Details for: MTMR4

Gene ID: 9110

Gene Type:  Protein-coding  - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.

Symbol: MTMR4

Ensembl ID: ENSG00000108389

Description: myotubularin related protein 4

Selected Context(s):  Overall

Cell Significance Landscape

Contexts:

Associated with

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

  • cerebral cortex endothelial cell CL1001602
    CSI 10.8
    rCSI 18.68%
    PRS 62.34
  • lung neuroendocrine cell CL1000223
    CSI 7.28
    rCSI 10.77%
    PRS 76.52
  • choroid plexus epithelial cell CL0000706
    CSI 6.75
    rCSI 11.06%
    PRS 60.75
  • unswitched memory B cell CL0000970
    CSI 6.35
    rCSI 5.35%
    PRS 86.55
  • progenitor cell CL0011026
    CSI 6.21
    rCSI 13.21%
    PRS 67.88
  • hematopoietic stem cell CL0000037
    CSI 6.06
    rCSI 4.03%
    PRS 74.67
  • hepatic stellate cell CL0000632
    CSI 5.24
    rCSI 19.62%
    PRS 63.67
  • CD4-positive, alpha-beta cytotoxic T cell CL0000934
    CSI 4.05
    rCSI 5.56%
    PRS 88.99
  • intestinal tuft cell CL0019032
    CSI 4.02
    rCSI 6.15%
    PRS 76.1
  • L5 extratelencephalic projecting glutamatergic cortical neuron CL4023041
    CSI 3.94
    rCSI 14.17%
    PRS 51.15
  • central memory CD4-positive, alpha-beta T cell CL0000904
    CSI 3.8
    rCSI 2.25%
    PRS 87.93
  • type B pancreatic cell CL0000169
    CSI 3.38
    rCSI 7.47%
    PRS 70.65
  • ON-bipolar cell CL0000749
    CSI 3.24
    rCSI 4.81%
    PRS 72.43
  • cerebral cortex GABAergic interneuron CL0010011
    CSI 3.2
    rCSI 9.46%
    PRS 73.76
  • midzonal region hepatocyte CL0019028
    CSI 3.13
    rCSI 7.34%
    PRS 73.98
  • renal beta-intercalated cell CL0002201
    CSI 3.12
    rCSI 7.45%
    PRS 72.07
  • precursor B cell CL0000817
    CSI 2.98
    rCSI 2.61%
    PRS 80.17
  • cerebral cortex neuron CL0010012
    CSI 2.96
    rCSI 12.04%
    PRS 64.53
  • Kupffer cell CL0000091
    CSI 2.84
    rCSI 6.49%
    PRS 72.46
  • class switched memory B cell CL0000972
    CSI 2.82
    rCSI 2.11%
    PRS 86.2
  • ON parasol ganglion cell CL4033052
    CSI 2.75
    rCSI 39%
    PRS 62.67
  • neural crest cell CL0011012
    CSI 2.74
    rCSI 2.17%
    PRS 59.23
  • melanocyte CL0000148
    CSI 2.72
    rCSI 2.01%
    PRS 64.58
  • retina horizontal cell CL0000745
    CSI 2.68
    rCSI 4.09%
    PRS 68.34
  • plasmablast CL0000980
    CSI 2.67
    rCSI 2.1%
    PRS 78.32
  • interstitial cell of Cajal CL0002088
    CSI 2.61
    rCSI 3.32%
    PRS 77.53
  • ionocyte CL0005006
    CSI 2.6
    rCSI 2.78%
    PRS 72.44
  • interneuron CL0000099
    CSI 2.53
    rCSI 5.08%
    PRS 61.14
  • pvalb GABAergic cortical interneuron CL4023018
    CSI 2.47
    rCSI 3.08%
    PRS 51.08
  • astrocyte of the cerebral cortex CL0002605
    CSI 2.44
    rCSI 5.46%
    PRS 53.61
  • hepatocyte CL0000182
    CSI 2.43
    rCSI 4.34%
    PRS 71.19
  • alveolar type 1 fibroblast cell CL4028004
    CSI 2.35
    rCSI 2.57%
    PRS 74.69
  • colon epithelial cell CL0011108
    CSI 2.31
    rCSI 2.42%
    PRS 68.86
  • central memory CD8-positive, alpha-beta T cell CL0000907
    CSI 2.31
    rCSI 1.55%
    PRS 84.97
  • sst GABAergic cortical interneuron CL4023017
    CSI 2.28
    rCSI 2.93%
    PRS 54.38
  • vascular leptomeningeal cell CL4023051
    CSI 2.27
    rCSI 3.98%
    PRS 64.38
  • IgA plasma cell CL0000987
    CSI 2.25
    rCSI 2.3%
    PRS 82.6
  • retinal bipolar neuron CL0000748
    CSI 2.21
    rCSI 4.13%
    PRS 59.56
  • inhibitory interneuron CL0000498
    CSI 2.18
    rCSI 5.04%
    PRS 59.86
  • regular ventricular cardiac myocyte CL0002131
    CSI 2.18
    rCSI 13.62%
    PRS 63.21
  • goblet cell CL0000160
    CSI 2.17
    rCSI 2.05%
    PRS 71.1
  • periportal region hepatocyte CL0019026
    CSI 2.16
    rCSI 8.4%
    PRS 73.75
  • lamp5 GABAergic cortical interneuron CL4023011
    CSI 2.14
