Details for: RGN

Gene ID: 9104

Symbol: RGN

Ensembl ID: ENSG00000130988

Description: regucalcin

Associated with

  • Calcium ion binding
    (GO:0005509)
  • Cytoplasm
    (GO:0005737)
  • Enzyme regulator activity
    (GO:0030234)
  • Gluconolactonase activity
    (GO:0004341)
  • Intracellular calcium ion homeostasis
    (GO:0006874)
  • Kidney development
    (GO:0001822)
  • L-ascorbic acid biosynthetic process
    (GO:0019853)
  • Liver regeneration
    (GO:0097421)
  • Negative regulation of apoptotic process
    (GO:0043066)
  • Negative regulation of bone development
    (GO:1903011)
  • Negative regulation of dna biosynthetic process
    (GO:2000279)
  • Negative regulation of dna catabolic process
    (GO:1903625)
  • Negative regulation of epithelial cell proliferation
    (GO:0050680)
  • Negative regulation of flagellated sperm motility
    (GO:1901318)
  • Negative regulation of nitric oxide biosynthetic process
    (GO:0045019)
  • Negative regulation of protein phosphorylation
    (GO:0001933)
  • Negative regulation of rna biosynthetic process
    (GO:1902679)
  • Nucleus
    (GO:0005634)
  • Positive regulation of atp-dependent activity
    (GO:0032781)
  • Positive regulation of fatty acid biosynthetic process
    (GO:0045723)
  • Positive regulation of glucose metabolic process
    (GO:0010907)
  • Positive regulation of proteolysis involved in protein catabolic process
    (GO:1903052)
  • Positive regulation of triglyceride biosynthetic process
    (GO:0010867)
  • Regulation of calcium-mediated signaling
    (GO:0050848)
  • Spermatogenesis
    (GO:0007283)
  • Zinc ion binding
    (GO:0008270)

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 4.53
    Marker Score: 6,985
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 3.77
    Marker Score: 50,120
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.7
    Marker Score: 7,132
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 1.7
    Marker Score: 9,121
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.68
    Marker Score: 10,793
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.59
    Marker Score: 1,157
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 1.59
    Marker Score: 6,842
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 168,864
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.36
    Marker Score: 860
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 1.32
    Marker Score: 386
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 1.24
    Marker Score: 423
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 1.12
    Marker Score: 1,354
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.09
    Marker Score: 7,218
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 1.09
    Marker Score: 24,254
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.03
    Marker Score: 787
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 1.02
    Marker Score: 3,616
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 1.01
    Marker Score: 687
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,801
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,025
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,407
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 503
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 457
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,411
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5,343
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.93
    Marker Score: 453
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.92
    Marker Score: 369
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.92
    Marker Score: 956
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,734
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.91
    Marker Score: 19,396
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 322
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,296
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.86
    Marker Score: 1,896
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.85
    Marker Score: 1,379
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.82
    Marker Score: 260
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.82
    Marker Score: 1,735
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.77
    Marker Score: 1,456
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.76
    Marker Score: 1,019
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 391
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.74
    Marker Score: 679
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.74
    Marker Score: 11,535
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.73
    Marker Score: 3,083
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 0.73
    Marker Score: 584
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.73
    Marker Score: 669
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 0.72
    Marker Score: 211
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 0.7
    Marker Score: 747
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.69
    Marker Score: 1,845
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 175
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 0.65
    Marker Score: 268
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.62
    Marker Score: 1,464
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 0.62
    Marker Score: 1,554
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.61
    Marker Score: 255
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 0.61
    Marker Score: 2,171
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.6
    Marker Score: 638
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.59
    Marker Score: 740
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.57
    Marker Score: 5,436
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 441
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.55
    Marker Score: 146
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.55
    Marker Score: 206
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.54
    Marker Score: 4,649
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.54
    Marker Score: 315
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.54
    Marker Score: 20,419
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.53
    Marker Score: 1,028
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.53
    Marker Score: 200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.53
    Marker Score: 336
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.53
    Marker Score: 5,284
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 0.52
    Marker Score: 339
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.5
    Marker Score: 1,024
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.49
    Marker Score: 321
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.48
    Marker Score: 29,779
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 0.48
    Marker Score: 267
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.47
    Marker Score: 729
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.46
    Marker Score: 1,057
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 0.46
    Marker Score: 1,214
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.46
    Marker Score: 651
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.46
    Marker Score: 354
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 0.45
    Marker Score: 181
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.45
    Marker Score: 187
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 0.43
    Marker Score: 413
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 0.43
    Marker Score: 597
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.42
    Marker Score: 108
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.42
    Marker Score: 283
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.41
    Marker Score: 3,152
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.41
    Marker Score: 189
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.4
    Marker Score: 127
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 0.4
    Marker Score: 104
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 0.4
    Marker Score: 148
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.4
    Marker Score: 383
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.4
    Marker Score: 635
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 0.38
    Marker Score: 161
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.38
    Marker Score: 2,308
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.38
    Marker Score: 412
  • Cell Name: fat cell (CL0000136)
    Fold Change: 0.38
    Marker Score: 213
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.37
    Marker Score: 223
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.36
    Marker Score: 367
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.36
    Marker Score: 246
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.36
    Marker Score: 738
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.36
    Marker Score: 2,150
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 0.36
    Marker Score: 306
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 0.35
    Marker Score: 587
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.35
    Marker Score: 96

