SMC3 | ENSG00000108055 | NCBI 9126

Details for: SMC3

Gene ID: 9126

Symbol: SMC3

Ensembl ID: ENSG00000108055

Description: structural maintenance of chromosomes 3

Associated with

Cell cycle
(R-HSA-1640170)
Cell cycle, mitotic
(R-HSA-69278)
Cohesin loading onto chromatin
(R-HSA-2470946)
Esr-mediated signaling
(R-HSA-8939211)
Establishment of sister chromatid cohesion
(R-HSA-2468052)
Estrogen-dependent gene expression
(R-HSA-9018519)
Meiosis
(R-HSA-1500620)
Meiotic synapsis
(R-HSA-1221632)
Metabolism of proteins
(R-HSA-392499)
Mitotic anaphase
(R-HSA-68882)
Mitotic metaphase and anaphase
(R-HSA-2555396)
Mitotic prometaphase
(R-HSA-68877)
Mitotic telophase/cytokinesis
(R-HSA-68884)
M phase
(R-HSA-68886)
Post-translational protein modification
(R-HSA-597592)
Reproduction
(R-HSA-1474165)
Resolution of sister chromatid cohesion
(R-HSA-2500257)
Separation of sister chromatids
(R-HSA-2467813)
Signaling by nuclear receptors
(R-HSA-9006931)
Signal transduction
(R-HSA-162582)
S phase
(R-HSA-69242)
Sumo e3 ligases sumoylate target proteins
(R-HSA-3108232)
Sumoylation
(R-HSA-2990846)
Sumoylation of dna damage response and repair proteins
(R-HSA-3108214)
Atp binding
(GO:0005524)
Atp hydrolysis activity
(GO:0016887)
Beta-tubulin binding
(GO:0048487)
Cell division
(GO:0051301)
Chromatin
(GO:0000785)
Chromatin binding
(GO:0003682)
Chromosome
(GO:0005694)
Chromosome, centromeric region
(GO:0000775)
Cohesin complex
(GO:0008278)
Cytosol
(GO:0005829)
Dna repair
(GO:0006281)
Double-stranded dna binding
(GO:0003690)
Dynein complex binding
(GO:0070840)
Establishment of meiotic sister chromatid cohesion
(GO:0034089)
Establishment of mitotic sister chromatid cohesion
(GO:0034087)
Lateral element
(GO:0000800)
Mediator complex binding
(GO:0036033)
Meiotic cell cycle
(GO:0051321)
Meiotic cohesin complex
(GO:0030893)
Microtubule motor activity
(GO:0003777)
Mitotic cell cycle
(GO:0000278)
Mitotic cohesin complex
(GO:0030892)
Mitotic sister chromatid cohesion
(GO:0007064)
Mitotic spindle assembly
(GO:0090307)
Mitotic spindle pole
(GO:0097431)
Nuclear matrix
(GO:0016363)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Protein binding
(GO:0005515)
Protein heterodimerization activity
(GO:0046982)
Regulation of dna replication
(GO:0006275)
Sister chromatid cohesion
(GO:0007062)
Stem cell population maintenance
(GO:0019827)

Other Information

Proteins

Structural maintenance of chromosomes protein 3

Genular Protein ID: 1801393708

Symbol: SMC3_HUMAN

Name: Structural maintenance of chromosomes protein 3

UniProtKB Accession Codes:

Q9UQE7 A8K156 O60464 Q5T482

Database IDs:

Citations:

PubMed ID: 9506951

Title: Complex formation of SMAP/KAP3, a KIF3A/B ATPase motor-associated protein, with a human chromosome-associated polypeptide.

PubMed ID: 9506951

DOI: 10.1074/jbc.273.12.6591

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 11042152

Title: Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.

PubMed ID: 11042152

DOI: 10.1101/gr.140200

PubMed ID: 18614053

Title: Acetylation of Smc3 by Eco1 is required for S phase sister chromatid cohesion in both human and yeast.

PubMed ID: 18614053

DOI: 10.1016/j.molcel.2008.06.006

PubMed ID: 11076961

Title: Characterization of vertebrate cohesin complexes and their regulation in prophase.

