Details for: SMC3
Gene ID: 9126
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: SMC3
Ensembl ID: ENSG00000108055
Description: structural maintenance of chromosomes 3
Selected Context(s): Overall
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
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CSI 34.55rCSI 31.2%PRS 20.9
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CSI 31.73rCSI 36.33%PRS 45.44
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CSI 29.24rCSI 36.7%PRS 29.88
-
CSI 26.66rCSI 30.79%PRS 19.89
-
CSI 23.58rCSI 45.85%PRS 23.6
-
CSI 23.18rCSI 18.75%PRS 23.19
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CSI 22.93rCSI 17.34%PRS 31.66
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CSI 20.96rCSI 51.89%PRS 21.29
-
CSI 20.21rCSI 57.7%PRS 38.08
-
CSI 19.27rCSI 18.55%PRS 23.79
-
CSI 17.06rCSI 14.13%PRS 23.4
-
CSI 15.6rCSI 50.07%PRS 31.95
-
CSI 13.97rCSI 10.5%PRS 24.69
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CSI 13.31rCSI 27.33%PRS 47.1
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CSI 12.81rCSI 17.8%PRS 23.26
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CSI 12.7rCSI 9.4%PRS 19.76
-
CSI 11.75rCSI 45.73%PRS 37.61
-
CSI 11.26rCSI 9.75%PRS 25.96
-
CSI 11.23rCSI 11.77%PRS 24.38
-
CSI 11.06rCSI 57.09%PRS 44
-
CSI 11.01rCSI 19.04%PRS 17.53
-
CSI 11rCSI 8.69%PRS 15.76
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CSI 10.92rCSI 14.92%PRS 25.53
-
CSI 10.55rCSI 12.67%PRS 22.36
-
CSI 10.29rCSI 41.92%PRS 32.57
-
CSI 9.96rCSI 43.84%PRS 21.07
-
CSI 9.5rCSI 19.71%PRS 22.91
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CSI 9.36rCSI 6.52%PRS 32.55
-
CSI 9.23rCSI 29.54%PRS 18.78
-
CSI 8.59rCSI 10.26%PRS 13.47
-
CSI 8.5rCSI 30.23%PRS 63.42
-
CSI 8.39rCSI 14.8%PRS 29.71
-
CSI 8.06rCSI 43.47%PRS 38.42
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CSI 7.62rCSI 22.49%PRS 27
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CSI 7.56rCSI 10.11%PRS 29.49
-
CSI 7.5rCSI 5.81%PRS 22.16
-
CSI 7.25rCSI 11.06%PRS 21.18
-
CSI 7.2rCSI 8.46%PRS 26.32
-
CSI 7.19rCSI 41.46%PRS 28.7
-
CSI 7.13rCSI 9.71%PRS 51.5
-
CSI 7.12rCSI 9.71%PRS 20.12
-
CSI 6.99rCSI 4.65%PRS 27.56
-
CSI 6.93rCSI 5.2%PRS 59.05
-
CSI 6.92rCSI 7.09%PRS 41.16
-
CSI 6.89rCSI 16.43%PRS 25.94
-
CSI 6.86rCSI 9.37%PRS 25.96
-
CSI 6.7rCSI 5.01%PRS 36.12
-
CSI 6.61rCSI 5.54%PRS 27.22