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** Regucalcin is a calcium-binding protein that exhibits a unique ability to regulate calcium-mediated signaling pathways. It is involved in the following key characteristics: 1. **Calcium ion binding**: Regucalcin binds to calcium ions, which is essential for maintaining calcium homeostasis within cells. 2. **Enzyme regulator activity**: Regucalcin regulates the activity of various enzymes, including gluconolactonase, which is involved in the L-ascorbic acid biosynthetic process. 3. **Negative regulation of apoptotic process**: Regucalcin negatively regulates apoptosis, which is a critical process for maintaining cellular homeostasis. 4. **Negative regulation of proliferative processes**: Regucalcin also negatively regulates cell proliferation, which is essential for preventing uncontrolled cell growth. **Pathways and Functions:** Regucalcin is involved in various cellular pathways, including: 1. **Intracellular calcium ion homeostasis**: Regucalcin helps maintain calcium homeostasis within cells by regulating calcium ion binding and release. 2. **Regulation of bone development**: Regucalcin negatively regulates bone development, which is essential for preventing excessive bone growth. 3. **Regulation of epithelial cell proliferation**: Regucalcin negatively regulates epithelial cell proliferation, which is critical for maintaining tissue homeostasis. 4. **Regulation of spermatogenesis**: Regucalcin is involved in regulating spermatogenesis, which is the process of sperm production. **Clinical Significance:** Regucalcin has significant clinical implications in various diseases, including: 1. **Bone disorders**: Regucalcin dysregulation has been implicated in bone disorders, such as osteoporosis and hypercalcemia. 2. **Cancer**: Regucalcin dysregulation has been linked to various cancers, including colorectal cancer and breast cancer. 3. **Cardiovascular disease**: Regucalcin dysregulation has been implicated in cardiovascular disease, including hypertension and atherosclerosis. 4. **Neurological disorders**: Regucalcin dysregulation has been linked to neurological disorders, including Alzheimer's disease and Parkinson's disease. In conclusion, regucalcin is a multifaceted gene that plays a crucial role in maintaining calcium homeostasis and regulating various cellular processes. Its dysregulation has significant clinical implications in various diseases, highlighting the importance of further research into the molecular mechanisms underlying regucalcin function.

Genular Protein ID: 3651946858

Symbol: RGN_HUMAN

Name: Regucalcin

UniProtKB Accession Codes:

Q15493 A4FTW1 A8K271 Q53FC9 Q5JRR5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChEBI 11 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 3 EC 2 EMBL 8 Ensembl 4 EvolutionaryTrace 1 ExpressionAtlas 1 GO 26 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 6 PDBsum 4 PIR 1 PRINTS 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 RefSeq 5 Rhea 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 7548213

Title: Isolation of cDNA clone encoding human homologue of senescence marker protein-30 (SMP30) and its location on the X chromosome.

PubMed ID: 7548213

DOI: 10.1016/0167-4781(95)00120-6

PubMed ID: 10677570

Title: Transcript heterogeneity of the human gene for Ca2+-binding protein regucalcin.

PubMed ID: 10677570

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 20329768

Title: Crystal structure of human senescence marker protein 30: insights linking structural, enzymatic, and physiological functions.

PubMed ID: 20329768

DOI: 10.1021/bi9022297

PubMed ID: 23349732

Title: Structural basis of the gamma-lactone-ring formation in ascorbic acid biosynthesis by the senescence marker protein-30/gluconolactonase.

PubMed ID: 23349732

DOI: 10.1371/journal.pone.0053706

Sequence Information:

  • Length: 299
  • Mass: 33253
  • Checksum: 95BA1C73B7B77635
  • Sequence:
    • MSSIKIECVL PENCRCGESP VWEEVSNSLL FVDIPAKKVC RWDSFTKQVQ RVTMDAPVSS 
VALRQSGGYV ATIGTKFCAL NWKEQSAVVL ATVDNDKKNN RFNDGKVDPA GRYFAGTMAE 
ETAPAVLERH QGALYSLFPD HHVKKYFDQV DISNGLDWSL DHKIFYYIDS LSYSVDAFDY 
DLQTGQISNR RSVYKLEKEE QIPDGMCIDA EGKLWVACYN GGRVIRLDPV TGKRLQTVKL 
PVDKTTSCCF GGKNYSEMYV TCARDGMDPE GLLRQPEAGG IFKITGLGVK GIAPYSYAG

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.