Details for: CD1E

Gene ID: 913

Symbol: CD1E

Ensembl ID: ENSG00000158488

Description: CD1e molecule

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 10.9723
    Cell Significance Index: -4.5200
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.5745
    Cell Significance Index: 24.3600
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.7620
    Cell Significance Index: 9.4300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.2519
    Cell Significance Index: 11.8400
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.2475
    Cell Significance Index: 1.0300
  • Cell Name: liver dendritic cell (CL2000055)
    Fold Change: 0.1403
    Cell Significance Index: 0.3700
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 0.0145
    Cell Significance Index: 0.1500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.0068
    Cell Significance Index: 0.6900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0001
    Cell Significance Index: 0.0000
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.0014
    Cell Significance Index: -0.0200
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0014
    Cell Significance Index: -0.0600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0075
    Cell Significance Index: -5.6900
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0078
    Cell Significance Index: -0.2000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0084
    Cell Significance Index: -1.0800
  • Cell Name: brain vascular cell (CL4023072)
    Fold Change: -0.0112
    Cell Significance Index: -0.1300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0304
    Cell Significance Index: -6.0300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0384
    Cell Significance Index: -6.5500
  • Cell Name: monocyte-derived dendritic cell (CL0011031)
    Fold Change: -0.0390
    Cell Significance Index: -0.6700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0443
    Cell Significance Index: -5.2300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0466
    Cell Significance Index: -6.4000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0589
    Cell Significance Index: -6.7500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0627
    Cell Significance Index: -1.7500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0802
    Cell Significance Index: -5.1800
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0814
    Cell Significance Index: -0.9900
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.0849
    Cell Significance Index: -1.2900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0870
    Cell Significance Index: -4.5300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0875
    Cell Significance Index: -2.3400
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.1203
    Cell Significance Index: -1.1900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1207
    Cell Significance Index: -6.2700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.1227
    Cell Significance Index: -5.5600
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.1235
    Cell Significance Index: -1.5600
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: -0.1295
    Cell Significance Index: -1.4500
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.1334
    Cell Significance Index: -1.4500
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.1381
    Cell Significance Index: -2.0200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1592
    Cell Significance Index: -4.6900
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.1598
    Cell Significance Index: -3.9900
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: -0.1680
    Cell Significance Index: -1.7500
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.1682
    Cell Significance Index: -2.3900
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1686
    Cell Significance Index: -6.1900
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.1908
    Cell Significance Index: -4.8600
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.1955
    Cell Significance Index: -2.3100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.2041
    Cell Significance Index: -5.4700
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.2115
    Cell Significance Index: -3.0700
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.2143
    Cell Significance Index: -3.6400
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.2202
    Cell Significance Index: -3.0200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2210
    Cell Significance Index: -5.8100
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.2219
    Cell Significance Index: -5.3800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.2292
    Cell Significance Index: -6.1200
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.2460
    Cell Significance Index: -4.8100
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.2471
    Cell Significance Index: -2.9200
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.2475
    Cell Significance Index: -2.9100
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.2493
    Cell Significance Index: -2.8300
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.2516
    Cell Significance Index: -4.6500
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.2568
    Cell Significance Index: -2.1700
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.2630
    Cell Significance Index: -4.2600
  • Cell Name: CD141-positive myeloid dendritic cell (CL0002394)
    Fold Change: -0.2636
    Cell Significance Index: -2.8500
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.2749
    Cell Significance Index: -6.0200
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.2830
    Cell Significance Index: -3.7000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.2858
    Cell Significance Index: -3.9000
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.2888
    Cell Significance Index: -3.7900
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.2948
    Cell Significance Index: -3.1700
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.2968
    Cell Significance Index: -4.1700
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.2971
    Cell Significance Index: -7.4100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.3086
    Cell Significance Index: -8.4000