    rCSI 3.6%
    PRS 53.01
  • placental villous trophoblast CL2000060
    CSI 2.1
    rCSI 3.24%
    PRS 70.82
  • Mueller cell CL0000636
    CSI 2.07
    rCSI 4.72%
    PRS 63.08
  • intestinal epithelial cell CL0002563
    CSI 2.07
    rCSI 2.16%
    PRS 69.54
  • megakaryocyte-erythroid progenitor cell CL0000050
    CSI 2.06
    rCSI 1.86%
    PRS 69.19
  • neuroblast (sensu Nematoda and Protostomia) CL0000338
    CSI 2.03
    rCSI 2.35%
    PRS 64.14
  • ON midget ganglion cell CL4033046
    CSI 2.03
    rCSI 41.25%
    PRS 61.83
  • cerebellar granule cell CL0001031
    CSI 1.98
    rCSI 2.92%
    PRS 64.86
  • colonocyte CL1000347
    CSI 1.96
    rCSI 2.81%
    PRS 73.81
  • myeloid leukocyte CL0000766
    CSI 1.92
    rCSI 1.77%
    PRS 73.44
  • extravillous trophoblast CL0008036
    CSI 1.91
    rCSI 2.37%
    PRS 69.06
  • OFF midget ganglion cell CL4033047
    CSI 1.86
    rCSI 37.8%
    PRS 63.31
  • glycinergic amacrine cell CL4030028
    CSI 1.82
    rCSI 4.75%
    PRS 67.84
  • centrilobular region hepatocyte CL0019029
    CSI 1.8
    rCSI 4.7%
    PRS 72.59
  • peripheral nervous system neuron CL2000032
    CSI 1.8
    rCSI 2.45%
    PRS 63.11
  • neuroblast (sensu Vertebrata) CL0000031
    CSI 1.79
    rCSI 2.3%
    PRS 68.39
  • Bergmann glial cell CL0000644
    CSI 1.77
    rCSI 2.42%
    PRS 63.9
  • fallopian tube secretory epithelial cell CL4030006
    CSI 1.76
    rCSI 1.7%
    PRS 71.48
  • epithelial cell of proximal tubule CL0002306
    CSI 1.69
    rCSI 4.14%
    PRS 64.85
  • ciliated epithelial cell CL0000067
    CSI 1.69
    rCSI 1.49%
    PRS 60.04
  • retinal ganglion cell CL0000740
    CSI 1.66
    rCSI 3.67%
    PRS 57.56
  • retinal rod cell CL0000604
    CSI 1.58
    rCSI 2.79%
    PRS 67.84
  • VIP GABAergic cortical interneuron CL4023016
    CSI 1.56
    rCSI 1.86%
    PRS 52.86
  • retinal cone cell CL0000573
    CSI 1.54
    rCSI 2.48%
    PRS 61.25
  • lung pericyte CL0009089
    CSI 1.31
    rCSI 3.45%
    PRS 79.98
  • caudal ganglionic eminence derived cortical interneuron CL4023064
    CSI 1.31
    rCSI 2.31%
    PRS 52.09
  • sncg GABAergic cortical interneuron CL4023015
    CSI 1.3
    rCSI 2.09%
    PRS 54.88
  • amacrine cell CL0000561
    CSI 1.29
    rCSI 3.73%
    PRS 60.96
  • cardiac muscle cell CL0000746
    CSI 1.26
    rCSI 1.81%
    PRS 61.21
  • syncytiotrophoblast cell CL0000525
    CSI 1.2
    rCSI 3.44%
    PRS 81.75
  • mature B cell CL0000785
    CSI 1.15
    rCSI 1%
    PRS 82.25
  • basal cell of epidermis CL0002187
    CSI 1.13
    rCSI 2.01%
    PRS 42.69
  • cardiac neuron CL0010022
    CSI 1.11
    rCSI 3.56%
    PRS 68.88
  • chandelier pvalb GABAergic cortical interneuron CL4023036
    CSI 1.08
    rCSI 3.37%
    PRS 57.28
  • melanocyte of skin CL1000458
    CSI 1.05
    rCSI 1.43%
    PRS 39.74
  • CD8-positive, alpha-beta memory T cell, CD45RO-positive CL0001203
    CSI 1.01
    rCSI 1.23%
    PRS 54.93
  • L6b glutamatergic cortical neuron CL4023038
    CSI 0.97
    rCSI 3.02%
    PRS 54.82
  • L2/3-6 intratelencephalic projecting glutamatergic neuron CL4023040
    CSI 0.96
    rCSI 2.34%
    PRS 51.36
  • glial cell CL0000125
    CSI 0.95
    rCSI 3.64%
    PRS 62.19
  • near-projecting glutamatergic cortical neuron CL4023012
    CSI 0.92
    rCSI 3.49%
    PRS 53.57
  • central nervous system neuron CL2000029
    CSI 0.84
    rCSI 6.16%
    PRS 58.51
  • GABAergic neuron CL0000617
    CSI 0.84
    rCSI 2.81%
    PRS 56.19
  • blood vessel smooth muscle cell CL0019018
    CSI 0.84
    rCSI 6.81%
    PRS 65.22
  • corticothalamic-projecting glutamatergic cortical neuron CL4023013
    CSI 0.57
    rCSI 3.37%
    PRS 54.12
  • indirect pathway medium spiny neuron CL4023029
    CSI 0.5
    rCSI 12.11%
    PRS 52.52
  • direct pathway medium spiny neuron CL4023026
    CSI 0.4
    rCSI 9.51%
    PRS 51.9

