Details for: PRPF3
Associated with
Cells (max top 100)
(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: germ cell (CL0000586)
Fold Change: 1.96
Marker Score: 3,431 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 1.88
Marker Score: 2,271 - Cell Name: anterior lens cell (CL0002223)
Fold Change: 1.83
Marker Score: 2,461 - Cell Name: pulmonary interstitial fibroblast (CL0002241)
Fold Change: 1.73
Marker Score: 1,381 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 1.62
Marker Score: 6,764 - Cell Name: epicardial adipocyte (CL1000309)
Fold Change: 1.61
Marker Score: 784 - Cell Name: cardiac muscle cell (CL0000746)
Fold Change: 1.59
Marker Score: 21,206 - Cell Name: corneal epithelial cell (CL0000575)
Fold Change: 1.29
Marker Score: 1,428 - Cell Name: corneal endothelial cell (CL0000132)
Fold Change: 1.28
Marker Score: 744 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: 1.23
Marker Score: 718 - Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: 1.22
Marker Score: 26,032 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 1.21
Marker Score: 355 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 1.21
Marker Score: 74,542 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: 1.21
Marker Score: 11,496 - Cell Name: extravillous trophoblast (CL0008036)
Fold Change: 1.15
Marker Score: 1,023 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: 1.13
Marker Score: 9,738 - Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: 1.12
Marker Score: 10,580 - Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: 1.12
Marker Score: 41,224 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: 1.1
Marker Score: 1,703 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 1.09
Marker Score: 2,401 - Cell Name: OFF retinal ganglion cell (CL4023033)
Fold Change: 1.05
Marker Score: 441 - Cell Name: vip GABAergic cortical interneuron (CL4023016)
Fold Change: 1.05
Marker Score: 39,690 - Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: 1.03
Marker Score: 15,393 - Cell Name: sncg GABAergic cortical interneuron (CL4023015)
Fold Change: 1.02
Marker Score: 7,802 - Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
Fold Change: 1.01
Marker Score: 4,179 - Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71,691 - Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 47,915 - Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.99
Marker Score: 3,822 - Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30,394 - Cell Name: oogonial cell (CL0000024)
Fold Change: 0.96
Marker Score: 1,386 - Cell Name: A2 amacrine cell (CL0004219)
Fold Change: 0.96
Marker Score: 305 - Cell Name: nasal mucosa goblet cell (CL0002480)
Fold Change: 0.95
Marker Score: 635 - Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: 0.95
Marker Score: 18,852 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.94
Marker Score: 2,394 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.92
Marker Score: 474 - Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.91
Marker Score: 430 - Cell Name: abnormal cell (CL0001061)
Fold Change: 0.9
Marker Score: 2,699 - Cell Name: retinal ganglion cell (CL0000740)
Fold Change: 0.9
Marker Score: 1,119 - Cell Name: proerythroblast (CL0000547)
Fold Change: 0.89
Marker Score: 601 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5,294 - Cell Name: ependymal cell (CL0000065)
Fold Change: 0.86
Marker Score: 300 - Cell Name: interneuron (CL0000099)
Fold Change: 0.86
Marker Score: 391 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.85
Marker Score: 307 - Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
Fold Change: 0.85
Marker Score: 721 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: 0.85
Marker Score: 267 - Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.84
Marker Score: 4,815 - Cell Name: hematopoietic cell (CL0000988)
Fold Change: 0.84
Marker Score: 559 - Cell Name: ON retinal ganglion cell (CL4023032)
Fold Change: 0.84
Marker Score: 229 - Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
Fold Change: 0.82
Marker Score: 889 - Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.81
Marker Score: 1,313 - Cell Name: large pre-B-II cell (CL0000957)
Fold Change: 0.79
Marker Score: 2,158 - Cell Name: vascular leptomeningeal cell (CL4023051)
Fold Change: 0.79
Marker Score: 911 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: 0.79
Marker Score: 269 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.76
