Details for: CD2

Gene ID: 914

Symbol: CD2

Ensembl ID: ENSG00000116824

Description: CD2 molecule

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 118.8400
    Cell Significance Index: -18.4900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 75.6968
    Cell Significance Index: -19.2000
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 47.4936
    Cell Significance Index: -24.4300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 14.9113
    Cell Significance Index: -18.3900
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: 13.8360
    Cell Significance Index: 37.0700
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 7.4037
    Cell Significance Index: -22.7400
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 6.0745
    Cell Significance Index: 178.4000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 4.4377
    Cell Significance Index: 110.9300
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 2.6374
    Cell Significance Index: 26.4500
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 2.1262
    Cell Significance Index: 6.4800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.6363
    Cell Significance Index: 74.1700
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 1.3864
    Cell Significance Index: 14.3800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.0593
    Cell Significance Index: 22.9500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.8835
    Cell Significance Index: 87.4000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.7508
    Cell Significance Index: 677.9600
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.6015
    Cell Significance Index: 3.2800
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 0.4047
    Cell Significance Index: 3.5400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3652
    Cell Significance Index: 59.4000
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 0.3124
    Cell Significance Index: 2.4300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2267
    Cell Significance Index: 24.6600
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 0.1446
    Cell Significance Index: 1.2200
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 0.1291
    Cell Significance Index: 1.1000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0853
    Cell Significance Index: 16.2400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0348
    Cell Significance Index: 2.4100
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 0.0306
    Cell Significance Index: 0.2900
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 0.0281
    Cell Significance Index: 0.2700
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: 0.0182
    Cell Significance Index: 0.1700
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 0.0128
    Cell Significance Index: 0.2200
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: 0.0020
    Cell Significance Index: 0.0200
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.0015
    Cell Significance Index: -0.0100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0060
    Cell Significance Index: -0.2100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0101
    Cell Significance Index: -19.0700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0115
    Cell Significance Index: -21.1300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0121
    Cell Significance Index: -0.3500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0133
    Cell Significance Index: -20.5500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0154
    Cell Significance Index: -20.9800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0200
    Cell Significance Index: -15.1200
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0213
    Cell Significance Index: -0.5500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0262
    Cell Significance Index: -19.4300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0302
    Cell Significance Index: -1.5300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0336
    Cell Significance Index: -24.6100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0350
    Cell Significance Index: -0.7500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0356
    Cell Significance Index: -20.1000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0369
    Cell Significance Index: -20.1400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0387
    Cell Significance Index: -24.6100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0421
    Cell Significance Index: -18.6200
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0453
    Cell Significance Index: -0.7700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0502
    Cell Significance Index: -22.7800
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0533
    Cell Significance Index: -0.7800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0539
    Cell Significance Index: -19.3300
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0664
    Cell Significance Index: -1.0000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0702
    Cell Significance Index: -13.9400
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0735
    Cell Significance Index: -1.0000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0755
    Cell Significance Index: -21.7100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0779
    Cell Significance Index: -9.1900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0980
    Cell Significance Index: -19.6500
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0983
    Cell Significance Index: -4.0300
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.1012
    Cell Significance Index: -4.4000
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: -0.1043
    Cell Significance Index: -0.8500
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.1050
    Cell Significance Index: -1.2400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1143
    Cell Significance Index: -19.5200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.1225
    Cell Significance Index: -22.0900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1354
    Cell Significance Index: -15.7800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.1406
    Cell Significance Index: -19.3100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1486
    Cell Significance Index: -6.9900
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: -0.1529