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

Comma-separated if multiple.
Comma-separated if multiple.
Legend:
  • Query Gene
  • Node Color (Target Cell CSI, relative to current network):
    • Very High
    • High
    • Medium
    • Low
    • Very Low
    • CSI N/A
  • Node Size: Proportional to Target Cell CSI magnitude
  • STRING PPI Edge
  • Shared Pathway Edge (ONTOLOGY)

Loading network (please wait)...

Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

## Summary Analyzed for its expression specificity (CSI Z-Score), Myotubularin Related Protein 4 ([MTMR4](/details-gene/9110)) does not appear to serve as a defining marker for any specific cell type. Instead, the data indicate it is a broadly expressed phosphatase involved in fundamental and ubiquitous cellular processes, including the regulation of endosomal trafficking, autophagy, and the negative modulation of TGF-beta signaling pathways. Its function appears critical for cellular homeostasis across a diverse range of tissues rather than for establishing a unique cellular identity. ## Cellular Roles and Expression Landscape The expression profile of [MTMR4](/details-gene/9110), when analyzed for cell-type specificity, reveals a pattern of broad, rather than restricted, expression. Across a wide array of phenotypically distinct cell types—including endothelial cells like [cerebral cortex endothelial cell](/details-cell/CL1001602), epithelial cells like [choroid plexus epithelial cell](/details-cell/CL0000706), neurons such as [L5 extratelencephalic projecting glutamatergic cortical neuron](/details-cell/CL4023041), and various immune lineages like the [unswitched memory B cell](/details-cell/CL0000970)—[MTMR4](/details-gene/9110) exhibits a Cell Significance Index (Z-SCORE) of 0.00 with non-significant p-values (p > 0.3). This consistent lack of a significant Z-score in any context strongly suggests that [MTMR4](/details-gene/9110) functions as a housekeeping gene. Its role is not to define a cell's unique identity but rather to perform fundamental maintenance tasks required by nearly all cells. Its widespread expression underscores its importance in core cellular machinery that is conserved across different lineages. ## Pathways and Molecular Function The ubiquitous expression pattern of [MTMR4](/details-gene/9110) is highly consistent with its well-documented involvement in fundamental cellular machinery. As a phosphoinositide phosphatase, its primary molecular function is the dephosphorylation of phosphatidylinositol 3-phosphate (PI(3)P) and phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2), as established by early research ([PubMed: 11302699](https://pubmed.ncbi.nlm.nih.gov/11302699)). This enzymatic activity is central to [Phospholipid metabolism](/details-pathway/R-HSA-1483257) ([R-HSA-1483257](https://reactome.org/content/detail/R-HSA-1483257)) and is critical for regulating the identity and function of various endosomal compartments. Functionally, [MTMR4](/details-gene/9110) is localized to endosome membranes ([GO:0010008](https://www.ebi.ac.uk/QuickGO/term/GO:0010008)) and plays a crucial role in membrane trafficking events. It regulates sorting from early endosomes ([PubMed: 20736309](https://pubmed.ncbi.nlm.nih.gov/20736309)), phagosome maturation ([GO:0090382](https://www.ebi.ac.uk/QuickGO/term/GO:0090382)), and the broader endocytic and autophagic pathways ([PubMed: 29962048](https://pubmed.ncbi.nlm.nih.gov/29962048)). Beyond its role in lipid metabolism, [MTMR4](/details-gene/9110) is a key negative regulator of major signaling cascades. It directly attenuates [TGF-beta receptor signaling](/details-pathway/R-HSA-170834) ([R-HSA-170834](https://reactome.org/content/detail/R-HSA-170834)) by dephosphorylating receptor-regulated Smads (R-Smads) on endosomes, thereby terminating the signal ([PubMed: 20061380](https://pubmed.ncbi.nlm.nih.gov/20061380)). It similarly downregulates the BMP signaling pathway ([PubMed: 23150675](https://pubmed.ncbi.nlm.nih.gov/23150675)). Furthermore, it