CD1C | ENSG00000158481 | NCBI 911

Details for: CD1C

Gene ID: 911

Symbol: CD1C

Ensembl ID: ENSG00000158481

Description: CD1c molecule

Associated with

Adaptive immune system
(R-HSA-1280218)
Immune system
(R-HSA-168256)
Immunoregulatory interactions between a lymphoid and a non-lymphoid cell
(R-HSA-198933)
Adaptive immune response
(GO:0002250)
Antigen processing and presentation, endogenous lipid antigen via mhc class ib
(GO:0048006)
Antigen processing and presentation, exogenous lipid antigen via mhc class ib
(GO:0048007)
Endogenous lipid antigen binding
(GO:0030883)
Endoplasmic reticulum
(GO:0005783)
Endosome membrane
(GO:0010008)
Exogenous lipid antigen binding
(GO:0030884)
External side of plasma membrane
(GO:0009897)
Extracellular space
(GO:0005615)
Glycolipid binding
(GO:0051861)
Golgi apparatus
(GO:0005794)
Immune response
(GO:0006955)
Intracellular membrane-bounded organelle
(GO:0043231)
Lipopeptide binding
(GO:0071723)
Lysosome
(GO:0005764)
Plasma membrane
(GO:0005886)
Positive regulation of t cell mediated cytotoxicity
(GO:0001916)
Protein binding
(GO:0005515)
T cell activation involved in immune response
(GO:0002286)

Other Information

Proteins

T-cell surface glycoprotein CD1c

Genular Protein ID: 2477660896

Symbol: CD1C_HUMAN

Name: T-cell surface glycoprotein CD1c

UniProtKB Accession Codes:

P29017 Q5TDJ7 Q6IAS4 Q9UMM0 Q9UN96

Database IDs:

Citations:

PubMed ID: 2447586

Title: Structure and expression of the human thymocyte antigens CD1a, CD1b, and CD1c.

PubMed ID: 2447586

DOI: 10.1073/pnas.84.24.9189

PubMed ID: 2701945

Title: Expression of cDNA clones encoding the thymocyte antigens CD1a, b, c demonstrates a hierarchy of exclusion in fibroblasts.

PubMed ID: 2701945

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10488738

Title: Polymorphism of human CD1 genes.

PubMed ID: 10488738

DOI: 10.1034/j.1399-0039.1999.540202.x

PubMed ID: 3097645

Title: Isolation of CD1 genes: a family of major histocompatibility complex-related differentiation antigens.

PubMed ID: 3097645

DOI: 10.1073/pnas.83.23.9154

PubMed ID: 10899914

Title: Human CD1b and CD1c isoforms survey different intracellular compartments for the presentation of microbial lipid antigens.

PubMed ID: 10899914

DOI: 10.1084/jem.192.2.281

PubMed ID: 10786796

Title: CD1c-mediated T-cell recognition of isoprenoid glycolipids in Mycobacterium tuberculosis infection.

PubMed ID: 10786796

DOI: 10.1038/35009119

PubMed ID: 10890914

Title: CD1c molecules broadly survey the endocytic system.

PubMed ID: 10890914

DOI: 10.1073/pnas.150236797

PubMed ID: 19349973

Title: Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins.

PubMed ID: 19349973

DOI: 10.1038/nbt.1532

PubMed ID: 21167756

Title: The 2.5 a structure of CD1c in complex with a mycobacterial lipid reveals an open groove ideally suited for diverse antigen presentation.

PubMed ID: 21167756

DOI: 10.1016/j.immuni.2010.11.026

Sequence Information:

Length: 333
Mass: 37654
Checksum: 8E4E057097E3E440
Sequence:

MLFLQFLLLA LLLPGGDNAD ASQEHVSFHV IQIFSFVNQS WARGQGSGWL DELQTHGWDS 
ESGTIIFLHN WSKGNFSNEE LSDLELLFRF YLFGLTREIQ DHASQDYSKY PFEVQVKAGC 
ELHSGKSPEG FFQVAFNGLD LLSFQNTTWV PSPGCGSLAQ SVCHLLNHQY EGVTETVYNL 
IRSTCPRFLL GLLDAGKMYV HRQVRPEAWL SSRPSLGSGQ LLLVCHASGF YPKPVWVTWM 
RNEQEQLGTK HGDILPNADG TWYLQVILEV ASEEPAGLSC RVRHSSLGGQ DIILYWGHHF 
SMNWIALVVI VPLVILIVLV LWFKKHCSYQ DIL

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: CD1C

Associated with

Other Information

Structure and expression of the human thymocyte antigens CD1a, CD1b, and CD1c. PubMed ID: 2447586

Expression of cDNA clones encoding the thymocyte antigens CD1a, b, c demonstrates a hierarchy of exclusion in fibroblasts. PubMed ID: 2701945

The DNA sequence and biological annotation of human chromosome 1. PubMed ID: 16710414

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Polymorphism of human CD1 genes. PubMed ID: 10488738

Isolation of CD1 genes: a family of major histocompatibility complex-related differentiation antigens. PubMed ID: 3097645

Human CD1b and CD1c isoforms survey different intracellular compartments for the presentation of microbial lipid antigens. PubMed ID: 10899914

CD1c-mediated T-cell recognition of isoprenoid glycolipids in Mycobacterium tuberculosis infection. PubMed ID: 10786796

CD1c molecules broadly survey the endocytic system. PubMed ID: 10890914

Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins. PubMed ID: 19349973

The 2.5 a structure of CD1c in complex with a mycobacterial lipid reveals an open groove ideally suited for diverse antigen presentation. PubMed ID: 21167756