-
CSI 6.51rCSI 5.72%PRS 26.63
-
CSI 6.49rCSI 5.71%PRS 16.71
-
CSI 6.46rCSI 28.37%PRS 41.47
-
CSI 6.46rCSI 28.7%PRS 22.38
-
CSI 6.24rCSI 10.68%PRS 31.17
-
CSI 6.01rCSI 4.18%PRS 27.83
-
CSI 5.99rCSI 24.87%PRS 39.19
-
CSI 5.94rCSI 9.62%PRS 23.07
-
CSI 5.91rCSI 9.21%PRS 50.54
-
CSI 5.9rCSI 5.24%PRS 23.17
-
CSI 5.83rCSI 42.86%PRS 14.08
-
CSI 5.69rCSI 7.78%PRS 34.69
-
CSI 5.68rCSI 7.44%PRS 32.88
-
CSI 5.6rCSI 6.93%PRS 20.16
-
CSI 5.41rCSI 14.05%PRS 29.12
-
CSI 5.39rCSI 33.7%PRS 17.95
-
CSI 5.39rCSI 4.72%PRS 30.42
-
CSI 5.25rCSI 11.78%PRS 14.27
-
CSI 5.19rCSI 13.7%PRS 27.45
-
CSI 4.79rCSI 10.96%PRS 22.42
-
CSI 4.74rCSI 4.57%PRS 16.78
-
CSI 4.72rCSI 6.81%PRS 32.05
-
CSI 4.72rCSI 17.81%PRS 28.5
-
CSI 4.6rCSI 7.42%PRS 34.36
-
CSI 4.54rCSI 3.82%PRS 36.37
-
CSI 4.53rCSI 5.48%PRS 27.87
-
CSI 4.53rCSI 18.03%PRS 38.63
-
CSI 4.5rCSI 12.38%PRS 37.24
-
CSI 4.46rCSI 3.47%PRS 33.86
-
CSI 4.38rCSI 9.84%PRS 43.87
-
CSI 4.22rCSI 3.9%PRS 41.09
-
CSI 4.18rCSI 4.1%PRS 35.67
-
CSI 4.14rCSI 6.6%PRS 19.53
-
CSI 4.11rCSI 7.83%PRS 35.9
-
CSI 4.01rCSI 4.86%PRS 28.09
-
CSI 3.99rCSI 23.51%PRS 14.29
-
CSI 3.98rCSI 3.13%PRS 27.94
-
CSI 3.98rCSI 3.67%PRS 24.05
-
CSI 3.97rCSI 4.05%PRS 32.82
-
CSI 3.95rCSI 6.97%PRS 13.5
-
CSI 3.93rCSI 14.27%PRS 64.89
-
CSI 3.91rCSI 4.53%PRS 56.86
-
CSI 3.86rCSI 25.3%PRS 55.29
-
CSI 3.77rCSI 5.22%PRS 31.6
-
CSI 3.75rCSI 9.52%PRS 22.88
-
CSI 3.67rCSI 8.48%PRS 18.49
-
CSI 3.67rCSI 3.61%PRS 24.7
-
CSI 3.65rCSI 4.65%PRS 26.52
-
CSI 3.59rCSI 29.2%PRS 22.46
-
CSI 3.58rCSI 4.5%PRS 35.05
-
CSI 3.57rCSI 5.75%PRS 17.53
-
CSI 3.53rCSI 2.93%PRS 21.83
-
CSI 0.1rCSI 0.3%PRS 43.4%
-
CSI 0.1rCSI 1.1%PRS 12.4%
-
CSI 0.2rCSI 0.9%PRS 33.9%
-
CSI 0.2rCSI 3.5%PRS 69.5%
-
CSI 0.2rCSI 3.5%PRS 52.7%
-
CSI 0.3rCSI 1.7%PRS 43.3%
-
CSI 0.3rCSI 2.9%PRS 54.5%
-
CSI 0.3rCSI 1.8%PRS 66.4%
-
CSI 0.4rCSI 2.4%PRS 24.2%
-
CSI 0.4rCSI 3.7%PRS 72.4%
-
CSI 0.4rCSI 1.4%PRS 12.8%
-
CSI 0.4rCSI 3.1%PRS 41.4%
-
CSI 0.4rCSI 1.1%PRS 29.1%
-
CSI 0.4rCSI 4.7%PRS 43.0%
-
CSI 0.4rCSI 2.2%PRS 24.7%
-
CSI 0.4rCSI 0.8%PRS 34.9%
-
CSI 0.5rCSI 7.0%PRS 57.5%
-
CSI 0.5rCSI 0.9%PRS 29.2%
-
CSI 0.6rCSI 9.5%PRS 66.4%
-
CSI 0.6rCSI 1.5%PRS 35.3%
-
CSI 0.6rCSI 3.1%PRS 50.4%
-
CSI 0.6rCSI 6.5%PRS 51.6%
-
CSI 0.6rCSI 0.9%PRS 23.5%
-
CSI 0.6rCSI 1.3%PRS 16.4%
-
CSI 0.7rCSI 2.0%PRS 49.7%
-
CSI 0.7rCSI 1.6%PRS 28.3%
-
CSI 0.7rCSI 3.1%PRS 48.3%
-
