Details for: KRT75

Gene ID: 9119

Symbol: KRT75

Ensembl ID: ENSG00000170454

Description: keratin 75

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 9.08
    Marker Score: 5,029
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 4.28
    Marker Score: 5,294
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 4.26
    Marker Score: 2,418
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 3.87
    Marker Score: 5,343
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 3.39
    Marker Score: 1,785
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 2.4
    Marker Score: 2,413
  • Cell Name: T cell (CL0000084)
    Fold Change: 2.33
    Marker Score: 4,016
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 2.26
    Marker Score: 4,116
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 1.99
    Marker Score: 2,219
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 1.83
    Marker Score: 764
  • Cell Name: pericyte (CL0000669)
    Fold Change: 1.81
    Marker Score: 1,060
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 1.57
    Marker Score: 1,036
  • Cell Name: B cell (CL0000236)
    Fold Change: 1.27
    Marker Score: 1,205
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.16
    Marker Score: 7,693
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,743
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47,983
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,403
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,413
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5,346
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2,742
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,289
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.87
    Marker Score: 502
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.84
    Marker Score: 1,364
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 714
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.78
    Marker Score: 404
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.75
    Marker Score: 1,195
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.72
    Marker Score: 691
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.68
    Marker Score: 540
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.48
    Marker Score: 914
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.48
    Marker Score: 285
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.43
    Marker Score: 387
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 0.42
    Marker Score: 106
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.41
    Marker Score: 197
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.41
    Marker Score: 477
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.35
    Marker Score: 92
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.34
    Marker Score: 2,059
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.33
    Marker Score: 103
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 0.32
    Marker Score: 107
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.3
    Marker Score: 95
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.29
    Marker Score: 222
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 0.29
    Marker Score: 106
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.28
    Marker Score: 4,357
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.28
    Marker Score: 101
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.27
    Marker Score: 99
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.26
    Marker Score: 538
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.25
    Marker Score: 508
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.23
    Marker Score: 75
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.23
    Marker Score: 104
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.2
    Marker Score: 119
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.19
    Marker Score: 122
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.17
    Marker Score: 119
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.17
    Marker Score: 106
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 0.17
    Marker Score: 1,086
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 0.17
    Marker Score: 115
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.17
    Marker Score: 87
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.15
    Marker Score: 92
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 0.15
    Marker Score: 209
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.14
    Marker Score: 77
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.14
    Marker Score: 150
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.14
    Marker Score: 96
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 0.14
    Marker Score: 107
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: 0.13
    Marker Score: 104
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.13
    Marker Score: 167
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.12
    Marker Score: 54
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.12
    Marker Score: 93
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 0.12
    Marker Score: 103
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.11
    Marker Score: 266
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.11
    Marker Score: 204
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.11
    Marker Score: 92
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 0.1
    Marker Score: 107
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 0.1
    Marker Score: 88
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.1
    Marker Score: 107
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.1
    Marker Score: 297
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.09
    Marker Score: 97
  • Cell Name: club cell (CL0000158)
    Fold Change: 0.09
    Marker Score: 107
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 0.09
    Marker Score: 107
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.09
    Marker Score: 90
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.09
    Marker Score: 96
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.08
    Marker Score: 111
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.08
    Marker Score: 80
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.07
    Marker Score: 121
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 0.07
    Marker Score: 100
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.07
    Marker Score: 97
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 0.06
    Marker Score: 314
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.06
    Marker Score: 82
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.06
    Marker Score: 103
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 0.05
    Marker Score: 103
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.05
    Marker Score: 84
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.05
    Marker Score: 89
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.05
    Marker Score: 107
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.04
    Marker Score: 107
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.04
    Marker Score: 104
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.04
    Marker Score: 107
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 0.04
    Marker Score: 441
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.04
    Marker Score: 116
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.04
    Marker Score: 107
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 0.04
    Marker Score: 106
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.04
    Marker Score: 106
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 0.03
    Marker Score: 468
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.03
    Marker Score: 106

