CCNE2 | ENSG00000175305 | NCBI 9134

Details for: CCNE2

Gene ID: 9134

Symbol: CCNE2

Ensembl ID: ENSG00000175305

Description: cyclin E2

Associated with

Aberrant regulation of mitotic cell cycle due to rb1 defects
(R-HSA-9687139)
Aberrant regulation of mitotic g1/s transition in cancer due to rb1 defects
(R-HSA-9659787)
Association of tric/cct with target proteins during biosynthesis
(R-HSA-390471)
Cdk-mediated phosphorylation and removal of cdc6
(R-HSA-69017)
Cell cycle
(R-HSA-1640170)
Cell cycle, mitotic
(R-HSA-69278)
Cell cycle checkpoints
(R-HSA-69620)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular senescence
(R-HSA-2559583)
Chaperonin-mediated protein folding
(R-HSA-390466)
Cyclin a:cdk2-associated events at s phase entry
(R-HSA-69656)
Cyclin d associated events in g1
(R-HSA-69231)
Cyclin e associated events during g1/s transition
(R-HSA-69202)
Defective binding of rb1 mutants to e2f1,(e2f2, e2f3)
(R-HSA-9661069)
Disease
(R-HSA-1643685)
Diseases of mitotic cell cycle
(R-HSA-9675126)
Dna damage/telomere stress induced senescence
(R-HSA-2559586)
Dna replication
(R-HSA-69306)
G0 and early g1
(R-HSA-1538133)
G1 phase
(R-HSA-69236)
G1/s dna damage checkpoints
(R-HSA-69615)
G1/s transition
(R-HSA-69206)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Metabolism of proteins
(R-HSA-392499)
Mitotic g1 phase and g1/s transition
(R-HSA-453279)
P53-dependent g1 dna damage response
(R-HSA-69563)
P53-dependent g1/s dna damage checkpoint
(R-HSA-69580)
Phosphorylation of proteins involved in g1/s transition by active cyclin e:cdk2 complexes
(R-HSA-69200)
Protein folding
(R-HSA-391251)
Rna polymerase ii transcription
(R-HSA-73857)
Scf(skp2)-mediated degradation of p27/p21
(R-HSA-187577)
S phase
(R-HSA-69242)
Switching of origins to a post-replicative state
(R-HSA-69052)
Synthesis of dna
(R-HSA-69239)
Tp53 regulates transcription of cell cycle genes
(R-HSA-6791312)
Tp53 regulates transcription of genes involved in g1 cell cycle arrest
(R-HSA-6804116)
Transcriptional regulation by tp53
(R-HSA-3700989)
Cell division
(GO:0051301)
Centrosome
(GO:0005813)
Cyclin-dependent protein serine/threonine kinase regulator activity
(GO:0016538)
Cyclin e1-cdk2 complex
(GO:0097134)
Cyclin e2-cdk2 complex
(GO:0097135)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Dna replication initiation
(GO:0006270)
G1/s transition of mitotic cell cycle
(GO:0000082)
Homologous chromosome pairing at meiosis
(GO:0007129)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Positive regulation of g1/s transition of mitotic cell cycle
(GO:1900087)
Protein binding
(GO:0005515)
Protein kinase binding
(GO:0019901)
Regulation of cyclin-dependent protein serine/threonine kinase activity
(GO:0000079)
Regulation of protein localization
(GO:0032880)
Telomere maintenance
(GO:0000723)

Other Information

Proteins

G1/S-specific cyclin-E2

Genular Protein ID: 1095091524

Symbol: CCNE2_HUMAN

Name: G1/S-specific cyclin-E2

UniProtKB Accession Codes:

O96020 O95439

Database IDs:

Citations:

PubMed ID: 9858585

Title: Cyclin E2, a novel G1 cyclin that binds Cdk2 and is aberrantly expressed in human cancers.

PubMed ID: 9858585

DOI: 10.1128/mcb.19.1.612

PubMed ID: 9840927

Title: Cyclin E2: a novel CDK2 partner in the late G1 and S phases of the mammalian cell cycle.

PubMed ID: 9840927

DOI: 10.1038/sj.onc.1202477

PubMed ID: 9840943

Title: Cyclin E2, a novel human G1 cyclin and activating partner of CDK2 and CDK3, is induced by viral oncoproteins.

PubMed ID: 9840943

DOI: 10.1038/sj.onc.1202505

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

Sequence Information:

Length: 404
Mass: 46757
Checksum: D7DC9BEEF3FD62EC
Sequence:

MSRRSSRLQA KQQPQPSQTE SPQEAQIIQA KKRKTTQDVK KRREEVTKKH QYEIRNCWPP 
VLSGGISPCI IIETPHKEIG TSDFSRFTNY RFKNLFINPS PLPDLSWGCS KEVWLNMLKK 
ESRYVHDKHF EVLHSDLEPQ MRSILLDWLL EVCEVYTLHR ETFYLAQDFF DRFMLTQKDI 
NKNMLQLIGI TSLFIASKLE EIYAPKLQEF AYVTDGACSE EDILRMELII LKALKWELCP 
VTIISWLNLF LQVDALKDAP KVLLPQYSQE TFIQIAQLLD LCILAIDSLE FQYRILTAAA 
LCHFTSIEVV KKASGLEWDS ISECVDWMVP FVNVVKSTSP VKLKTFKKIP MEDRHNIQTH 
TNYLAMLEEV NYINTFRKGG QLSPVCNGGI MTPPKSTEKP PGKH

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: CCNE2

Associated with

Other Information

Cyclin E2, a novel G1 cyclin that binds Cdk2 and is aberrantly expressed in human cancers. PubMed ID: 9858585

Cyclin E2: a novel CDK2 partner in the late G1 and S phases of the mammalian cell cycle. PubMed ID: 9840927

Cyclin E2, a novel human G1 cyclin and activating partner of CDK2 and CDK3, is induced by viral oncoproteins. PubMed ID: 9840943

Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. PubMed ID: 18691976

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Large-scale proteomics analysis of the human kinome. PubMed ID: 19369195

Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. PubMed ID: 19690332

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163