No CSI details found for gene ID: 9119
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 3556935241
Symbol: K2C75_HUMAN
Name: Keratin, type II cytoskeletal 75
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 9856802
Title: A novel human type II cytokeratin, K6hf, specifically expressed in the companion layer of the hair follicle.
PubMed ID: 9856802
PubMed ID: 10692104
Title: Characterization of a 300 kbp region of human DNA containing the type II hair keratin.
PubMed ID: 10692104
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 16541075
Title: The finished DNA sequence of human chromosome 12.
PubMed ID: 16541075
DOI: 10.1038/nature04569
PubMed ID: 14675170
Title: Type II epithelial keratin 6hf (K6hf) is expressed in the companion layer, matrix, and medulla in anagen-stage hair follicles.
PubMed ID: 14675170
PubMed ID: 15292489
Title: Dermal papilla-induced hair differentiation of adult epithelial stem cells from human skin.
PubMed ID: 15292489
PubMed ID: 18032949
Title: Expression of follicular sheath keratins in the normal nail with special reference to the morphological analysis of the distal nail unit.
PubMed ID: 18032949
PubMed ID: 11939812
Title: Is the loose anagen hair syndrome a keratin disorder? A clinical and molecular study.
PubMed ID: 11939812
PubMed ID: 15086549
Title: An unusual Ala12Thr polymorphism in the 1A alpha-helical segment of the companion layer-specific keratin K6hf: evidence for a risk factor in the etiology of the common hair disorder pseudofolliculitis barbae.
PubMed ID: 15086549
Sequence Information:
- Length: 551
- Mass: 59560
- Checksum: 9099CD53A0BAF1EB
- Sequence:
MSRQSSITFQ SGSRRGFSTT SAITPAAGRS RFSSVSVARS AAGSGGLGRI SSAGASFGSR SLYNLGGAKR VSINGCGSSC RSGFGGRASN RFGVNSGFGY GGGVGGGFSG PSFPVCPPGG IQEVTVNQSL LTPLHLQIDP TIQRVRAEER EQIKTLNNKF ASFIDKVRFL EQQNKVLETK WALLQEQGSR TVRQNLEPLF DSYTSELRRQ LESITTERGR LEAELRNMQD VVEDFKVRYE DEINKRTAAE NEFVALKKDV DAAYMNKVEL EAKVKSLPEE INFIHSVFDA ELSQLQTQVG DTSVVLSMDN NRNLDLDSII AEVKAQYEDI ANRSRAEAES WYQTKYEELQ VTAGRHGDDL RNTKQEISEM NRMIQRLRAE IDSVKKQCSS LQTAIADAEQ RGELALKDAR AKLVDLEEAL QKAKQDMARL LREYQELMNI KLALDVEIAT YRKLLEGEEC RLSGEGVSPV NISVVTSTLS SGYGSGSSIG GGNLGLGGGS GYSFTTSGGH SLGAGLGGSG FSATSNRGLG GSGSSVKFVS TTSSSQKSYT H
Details Unavailable
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{
"geneID": 9119,
"tax": {
"id": 9606,
"name": [
{
"name": "Homo sapiens Linnaeus 1758"
},
{
"name": "Homo sapiens",
"type": 0
},
{
"name": "human",
"type": 4
}
]
},
"accession": {
"gene": [
"AC055736.20"
]
},
"genePos": {
"start": 4956,
"end": 15257
},
"orientation": true,
"symbol": "KRT75",
"created": {
"$date": {
"$numberLong": "1738333349795"
}
},
"crossReference": {
"enseGeneID": "ENSG00000170454",
"enseRnaID": [
"ENST00000252245.6"
],
"enseProtID": [
"ENSP00000252245.5"
]
},
"chrom": {
"pos": "12",
"type": 1,
"loc": "12q13.13"
},
"desc": "keratin 75",
"geneType": 5,
"ontology": [
{
"id": "R-HSA-1266738",
"term": "Developmental Biology",