has been implicated in the final stages of cell division, interacting with key proteins to ensure proper midbody abscission ([GO:0061952](https://www.ebi.ac.uk/QuickGO/term/GO:0061952), [PubMed: 25659891](https://pubmed.ncbi.nlm.nih.gov/25659891)). Its role in stabilizing the *Salmonella*-containing vacuole highlights its relevance in host-pathogen interactions ([PubMed: 27625994](https://pubmed.ncbi.nlm.nih.gov/27625994)). ## Research Directions The current dataset, focusing on an **Overall** context, does not permit a comparative analysis of [MTMR4](/details-gene/9110) expression across different biological states, such as healthy versus diseased tissue. Such analysis would be critical to understanding if its housekeeping role becomes dysregulated or more specialized under pathological conditions. **Testable Hypotheses:** 1. **Hypothesis:** In immune cells, such as [CD4-positive, alpha-beta cytotoxic T cell](/details-cell/CL0000934), [MTMR4](/details-gene/9110) functions as a crucial brake on TGF-beta-mediated immunosuppression. Loss-of-function mutations in [MTMR4](/details-gene/9110) within the tumor microenvironment could lead to T cell hyper-responsiveness to TGF-beta, promoting premature T cell exhaustion and impairing anti-tumor immunity. * **Experimental Approach:** Generate a conditional knockout of [MTMR4](/details-gene/9110) in mouse T cells (CD4-Cre) and implant them into a syngeneic tumor model (e.g., B16 melanoma). Analyze tumor growth and the phenotype of tumor-infiltrating lymphocytes, specifically assessing markers of exhaustion (PD-1, TIM-3, LAG-3) and Smad2/3 phosphorylation status via flow cytometry and phospho-proteomics. 2. **Hypothesis:** [MTMR4](/details-gene/9110) dysregulation in endothelial cells, such as [cerebral cortex endothelial cell](/details-cell/CL1001602), compromises blood-brain barrier integrity by disrupting endosomal recycling of cell-cell junction proteins (e.g., cadherins, claudins), contributing to neuroinflammatory conditions. * **Experimental Approach:** Utilize siRNA to knockdown [MTMR4](/details-gene/9110) in an in vitro model of the human blood-brain barrier using co-cultured endothelial cells and astrocytes. Measure barrier integrity using transendothelial electrical resistance (TEER) and assess the localization and turnover of key junctional proteins using immunofluorescence and protein pulse-chase assays. 3. **Hypothesis:** [MTMR4](/details-gene/9110) is a key regulator of cellular metabolism through its control of autophagy. In metabolically active cells like [midzonal region hepatocyte](/details-cell/CL0019028), reduced [MTMR4](/details-gene/9110) activity impairs autophagic flux, leading to the accumulation of damaged mitochondria and lipids, thereby promoting the progression of non-alcoholic fatty liver disease (NAFLD). * **Experimental Approach:** Use AAV-delivered shRNA to specifically knock down [MTMR4](/details-gene/9110) in the livers of mice fed a high-fat diet. Analyze liver histology for steatosis, inflammation, and fibrosis. Perform electron microscopy to assess mitochondrial morphology and quantify autophagic flux in isolated hepatocytes using LC3-II turnover assays. **Therapeutic Potential:** Given its role as a negative regulator of the pro-fibrotic and immunosuppressive TGF-beta pathway, targeting [MTMR4](/details-gene/9110) is a plausible therapeutic concept. Small molecule inhibitors of [MTMR4](/details-gene/9110) could potentiate TGF-beta signaling, which might be beneficial in certain contexts. More compellingly, strategies to enhance [MTMR4](/details-gene/9110) activity or expression could serve as a novel anti-fibrotic or anti-cancer therapy by dampening excessive TGF-beta signaling. However, its ubiquitous expression profile presents a significant challenge, as systemic modulation would likely cause substantial off-target effects. Therefore, the development of cell-type-specific delivery systems or highly targeted therapeutic modalities would be essential for clinical translation.