CSI 0.7rCSI 3.0%PRS 39.2%
-
CSI 0.7rCSI 2.3%PRS 56.9%
-
CSI 0.7rCSI 2.0%PRS 29.8%
-
CSI 0.7rCSI 1.8%PRS 33.3%
-
CSI 0.8rCSI 1.9%PRS 17.4%
-
CSI 0.8rCSI 1.2%PRS 29.4%
-
CSI 0.8rCSI 2.7%PRS 19.9%
-
CSI 0.8rCSI 0.8%PRS 45.5%
-
CSI 0.8rCSI 2.3%PRS 60.3%
-
CSI 0.9rCSI 1.9%PRS 34.4%
-
CSI 0.9rCSI 3.0%PRS 67.8%
-
CSI 0.9rCSI 2.5%PRS 39.6%
-
CSI 0.9rCSI 2.6%PRS 17.8%
-
CSI 0.9rCSI 3.5%PRS 22.0%
-
CSI 0.9rCSI 2.1%PRS 21.2%
-
CSI 0.9rCSI 1.5%PRS 14.9%
-
CSI 0.9rCSI 1.3%PRS 17.8%
-
CSI 1.0rCSI 1.6%PRS 13.7%
-
CSI 1.0rCSI 2.7%PRS 35.4%
-
CSI 1.0rCSI 1.4%PRS 24.4%
-
CSI 1.0rCSI 1.3%PRS 25.2%
-
CSI 1.0rCSI 2.3%PRS 50.8%
-
CSI 1.0rCSI 2.0%PRS 38.3%
-
CSI 1.0rCSI 0.8%PRS 38.4%
-
CSI 1.0rCSI 3.9%PRS 14.1%
-
CSI 1.1rCSI 1.6%PRS 27.7%
-
CSI 1.1rCSI 25.7%PRS 13.1%
-
CSI 1.1rCSI 19.6%PRS 61.0%
-
CSI 1.1rCSI 1.1%PRS 27.2%
-
CSI 1.1rCSI 2.0%PRS 22.4%
-
CSI 1.1rCSI 14.9%PRS 61.6%
-
CSI 1.1rCSI 1.5%PRS 34.5%
-
CSI 1.1rCSI 4.1%PRS 39.3%
-
CSI 1.1rCSI 1.4%PRS 39.7%
-
CSI 1.2rCSI 1.8%PRS 29.9%
-
CSI 1.2rCSI 1.7%PRS 30.1%
-
CSI 1.2rCSI 2.8%PRS 33.9%
-
CSI 1.2rCSI 7.5%PRS 34.5%
-
CSI 1.2rCSI 2.6%PRS 30.5%
-
CSI 1.2rCSI 2.8%PRS 36.3%
-
CSI 1.2rCSI 1.8%PRS 36.8%
-
CSI 1.2rCSI 2.4%PRS 33.8%
-
CSI 1.2rCSI 2.3%PRS 50.8%
-
CSI 1.2rCSI 2.6%PRS 36.1%
-
CSI 1.2rCSI 6.9%PRS 33.8%
-
CSI 1.2rCSI 9.5%PRS 43.5%
-
CSI 1.2rCSI 1.9%PRS 23.2%
-
CSI 1.2rCSI 2.2%PRS 21.2%
-
CSI 1.3rCSI 1.9%PRS 35.7%
-
CSI 1.3rCSI 1.7%PRS 22.6%
-
CSI 1.3rCSI 1.7%PRS 43.8%
-
CSI 1.3rCSI 1.8%PRS 32.2%
-
CSI 1.3rCSI 1.9%PRS 26.0%
-
CSI 1.3rCSI 4.5%PRS 16.6%
-
CSI 1.4rCSI 33.0%PRS 12.2%
-
CSI 1.4rCSI 2.2%PRS 21.5%
-
CSI 1.4rCSI 3.5%PRS 13.4%
-
CSI 1.5rCSI 3.8%PRS 54.1%
-
CSI 1.5rCSI 1.9%PRS 14.2%
-
CSI 1.5rCSI 2.7%PRS 19.0%
-
CSI 1.5rCSI 8.0%PRS 68.7%
-
CSI 1.5rCSI 2.5%PRS 27.2%
-
CSI 1.6rCSI 3.3%PRS 44.8%
-
CSI 1.6rCSI 4.6%PRS 25.8%
-
CSI 1.6rCSI 2.3%PRS 35.9%
-
CSI 1.7rCSI 1.1%PRS 28.6%
-
CSI 1.7rCSI 3.8%PRS 23.6%
-
CSI 1.7rCSI 3.3%PRS 24.0%
-
CSI 1.7rCSI 1.8%PRS 21.2%
-
CSI 1.7rCSI 3.6%PRS 34.0%
-
CSI 1.7rCSI 1.4%PRS 24.1%
-
CSI 1.7rCSI 1.3%PRS 21.5%
-
CSI 1.8rCSI 2.8%PRS 25.2%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 1801393708
Symbol: SMC3_HUMAN
Name: Structural maintenance of chromosomes protein 3
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 9506951
Title: Complex formation of SMAP/KAP3, a KIF3A/B ATPase motor-associated protein, with a human chromosome-associated polypeptide.