    Cell Significance Index: -1.3800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1644
    Cell Significance Index: -21.2400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1668
    Cell Significance Index: -24.2400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.1688
    Cell Significance Index: -20.7600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.1702
    Cell Significance Index: -21.8200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1791
    Cell Significance Index: -18.3000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1799
    Cell Significance Index: -20.6100
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: -0.2010
    Cell Significance Index: -1.8600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2027
    Cell Significance Index: -12.4300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.2079
    Cell Significance Index: -12.4800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2245
    Cell Significance Index: -7.1900
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.2338
    Cell Significance Index: -4.8500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.2761
    Cell Significance Index: -19.5300
  • Cell Name: mature T cell (CL0002419)
    Fold Change: -0.2779
    Cell Significance Index: -2.0000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2830
    Cell Significance Index: -21.7200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2850
    Cell Significance Index: -21.2400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2958
    Cell Significance Index: -19.8900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.3433
    Cell Significance Index: -22.1500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.3771
    Cell Significance Index: -21.1600
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.4045
    Cell Significance Index: -4.2000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.4106
    Cell Significance Index: -21.3300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.4224
    Cell Significance Index: -11.3000
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.4435
    Cell Significance Index: -4.4800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.4603
    Cell Significance Index: -21.4600
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.4977
    Cell Significance Index: -5.0500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.5056
    Cell Significance Index: -22.3700
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: -0.5197
    Cell Significance Index: -5.5300
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.5293
    Cell Significance Index: -19.4300
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: -0.5346
    Cell Significance Index: -2.2300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.5669
    Cell Significance Index: -19.8600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.5913
    Cell Significance Index: -22.3900
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.5992
    Cell Significance Index: -9.2700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.6029
    Cell Significance Index: -19.7400
  • Cell Name: CD8-alpha alpha positive, gamma-delta intraepithelial T cell (CL0000802)
    Fold Change: -0.6053
    Cell Significance Index: -3.5100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.6196
    Cell Significance Index: -19.7400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Cell surface glycoprotein**: The CD2 molecule is a transmembrane glycoprotein, meaning it spans the cell membrane and has carbohydrate chains attached to it. 2. **T cell-specific**: The CD2 molecule is specifically expressed on the surface of mature T cells, including CD4+ and CD8+ T cells. 3. **Cell-cell adhesion**: The CD2 molecule interacts with other molecules, such as CD4 and CD8, to facilitate cell-cell adhesion and interaction between T cells. 4. **Signaling molecule**: The CD2 molecule can also act as a signaling molecule, transmitting signals between T cells and other immune cells. 5. **Regulatory function**: The CD2 molecule plays a regulatory role in T cell activation, differentiation, and proliferation. **Pathways and Functions** The CD2 molecule is involved in various signaling pathways, including: 1. **T cell activation**: The CD2 molecule interacts with CD4 and CD8 to facilitate T cell activation and proliferation. 2. **Natural killer cell activation**: The CD2 molecule is expressed on natural killer cells and plays a role in their activation and function. 3. **Regulation of T cell differentiation**: The CD2 molecule regulates the differentiation of T cells into various subsets, including effector and memory T cells. 4. **Signaling receptor activity**: The CD2 molecule can act as a signaling receptor, transmitting signals between T cells and other immune cells. The CD2 molecule functions in the following ways: 1. **Cell-cell adhesion**: The CD2 molecule facilitates cell-cell adhesion between T cells and other immune cells. 2. **Signaling**: The CD2 molecule transmits signals between T cells and other immune cells, regulating their activation, proliferation, and differentiation. 3. **Immune regulation**: The CD2 molecule plays a regulatory role in immune responses, including the activation of natural killer cells and the regulation of T cell differentiation. **Clinical Significance** The CD2 molecule has significant implications for the understanding and treatment of various immune-related disorders, including: 1. **Cancer**: The CD2 molecule is expressed on the surface of cancer cells, making it a potential target for cancer immunotherapy. 2. **Autoimmune diseases**: The CD2 molecule plays a regulatory role in the immune system, and its dysregulation has been implicated in autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis. 3. **Vaccine development**: The CD2 molecule is a potential target for vaccine development, as it can be used to stimulate immune responses against specific antigens. 4. **Immunotherapy**: The CD2 molecule has been shown to be a target for immunotherapy, including adoptive T cell therapy and checkpoint inhibitors. In conclusion, the CD2 gene encodes for a critical transmembrane glycoprotein that plays a central role in the functioning of T cells and other immune cells. Its dysregulation has been implicated in various immune-related disorders, making it a potential target for the development of novel therapies.