Genular Protein ID: 943657484

Symbol: MTMR4_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q9NYA4 D3DTZ6 Q8IV27 Q9Y4D5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 3 CTD 1 ChEBI 45 ChiTaRS 1 DEPOD 1 DMDM 1 DNASU 1 DisGeNET 1 EC 1 EMBL 6 Ensembl 1 ExpressionAtlas 1 GO 25 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 12 KEGG 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 4 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 3 RefSeq 3 Rhea 8 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 11302699

Title: FYVE-DSP2, a FYVE domain-containing dual specificity protein phosphatase that dephosphorylates phosphatidylinositol 3-phosphate.

PubMed ID: 11302699

DOI: 10.1006/excr.2001.5185

PubMed ID: 9734811

Title: Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.

PubMed ID: 9734811

DOI: 10.1093/dnares/5.3.169

PubMed ID: 12168954

Title: Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.

PubMed ID: 12168954

DOI: 10.1093/dnares/9.3.99

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16787938

Title: Systematic analysis of myotubularins: heteromeric interactions, subcellular localisation and endosome related functions.

PubMed ID: 16787938

DOI: 10.1242/jcs.03040

PubMed ID: 19125695

Title: The inositol phosphatase MTMR4 is a novel target of the ubiquitin ligase Nedd4.

PubMed ID: 19125695

DOI: 10.1042/bj20081866

PubMed ID: 20061380

Title: MTMR4 attenuates transforming growth factor beta (TGFbeta) signaling by dephosphorylating R-Smads in endosomes.

PubMed ID: 20061380

DOI: 10.1074/jbc.m109.075036

PubMed ID: 20736309

Title: The myotubularin phosphatase MTMR4 regulates sorting from early endosomes.

PubMed ID: 20736309

DOI: 10.1242/jcs.060103

PubMed ID: 23150675

Title: Myotubularin-related protein 4 (MTMR4) attenuates BMP/Dpp signaling by dephosphorylation of Smad proteins.

PubMed ID: 23150675

DOI: 10.1074/jbc.m112.413856

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25659891

Title: Myotubularin-related proteins 3 and 4 interact with polo-like kinase 1 and centrosomal protein of 55 kDa to ensure proper abscission.