Marker Score: 306 - Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.76
Marker Score: 577 - Cell Name: kidney interstitial fibroblast (CL1000692)
Fold Change: 0.75
Marker Score: 1,450 - Cell Name: fat cell (CL0000136)
Fold Change: 0.75
Marker Score: 419 - Cell Name: choroid plexus epithelial cell (CL0000706)
Fold Change: 0.73
Marker Score: 674 - Cell Name: luminal epithelial cell of mammary gland (CL0002326)
Fold Change: 0.73
Marker Score: 1,295 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.73
Marker Score: 3,050 - Cell Name: podocyte (CL0000653)
Fold Change: 0.72
Marker Score: 268 - Cell Name: fibroblast of breast (CL4006000)
Fold Change: 0.72
Marker Score: 412 - Cell Name: Sertoli cell (CL0000216)
Fold Change: 0.72
Marker Score: 4,278 - Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: 0.72
Marker Score: 508 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 0.72
Marker Score: 756 - Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.72
Marker Score: 371 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 0.72
Marker Score: 24,362 - Cell Name: thymocyte (CL0000893)
Fold Change: 0.72
Marker Score: 749 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 0.71
Marker Score: 211 - Cell Name: primordial germ cell (CL0000670)
Fold Change: 0.71
Marker Score: 884 - Cell Name: skeletal muscle satellite cell (CL0000594)
Fold Change: 0.7
Marker Score: 470 - Cell Name: blood cell (CL0000081)
Fold Change: 0.7
Marker Score: 8,144 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.69
Marker Score: 1,020 - Cell Name: hepatic stellate cell (CL0000632)
Fold Change: 0.69
Marker Score: 261 - Cell Name: male germ cell (CL0000015)
Fold Change: 0.69
Marker Score: 198 - Cell Name: oocyte (CL0000023)
Fold Change: 0.68
Marker Score: 169 - Cell Name: brush cell (CL0002204)
Fold Change: 0.68
Marker Score: 622 - Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
Fold Change: 0.68
Marker Score: 294 - Cell Name: melanocyte (CL0000148)
Fold Change: 0.68
Marker Score: 276 - Cell Name: Unknown (CL0002371)
Fold Change: 0.68
Marker Score: 722 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.68
Marker Score: 174 - Cell Name: cardiac neuron (CL0010022)
Fold Change: 0.68
Marker Score: 846 - Cell Name: squamous epithelial cell (CL0000076)
Fold Change: 0.68
Marker Score: 462 - Cell Name: ovarian surface epithelial cell (CL2000064)
Fold Change: 0.67
Marker Score: 1,836 - Cell Name: Schwann cell (CL0002573)
Fold Change: 0.67
Marker Score: 231 - Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: 0.66
Marker Score: 397 - Cell Name: Bergmann glial cell (CL0000644)
Fold Change: 0.66
Marker Score: 270 - Cell Name: renal principal cell (CL0005009)
Fold Change: 0.66
Marker Score: 509 - Cell Name: skeletal muscle satellite stem cell (CL0008011)
Fold Change: 0.66
Marker Score: 703 - Cell Name: renal interstitial pericyte (CL1001318)
Fold Change: 0.66
Marker Score: 627 - Cell Name: precursor B cell (CL0000817)
Fold Change: 0.66
Marker Score: 434 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: 0.65
Marker Score: 680 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.65
Marker Score: 1,942 - Cell Name: classical monocyte (CL0000860)
Fold Change: 0.65
Marker Score: 2,712 - Cell Name: respiratory epithelial cell (CL0002368)
Fold Change: 0.65
Marker Score: 357 - Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
Fold Change: 0.65
Marker Score: 194 - Cell Name: type I NK T cell (CL0000921)
Fold Change: 0.65
Marker Score: 507 - Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
Fold Change: 0.64
Marker Score: 359 - Cell Name: primitive red blood cell (CL0002355)
Fold Change: 0.64
Marker Score: 479 - Cell Name: cerebellar granule cell precursor (CL0002362)
Fold Change: 0.64
Marker Score: 358
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 2305349608
Symbol: PRPF3_HUMAN
Name: U4/U6 small nuclear ribonucleoprotein Prp3
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 9328476
Title: Identification and characterization of human genes encoding Hprp3p and Hprp4p, interacting components of the spliceosome.
PubMed ID: 9328476
PubMed ID: 9404889
Title: A new cyclophilin and the human homologues of yeast Prp3 and Prp4 form a complex associated with U4/U6 snRNPs.
PubMed ID: 9404889
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 16710414
Title: The DNA sequence and biological annotation of human chromosome 1.
