Details for: USP10
Gene ID: 9100
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: USP10
Ensembl ID: ENSG00000103194
Description: ubiquitin specific peptidase 10
Selected Context(s): Overall
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
-
CSI 14.58rCSI 38.7%PRS 42.87
-
CSI 11.68rCSI 13.72%PRS 33.63
-
CSI 9.81rCSI 15.16%PRS 28.21
-
CSI 8.43rCSI 14.88%PRS 18.08
-
CSI 7.75rCSI 17.15%PRS 27.65
-
CSI 7.64rCSI 6.9%PRS 27.38
-
CSI 7.17rCSI 20.37%PRS 31.77
-
CSI 6.62rCSI 22.19%PRS 22.12
-
CSI 6.4rCSI 10.3%PRS 23.14
-
CSI 6.26rCSI 20.04%PRS 26.59
-
CSI 6.23rCSI 23.34%PRS 25.31
-
CSI 6.04rCSI 8.94%PRS 33.85
-
CSI 5.96rCSI 34.37%PRS 34.64
-
CSI 5.44rCSI 29.25%PRS 46.63
-
CSI 5.41rCSI 5.8%PRS 27.8
-
CSI 5.15rCSI 7.46%PRS 43.85
-
CSI 4.9rCSI 11.73%PRS 21.9
-
CSI 4.71rCSI 4.35%PRS 31.04
-
CSI 4.62rCSI 3.5%PRS 40.25
-
CSI 4.54rCSI 29.79%PRS 67.77
-
CSI 4.53rCSI 7.41%PRS 23.35
-
CSI 4.48rCSI 10.24%PRS 29.43
-
CSI 4.48rCSI 19.89%PRS 28.83
-
CSI 4.4rCSI 10.59%PRS 45.22
-
CSI 4.3rCSI 6.91%PRS 20.29
-
CSI 4.3rCSI 11.34%PRS 35.41
-
CSI 4.26rCSI 5.58%PRS 41.31
-
CSI 4.04rCSI 14.55%PRS 17.71
-
CSI 3.98rCSI 5.88%PRS 44.87
-
CSI 3.85rCSI 3.24%PRS 45.13
-
CSI 3.82rCSI 31.06%PRS 27.7
-
CSI 3.8rCSI 3.05%PRS 49.7
-
CSI 3.69rCSI 10.58%PRS 44
-
CSI 3.51rCSI 6.27%PRS 45.45
-
CSI 3.51rCSI 4.12%PRS 41.7
-
CSI 3.45rCSI 8.18%PRS 35.71
-
CSI 3.38rCSI 8.58%PRS 23.19
-
CSI 3.38rCSI 10.55%PRS 19.51
-
CSI 3.35rCSI 2.54%PRS 38.98
-
CSI 3.34rCSI 4.92%PRS 27.74
-
CSI 3.26rCSI 3.91%PRS 47.99
-
CSI 3.25rCSI 3.13%PRS 54.01
-
CSI 3.23rCSI 3.88%PRS 28.86
-
CSI 3.14rCSI 7.63%PRS 18.15
-
CSI 2.93rCSI 9.15%PRS 21.22
-
CSI 2.89rCSI 17%PRS 19.63
-
CSI 2.7rCSI 12.93%PRS 27.19
-
CSI 2.7rCSI 3.28%PRS 36.49
-
CSI 2.69rCSI 3.46%PRS 28.52
-
CSI 2.65rCSI 2.19%PRS 30.4
-
CSI 2.64rCSI 2.77%PRS 31.64
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CSI 2.58rCSI 2.35%PRS 43.56
-
CSI 2.57rCSI 4.31%PRS 18.64
-
CSI 2.55rCSI 2.51%PRS 31.98
-
CSI 2.55rCSI 60.96%PRS 17.81
-
CSI 2.53rCSI 5.85%PRS 24.54
-
CSI 2.53rCSI 1.68%PRS 34.36
-
CSI 2.53rCSI 11.11%PRS 28.1
-
CSI 2.5rCSI 6.32%PRS 36.49
-
CSI 2.47rCSI 7.93%PRS 39.05
-
CSI 2.46rCSI 1.76%PRS 40.25