PubMed ID: 9506951
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 15164054
Title: The DNA sequence and comparative analysis of human chromosome 10.
PubMed ID: 15164054
DOI: 10.1038/nature02462
PubMed ID: 11042152
Title: Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.
PubMed ID: 11042152
DOI: 10.1101/gr.140200
PubMed ID: 18614053
Title: Acetylation of Smc3 by Eco1 is required for S phase sister chromatid cohesion in both human and yeast.
PubMed ID: 18614053
PubMed ID: 11076961
Title: Characterization of vertebrate cohesin complexes and their regulation in prophase.
PubMed ID: 11076961
PubMed ID: 11590136
Title: A potential role for human cohesin in mitotic spindle aster assembly.
PubMed ID: 11590136
PubMed ID: 12198550
Title: A chromatin remodelling complex that loads cohesin onto human chromosomes.
PubMed ID: 12198550
DOI: 10.1038/nature01024
PubMed ID: 15656913
Title: Hinderin, a five-domains protein including coiled-coil motifs that binds to SMC3.
PubMed ID: 15656913
PubMed ID: 15837422
Title: Sororin, a substrate of the anaphase-promoting complex, is required for sister chromatid cohesion in vertebrates.
PubMed ID: 15837422
PubMed ID: 17105772
Title: The DNA helicase ChlR1 is required for sister chromatid cohesion in mammalian cells.
PubMed ID: 17105772
DOI: 10.1242/jcs.03262
PubMed ID: 17525332
Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.
PubMed ID: 17525332
PubMed ID: 19367720
Title: Phosphorylation analysis of primary human T lymphocytes using sequential IMAC and titanium oxide enrichment.
PubMed ID: 19367720
DOI: 10.1021/pr800500r
PubMed ID: 18691976
Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.
PubMed ID: 18691976
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 19907496
Title: Cohesin acetylation speeds the replication fork.
PubMed ID: 19907496
DOI: 10.1038/nature08550
PubMed ID: 19690332
Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
PubMed ID: 19690332
PubMed ID: 19608861
Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.
PubMed ID: 19608861
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 21406692
Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
PubMed ID: 21406692
PubMed ID: 22885700
Title: HDAC8 mutations in Cornelia de Lange syndrome affect the cohesin acetylation cycle.