PubMed ID: 16710414
DOI: 10.1038/nature04727
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 15314151
Title: Human U4/U6 snRNP recycling factor p110: mutational analysis reveals the function of the tetratricopeptide repeat domain in recycling.
PubMed ID: 15314151
PubMed ID: 17081983
Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
PubMed ID: 17081983
PubMed ID: 16723661
Title: The network of protein-protein interactions within the human U4/U6.U5 tri-snRNP.
PubMed ID: 16723661
DOI: 10.1261/rna.55406
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 18318008
Title: Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography.
PubMed ID: 18318008
PubMed ID: 19413330
Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
PubMed ID: 19413330
DOI: 10.1021/ac9004309
PubMed ID: 19690332
Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
PubMed ID: 19690332
PubMed ID: 20595234
Title: The Prp19 complex and the Usp4Sart3 deubiquitinating enzyme control reversible ubiquitination at the spliceosome.
PubMed ID: 20595234
DOI: 10.1101/gad.1925010
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 21406692
Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
PubMed ID: 21406692
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 26030138
Title: Identification of Novel Proteins Co-Purifying with Cockayne Syndrome Group B (CSB) Reveals Potential Roles for CSB in RNA Metabolism and Chromatin Dynamics.
PubMed ID: 26030138
PubMed ID: 28112733
Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.
PubMed ID: 28112733
DOI: 10.1038/nsmb.3366
PubMed ID: 26912367
Title: Molecular architecture of the human U4/U6.U5 tri-snRNP.
PubMed ID: 26912367
PubMed ID: 28781166
Title: Cryo-EM Structure of a Pre-catalytic Human Spliceosome Primed for Activation.
PubMed ID: 28781166
PubMed ID: 11773002
Title: Mutations in HPRP3, a third member of pre-mRNA splicing factor genes, implicated in autosomal dominant retinitis pigmentosa.
PubMed ID: 11773002
DOI: 10.1093/hmg/11.1.87
PubMed ID: 12714658
Title: Mutations in the pre-mRNA splicing-factor genes PRPF3, PRPF8, and PRPF31 in Spanish families with autosomal dominant retinitis pigmentosa.
PubMed ID: 12714658
DOI: 10.1167/iovs.02-0871
PubMed ID: 17932117
Title: Mutation in the splicing factor Hprp3p linked to retinitis pigmentosa impairs interactions within the U4/U6 snRNP complex.
PubMed ID: 17932117
DOI: 10.1093/hmg/ddm300
Sequence Information:
- Length: 683
- Mass: 77529
- Checksum: 4AA6AA4C99110284
- Sequence:
MALSKRELDE LKPWIEKTVK RVLGFSEPTV VTAALNCVGK GMDKKKAADH LKPFLDDSTL RFVDKLFEAV EEGRSSRHSK SSSDRSRKRE LKEVFGDDSE ISKESSGVKK RRIPRFEEVE EEPEVIPGPP SESPGMLTKL QIKQMMEAAT RQIEERKKQL SFISPPTPQP KTPSSSQPER LPIGNTIQPS QAATFMNDAI EKARKAAELQ ARIQAQLALK PGLIGNANMV GLANLHAMGI APPKVELKDQ TKPTPLILDE QGRTVDATGK EIELTHRMPT LKANIRAVKR EQFKQQLKEK PSEDMESNTF FDPRVSIAPS QRQRRTFKFH DKGKFEKIAQ RLRTKAQLEK LQAEISQAAR KTGIHTSTRL ALIAPKKELK EGDIPEIEWW DSYIIPNGFD LTEENPKRED YFGITNLVEH PAQLNPPVDN DTPVTLGVYL TKKEQKKLRR QTRREAQKEL QEKVRLGLMP PPEPKVRISN LMRVLGTEAV QDPTKVEAHV RAQMAKRQKA HEEANAARKL TAEQRKVKKI KKLKEDISQG VHISVYRVRN LSNPAKKFKI EANAGQLYLT GVVVLHKDVN VVVVEGGPKA QKKFKRLMLH RIKWDEQTSN TKGDDDEESD EEAVKKTNKC VLVWEGTAKD RSFGEMKFKQ CPTENMAREH FKKHGAEHYW DLALSESVLE STD
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.