-
CSI 2.45rCSI 3.28%PRS 37.01
-
CSI 2.44rCSI 4.44%PRS 44.14
-
CSI 2.43rCSI 58.62%PRS 18.57
-
CSI 2.42rCSI 5.02%PRS 29.3
-
CSI 2.39rCSI 1.66%PRS 36.05
-
CSI 2.37rCSI 1.4%PRS 41.48
-
CSI 2.37rCSI 3.76%PRS 38.23
-
CSI 2.35rCSI 1.63%PRS 40.94
-
CSI 2.32rCSI 4.52%PRS 30.95
-
CSI 2.31rCSI 2.05%PRS 29.81
-
CSI 2.31rCSI 12.92%PRS 45.39
-
CSI 2.3rCSI 3.68%PRS 25.51
-
CSI 2.26rCSI 1.67%PRS 25.71
-
CSI 2.21rCSI 1.85%PRS 34.73
-
CSI 2.19rCSI 6.33%PRS 52.34
-
CSI 2.16rCSI 1.61%PRS 47.06
-
CSI 2.15rCSI 1.7%PRS 20.85
-
CSI 2.12rCSI 2.7%PRS 34.23
-
CSI 2.1rCSI 3%PRS 32.6
-
CSI 2.09rCSI 12%PRS 40.97
-
CSI 2.08rCSI 2.77%PRS 31.96
-
CSI 2.06rCSI 4.24%PRS 27.97
-
CSI 2.04rCSI 6.01%PRS 34.61
-
CSI 2.03rCSI 2.22%PRS 33.16
-
CSI 2.02rCSI 1.99%PRS 43.91
-
CSI 2rCSI 6.17%PRS 41.79
-
CSI 1.97rCSI 1.53%PRS 29.37
-
CSI 1.95rCSI 5.02%PRS 35.37
-
CSI 1.94rCSI 2.97%PRS 30.22
-
CSI 1.94rCSI 1.79%PRS 49.51
-
CSI 1.92rCSI 9.48%PRS 39.44
-
CSI 1.92rCSI 16.55%PRS 19.12
-
CSI 1.92rCSI 3.85%PRS 22.46
-
CSI 1.91rCSI 2.45%PRS 28.35
-
CSI 1.9rCSI 1.98%PRS 30.59
-
CSI 1.89rCSI 6.15%PRS 34.29
-
CSI 1.89rCSI 3.07%PRS 29.62
-
CSI 1.85rCSI 4.08%PRS 43.37
-
CSI 1.84rCSI 1.42%PRS 28.31
-
CSI 0.1rCSI 1.0%PRS 47.7%
-
CSI 0.2rCSI 4.0%PRS 25.1%
-
CSI 0.2rCSI 0.5%PRS 25.2%
-
CSI 0.2rCSI 4.2%PRS 26.5%
-
CSI 0.3rCSI 4.6%PRS 31.3%
-
CSI 0.3rCSI 2.0%PRS 24.3%
-
CSI 0.3rCSI 1.9%PRS 56.5%
-
CSI 0.5rCSI 1.9%PRS 47.5%
-
CSI 0.5rCSI 1.4%PRS 45.3%
-
CSI 0.5rCSI 2.2%PRS 46.4%
-
CSI 0.5rCSI 1.8%PRS 42.3%
-
CSI 0.5rCSI 16.2%PRS 55.6%
-
CSI 0.6rCSI 3.2%PRS 19.5%
-
CSI 0.6rCSI 2.9%PRS 52.9%
-
CSI 0.6rCSI 2.5%PRS 49.8%
-
CSI 0.6rCSI 4.2%PRS 20.3%
-
CSI 0.7rCSI 5.0%PRS 49.9%
-
CSI 0.7rCSI 1.4%PRS 39.9%
-
CSI 0.7rCSI 1.9%PRS 38.1%
-
CSI 0.7rCSI 3.6%PRS 46.1%
-
CSI 0.7rCSI 7.5%PRS 51.2%
-
CSI 0.7rCSI 2.0%PRS 44.2%
-
CSI 0.7rCSI 1.0%PRS 39.5%
-
CSI 0.7rCSI 1.6%PRS 21.6%
-
CSI 0.7rCSI 1.1%PRS 35.4%
-
CSI 0.8rCSI 0.8%PRS 48.7%
-
CSI 0.8rCSI 1.9%PRS 34.9%
-
CSI 0.8rCSI 1.5%PRS 23.1%
-
CSI 0.9rCSI 9.6%PRS 59.5%
-
CSI 0.9rCSI 1.2%PRS 25.9%
-
CSI 0.9rCSI 3.9%PRS 58.8%
-
CSI 0.9rCSI 2.0%PRS 29.9%
-
CSI 0.9rCSI 1.9%PRS 38.9%
-
CSI 0.9rCSI 2.0%PRS 22.9%
-
CSI 0.9rCSI 3.5%PRS 50.5%