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Structural protein:** KRT75 is a type II keratin, which means it is a member of the keratin family that typically forms a homodimeric structure with another keratin protein. 2. **Cornified envelope component:** KRT75 is a critical component of the cornified envelope, a specialized outer layer of the skin that provides mechanical strength and barrier function. 3. **Widespread expression:** KRT75 is expressed in a variety of cell types, including erythrocytes, oligodendrocyte precursor cells, megakaryocytes, and hematopoietic stem cells. 4. **Cell-type specific expression:** The expression of KRT75 varies across different cell types, with some cells expressing high levels of KRT75 and others expressing low levels. **Pathways and Functions:** 1. **Keratin filament formation:** KRT75 forms a homodimeric structure with other keratin proteins, which then assemble into a keratin filament. This filament provides mechanical stability and support to epithelial cells. 2. **Extracellular vesicle formation:** KRT75 has been implicated in the formation of extracellular vesicles, which are small membrane-bound particles that can carry proteins, lipids, and other molecules between cells. 3. **Hematopoiesis:** KRT75 is involved in the development and differentiation of hematopoietic stem cells, suggesting a role in regulating blood cell production. 4. **Immune cell development:** KRT75 has been found to be expressed in various immune cells, including T cells, suggesting a potential role in immune cell development and function. **Clinical Significance:** 1. **Skin disorders:** Mutations in the KRT75 gene have been associated with skin disorders, such as epidermolysis bullosa simplex, which highlights the importance of KRT75 in maintaining skin integrity. 2. **Hematological disorders:** Abnormalities in KRT75 expression have been linked to hematological disorders, such as anemia and leukemia, suggesting a potential role in regulating blood cell production. 3. **Cancer:** KRT75 has been found to be overexpressed in certain types of cancer, including breast and lung cancer, which may contribute to tumorigenesis and metastasis. 4. **Neurological disorders:** KRT75 has been implicated in neurological disorders, such as multiple sclerosis, which may be related to its role in oligodendrocyte precursor cell development and differentiation. In conclusion, KRT75 is a multifaceted protein that plays a critical role in maintaining epithelial integrity, regulating hematopoiesis, and modulating immune cell development. Further research is needed to fully elucidate the mechanisms underlying KRT75's functions and its clinical significance in various diseases.

Genular Protein ID: 3556935241

Symbol: K2C75_HUMAN

Name: Keratin, type II cytoskeletal 75

UniProtKB Accession Codes:

O95678 B4DQU4 Q9NSA9

Database IDs:

AGR 1 Allergome 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 4 EPD 1 Ensembl 1 GO 10 Gene3D 3 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 4 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRIDE 1 PRINTS 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 1 SAM 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9856802

Title: A novel human type II cytokeratin, K6hf, specifically expressed in the companion layer of the hair follicle.

PubMed ID: 9856802

DOI: 10.1046/j.1523-1747.1998.00456.x

PubMed ID: 10692104

Title: Characterization of a 300 kbp region of human DNA containing the type II hair keratin.

PubMed ID: 10692104

DOI: 10.1046/j.1523-1747.2000.00910.x

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 14675170

Title: Type II epithelial keratin 6hf (K6hf) is expressed in the companion layer, matrix, and medulla in anagen-stage hair follicles.

PubMed ID: 14675170

DOI: 10.1111/j.1523-1747.2003.12644.x

PubMed ID: 15292489

Title: Dermal papilla-induced hair differentiation of adult epithelial stem cells from human skin.

PubMed ID: 15292489

DOI: 10.1152/physiolgenomics.00134.2004

PubMed ID: 18032949

Title: Expression of follicular sheath keratins in the normal nail with special reference to the morphological analysis of the distal nail unit.

PubMed ID: 18032949

DOI: 10.1097/dad.0b013e318158d741

PubMed ID: 11939812

Title: Is the loose anagen hair syndrome a keratin disorder? A clinical and molecular study.

PubMed ID: 11939812

DOI: 10.1001/archderm.138.4.501

PubMed ID: 15086549

Title: An unusual Ala12Thr polymorphism in the 1A alpha-helical segment of the companion layer-specific keratin K6hf: evidence for a risk factor in the etiology of the common hair disorder pseudofolliculitis barbae.

PubMed ID: 15086549

DOI: 10.1111/j.0022-202x.2004.22309.x

Sequence Information:

  • Length: 551
  • Mass: 59560
  • Checksum: 9099CD53A0BAF1EB
  • Sequence:
    • MSRQSSITFQ SGSRRGFSTT SAITPAAGRS RFSSVSVARS AAGSGGLGRI SSAGASFGSR 
SLYNLGGAKR VSINGCGSSC RSGFGGRASN RFGVNSGFGY GGGVGGGFSG PSFPVCPPGG 
IQEVTVNQSL LTPLHLQIDP TIQRVRAEER EQIKTLNNKF ASFIDKVRFL EQQNKVLETK 
WALLQEQGSR TVRQNLEPLF DSYTSELRRQ LESITTERGR LEAELRNMQD VVEDFKVRYE 
DEINKRTAAE NEFVALKKDV DAAYMNKVEL EAKVKSLPEE INFIHSVFDA ELSQLQTQVG 
DTSVVLSMDN NRNLDLDSII AEVKAQYEDI ANRSRAEAES WYQTKYEELQ VTAGRHGDDL 
RNTKQEISEM NRMIQRLRAE IDSVKKQCSS LQTAIADAEQ RGELALKDAR AKLVDLEEAL 
QKAKQDMARL LREYQELMNI KLALDVEIAT YRKLLEGEEC RLSGEGVSPV NISVVTSTLS 
SGYGSGSSIG GGNLGLGGGS GYSFTTSGGH SLGAGLGGSG FSATSNRGLG GSGSSVKFVS 
TTSSSQKSYT H

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.