PubMed ID: 11076961

DOI: 10.1083/jcb.151.4.749

PubMed ID: 11590136

Title: A potential role for human cohesin in mitotic spindle aster assembly.

PubMed ID: 11590136

DOI: 10.1074/jbc.m103364200

PubMed ID: 12198550

Title: A chromatin remodelling complex that loads cohesin onto human chromosomes.

PubMed ID: 12198550

DOI: 10.1038/nature01024

PubMed ID: 15656913

Title: Hinderin, a five-domains protein including coiled-coil motifs that binds to SMC3.

PubMed ID: 15656913

DOI: 10.1186/1471-2121-6-3

PubMed ID: 15837422

Title: Sororin, a substrate of the anaphase-promoting complex, is required for sister chromatid cohesion in vertebrates.

PubMed ID: 15837422

DOI: 10.1016/j.molcel.2005.03.017

PubMed ID: 17105772

Title: The DNA helicase ChlR1 is required for sister chromatid cohesion in mammalian cells.

PubMed ID: 17105772

DOI: 10.1242/jcs.03262

PubMed ID: 17525332

Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

PubMed ID: 17525332

DOI: 10.1126/science.1140321

PubMed ID: 19367720

Title: Phosphorylation analysis of primary human T lymphocytes using sequential IMAC and titanium oxide enrichment.

PubMed ID: 19367720

DOI: 10.1021/pr800500r

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19907496

Title: Cohesin acetylation speeds the replication fork.

PubMed ID: 19907496

DOI: 10.1038/nature08550

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22885700

Title: HDAC8 mutations in Cornelia de Lange syndrome affect the cohesin acetylation cycle.

PubMed ID: 22885700

DOI: 10.1038/nature11316

PubMed ID: 22628566

Title: In vitro loading of human cohesin on DNA by the human Scc2-Scc4 loader complex.

PubMed ID: 22628566

DOI: 10.1073/pnas.1206840109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 31334757

Title: Cohesin complex-associated holoprosencephaly.

PubMed ID: 31334757

DOI: 10.1093/brain/awz210

PubMed ID: 31452512

Title: Systematic identification of cancer cell vulnerabilities to natural killer cell-mediated immune surveillance.

PubMed ID: 31452512

DOI: 10.7554/elife.47362

PubMed ID: 32409525

Title: Cryo-EM structure of the human cohesin-NIPBL-DNA complex.

PubMed ID: 32409525

DOI: 10.1126/science.abb0981

PubMed ID: 17273969

Title: Mutations in cohesin complex members SMC3 and SMC1A cause a mild variant of Cornelia de Lange syndrome with predominant mental retardation.

PubMed ID: 17273969

DOI: 10.1086/511888

PubMed ID: 18996922

Title: Cornelia de Lange syndrome mutations in SMC1A or SMC3 affect binding to DNA.

PubMed ID: 18996922

DOI: 10.1093/hmg/ddn369

Sequence Information:

Length: 1217
Mass: 141542
Checksum: 21EF9A08A5D8096A
Sequence:

MYIKQVIIQG FRSYRDQTIV DPFSSKHNVI VGRNGSGKSN FFYAIQFVLS DEFSHLRPEQ 
RLALLHEGTG PRVISAFVEI IFDNSDNRLP IDKEEVSLRR VIGAKKDQYF LDKKMVTKND 
VMNLLESAGF SRSNPYYIVK QGKINQMATA PDSQRLKLLR EVAGTRVYDE RKEESISLMK 
ETEGKREKIN ELLKYIEERL HTLEEEKEEL AQYQKWDKMR RALEYTIYNQ ELNETRAKLD 
ELSAKRETSG EKSRQLRDAQ QDARDKMEDI ERQVRELKTK ISAMKEEKEQ LSAERQEQIK 
QRTKLELKAK DLQDELAGNS EQRKRLLKER QKLLEKIEEK QKELAETEPK FNSVKEKEER 
GIARLAQATQ ERTDLYAKQG RGSQFTSKEE RDKWIKKELK SLDQAINDKK RQIAAIHKDL 
EDTEANKEKN LEQYNKLDQD LNEVKARVEE LDRKYYEVKN KKDELQSERN YLWREENAEQ 
QALAAKREDL EKKQQLLRAA TGKAILNGID SINKVLDHFR RKGINQHVQN GYHGIVMNNF 
ECEPAFYTCV EVTAGNRLFY HIVDSDEVST KILMEFNKMN LPGEVTFLPL NKLDVRDTAY 
PETNDAIPMI SKLRYNPRFD KAFKHVFGKT LICRSMEVST QLARAFTMDC ITLEGDQVSH 
RGALTGGYYD TRKSRLELQK DVRKAEEELG ELEAKLNENL RRNIERINNE IDQLMNQMQQ 
IETQQRKFKA SRDSILSEMK MLKEKRQQSE KTFMPKQRSL QSLEASLHAM ESTRESLKAE 
LGTDLLSQLS LEDQKRVDAL NDEIRQLQQE NRQLLNERIK LEGIITRVET YLNENLRKRL 
DQVEQELNEL RETEGGTVLT ATTSELEAIN KRVKDTMARS EDLDNSIDKT EAGIKELQKS 
MERWKNMEKE HMDAINHDTK ELEKMTNRQG MLLKKKEECM KKIRELGSLP QEAFEKYQTL 
SLKQLFRKLE QCNTELKKYS HVNKKALDQF VNFSEQKEKL IKRQEELDRG YKSIMELMNV 
LELRKYEAIQ LTFKQVSKNF SEVFQKLVPG GKATLVMKKG DVEGSQSQDE GEGSGESERG 
SGSQSSVPSV DQFTGVGIRV SFTGKQGEMR EMQQLSGGQK SLVALALIFA IQKCDPAPFY 
LFDEIDQALD AQHRKAVSDM IMELAVHAQF ITTTFRPELL ESADKFYGVK FRNKVSHIDV 
ITAEMAKDFV EDDTTHG

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: SMC3

Associated with

Other Information

Complex formation of SMAP/KAP3, a KIF3A/B ATPase motor-associated protein, with a human chromosome-associated polypeptide. PubMed ID: 9506951

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence and comparative analysis of human chromosome 10. PubMed ID: 15164054

Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. PubMed ID: 11042152

Acetylation of Smc3 by Eco1 is required for S phase sister chromatid cohesion in both human and yeast. PubMed ID: 18614053

Characterization of vertebrate cohesin complexes and their regulation in prophase. PubMed ID: 11076961

A potential role for human cohesin in mitotic spindle aster assembly. PubMed ID: 11590136

A chromatin remodelling complex that loads cohesin onto human chromosomes. PubMed ID: 12198550

Hinderin, a five-domains protein including coiled-coil motifs that binds to SMC3. PubMed ID: 15656913

Sororin, a substrate of the anaphase-promoting complex, is required for sister chromatid cohesion in vertebrates. PubMed ID: 15837422

The DNA helicase ChlR1 is required for sister chromatid cohesion in mammalian cells. PubMed ID: 17105772

ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. PubMed ID: 17525332

Phosphorylation analysis of primary human T lymphocytes using sequential IMAC and titanium oxide enrichment. PubMed ID: 19367720

Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. PubMed ID: 18691976

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Cohesin acetylation speeds the replication fork. PubMed ID: 19907496

Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. PubMed ID: 19690332

Lysine acetylation targets protein complexes and co-regulates major cellular functions. PubMed ID: 19608861

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

Initial characterization of the human central proteome. PubMed ID: 21269460

System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. PubMed ID: 21406692

HDAC8 mutations in Cornelia de Lange syndrome affect the cohesin acetylation cycle. PubMed ID: 22885700

In vitro loading of human cohesin on DNA by the human Scc2-Scc4 loader complex. PubMed ID: 22628566

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

Cohesin complex-associated holoprosencephaly. PubMed ID: 31334757

Systematic identification of cancer cell vulnerabilities to natural killer cell-mediated immune surveillance. PubMed ID: 31452512

Cryo-EM structure of the human cohesin-NIPBL-DNA complex. PubMed ID: 32409525

Mutations in cohesin complex members SMC3 and SMC1A cause a mild variant of Cornelia de Lange syndrome with predominant mental retardation. PubMed ID: 17273969

Cornelia de Lange syndrome mutations in SMC1A or SMC3 affect binding to DNA. PubMed ID: 18996922