a transmembrane domain, and an intracellular domain. The extracellular domain binds to Activin A, while the intracellular domain phosphorylates and activates Smad proteins. 2. **Signaling Pathway**: The ACVR1B receptor is part of the Activin signaling pathway, which is involved in various physiological processes, including embryonic development, cell growth, and differentiation. 3. **Cellular Distribution**: The ACVR1B receptor is expressed in various cell types, including neurons, kidney cells, and epithelial cells, highlighting its role in multiple tissue types. 4. **Regulatory Mechanisms**: The ACVR1B receptor is subject to various regulatory mechanisms, including negative regulation of cell growth and gene expression, indicating its complex role in cellular processes. **Pathways and Functions** The ACVR1B receptor is involved in several signaling pathways, including: 1. **Activin Signaling Pathway**: The ACVR1B receptor is the primary receptor for Activin A, which triggers the phosphorylation and activation of Smad proteins, leading to the transcription of target genes. 2. **Nodal Signaling Pathway**: The ACVR1B receptor is also involved in the Nodal signaling pathway, which plays a crucial role in embryonic development and cell fate determination. 3. **G1/S Transition of Mitotic Cell Cycle**: The ACVR1B receptor regulates the G1/S transition of the mitotic cell cycle, ensuring proper cell proliferation and differentiation. 4. **Hair Follicle Development**: The ACVR1B receptor is involved in hair follicle development, highlighting its role in skin development and homeostasis. **Clinical Significance** Dysregulation of the ACVR1B receptor has been implicated in various diseases and disorders, including: 1. **Dermatological Disorders**: Mutations in the ACVR1B gene have been associated with dermatological disorders, such as ichthyosis and congenital ichthyosis. 2. **Neurological Disorders**: The ACVR1B receptor has been implicated in neurological disorders, including Alzheimer's disease and Parkinson's disease. 3. **Cancer**: The ACVR1B receptor has been shown to play a role in cancer development and progression, highlighting its potential as a therapeutic target. In conclusion, the ACVR1B gene plays a crucial role in various physiological processes, including embryonic development, cell growth, and differentiation. Its dysregulation has been implicated in various diseases and disorders, highlighting the need for further research into its role in human health and disease.

Genular Protein ID: 2057999171

Symbol: ACV1B_HUMAN

Name: Activin receptor type-1B

UniProtKB Accession Codes:

P36896 B7Z5L8 B7Z5W5 Q15479 Q15480 Q15481 Q15482

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 1 CTD 1 ChEBI 14 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 2 DrugCentral 1 EC 3 EMBL 13 Ensembl 5 ExpressionAtlas 1 GO 35 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PIR 3 PRO 1 PROSITE 4 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 5 RNAct 1 Reactome 3 RefSeq 3 Rhea 6 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8397373

Title: Activin receptor-like kinases: a novel subclass of cell-surface receptors with predicted serine/threonine kinase activity.

PubMed ID: 8397373

PubMed ID: 8196624

Title: Type I receptors specify growth-inhibitory and transcriptional responses to transforming growth factor beta and activin.

PubMed ID: 8196624

DOI: 10.1128/mcb.14.6.3810-3821.1994

PubMed ID: 8058741

Title: Genomic structure and cloned cDNAs predict that four variants in the kinase domain of serine/threonine kinase receptors arise by alternative splicing and poly(A) addition.

PubMed ID: 8058741

DOI: 10.1073/pnas.91.17.7957

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8622651

Title: Activation of signalling by the activin receptor complex.

PubMed ID: 8622651

DOI: 10.1128/mcb.16.3.1066

PubMed ID: 9032295

Title: Activin and inhibin have antagonistic effects on ligand-dependent heteromerization of the type I and type II activin receptors and human erythroid differentiation.

PubMed ID: 9032295

DOI: 10.1128/mcb.17.3.1682

PubMed ID: 9892009

Title: Roles of pathway-specific and inhibitory Smads in activin receptor signaling.

PubMed ID: 9892009

DOI: 10.1210/mend.13.1.0218

PubMed ID: 11266516

Title: Modulation of activin signal transduction by inhibin B and inhibin-binding protein (INhBP).