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.3136
    Cell Significance Index: -6.1200
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.3223
    Cell Significance Index: -5.5100
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.3282
    Cell Significance Index: -5.5200
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.3305
    Cell Significance Index: -6.5900
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: -0.3341
    Cell Significance Index: -2.6200
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: -0.3363
    Cell Significance Index: -3.0400
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.3369
    Cell Significance Index: -4.3600
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.3389
    Cell Significance Index: -3.6000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.3406
    Cell Significance Index: -5.7000
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.3415
    Cell Significance Index: -7.8900
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: -0.3553
    Cell Significance Index: -4.5000
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.3627
    Cell Significance Index: -6.1100
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.3691
    Cell Significance Index: -7.4100
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.3729
    Cell Significance Index: -4.0200
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.3786
    Cell Significance Index: -3.1800
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.3812
    Cell Significance Index: -4.8300
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.3816
    Cell Significance Index: -4.4900
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: -0.3888
    Cell Significance Index: -4.5200
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.3891
    Cell Significance Index: -5.1700
  • Cell Name: granulocyte (CL0000094)
    Fold Change: -0.3896
    Cell Significance Index: -4.7000
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: -0.3993
    Cell Significance Index: -3.0500
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.4036
    Cell Significance Index: -5.4900
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.4058
    Cell Significance Index: -5.3400
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.4064
    Cell Significance Index: -6.0000
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: -0.4087
    Cell Significance Index: -3.3800
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.4092
    Cell Significance Index: -5.0300
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: -0.4131
    Cell Significance Index: -4.9100
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.4144
    Cell Significance Index: -5.4200
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -0.4220
    Cell Significance Index: -5.0100
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.4223
    Cell Significance Index: -5.2800
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.4255
    Cell Significance Index: -6.2800
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.4289
    Cell Significance Index: -5.5100
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: -0.4290
    Cell Significance Index: -3.4800
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.4302
    Cell Significance Index: -5.5100
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.4324
    Cell Significance Index: -6.8600
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.4345
    Cell Significance Index: -5.1300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Structure and Function:** CD1E is a transmembrane glycoprotein that spans the plasma membrane and has a cytoplasmic tail. It interacts with lipid antigens and presents them to T cells via MHC class Ib, a chaperone that facilitates the loading of lipid antigens onto the MHC molecule. 2. **Expression Patterns:** CD1E is expressed on various immune cells, including thymocytes, double-positive alpha-beta T cells, gamma-delta T cells, and CD1c-positive myeloid dendritic cells. It is also found on non-immune cells, such as fallopian tube secretory epithelial cells and intestinal crypt stem cells. 3. **Lipid Antigen Binding:** CD1E binds to a wide range of lipid antigens, including sphingolipids, glycerophospholipids, and cholesterol esters. This binding is critical for the presentation of lipid antigens to T cells via MHC class Ib. **Pathways and Functions:** 1. **Antigen Processing and Presentation:** CD1E is involved in the processing and presentation of lipid antigens to T cells via MHC class Ib. This process is essential for the activation of T cells and the initiation of an immune response. 2. **Endogenous Lipid Antigen Presentation:** CD1E presents endogenous lipid antigens, such as those derived from cellular membranes, to T cells via MHC class Ib. 3. **Exogenous Lipid Antigen Presentation:** CD1E presents exogenous lipid antigens, such as those derived from dietary sources, to T cells via MHC class Ib. 4. **Regulation of T Cell-Mediated Cytotoxicity:** CD1E has been shown to positively regulate T cell-mediated cytotoxicity, highlighting its role in modulating the immune response. **Clinical Significance:** Dysregulation of CD1E has been implicated in various immune-related disorders, including: 1. **Autoimmune Diseases:** CD1E has been implicated in the pathogenesis of autoimmune diseases, such as multiple sclerosis and type 1 diabetes, where dysregulation of lipid antigen presentation leads to immune dysregulation. 2. **Cancer:** CD1E has been shown to be overexpressed in certain types of cancer, such as melanoma and lung cancer, where it facilitates the presentation of lipid antigens to T cells, leading to immune evasion. 3. **Viral Infections:** CD1E has been implicated in the pathogenesis of viral infections, such as HIV and influenza, where dysregulation of lipid antigen presentation leads to immune suppression. In conclusion, CD1E is a critical component of the immune system, involved in the presentation of lipid antigens to T cells via MHC class Ib. Its dysregulation has been implicated in various immune-related disorders, highlighting its importance in maintaining immune homeostasis. Further research is necessary to fully elucidate the function and clinical significance of CD1E.

