Details for: CD1B

Gene ID: 910

Symbol: CD1B

Ensembl ID: ENSG00000158485

Description: CD1b molecule

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.6735
    Cell Significance Index: 10.4200
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.2660
    Cell Significance Index: 3.1300
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.1496
    Cell Significance Index: 1.8500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.0437
    Cell Significance Index: 1.1700
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.0370
    Cell Significance Index: 0.4500
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.0327
    Cell Significance Index: 0.5300
  • Cell Name: adipocyte (CL0000136)
    Fold Change: -0.0015
    Cell Significance Index: -0.0200
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.0025
    Cell Significance Index: -0.0300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0037
    Cell Significance Index: -0.4700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0055
    Cell Significance Index: -4.1500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0085
    Cell Significance Index: -0.9900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0157
    Cell Significance Index: -4.5100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0214
    Cell Significance Index: -2.1900
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0243
    Cell Significance Index: -0.6200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0370
    Cell Significance Index: -4.3600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0373
    Cell Significance Index: -1.0200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0414
    Cell Significance Index: -1.0600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0676
    Cell Significance Index: -4.3600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0691
    Cell Significance Index: -3.6000
  • Cell Name: myoepithelial cell (CL0000185)
    Fold Change: -0.0793
    Cell Significance Index: -0.9000
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.0896
    Cell Significance Index: -0.9100
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.0931
    Cell Significance Index: -0.9200
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.0942
    Cell Significance Index: -1.1900
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0964
    Cell Significance Index: -1.0900
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: -0.1055
    Cell Significance Index: -0.9800
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.1087
    Cell Significance Index: -1.4900
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.1280
    Cell Significance Index: -3.1000
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1338
    Cell Significance Index: -4.9100
  • Cell Name: epithelial cell of thymus (CL0002293)
    Fold Change: -0.1418
    Cell Significance Index: -1.0900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1513
    Cell Significance Index: -4.0600
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.1594
    Cell Significance Index: -4.0600
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1599
    Cell Significance Index: -4.7100
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.1730
    Cell Significance Index: -3.4500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1745
    Cell Significance Index: -4.6600
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: -0.1786
    Cell Significance Index: -1.8500
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.1814
    Cell Significance Index: -4.5300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1863
    Cell Significance Index: -4.9000
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.1935
    Cell Significance Index: -2.8100
  • Cell Name: granulocyte (CL0000094)
    Fold Change: -0.1990
    Cell Significance Index: -2.4000
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.2046
    Cell Significance Index: -4.0000
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.2083
    Cell Significance Index: -3.8500
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.2110
    Cell Significance Index: -4.6200
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: -0.2194
    Cell Significance Index: -2.1900
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.2251
    Cell Significance Index: -5.2000
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.2301
    Cell Significance Index: -3.3000
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: -0.2360
    Cell Significance Index: -2.0100
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.2411
    Cell Significance Index: -3.2800
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.2432
    Cell Significance Index: -4.0900
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.2445
    Cell Significance Index: -4.1800
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.2455
    Cell Significance Index: -2.6400
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.2543
    Cell Significance Index: -3.2900
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.2564
    Cell Significance Index: -3.0300
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.2631
    Cell Significance Index: -3.7700
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.2636
    Cell Significance Index: -4.4400
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.2750
    Cell Significance Index: -4.0600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.2755
    Cell Significance Index: -4.6100
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.2778
    Cell Significance Index: -3.2800
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: -0.2781
    Cell Significance Index: -2.6900
  • Cell Name: CD141-positive myeloid dendritic cell (CL0002394)
    Fold Change: -0.2862
    Cell Significance Index: -3.1000
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: -0.2938
    Cell Significance Index: -3.4200
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.2968
    Cell Significance Index: -3.2000
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: -0.2987
    Cell Significance Index: -3.6100
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: -0.2995
    Cell Significance Index: -3.5600
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: -0.3057
    Cell Significance Index: -3.4000
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.3062
    Cell Significance Index: -3.8800
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.3115