PubMed ID: 25659891

DOI: 10.1074/mcp.m114.046086

PubMed ID: 27625994

Title: MTMR4 Is Required for the Stability of the Salmonella-Containing Vacuole.

PubMed ID: 27625994

DOI: 10.3389/fcimb.2016.00091

PubMed ID: 29962048

Title: MTMR4, a phosphoinositide-specific 3'-phosphatase, regulates TFEB activity and the endocytic and autophagic pathways.

PubMed ID: 29962048

DOI: 10.1111/gtc.12609

PubMed ID: 30944173

Title: PtdIns3P phosphatases MTMR3 and MTMR4 negatively regulate innate immune responses to DNA through modulating STING trafficking.

PubMed ID: 30944173

DOI: 10.1074/jbc.ra118.005731

PubMed ID: 31543504

Title: The myotubularin MTMR4 regulates phagosomal phosphatidylinositol 3-phosphate turnover and phagocytosis.

PubMed ID: 31543504

DOI: 10.1074/jbc.ra119.009133

Sequence Information:

  • Length: 1195
  • Mass: 133353
  • Checksum: 936EC3F69335CEB4
  • Sequence:
    • MGEEGPPSLE YIQAKDLFPP KELVKEEENL QVPFTVLQGE GVEFLGRAAD ALIAISNYRL 
HIKFKDSVIN VPLRMIDSVE SRDMFQLHIS CKDSKVVRCH FSTFKQCQEW LSRLSRATAR 
PAKPEDLFAF AYHAWCLGLT EEDQHTHLCQ PGEHIRCRQE AELARMGFDL QNVWRVSHIN 
SNYKLCPSYP QKLLVPVWIT DKELENVASF RSWKRIPVVV YRHLRNGAAI ARCSQPEISW 
WGWRNADDEY LVTSIAKACA LDPGTRATGG SLSTGNNDTS EACDADFDSS LTACSGVEST 
AAPQKLLILD ARSYTAAVAN RAKGGGCECE EYYPNCEVVF MGMANIHAIR NSFQYLRAVC 
SQMPDPSNWL SALESTKWLQ HLSVMLKAAV LVANTVDREG RPVLVHCSDG WDRTPQIVAL 
AKILLDPYYR TLEGFQVLVE SDWLDFGHKF GDRCGHQENV EDQNEQCPVF LQWLDSVHQL 
LKQFPCLFEF NEAFLVKLVQ HTYSCLYGTF LANNPCEREK RNIYKRTCSV WALLRAGNKN 
FHNFLYTPSS DMVLHPVCHV RALHLWTAVY LPASSPCTLG EENMDLYLSP VAQSQEFSGR 
SLDRLPKTRS MDDLLSACDT SSPLTRTSSD PNLNNHCQEV RVGLEPWHSN PEGSETSFVD 
SGVGGPQQTV GEVGLPPPLP SSQKDYLSNK PFKSHKSCSP SYKLLNTAVP REMKSNTSDP 
EIKVLEETKG PAPDPSAQDE LGRTLDGIGE PPEHCPETEA VSALSKVISN KCDGVCNFPE 
SSQNSPTGTP QQAQPDSMLG VPSKCVLDHS LSTVCNPPSA ACQTPLDPST DFLNQDPSGS 
VASISHQEQL SSVPDLTHGE EDIGKRGNNR NGQLLENPRF GKMPLELVRK PISQSQISEF 
SFLGSNWDSF QGMVTSFPSG EATPRRLLSY GCCSKRPNSK QMRATGPCFG GQWAQREGVK 
SPVCSSHSNG HCTGPGGKNQ MWLSSHPKQV SSTKPVPLNC PSPVPPLYLD DDGLPFPTDV 
IQHRLRQIEA GYKQEVEQLR RQVRELQMRL DIRHCCAPPA EPPMDYEDDF TCLKESDGSD 
TEDFGSDHSE DCLSEASWEP VDKKETEVTR WVPDHMASHC YNCDCEFWLA KRRHHCRNCG 
NVFCAGCCHL KLPIPDQQLY DPVLVCNSCY EHIQVSRARE LMSQQLKKPI ATASS