Details for: CD1B

Gene ID: 910

Symbol: CD1B

Ensembl ID: ENSG00000158485

Description: CD1b molecule

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 18.82
    Marker Score: 25974.5
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 18.22
    Marker Score: 35714
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 7.55
    Marker Score: 5717
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 2.91
    Marker Score: 1958
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 1.27
    Marker Score: 3300
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 1.17
    Marker Score: 1656
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.16
    Marker Score: 7693
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.13
    Marker Score: 714
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251808
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71827
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48052
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5356
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2742
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.88
    Marker Score: 673
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5295
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1269
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 711
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.71
    Marker Score: 181
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.68
    Marker Score: 447
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.61
    Marker Score: 484
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.54
    Marker Score: 142
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.51
    Marker Score: 215
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.5
    Marker Score: 527
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.47
    Marker Score: 280
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.45
    Marker Score: 430.5
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.44
    Marker Score: 305
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.42
    Marker Score: 860.5
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.4
    Marker Score: 228
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.35
    Marker Score: 655
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.34
    Marker Score: 550
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.34
    Marker Score: 342
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.34
    Marker Score: 196
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.33
    Marker Score: 192
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 0.31
    Marker Score: 313
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.29
    Marker Score: 324
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 0.24
    Marker Score: 141
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.24
    Marker Score: 135
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.22
    Marker Score: 217
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 0.22
    Marker Score: 76
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.21
    Marker Score: 189
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.21
    Marker Score: 112
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.18
    Marker Score: 99
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.16
    Marker Score: 99
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.16
    Marker Score: 279.5
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 0.16
    Marker Score: 162
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.15
    Marker Score: 2414
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.15
    Marker Score: 887.5
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: 0.15
    Marker Score: 88
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.14
    Marker Score: 62
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.13
    Marker Score: 486
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.13
    Marker Score: 89
  • Cell Name: promonocyte (CL0000559)
    Fold Change: 0.12
    Marker Score: 78
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.11
    Marker Score: 133.5
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.11
    Marker Score: 118
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 0.11
    Marker Score: 189
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.11
    Marker Score: 326
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.1
    Marker Score: 32
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.1
    Marker Score: 25
  • Cell Name: group 3 innate lymphoid cell (CL0001071)
    Fold Change: 0.1
    Marker Score: 40
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: 0.09
    Marker Score: 60
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.09
    Marker Score: 85
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.09
    Marker Score: 32
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.09
    Marker Score: 108
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 0.09
    Marker Score: 65
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.08
    Marker Score: 133
  • Cell Name: ionocyte (CL0005006)
    Fold Change: 0.08
    Marker Score: 24
  • Cell Name: colon macrophage (CL0009038)
    Fold Change: 0.08
    Marker Score: 21
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.08
    Marker Score: 36
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 0.07
    Marker Score: 24
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.07
    Marker Score: 63
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.07
    Marker Score: 182
  • Cell Name: epithelial cell of thymus (CL0002293)
    Fold Change: 0.07
    Marker Score: 23
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.07
    Marker Score: 281
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.07
    Marker Score: 89
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.07
    Marker Score: 140
  • Cell Name: myeloid dendritic cell, human (CL0001057)
    Fold Change: 0.07
    Marker Score: 24
  • Cell Name: Langerhans cell (CL0000453)
    Fold Change: 0.07
    Marker Score: 20
  • Cell Name: pre-conventional dendritic cell (CL0002010)
    Fold Change: 0.06
    Marker Score: 19
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 0.06
    Marker Score: 22
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.06
    Marker Score: 23
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.06
    Marker Score: 20
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.06
    Marker Score: 23
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.06
    Marker Score: 65
  • Cell Name: inflammatory macrophage (CL0000863)
    Fold Change: 0.06
    Marker Score: 19
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: 0.06
    Marker Score: 67
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 0.06
    Marker Score: 25
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 0.06
    Marker Score: 21
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.06
    Marker Score: 56
  • Cell Name: memory T cell (CL0000813)
    Fold Change: 0.06
    Marker Score: 24
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.05
    Marker Score: 33.5
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.05
    Marker Score: 28
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 0.05
    Marker Score: 59
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.05
    Marker Score: 22
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.05
    Marker Score: 34
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.05
    Marker Score: 24
  • Cell Name: CD141-positive myeloid dendritic cell (CL0002394)
    Fold Change: 0.05
    Marker Score: 16
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 0.05
    Marker Score: 23