-
CSI 0.9rCSI 2.4%PRS 30.0%
-
CSI 1.0rCSI 1.4%PRS 23.6%
-
CSI 1.0rCSI 4.3%PRS 26.3%
-
CSI 1.0rCSI 1.2%PRS 35.7%
-
CSI 1.0rCSI 2.5%PRS 41.1%
-
CSI 1.0rCSI 2.9%PRS 47.7%
-
CSI 1.0rCSI 1.7%PRS 25.3%
-
CSI 1.0rCSI 1.6%PRS 27.6%
-
CSI 1.1rCSI 1.1%PRS 34.9%
-
CSI 1.1rCSI 5.4%PRS 38.8%
-
CSI 1.1rCSI 1.8%PRS 34.7%
-
CSI 1.1rCSI 1.6%PRS 38.7%
-
CSI 1.1rCSI 1.9%PRS 37.5%
-
CSI 1.1rCSI 1.7%PRS 30.8%
-
CSI 1.1rCSI 1.0%PRS 22.1%
-
CSI 1.1rCSI 2.1%PRS 37.7%
-
CSI 1.1rCSI 2.4%PRS 38.9%
-
CSI 1.1rCSI 1.7%PRS 45.6%
-
CSI 1.1rCSI 3.3%PRS 23.8%
-
CSI 1.1rCSI 3.1%PRS 28.0%
-
CSI 1.1rCSI 1.6%PRS 38.1%
-
CSI 1.1rCSI 1.4%PRS 48.5%
-
CSI 1.2rCSI 1.8%PRS 30.4%
-
CSI 1.2rCSI 1.3%PRS 22.4%
-
CSI 1.2rCSI 2.8%PRS 28.4%
-
CSI 1.2rCSI 3.8%PRS 30.7%
-
CSI 1.2rCSI 2.2%PRS 25.8%
-
CSI 1.2rCSI 1.6%PRS 34.3%
-
CSI 1.3rCSI 1.8%PRS 31.8%
-
CSI 1.3rCSI 4.9%PRS 39.3%
-
CSI 1.3rCSI 3.1%PRS 28.1%
-
CSI 1.3rCSI 2.3%PRS 25.0%
-
CSI 1.3rCSI 1.8%PRS 32.9%
-
CSI 1.3rCSI 1.6%PRS 18.4%
-
CSI 1.3rCSI 5.1%PRS 27.2%
-
CSI 1.3rCSI 1.3%PRS 22.6%
-
CSI 1.4rCSI 2.4%PRS 28.1%
-
CSI 1.4rCSI 2.4%PRS 38.8%
-
CSI 1.4rCSI 1.2%PRS 33.3%
-
CSI 1.4rCSI 1.6%PRS 26.0%
-
CSI 1.4rCSI 3.3%PRS 32.9%
-
CSI 1.4rCSI 2.1%PRS 37.8%
-
CSI 1.4rCSI 1.3%PRS 30.8%
-
CSI 1.4rCSI 2.5%PRS 29.1%
-
CSI 1.4rCSI 1.8%PRS 38.1%
-
CSI 1.4rCSI 2.0%PRS 30.1%
-
CSI 1.4rCSI 1.1%PRS 32.0%
-
CSI 1.4rCSI 3.3%PRS 36.8%
-
CSI 1.5rCSI 3.0%PRS 17.1%
-
CSI 1.5rCSI 3.2%PRS 33.5%
-
CSI 1.5rCSI 1.8%PRS 26.6%
-
CSI 1.5rCSI 1.5%PRS 30.6%
-
CSI 1.5rCSI 3.5%PRS 47.6%
-
CSI 1.5rCSI 3.5%PRS 42.1%
-
CSI 1.5rCSI 1.2%PRS 30.9%
-
CSI 1.5rCSI 1.5%PRS 25.6%
-
CSI 1.5rCSI 1.0%PRS 37.3%
-
CSI 1.5rCSI 3.4%PRS 19.3%
-
CSI 1.5rCSI 4.0%PRS 28.7%
-
CSI 1.5rCSI 2.2%PRS 27.8%
-
CSI 1.5rCSI 1.3%PRS 28.5%
-
CSI 1.5rCSI 2.9%PRS 22.3%
-
CSI 1.6rCSI 5.9%PRS 19.4%
-
CSI 1.6rCSI 6.3%PRS 30.0%
-
CSI 1.6rCSI 4.6%PRS 32.9%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 3205072775
Symbol: UBP10_HUMAN
Name: Deubiquitinating enzyme 10
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 11439350
Title: Ras-GAP SH3 domain binding protein (G3BP) is a modulator of USP10, a novel human ubiquitin specific protease.