"cat": 10
},
{
"id": "R-HSA-6805567",
"term": "Keratinization",
"cat": 11
},
{
"id": "R-HSA-6809371",
"term": "Formation of the cornified envelope",
"cat": 12
},
{
"id": "GO:0005198",
"term": "structural molecule activity",
"pubMed": [
9856802
],
"cat": 0
},
{
"id": "GO:0005515",
"term": "protein binding",
"pubMed": [
32296183
],
"cat": 0
},
{
"id": "GO:0030280",
"term": "structural constituent of skin epidermis",
"cat": 0
},
{
"id": "GO:0002244",
"term": "hematopoietic progenitor cell differentiation",
"cat": 1
},
{
"id": "GO:0031424",
"term": "keratinization",
"cat": 1
},
{
"id": "GO:0045109",
"term": "intermediate filament organization",
"cat": 1
},
{
"id": "GO:0001533",
"term": "cornified envelope",
"cat": 2
},
{
"id": "GO:0005829",
"term": "cytosol",
"cat": 2
},
{
"id": "GO:0005882",
"term": "intermediate filament",
"pubMed": [
15086549
],
"cat": 2
},
{
"id": "GO:0045095",
"term": "keratin filament",
"cat": 2
},
{
"id": "GO:0070062",
"term": "extracellular exosome",
"pubMed": [
23533145
],
"cat": 2
}
],
"protein": [
{
"symbol": "K2C75_HUMAN",
"name": "Keratin, type II cytoskeletal 75",
"accession": [
"O95678",
"B4DQU4",
"Q9NSA9"
],
"databaseIDs": {
"NCBI Taxonomy": [
"9606"
],
"MIM": [
"600628",
"600628",
"609025",
"612318"
],
"EMBL": [
"Y17282",
"Y19212",
"AK298960",
"AC055736"
],
"CCDS": [
"CCDS8827.1"
],
"RefSeq": [
"NP_004684.2"
],
"AlphaFoldDB": [
"O95678"
],
"SMR": [
"O95678"
],
"BioGRID": [
"114567"
],
"IntAct": [
"O95678"
],
"MINT": [
"O95678"
],
"STRING": [
"9606.ENSP00000252245"
],
"Allergome": [
"415"
],
"GlyGen": [
"O95678"
],
"iPTMnet": [
"O95678"
],
"PhosphoSitePlus": [
"O95678"
],
"SwissPalm": [
"O95678"
],
"BioMuta": [
"KRT75"
],
"jPOST": [
"O95678"
],
"MassIVE": [
"O95678"
],
"PaxDb": [
"9606-ENSP00000252245"
],
"PeptideAtlas": [
"O95678"
],
"PRIDE": [
"O95678"
],
"ProteomicsDB": [
"50995"
],
"Antibodypedia": [
"14610"
],
"DNASU": [
"9119"
],
"Ensembl": [
"ENST00000252245.6"
],
"KEGG": [
"hsa:9119"
],
"MANE-Select": [
"ENST00000252245.6"
],
"UCSC": [
"uc001saj.3"
],
"AGR": [
"HGNC:24431"
],
"CTD": [
"9119"
],
"DisGeNET": [
"9119"
],
"GeneCards": [
"KRT75"
],
"HGNC": [
"HGNC:24431"
],
"HPA": [
"ENSG00000170454"
],
"MalaCards": [
"KRT75"
],
"neXtProt": [
"NX_O95678"
],
"OpenTargets": [
"ENSG00000170454"
],
"PharmGKB": [
"PA147357763"
],
"VEuPathDB": [
"HostDB:ENSG00000170454"
],
"eggNOG": [
"ENOG502RTYA"
],
"GeneTree": [
"ENSGT00940000155862"
],
"HOGENOM": [
"CLU_012560_6_1_1"
],
"InParanoid": [
"O95678"
],
"OMA": [
"SIKKQCS"
],
"OrthoDB": [
"4640531at2759"
],
"PhylomeDB": [
"O95678"
],
"TreeFam": [
"TF317854"
],
"PathwayCommons": [
"O95678"
],
"Reactome": [
"R-HSA-6805567",
"R-HSA-6809371"
],
"SignaLink": [
"O95678"
],
"BioGRID-ORCS": [
"9119"
],
"ChiTaRS": [
"KRT75"
],
"GenomeRNAi": [
"9119"
],
"Pharos": [
"O95678"
],
"PRO": [
"PR:O95678"
],
"Proteomes": [
"UP000005640"
],
"RNAct": [
"O95678"
],
"Bgee": [
"ENSG00000170454"
],
"GO": [
"GO:0001533",
"GO:0005829",
"GO:0070062",