    Cell Significance Index: -4.5400
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: -0.3209
    Cell Significance Index: -3.4600
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: -0.3217
    Cell Significance Index: -3.9100
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.3227
    Cell Significance Index: -4.2200
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.3249
    Cell Significance Index: -4.2400
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.3250
    Cell Significance Index: -4.0600
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.3271
    Cell Significance Index: -4.0200
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.3313
    Cell Significance Index: -4.8900
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.3334
    Cell Significance Index: -3.9200
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -0.3344
    Cell Significance Index: -3.9700
  • Cell Name: kidney interstitial alternatively activated macrophage (CL1000695)
    Fold Change: -0.3355
    Cell Significance Index: -3.4300
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: -0.3361
    Cell Significance Index: -2.7800
  • Cell Name: erythroid lineage cell (CL0000764)
    Fold Change: -0.3365
    Cell Significance Index: -3.7100
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.3377
    Cell Significance Index: -3.9900
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: -0.3401
    Cell Significance Index: -3.8500
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.3437
    Cell Significance Index: -4.5100
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: -0.3489
    Cell Significance Index: -3.7900
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: -0.3495
    Cell Significance Index: -3.9700
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: -0.3497
    Cell Significance Index: -4.5800
  • Cell Name: myelocyte (CL0002193)
    Fold Change: -0.3500
    Cell Significance Index: -3.7400
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.3511
    Cell Significance Index: -4.6200
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.3529
    Cell Significance Index: -4.2200
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.3531
    Cell Significance Index: -4.6100
  • Cell Name: club cell (CL0000158)
    Fold Change: -0.3534
    Cell Significance Index: -3.8500
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.3542
    Cell Significance Index: -4.7800
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: -0.3557
    Cell Significance Index: -3.8500
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.3565
    Cell Significance Index: -3.8600
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.3568
    Cell Significance Index: -5.0700
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.3571
    Cell Significance Index: -4.2200
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: -0.3586
    Cell Significance Index: -3.9700
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.3590
    Cell Significance Index: -4.9300
  • Cell Name: erythroblast (CL0000765)
    Fold Change: -0.3598
    Cell Significance Index: -4.2900
  • Cell Name: alveolar type 1 fibroblast cell (CL4028004)
    Fold Change: -0.3619
    Cell Significance Index: -3.8300
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.3628
    Cell Significance Index: -4.3800
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.3631
    Cell Significance Index: -5.3100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** CD1B is a type I transmembrane glycoprotein, consisting of a variable region, a constant region, and a lipid-binding domain. It is expressed on various cell types, including thymocytes, dendritic cells, and epithelial cells. Notably, CD1B is unique in its ability to bind and present both endogenous and exogenous lipids, which are essential for the activation of T cells. Its expression is restricted to cells of the immune system, underscoring its critical role in immune regulation. **Pathways and Functions:** CD1B operates within multiple cellular compartments, including the endosomal and Golgi apparatus, where it interacts with lipid antigens. Upon binding to lipids, CD1B undergoes conformational changes, facilitating the transport of lipid-peptide complexes to the surface of antigen-presenting cells (APCs). This process enables the presentation of lipid antigens to T cells via MHC class Ib, a unique pathway that is distinct from the conventional MHC class I and II pathways. The presentation of lipid antigens by CD1B has far-reaching consequences for the immune system. It can modulate T cell responses, influencing the activation and differentiation of T cells. Moreover, CD1B has been implicated in the regulation of immune responses, with studies suggesting its role in the prevention of autoimmunity and the promotion of tolerance. **Clinical Significance:** CD1B's involvement in immune regulation has significant implications for the diagnosis and treatment of various diseases, including autoimmune disorders and cancer. For instance, alterations in CD1B expression have been observed in patients with multiple sclerosis and type 1 diabetes, suggesting a potential link between CD1B dysfunction and these diseases. Furthermore, CD1B's role in lipid antigen presentation has sparked interest in its potential as a therapeutic target. By modulating CD1B's function, researchers may be able to develop novel immunotherapies that harness the power of lipid antigens to regulate immune responses. In conclusion, CD1B is a complex and multifaceted molecule that plays a critical role in the presentation of lipid antigens and the regulation of immune responses. As we continue to unravel the intricacies of CD1B's function, we may uncover new avenues for the diagnosis and treatment of immune-related disorders. **Significantly Expressed Cells:** The following cell types have been identified as significant expressors of CD1B: * Double-negative thymocytes * Double-positive thymocytes * Alpha-beta thymocytes * Alpha-beta T cells * Gamma-delta T cells * CD1c-positive myeloid dendritic cells * CD8-alpha-alpha-positive alpha-beta intraepithelial T cells * Goblet cells * Granulocyte-monocyte progenitor cells * Fallopian tube secretory epithelial cells * Cerebral cortex GABAergic interneurons **Proteins:** The CD1B protein, also known as T-cell surface glycoprotein CD1b, is encoded by the CD1B gene (ENSG00000158485).