PubMed ID: 11439350
PubMed ID: 8724849
Title: Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1.
PubMed ID: 8724849
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 17974005
Title: The full-ORF clone resource of the German cDNA consortium.
PubMed ID: 17974005
PubMed ID: 15616553
Title: The sequence and analysis of duplication-rich human chromosome 16.
PubMed ID: 15616553
DOI: 10.1038/nature03187
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 17081983
Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
PubMed ID: 17081983
PubMed ID: 16964243
Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.
PubMed ID: 16964243
DOI: 10.1038/nbt1240
PubMed ID: 17487921
Title: Toward a global characterization of the phosphoproteome in prostate cancer cells: identification of phosphoproteins in the LNCaP cell line.
PubMed ID: 17487921
PubMed ID: 17693683
Title: Quantitative phosphoproteome profiling of Wnt3a-mediated signaling network: indicating the involvement of ribonucleoside-diphosphate reductase M2 subunit phosphorylation at residue serine 20 in canonical Wnt signal transduction.
PubMed ID: 17693683
PubMed ID: 18632802
Title: Vasopressin-inducible ubiquitin-specific protease 10 increases ENaC cell surface expression by deubiquitylating and stabilizing sorting nexin 3.
PubMed ID: 18632802
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 18318008
Title: Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography.
PubMed ID: 18318008
PubMed ID: 19413330
Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
PubMed ID: 19413330
DOI: 10.1021/ac9004309
PubMed ID: 19398555
Title: The deubiquitinating enzyme USP10 regulates the post-endocytic sorting of cystic fibrosis transmembrane conductance regulator in airway epithelial cells.
PubMed ID: 19398555
PubMed ID: 19690332
Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
PubMed ID: 19690332
PubMed ID: 20096447
Title: USP10 regulates p53 localization and stability by deubiquitinating p53.
PubMed ID: 20096447
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 21962518
Title: Beclin1 controls the levels of p53 by regulating the deubiquitination activity of USP10 and USP13.
PubMed ID: 21962518
PubMed ID: 21406692
Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
PubMed ID: 21406692
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 23279204
Title: Both G3BP1 and G3BP2 contribute to stress granule formation.
PubMed ID: 23279204
DOI: 10.1111/gtc.12023
PubMed ID: 24845384
Title: Deubiquitination and stabilization of T-bet by USP10.
PubMed ID: 24845384
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 25861989
Title: TRAF family member-associated NF-kappaB activator (TANK) inhibits genotoxic nuclear factor kappaB activation by facilitating deubiquitinase USP10-dependent deubiquitination of TRAF6 ligase.
PubMed ID: 25861989
PubMed ID: 27022092
Title: G3BP-Caprin1-USP10 complexes mediate stress granule condensation and associate with 40S subunits.
PubMed ID: 27022092
PubMed ID: 32302570
Title: Competing protein-RNA interaction networks control multiphase intracellular organization.
PubMed ID: 32302570
PubMed ID: 32011234
Title: Distinct regulatory ribosomal ubiquitylation events are reversible and hierarchically organized.
PubMed ID: 32011234
DOI: 10.7554/elife.54023
PubMed ID: 31981475
Title: The G3BP1-family-USP10 deubiquitinase complex rescues ubiquitinated 40S subunits of ribosomes stalled in translation from lysosomal degradation.
PubMed ID: 31981475
PubMed ID: 34348161
Title: The E3 ubiquitin ligase RNF10 modifies 40S ribosomal subunits of ribosomes compromised in translation.
PubMed ID: 34348161
PubMed ID: 34469731
Title: iRQC, a surveillance pathway for 40S ribosomal quality control during mRNA translation initiation.
PubMed ID: 34469731
PubMed ID: 36183834
Title: Tryptophan mutations in G3BP1 tune the stability of a cellular signaling hub by weakening transient interactions with Caprin1 and USP10.
PubMed ID: 36183834
PubMed ID: 37582970
Title: MAVS-loaded unanchored Lys63-linked polyubiquitin chains activate the RIG-I-MAVS signaling cascade.