"GO:0005882",
"GO:0045095",
"GO:0030280",
"GO:0005198",
"GO:0002244",
"GO:0045109",
"GO:0031424"
],
"Gene3D": [
"1.20.5.170",
"1.20.5.500",
"1.20.5.1160"
],
"InterPro": [
"IPR018039",
"IPR039008",
"IPR032444",
"IPR003054"
],
"PANTHER": [
"PTHR45616",
"PTHR45616:SF13"
],
"Pfam": [
"PF00038",
"PF16208"
],
"PRINTS": [
"PR01276"
],
"SMART": [
"SM01391"
],
"SUPFAM": [
"SSF64593"
],
"PROSITE": [
"PS00226",
"PS51842"
]
},
"citations": [
{
"title": "A novel human type II cytokeratin, K6hf, specifically expressed in the companion layer of the hair follicle.",
"pubmedID": "9856802",
"doi": "10.1046\/j.1523-1747.1998.00456.x"
},
{
"title": "Characterization of a 300 kbp region of human DNA containing the type II hair keratin.",
"pubmedID": "10692104",
"doi": "10.1046\/j.1523-1747.2000.00910.x"
},
{
"title": "Complete sequencing and characterization of 21,243 full-length human cDNAs.",
"pubmedID": "14702039",
"doi": "10.1038\/ng1285"
},
{
"title": "The finished DNA sequence of human chromosome 12.",
"pubmedID": "16541075",
"doi": "10.1038\/nature04569"
},
{
"title": "Type II epithelial keratin 6hf (K6hf) is expressed in the companion layer, matrix, and medulla in anagen-stage hair follicles.",
"pubmedID": "14675170",
"doi": "10.1111\/j.1523-1747.2003.12644.x"
},
{
"title": "Dermal papilla-induced hair differentiation of adult epithelial stem cells from human skin.",
"pubmedID": "15292489",
"doi": "10.1152\/physiolgenomics.00134.2004"
},
{
"title": "Expression of follicular sheath keratins in the normal nail with special reference to the morphological analysis of the distal nail unit.",
"pubmedID": "18032949",
"doi": "10.1097\/dad.0b013e318158d741"
},
{
"title": "Is the loose anagen hair syndrome a keratin disorder? A clinical and molecular study.",
"pubmedID": "11939812",
"doi": "10.1001\/archderm.138.4.501"
},
{
"title": "An unusual Ala12Thr polymorphism in the 1A alpha-helical segment of the companion layer-specific keratin K6hf: evidence for a risk factor in the etiology of the common hair disorder pseudofolliculitis barbae.",
"pubmedID": "15086549",
"doi": "10.1111\/j.0022-202x.2004.22309.x"
}
],
"sequence": {
"length": 551,
"mass": 59560,
"checksum": "9099CD53A0BAF1EB",
"modified": {
"$date": {
"$numberLong": "1245110400000"
}
},
"version": 2,
"sequence": "MSRQSSITFQSGSRRGFSTTSAITPAAGRSRFSSVSVARSAAGSGGLGRISSAGASFGSRSLYNLGGAKRVSINGCGSSCRSGFGGRASNRFGVNSGFGYGGGVGGGFSGPSFPVCPPGGIQEVTVNQSLLTPLHLQIDPTIQRVRAEEREQIKTLNNKFASFIDKVRFLEQQNKVLETKWALLQEQGSRTVRQNLEPLFDSYTSELRRQLESITTERGRLEAELRNMQDVVEDFKVRYEDEINKRTAAENEFVALKKDVDAAYMNKVELEAKVKSLPEEINFIHSVFDAELSQLQTQVGDTSVVLSMDNNRNLDLDSIIAEVKAQYEDIANRSRAEAESWYQTKYEELQVTAGRHGDDLRNTKQEISEMNRMIQRLRAEIDSVKKQCSSLQTAIADAEQRGELALKDARAKLVDLEEALQKAKQDMARLLREYQELMNIKLALDVEIATYRKLLEGEECRLSGEGVSPVNISVVTSTLSSGYGSGSSIGGGNLGLGGGSGYSFTTSGGHSLGAGLGGSGFSATSNRGLGGSGSSVKFVSTTSSSQKSYTH"
},
"existence": 0,
"relevance": 1,
"proteinID": 3556935241
}
],
"singleCellExpressions": {
"cellSignificanceIndex": []
}
}