Details for: CD1C

Gene ID: 911

Symbol: CD1C

Ensembl ID: ENSG00000158481

Description: CD1c molecule

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 47.9282
    Cell Significance Index: -7.4600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 30.3182
    Cell Significance Index: -7.6900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 6.0606
    Cell Significance Index: -7.4700
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 2.7896
    Cell Significance Index: 11.6100
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.6566
    Cell Significance Index: 25.6300
  • Cell Name: liver dendritic cell (CL2000055)
    Fold Change: 1.1979
    Cell Significance Index: 3.1600
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 0.8050
    Cell Significance Index: -1.7600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.4064
    Cell Significance Index: 19.1000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.4046
    Cell Significance Index: 47.7200
  • Cell Name: B-1b B cell (CL0000821)
    Fold Change: 0.0698
    Cell Significance Index: 0.3500
  • Cell Name: helper T cell (CL0000912)
    Fold Change: 0.0493
    Cell Significance Index: 0.7000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0005
    Cell Significance Index: -0.0200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0045
    Cell Significance Index: -0.5800
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0063
    Cell Significance Index: -0.2600
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: -0.0087
    Cell Significance Index: -0.0900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0090
    Cell Significance Index: -6.8100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0134
    Cell Significance Index: -7.3100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0272
    Cell Significance Index: -5.4600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0274
    Cell Significance Index: -2.8000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0381
    Cell Significance Index: -7.5700
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0431
    Cell Significance Index: -0.6300
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: -0.0531
    Cell Significance Index: -0.4300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0536
    Cell Significance Index: -6.9300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0536
    Cell Significance Index: -7.3600
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0603
    Cell Significance Index: -2.6200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0640
    Cell Significance Index: -7.3300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0800
    Cell Significance Index: -5.1600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0912
    Cell Significance Index: -2.5500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0935
    Cell Significance Index: -6.9700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1032
    Cell Significance Index: -2.7600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1084
    Cell Significance Index: -2.2700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1085
    Cell Significance Index: -2.7900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1089
    Cell Significance Index: -8.3600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1162
    Cell Significance Index: -7.8100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.1399
    Cell Significance Index: -6.3400
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.1432
    Cell Significance Index: -1.9800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1478
    Cell Significance Index: -7.6800
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.1531
    Cell Significance Index: -2.6000
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.1566
    Cell Significance Index: -2.9000
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.1577
    Cell Significance Index: -1.5600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1656
    Cell Significance Index: -7.7200
  • Cell Name: myoepithelial cell (CL0000185)
    Fold Change: -0.1860
    Cell Significance Index: -2.1100
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: -0.1984
    Cell Significance Index: -2.4900
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.1988
    Cell Significance Index: -2.6500
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.2033
    Cell Significance Index: -2.2100
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.2266
    Cell Significance Index: -5.6600
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2313
    Cell Significance Index: -5.9100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.2341
    Cell Significance Index: -6.2500
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2370
    Cell Significance Index: -6.9800
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2375
    Cell Significance Index: -8.7200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2495
    Cell Significance Index: -6.5600
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.2634
    Cell Significance Index: -5.1400
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: -0.2639
    Cell Significance Index: -2.0700
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: -0.2641
    Cell Significance Index: -1.6000
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.2649
    Cell Significance Index: -5.1800
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.2700
    Cell Significance Index: -6.5400
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.2728
    Cell Significance Index: -6.9500
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.2740
    Cell Significance Index: -7.8200
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.2819
    Cell Significance Index: -7.0300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.2848
    Cell Significance Index: -7.6300
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.2953
    Cell Significance Index: -6.3800
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.3008
    Cell Significance Index: -3.2000
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.3024
    Cell Significance Index: -4.3900
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: -0.3028
    Cell Significance Index: -2.6600
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.3078
    Cell Significance Index: -6.7400
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.3095