PubMed ID: 22885700
DOI: 10.1038/nature11316
PubMed ID: 22628566
Title: In vitro loading of human cohesin on DNA by the human Scc2-Scc4 loader complex.
PubMed ID: 22628566
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 31334757
PubMed ID: 31452512
Title: Systematic identification of cancer cell vulnerabilities to natural killer cell-mediated immune surveillance.
PubMed ID: 31452512
DOI: 10.7554/elife.47362
PubMed ID: 32409525
Title: Cryo-EM structure of the human cohesin-NIPBL-DNA complex.
PubMed ID: 32409525
PubMed ID: 17273969
Title: Mutations in cohesin complex members SMC3 and SMC1A cause a mild variant of Cornelia de Lange syndrome with predominant mental retardation.
PubMed ID: 17273969
DOI: 10.1086/511888
PubMed ID: 18996922
Title: Cornelia de Lange syndrome mutations in SMC1A or SMC3 affect binding to DNA.
PubMed ID: 18996922
DOI: 10.1093/hmg/ddn369
Sequence Information:
- Length: 1217
- Mass: 141542
- Checksum: 21EF9A08A5D8096A
- Sequence:
MYIKQVIIQG FRSYRDQTIV DPFSSKHNVI VGRNGSGKSN FFYAIQFVLS DEFSHLRPEQ RLALLHEGTG PRVISAFVEI IFDNSDNRLP IDKEEVSLRR VIGAKKDQYF LDKKMVTKND VMNLLESAGF SRSNPYYIVK QGKINQMATA PDSQRLKLLR EVAGTRVYDE RKEESISLMK ETEGKREKIN ELLKYIEERL HTLEEEKEEL AQYQKWDKMR RALEYTIYNQ ELNETRAKLD ELSAKRETSG EKSRQLRDAQ QDARDKMEDI ERQVRELKTK ISAMKEEKEQ LSAERQEQIK QRTKLELKAK DLQDELAGNS EQRKRLLKER QKLLEKIEEK QKELAETEPK FNSVKEKEER GIARLAQATQ ERTDLYAKQG RGSQFTSKEE RDKWIKKELK SLDQAINDKK RQIAAIHKDL EDTEANKEKN LEQYNKLDQD LNEVKARVEE LDRKYYEVKN KKDELQSERN YLWREENAEQ QALAAKREDL EKKQQLLRAA TGKAILNGID SINKVLDHFR RKGINQHVQN GYHGIVMNNF ECEPAFYTCV EVTAGNRLFY HIVDSDEVST KILMEFNKMN LPGEVTFLPL NKLDVRDTAY PETNDAIPMI SKLRYNPRFD KAFKHVFGKT LICRSMEVST QLARAFTMDC ITLEGDQVSH RGALTGGYYD TRKSRLELQK DVRKAEEELG ELEAKLNENL RRNIERINNE IDQLMNQMQQ IETQQRKFKA SRDSILSEMK MLKEKRQQSE KTFMPKQRSL QSLEASLHAM ESTRESLKAE LGTDLLSQLS LEDQKRVDAL NDEIRQLQQE NRQLLNERIK LEGIITRVET YLNENLRKRL DQVEQELNEL RETEGGTVLT ATTSELEAIN KRVKDTMARS EDLDNSIDKT EAGIKELQKS MERWKNMEKE HMDAINHDTK ELEKMTNRQG MLLKKKEECM KKIRELGSLP QEAFEKYQTL SLKQLFRKLE QCNTELKKYS HVNKKALDQF VNFSEQKEKL IKRQEELDRG YKSIMELMNV LELRKYEAIQ LTFKQVSKNF SEVFQKLVPG GKATLVMKKG DVEGSQSQDE GEGSGESERG SGSQSSVPSV DQFTGVGIRV SFTGKQGEMR EMQQLSGGQK SLVALALIFA IQKCDPAPFY LFDEIDQALD AQHRKAVSDM IMELAVHAQF ITTTFRPELL ESADKFYGVK FRNKVSHIDV ITAEMAKDFV EDDTTHG