PubMed ID: 11266516

DOI: 10.1210/mend.15.4.0616

PubMed ID: 12023024

Title: Phosphorylation regulation of the interaction between Smad7 and activin type I receptor.

PubMed ID: 12023024

DOI: 10.1016/s0014-5793(02)02718-7

PubMed ID: 12364468

Title: Overexpression of wild-type activin receptor alk4-1 restores activin antiproliferative effects in human pituitary tumor cells.

PubMed ID: 12364468

DOI: 10.1210/jc.2002-020527

PubMed ID: 11909953

Title: Cripto-1 activates nodal- and ALK4-dependent and -independent signaling pathways in mammary epithelial Cells.

PubMed ID: 11909953

DOI: 10.1128/mcb.22.8.2586-2597.2002

PubMed ID: 12112843

Title: Identification of the phosphotyrosine proteome from thrombin activated platelets.

PubMed ID: 12112843

DOI: 10.1002/1615-9861(200206)2:6<642::aid-prot642>3.0.co;2-i

PubMed ID: 12639945

Title: Activin signaling through type IB activin receptor stimulates aromatase activity in the ovarian granulosa cell-like human granulosa (KGN) cells.

PubMed ID: 12639945

DOI: 10.1210/en.2002-220978

PubMed ID: 12665502

Title: Identification of a functional binding site for activin on the type I receptor ALK4.

PubMed ID: 12665502

DOI: 10.1074/jbc.m302015200

PubMed ID: 16720724

Title: FKBP12 functions as an adaptor of the Smad7-Smurf1 complex on activin type I receptor.

PubMed ID: 16720724

DOI: 10.1677/jme.1.01966

PubMed ID: 18039968

Title: Ttrap is an essential modulator of Smad3-dependent Nodal signaling during zebrafish gastrulation and left-right axis determination.

PubMed ID: 18039968

DOI: 10.1242/dev.000026

PubMed ID: 20226172

Title: Activin A induces neuronal differentiation and survival via ALK4 in a SMAD-independent manner in a subpopulation of human neuroblastomas.

PubMed ID: 20226172

DOI: 10.1016/j.bbrc.2010.03.039

PubMed ID: 20596523

Title: Development and validation of a method for profiling post-translational modification activities using protein microarrays.

PubMed ID: 20596523

DOI: 10.1371/journal.pone.0011332

PubMed ID: 21791611

Title: TSC-22 promotes transforming growth factor beta-mediated cardiac myofibroblast differentiation by antagonizing Smad7 activity.

PubMed ID: 21791611

DOI: 10.1128/mcb.05448-11

PubMed ID: 21377836

Title: Activation of the activin A-ALK-Smad pathway in systemic sclerosis.

PubMed ID: 21377836

DOI: 10.1016/j.jaut.2010.09.004

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

Sequence Information:

  • Length: 505
  • Mass: 56807
  • Checksum: 40A6C65CAA4C7573
  • Sequence:
    • MAESAGASSF FPLVVLLLAG SGGSGPRGVQ ALLCACTSCL QANYTCETDG ACMVSIFNLD 
GMEHHVRTCI PKVELVPAGK PFYCLSSEDL RNTHCCYTDY CNRIDLRVPS GHLKEPEHPS 
MWGPVELVGI IAGPVFLLFL IIIIVFLVIN YHQRVYHNRQ RLDMEDPSCE MCLSKDKTLQ 
DLVYDLSTSG SGSGLPLFVQ RTVARTIVLQ EIIGKGRFGE VWRGRWRGGD VAVKIFSSRE 
ERSWFREAEI YQTVMLRHEN ILGFIAADNK DNGTWTQLWL VSDYHEHGSL FDYLNRYTVT 
IEGMIKLALS AASGLAHLHM EIVGTQGKPG IAHRDLKSKN ILVKKNGMCA IADLGLAVRH 
DAVTDTIDIA PNQRVGTKRY MAPEVLDETI NMKHFDSFKC ADIYALGLVY WEIARRCNSG 
GVHEEYQLPY YDLVPSDPSI EEMRKVVCDQ KLRPNIPNWW QSYEALRVMG KMMRECWYAN 
GAARLTALRI KKTLSQLSVQ EDVKI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.