    Cell Significance Index: -2.6000
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.3126
    Cell Significance Index: -3.9500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.3143
    Cell Significance Index: -8.5600
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.3301
    Cell Significance Index: -4.7300
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.3370
    Cell Significance Index: -4.7300
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.3377
    Cell Significance Index: -3.9900
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.3488
    Cell Significance Index: -5.6500
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.3515
    Cell Significance Index: -3.9900
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.3616
    Cell Significance Index: -7.2100
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.3642
    Cell Significance Index: -4.5100
  • Cell Name: chondroblast (CL0000058)
    Fold Change: -0.3646
    Cell Significance Index: -2.1400
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.3722
    Cell Significance Index: -7.9000
  • Cell Name: muscle fibroblast (CL1001609)
    Fold Change: -0.3722
    Cell Significance Index: -2.2800
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.3881
    Cell Significance Index: -9.4700
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.3933
    Cell Significance Index: -6.9500
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.3982
    Cell Significance Index: -9.2000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.4033
    Cell Significance Index: -6.7500
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.4089
    Cell Significance Index: -5.9600
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.4121
    Cell Significance Index: -4.8700
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.4139
    Cell Significance Index: -5.5000
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.4142
    Cell Significance Index: -7.0800
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.4144
    Cell Significance Index: -5.4100
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.4175
    Cell Significance Index: -5.6800
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.4196
    Cell Significance Index: -5.4300
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.4283
    Cell Significance Index: -3.6200
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.4307
    Cell Significance Index: -6.9100
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.4374
    Cell Significance Index: -4.6100
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.4408
    Cell Significance Index: -6.0500
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.4412
    Cell Significance Index: -7.4200
  • Cell Name: embryonic fibroblast (CL2000042)
    Fold Change: -0.4474
    Cell Significance Index: -2.1400
  • Cell Name: immature NK T cell (CL0000914)
    Fold Change: -0.4484
    Cell Significance Index: -5.7400
  • Cell Name: B-2 B cell (CL0000822)
    Fold Change: -0.4524
    Cell Significance Index: -4.0100
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.4546
    Cell Significance Index: -5.8400
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: -0.4574
    Cell Significance Index: -9.5400
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.4595
    Cell Significance Index: -6.0300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** The CD1C gene is characterized by its involvement in several key pathways and functions, including: 1. **Antigen processing and presentation:** CD1c molecules process and present lipid antigens to T cells, which is essential for initiating and regulating immune responses. 2. **Lipid antigen binding:** CD1c molecules bind to lipid antigens, including glycolipids and fatty acids, which are derived from endogenous or exogenous sources. 3. **T cell activation:** CD1c molecules activate T cells, including cytotoxic T cells, which is essential for eliminating infected cells or tumor cells. 4. **Immunoregulatory interactions:** CD1c molecules interact with non-lymphoid cells, such as oligodendrocyte precursor cells and GABAergic interneurons, to regulate immune responses and maintain immune homeostasis. **Pathways and Functions:** The CD1C gene is involved in several key pathways, including: 1. **Adaptive immune response:** CD1c molecules play a crucial role in the adaptive immune response by presenting lipid antigens to T cells, which activates T cells and regulates immune responses. 2. **Antigen processing and presentation:** CD1c molecules process and present lipid antigens to T cells, which is essential for initiating and regulating immune responses. 3. **Endogenous lipid antigen via MHC class Ib:** CD1c molecules present endogenous lipid antigens to T cells via MHC class Ib molecules. 4. **Exogenous lipid antigen via MHC class Ib:** CD1c molecules present exogenous lipid antigens to T cells via MHC class Ib molecules. 5. **Endoplasmic reticulum and Golgi apparatus:** CD1c molecules are processed and presented in the endoplasmic reticulum and Golgi apparatus. 6. **Intracellular membrane-bounded organelle:** CD1c molecules are also found in intracellular membrane-bounded organelles, such as lysosomes and endosomes. **Clinical Significance:** The CD1C gene has significant clinical implications, particularly in the context of autoimmune diseases and cancer. Dysregulation of CD1c molecules has been implicated in various diseases, including: 1. **Multiple sclerosis:** CD1c molecules have been implicated in the pathogenesis of multiple sclerosis, a chronic autoimmune disease that affects the central nervous system. 2. **Rheumatoid arthritis:** CD1c molecules have been implicated in the pathogenesis of rheumatoid arthritis, a chronic autoimmune disease that affects the joints. 3. **Cancer:** CD1c molecules have been implicated in the pathogenesis of certain cancers, including breast cancer and lung cancer. In conclusion, the CD1C gene plays a crucial role in the presentation of lipid antigens to T cells and is involved in various aspects of the immune response. Dysregulation of CD1c molecules has significant clinical implications, particularly in the context of autoimmune diseases and cancer. Further research is needed to fully understand the complexities of CD1c molecules and their role in the immune system.