PubMed ID: 37582970
PubMed ID: 36279435
Title: Yin and yang regulation of stress granules by Caprin-1.
PubMed ID: 36279435
Sequence Information:
- Length: 798
- Mass: 87134
- Checksum: E6BA77E2B5CE2B3F
- Sequence:
MALHSPQYIF GDFSPDEFNQ FFVTPRSSVE LPPYSGTVLC GTQAVDKLPD GQEYQRIEFG VDEVIEPSDT LPRTPSYSIS STLNPQAPEF ILGCTASKIT PDGITKEASY GSIDCQYPGS ALALDGSSNV EAEVLENDGV SGGLGQRERK KKKKRPPGYY SYLKDGGDDS ISTEALVNGH ANSAVPNSVS AEDAEFMGDM PPSVTPRTCN SPQNSTDSVS DIVPDSPFPG ALGSDTRTAG QPEGGPGADF GQSCFPAEAG RDTLSRTAGA QPCVGTDTTE NLGVANGQIL ESSGEGTATN GVELHTTESI DLDPTKPESA SPPADGTGSA SGTLPVSQPK SWASLFHDSK PSSSSPVAYV ETKYSPPAIS PLVSEKQVEV KEGLVPVSED PVAIKIAELL ENVTLIHKPV SLQPRGLINK GNWCYINATL QALVACPPMY HLMKFIPLYS KVQRPCTSTP MIDSFVRLMN EFTNMPVPPK PRQALGDKIV RDIRPGAAFE PTYIYRLLTV NKSSLSEKGR QEDAEEYLGF ILNGLHEEML NLKKLLSPSN EKLTISNGPK NHSVNEEEQE EQGEGSEDEW EQVGPRNKTS VTRQADFVQT PITGIFGGHI RSVVYQQSSK ESATLQPFFT LQLDIQSDKI RTVQDALESL VARESVQGYT TKTKQEVEIS RRVTLEKLPP VLVLHLKRFV YEKTGGCQKL IKNIEYPVDL EISKELLSPG VKNKNFKCHR TYRLFAVVYH HGNSATGGHY TTDVFQIGLN GWLRIDDQTV KVINQYQVVK PTAERTAYLL YYRRVDLL
Genular Protein ID: 2302780509
Symbol: A0A7G6J4N4_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Sequence Information:
- Length: 802
- Mass: 87533
- Checksum: CBA33D0F268AEF5A
- Sequence:
MPWLPSPGIG QYIFGDFSPD EFNQFFVTPR SSVELPPYSG TVLCGTQAVD KLPDGQEYQR IEFGVDEVIE PSDTLPRTPS YSISSTLNPQ APEFILGCTA SKITPDGITK EASYGSIDCQ YPGSALALDG SSNVEAEVLE NDGVSGGLGQ RERKKKKKRP PGYYSYLKDG GDDSISTEAL VNGHANSAVP NSVSAEDAEF MGDMPPSVTP RTCNSPQNST DSVSDIVPDS PFPGALGSDT RTAGQPEGGP GADFGQSCFP AEAGRDTLSR TAGAQPCVGT DTTENLGVAN GQILESSGEG TATNGVELHT TESIDLDPTK PESASPPADG TGSASGTLPV SQPKSWASLF HDSKPSSSSP VAYVETKYSP PAISPLVSEK QVEVKEGLVP VSEDPVAIKI AELLENVTLI HKPVSLQPRG LINKGNWCYI NATLQALVAC PPMYHLMKFI PLYSKVQRPC TSTPMIDSFV RLMNEFTNMP VPPKPRQALG DKIVRDIRPG AAFEPTYIYR LLTVNKSSLS EKGRQEDAEE YLGFILNGLH EEMLNLKKLL SPSNEKLTIS NGPKNHSVNE EEQEEQGEGS EDEWEQVGPR NKTSVTRQAD FVQTPITGIF GGHIRSVVYQ QSSKESATLQ PFFTLQLDIQ SDKIRTVQDA LESLVARESV QGYTTKTKQE VEISRRVTLE KLPPVLVLHL KRFVYEKTGG CQKLIKNIEY PVDLEISKEL LSPGVKNKNF KCHRTYRLFA VVYHHGNSAT GGHYTTDVFQ IGLNGWLRID DQTVKVINQY QVVKPTAERT AYLLYYRRVD LL