Details for: RGN

Gene ID: 9104

Symbol: RGN

Ensembl ID: ENSG00000130988

Description: regucalcin

Associated with

  • Calcium ion binding
    (GO:0005509)
  • Cytoplasm
    (GO:0005737)
  • Enzyme regulator activity
    (GO:0030234)
  • Gluconolactonase activity
    (GO:0004341)
  • Intracellular calcium ion homeostasis
    (GO:0006874)
  • Kidney development
    (GO:0001822)
  • L-ascorbic acid biosynthetic process
    (GO:0019853)
  • Liver regeneration
    (GO:0097421)
  • Negative regulation of apoptotic process
    (GO:0043066)
  • Negative regulation of bone development
    (GO:1903011)
  • Negative regulation of dna biosynthetic process
    (GO:2000279)
  • Negative regulation of dna catabolic process
    (GO:1903625)
  • Negative regulation of epithelial cell proliferation
    (GO:0050680)
  • Negative regulation of flagellated sperm motility
    (GO:1901318)
  • Negative regulation of nitric oxide biosynthetic process
    (GO:0045019)
  • Negative regulation of protein phosphorylation
    (GO:0001933)
  • Negative regulation of rna biosynthetic process
    (GO:1902679)
  • Nucleus
    (GO:0005634)
  • Positive regulation of atp-dependent activity
    (GO:0032781)
  • Positive regulation of fatty acid biosynthetic process
    (GO:0045723)
  • Positive regulation of glucose metabolic process
    (GO:0010907)
  • Positive regulation of proteolysis involved in protein catabolic process
    (GO:1903052)
  • Positive regulation of triglyceride biosynthetic process
    (GO:0010867)
  • Regulation of calcium-mediated signaling
    (GO:0050848)
  • Spermatogenesis
    (GO:0007283)
  • Zinc ion binding
    (GO:0008270)

Other Information

Genular Protein ID: 3651946858

Symbol: RGN_HUMAN

Name: Regucalcin

UniProtKB Accession Codes:

Q15493 A4FTW1 A8K271 Q53FC9 Q5JRR5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChEBI 11 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 3 EC 2 EMBL 8 Ensembl 4 EvolutionaryTrace 1 ExpressionAtlas 1 GO 26 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 6 PDBsum 4 PIR 1 PRINTS 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 RefSeq 5 Rhea 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 7548213

Title: Isolation of cDNA clone encoding human homologue of senescence marker protein-30 (SMP30) and its location on the X chromosome.

PubMed ID: 7548213

DOI: 10.1016/0167-4781(95)00120-6

PubMed ID: 10677570

Title: Transcript heterogeneity of the human gene for Ca2+-binding protein regucalcin.

PubMed ID: 10677570

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 20329768

Title: Crystal structure of human senescence marker protein 30: insights linking structural, enzymatic, and physiological functions.

PubMed ID: 20329768

DOI: 10.1021/bi9022297

PubMed ID: 23349732

Title: Structural basis of the gamma-lactone-ring formation in ascorbic acid biosynthesis by the senescence marker protein-30/gluconolactonase.

PubMed ID: 23349732

DOI: 10.1371/journal.pone.0053706

Sequence Information:

  • Length: 299
  • Mass: 33253
  • Checksum: 95BA1C73B7B77635
  • Sequence:
    • MSSIKIECVL PENCRCGESP VWEEVSNSLL FVDIPAKKVC RWDSFTKQVQ RVTMDAPVSS 
VALRQSGGYV ATIGTKFCAL NWKEQSAVVL ATVDNDKKNN RFNDGKVDPA GRYFAGTMAE 
ETAPAVLERH QGALYSLFPD HHVKKYFDQV DISNGLDWSL DHKIFYYIDS LSYSVDAFDY 
DLQTGQISNR RSVYKLEKEE QIPDGMCIDA EGKLWVACYN GGRVIRLDPV TGKRLQTVKL 
PVDKTTSCCF GGKNYSEMYV TCARDGMDPE GLLRQPEAGG IFKITGLGVK GIAPYSYAG

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.