Genular Protein ID: 2477660896

Symbol: CD1C_HUMAN

Name: T-cell surface glycoprotein CD1c

UniProtKB Accession Codes:

P29017 Q5TDJ7 Q6IAS4 Q9UMM0 Q9UN96

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 12 Ensembl 1 ExpressionAtlas 1 GO 18 Gene3D 2 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 5 PDBsum 5 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2447586

Title: Structure and expression of the human thymocyte antigens CD1a, CD1b, and CD1c.

PubMed ID: 2447586

DOI: 10.1073/pnas.84.24.9189

PubMed ID: 2701945

Title: Expression of cDNA clones encoding the thymocyte antigens CD1a, b, c demonstrates a hierarchy of exclusion in fibroblasts.

PubMed ID: 2701945

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10488738

Title: Polymorphism of human CD1 genes.

PubMed ID: 10488738

DOI: 10.1034/j.1399-0039.1999.540202.x

PubMed ID: 3097645

Title: Isolation of CD1 genes: a family of major histocompatibility complex-related differentiation antigens.

PubMed ID: 3097645

DOI: 10.1073/pnas.83.23.9154

PubMed ID: 10899914

Title: Human CD1b and CD1c isoforms survey different intracellular compartments for the presentation of microbial lipid antigens.

PubMed ID: 10899914

DOI: 10.1084/jem.192.2.281

PubMed ID: 10786796

Title: CD1c-mediated T-cell recognition of isoprenoid glycolipids in Mycobacterium tuberculosis infection.

PubMed ID: 10786796

DOI: 10.1038/35009119

PubMed ID: 10890914

Title: CD1c molecules broadly survey the endocytic system.

PubMed ID: 10890914

DOI: 10.1073/pnas.150236797

PubMed ID: 19349973

Title: Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins.

PubMed ID: 19349973

DOI: 10.1038/nbt.1532

PubMed ID: 21167756

Title: The 2.5 a structure of CD1c in complex with a mycobacterial lipid reveals an open groove ideally suited for diverse antigen presentation.

PubMed ID: 21167756

DOI: 10.1016/j.immuni.2010.11.026

Sequence Information:

  • Length: 333
  • Mass: 37654
  • Checksum: 8E4E057097E3E440
  • Sequence:
    • MLFLQFLLLA LLLPGGDNAD ASQEHVSFHV IQIFSFVNQS WARGQGSGWL DELQTHGWDS 
ESGTIIFLHN WSKGNFSNEE LSDLELLFRF YLFGLTREIQ DHASQDYSKY PFEVQVKAGC 
ELHSGKSPEG FFQVAFNGLD LLSFQNTTWV PSPGCGSLAQ SVCHLLNHQY EGVTETVYNL 
IRSTCPRFLL GLLDAGKMYV HRQVRPEAWL SSRPSLGSGQ LLLVCHASGF YPKPVWVTWM 
RNEQEQLGTK HGDILPNADG TWYLQVILEV ASEEPAGLSC RVRHSSLGGQ DIILYWGHHF 
SMNWIALVVI VPLVILIVLV LWFKKHCSYQ DIL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.