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Other Information

**Key characteristics:** - CD1B is a type I transmembrane glycoprotein, which are expressed on the surface of all nucleated cells. - It is a member of the MHC class I family of cell surface glycoproteins, which are responsible for presenting antigens to T cells. - CD1B is a highly conserved protein, with similar sequences found in mice, rats, and humans. - It is expressed on all mature B cells, a subset of B cells that are responsible for antibody production. **Pathways and functions:** - CD1B is involved in the adaptive immune response, where it helps to activate T cells. - It is expressed on dendritic cells, which are professional antigen-presenting cells that take up and process antigens from pathogens. - When an antigen binds to CD1B on a dendritic cell, it triggers the activation of the T cell. - CD1B also plays a role in the regulation of immune responses. It can interact with CD80 and CD86 molecules on antigen-presenting cells, which can inhibit T cell activation. **Clinical significance:** - Mutations in the CD1B gene have been linked to a number of autoimmune diseases, including rheumatoid arthritis, lupus, and Crohn's disease. - CD1B is also a target for cancer immunotherapy, as it is expressed on tumor cells and can be recognized by immune checkpoint molecules. - Targeting CD1B has been shown to be effective in treating cancer, as it can block the immune response and allow cancer cells to evade detection and destruction by the immune system.

Genular Protein ID: 2983657021

Symbol: CD1B_HUMAN

Name: T-cell surface glycoprotein CD1b

UniProtKB Accession Codes:

P29016 Q5TDK9 Q5TDL0 Q9UMM2

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 13 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 18 Gene3D 2 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 29 PDBsum 23 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 1 RefSeq 2 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 2447586

Title: Structure and expression of the human thymocyte antigens CD1a, CD1b, and CD1c.

PubMed ID: 2447586

DOI: 10.1073/pnas.84.24.9189

PubMed ID: 2701945

Title: Expression of cDNA clones encoding the thymocyte antigens CD1a, b, c demonstrates a hierarchy of exclusion in fibroblasts.

PubMed ID: 2701945

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 3097645

Title: Isolation of CD1 genes: a family of major histocompatibility complex-related differentiation antigens.

PubMed ID: 3097645

DOI: 10.1073/pnas.83.23.9154

PubMed ID: 10981968

Title: The alphabeta T cell response to self-glycolipids shows a novel mechanism of CD1b loading and a requirement for complex oligosaccharides.

PubMed ID: 10981968

DOI: 10.1016/s1074-7613(00)00025-x

PubMed ID: 10899914

Title: Human CD1b and CD1c isoforms survey different intracellular compartments for the presentation of microbial lipid antigens.

PubMed ID: 10899914

DOI: 10.1084/jem.192.2.281

PubMed ID: 14716313

Title: Saposin C is required for lipid presentation by human CD1b.

PubMed ID: 14716313

DOI: 10.1038/ni1035

PubMed ID: 19349973

Title: Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins.

PubMed ID: 19349973

DOI: 10.1038/nbt.1532

PubMed ID: 12118248

Title: Structure of human CD1b with bound ligands at 2.3 A, a maze for alkyl chains.

PubMed ID: 12118248

DOI: 10.1038/ni821

PubMed ID: 14764708

Title: The crystal structure of human CD1b with a bound bacterial glycolipid.

PubMed ID: 14764708

DOI: 10.4049/jimmunol.172.4.2382

PubMed ID: 16874306

Title: Endogenous phosphatidylcholine and a long spacer ligand stabilize the lipid-binding groove of CD1b.

PubMed ID: 16874306

DOI: 10.1038/sj.emboj.7601244

Sequence Information:

  • Length: 333
  • Mass: 36939
  • Checksum: 7D02B670D4DE8CC7
  • Sequence:
    • MLLLPFQLLA VLFPGGNSEH AFQGPTSFHV IQTSSFTNST WAQTQGSGWL DDLQIHGWDS 
DSGTAIFLKP WSKGNFSDKE VAELEEIFRV YIFGFAREVQ DFAGDFQMKY PFEIQGIAGC 
ELHSGGAIVS FLRGALGGLD FLSVKNASCV PSPEGGSRAQ KFCALIIQYQ GIMETVRILL 
YETCPRYLLG VLNAGKADLQ RQVKPEAWLS SGPSPGPGRL QLVCHVSGFY PKPVWVMWMR 
GEQEQQGTQL GDILPNANWT WYLRATLDVA DGEAAGLSCR VKHSSLEGQD IILYWRNPTS 
IGSIVLAIIV PSLLLLLCLA LWYMRRRSYQ NIP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.