Genular Protein ID: 1944147403

Symbol: CD2_HUMAN

Name: T-cell surface antigen CD2

UniProtKB Accession Codes:

P06729 Q96TE5

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 2 DrugCentral 1 ELM 1 EMBL 14 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 26 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 7 PDBsum 7 PIR 1 PRINTS 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UniLectin 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2894031

Title: Exon-intron organization and sequence comparison of human and murine T11 (CD2) genes.

PubMed ID: 2894031

DOI: 10.1073/pnas.85.5.1615

PubMed ID: 2437578

Title: Molecular cloning of the CD2 antigen, the T-cell erythrocyte receptor, by a rapid immunoselection procedure.

PubMed ID: 2437578

DOI: 10.1073/pnas.84.10.3365

PubMed ID: 3490670

Title: Molecular cloning of the human T-lymphocyte surface CD2 (T11) antigen.

PubMed ID: 3490670

DOI: 10.1073/pnas.83.22.8718

PubMed ID: 2883656

Title: Molecular cloning and expression of T11 cDNAs reveal a receptor-like structure on human T lymphocytes.

PubMed ID: 2883656

DOI: 10.1073/pnas.84.9.2941

PubMed ID: 2901953

Title: The structure of the human CD2 gene and its expression in transgenic mice.

PubMed ID: 2901953

DOI: 10.1002/j.1460-2075.1988.tb02995.x

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2444890

Title: Monoclonal antibody and ligand binding sites of the T cell erythrocyte receptor (CD2).

PubMed ID: 2444890

DOI: 10.1038/329842a0

PubMed ID: 1377404

Title: Overlapping but nonidentical binding sites on CD2 for CD58 and a second ligand CD59.

PubMed ID: 1377404

DOI: 10.1126/science.1377404

PubMed ID: 9857189

Title: A cdc15-like adaptor protein (CD2BP1) interacts with the CD2 cytoplasmic domain and regulates CD2-triggered adhesion.

PubMed ID: 9857189

DOI: 10.1093/emboj/17.24.7320

PubMed ID: 23006327

Title: Human immunodeficiency-causing mutation defines CD16 in spontaneous NK cell cytotoxicity.

PubMed ID: 23006327

DOI: 10.1172/jci64837

PubMed ID: 7994575

Title: Crystal structure of the extracellular region of the human cell adhesion molecule CD2 at 2.5 A resolution.

PubMed ID: 7994575

DOI: 10.1016/s0969-2126(94)00076-x

PubMed ID: 7915183

Title: Structure of the glycosylated adhesion domain of human T lymphocyte glycoprotein CD2.

PubMed ID: 7915183

DOI: 10.1016/0969-2126(93)90009-6

PubMed ID: 7544493

Title: Conformation and function of the N-linked glycan in the adhesion domain of human CD2.

PubMed ID: 7544493

DOI: 10.1126/science.7544493

PubMed ID: 10380930

Title: Structure of a heterophilic adhesion complex between the human CD2 and CD58 (LFA-3) counterreceptors.

PubMed ID: 10380930

DOI: 10.1016/s0092-8674(00)80790-4

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 351
  • Mass: 39448
  • Checksum: A03D853C3B618917
  • Sequence:
    • MSFPCKFVAS FLLIFNVSSK GAVSKEITNA LETWGALGQD INLDIPSFQM SDDIDDIKWE 
KTSDKKKIAQ FRKEKETFKE KDTYKLFKNG TLKIKHLKTD DQDIYKVSIY DTKGKNVLEK 
IFDLKIQERV SKPKISWTCI NTTLTCEVMN GTDPELNLYQ DGKHLKLSQR VITHKWTTSL 
SAKFKCTAGN KVSKESSVEP VSCPEKGLDI YLIIGICGGG SLLMVFVALL VFYITKRKKQ 
RSRRNDEELE TRAHRVATEE RGRKPHQIPA STPQNPATSQ HPPPPPGHRS QAPSHRPPPP 
GHRVQHQPQK RPPAPSGTQV HQQKGPPLPR PRVQPKPPHG AAENSLSPSS N

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.