Genular Protein ID: 2983657021

Symbol: CD1B_HUMAN

Name: T-cell surface glycoprotein CD1b

UniProtKB Accession Codes:

P29016 Q5TDK9 Q5TDL0 Q9UMM2

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 13 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 18 Gene3D 2 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 23 PDBsum 23 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 1 RefSeq 2 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 2447586

Title: Structure and expression of the human thymocyte antigens CD1a, CD1b, and CD1c.

PubMed ID: 2447586

DOI: 10.1073/pnas.84.24.9189

PubMed ID: 2701945

Title: Expression of cDNA clones encoding the thymocyte antigens CD1a, b, c demonstrates a hierarchy of exclusion in fibroblasts.

PubMed ID: 2701945

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 3097645

Title: Isolation of CD1 genes: a family of major histocompatibility complex-related differentiation antigens.

PubMed ID: 3097645

DOI: 10.1073/pnas.83.23.9154

PubMed ID: 10981968

Title: The alphabeta T cell response to self-glycolipids shows a novel mechanism of CD1b loading and a requirement for complex oligosaccharides.

PubMed ID: 10981968

DOI: 10.1016/s1074-7613(00)00025-x

PubMed ID: 10899914

Title: Human CD1b and CD1c isoforms survey different intracellular compartments for the presentation of microbial lipid antigens.

PubMed ID: 10899914

DOI: 10.1084/jem.192.2.281

PubMed ID: 14716313

Title: Saposin C is required for lipid presentation by human CD1b.

PubMed ID: 14716313

DOI: 10.1038/ni1035

PubMed ID: 19349973

Title: Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins.

PubMed ID: 19349973

DOI: 10.1038/nbt.1532

PubMed ID: 12118248

Title: Structure of human CD1b with bound ligands at 2.3 A, a maze for alkyl chains.

PubMed ID: 12118248

DOI: 10.1038/ni821

PubMed ID: 14764708

Title: The crystal structure of human CD1b with a bound bacterial glycolipid.

PubMed ID: 14764708

DOI: 10.4049/jimmunol.172.4.2382

PubMed ID: 16874306

Title: Endogenous phosphatidylcholine and a long spacer ligand stabilize the lipid-binding groove of CD1b.

PubMed ID: 16874306

DOI: 10.1038/sj.emboj.7601244

Sequence Information:

  • Length: 333
  • Mass: 36939
  • Checksum: 7D02B670D4DE8CC7
  • Sequence:
    • MLLLPFQLLA VLFPGGNSEH AFQGPTSFHV IQTSSFTNST WAQTQGSGWL DDLQIHGWDS 
DSGTAIFLKP WSKGNFSDKE VAELEEIFRV YIFGFAREVQ DFAGDFQMKY PFEIQGIAGC 
ELHSGGAIVS FLRGALGGLD FLSVKNASCV PSPEGGSRAQ KFCALIIQYQ GIMETVRILL 
YETCPRYLLG VLNAGKADLQ RQVKPEAWLS SGPSPGPGRL QLVCHVSGFY PKPVWVMWMR 
GEQEQQGTQL GDILPNANWT WYLRATLDVA DGEAAGLSCR VKHSSLEGQD IILYWRNPTS 
IGSIVLAIIV PSLLLLLCLA LWYMRRRSYQ NIP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.