Genular Protein ID: 703904673

Symbol: CD1E_HUMAN

Name: T-cell surface glycoprotein CD1e, membrane-associated

UniProtKB Accession Codes:

P15812 B4DZV3 E7EP01 Q5TDJ9 Q5TDK3 Q5TDK4 Q5TDK5 Q5TDK6 Q5TDK8 Q5TDL1 Q712E4 Q712E5 Q712E6 Q712E7 Q712E8 Q712E9 Q712F0 Q712F1 Q712F2 Q712F3 Q712F4 Q712F5 Q96TD0 Q96TD1 Q9UMM1 Q9Y5M3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 13 CDD 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 33 Ensembl 13 EvolutionaryTrace 1 ExpressionAtlas 1 GO 17 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 12 RNAct 1 RefSeq 14 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 2467814

Title: Two classes of CD1 genes.

PubMed ID: 2467814

DOI: 10.1002/eji.1830190211

PubMed ID: 10948205

Title: Characterization of CD1e, a third type of CD1 molecule expressed in dendritic cells.

PubMed ID: 10948205

DOI: 10.1074/jbc.m007082200

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 10488738

Title: Polymorphism of human CD1 genes.

PubMed ID: 10488738

DOI: 10.1034/j.1399-0039.1999.540202.x

PubMed ID: 12144626

Title: Two novel CD1 E alleles identified in black African individuals.

PubMed ID: 12144626

DOI: 10.1034/j.1399-0039.2002.590509.x

PubMed ID: 11019917

Title: Identification of two novel human CD1E alleles.

PubMed ID: 11019917

DOI: 10.1034/j.1399-0039.2000.560208.x

PubMed ID: 3097645

Title: Isolation of CD1 genes: a family of major histocompatibility complex-related differentiation antigens.

PubMed ID: 3097645

DOI: 10.1073/pnas.83.23.9154

PubMed ID: 16311334

Title: Assistance of microbial glycolipid antigen processing by CD1e.

PubMed ID: 16311334

DOI: 10.1126/science.1115301

PubMed ID: 18208508

Title: Control of the intracellular pathway of CD1e.

PubMed ID: 18208508

DOI: 10.1111/j.1600-0854.2008.00707.x

PubMed ID: 19196239

Title: The assembly of CD1e is controlled by an N-terminal propeptide which is processed in endosomal compartments.

PubMed ID: 19196239

DOI: 10.1042/bj20082204

PubMed ID: 18325888

Title: A naturally occurring mutation in CD1e impairs lipid antigen presentation.

PubMed ID: 18325888

DOI: 10.4049/jimmunol.180.6.3642

PubMed ID: 21788486

Title: Crystal structure of human CD1e reveals a groove suited for lipid-exchange processes.

PubMed ID: 21788486

DOI: 10.1073/pnas.1105627108

Sequence Information:

  • Length: 388
  • Mass: 43626
  • Checksum: F6503AE9608C6568
  • Sequence:
    • MLLLFLLFEG LCCPGENTAA PQALQSYHLA AEEQLSFRML QTSSFANHSW AHSEGSGWLG 
DLQTHGWDTV LGTIRFLKPW SHGNFSKQEL KNLQSLFQLY FHSFIQIVQA SAGQFQLEYP 
FEIQILAGCR MNAPQIFLNM AYQGSDFLSF QGISWEPSPG AGIRAQNICK VLNRYLDIKE 
ILQSLLGHTC PRFLAGLMEA GESELKRKVK PEAWLSCGPS PGPGRLQLVC HVSGFYPKPV 
WVMWMRGEQE QRGTQRGDVL PNADETWYLR ATLDVAAGEA AGLSCRVKHS SLGGHDLIIH 
WGGYSIFLIL ICLTVIVTLV ILVVVDSRLK KQSSNKNILS PHTPSPVFLM GANTQDTKNS 
RHQFCLAQVS WIKNRVLKKW KTRLNQLW

Genular Protein ID: 3339576891

Symbol: A2RRL5_HUMAN

Name: N/A

UniProtKB Accession Codes:

A2RRL5

Database IDs:

ARBA 3 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 1 Gene3D 2 InterPro 8 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PeptideAtlas 1 Pfam 2 RefSeq 7 SAM 2 SMART 1 SMR 1 SUPFAM 2

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 333
  • Mass: 37251
  • Checksum: 9D47283D6ADE28E1
  • Sequence:
    • MLLLFLLFEG LCCPGENTAA PQALQSYHLA AEEQLSFRML QTSSFANHSW AHSEGSGWLG 
DLQTHGWDTV LGTIRFLKPW SHGNFSKQEL KNLQSLFQLY FHSFIQIVQA SAGQFQLEYP 
FEIQILAGCR MNAPQIFLNM AYQGSDFLSF QGISWEPSPG AGIRAQNICK VLNRYLDIKE 
ILQSLLGHTC PRFLAGLMEA GESELKRKVK PEAWLSCGPS PGPGRLQLVC HVSGFYPKPV 
WVMWMRGEQE QRGTQRGDVL PNADETWYLR ATLDVAAGEA AGLSCRVKHS SLGGHDLIIH 
WGGYSIFLIL ICLTVIVTLV ILVVVDSRLK KQR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.