CD2 | ENSG00000116824 | NCBI 914

Details for: CD2

Gene ID: 914

Symbol: CD2

Ensembl ID: ENSG00000116824

Description: CD2 molecule

Associated with

Cell surface interactions at the vascular wall
(R-HSA-202733)
Hemostasis
(R-HSA-109582)
Apoptotic process
(GO:0006915)
Cell-cell adhesion
(GO:0098609)
Cell-cell junction
(GO:0005911)
Cell surface
(GO:0009986)
Cell surface receptor signaling pathway
(GO:0007166)
Cytoplasmic side of plasma membrane
(GO:0009898)
External side of plasma membrane
(GO:0009897)
Extracellular region
(GO:0005576)
Golgi apparatus
(GO:0005794)
Heterotypic cell-cell adhesion
(GO:0034113)
Identical protein binding
(GO:0042802)
Membrane raft polarization
(GO:0001766)
Natural killer cell activation
(GO:0030101)
Natural killer cell mediated cytotoxicity
(GO:0042267)
Nucleoplasm
(GO:0005654)
Plasma membrane
(GO:0005886)
Positive regulation of interleukin-8 production
(GO:0032757)
Positive regulation of myeloid dendritic cell activation
(GO:0030887)
Positive regulation of tumor necrosis factor production
(GO:0032760)
Positive regulation of type ii interferon production
(GO:0032729)
Protein-containing complex
(GO:0032991)
Protein binding
(GO:0005515)
Protein self-association
(GO:0043621)
Receptor tyrosine kinase binding
(GO:0030971)
Regulation of t cell differentiation
(GO:0045580)
Signaling receptor activity
(GO:0038023)
Signaling receptor binding
(GO:0005102)
T cell activation
(GO:0042110)

Other Information

Proteins

T-cell surface antigen CD2

Genular Protein ID: 1944147403

Symbol: CD2_HUMAN

Name: T-cell surface antigen CD2

UniProtKB Accession Codes:

P06729 Q96TE5

Database IDs:

Citations:

PubMed ID: 2894031

Title: Exon-intron organization and sequence comparison of human and murine T11 (CD2) genes.

PubMed ID: 2894031

DOI: 10.1073/pnas.85.5.1615

PubMed ID: 2437578

Title: Molecular cloning of the CD2 antigen, the T-cell erythrocyte receptor, by a rapid immunoselection procedure.

PubMed ID: 2437578

DOI: 10.1073/pnas.84.10.3365

PubMed ID: 3490670

Title: Molecular cloning of the human T-lymphocyte surface CD2 (T11) antigen.

PubMed ID: 3490670

DOI: 10.1073/pnas.83.22.8718

PubMed ID: 2883656

Title: Molecular cloning and expression of T11 cDNAs reveal a receptor-like structure on human T lymphocytes.

PubMed ID: 2883656

DOI: 10.1073/pnas.84.9.2941

PubMed ID: 2901953

Title: The structure of the human CD2 gene and its expression in transgenic mice.

PubMed ID: 2901953

DOI: 10.1002/j.1460-2075.1988.tb02995.x

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2444890

Title: Monoclonal antibody and ligand binding sites of the T cell erythrocyte receptor (CD2).

PubMed ID: 2444890

DOI: 10.1038/329842a0

PubMed ID: 1377404

Title: Overlapping but nonidentical binding sites on CD2 for CD58 and a second ligand CD59.

PubMed ID: 1377404

DOI: 10.1126/science.1377404

PubMed ID: 9857189

Title: A cdc15-like adaptor protein (CD2BP1) interacts with the CD2 cytoplasmic domain and regulates CD2-triggered adhesion.

PubMed ID: 9857189

DOI: 10.1093/emboj/17.24.7320

PubMed ID: 23006327

Title: Human immunodeficiency-causing mutation defines CD16 in spontaneous NK cell cytotoxicity.

PubMed ID: 23006327

DOI: 10.1172/jci64837

PubMed ID: 7994575

Title: Crystal structure of the extracellular region of the human cell adhesion molecule CD2 at 2.5 A resolution.

PubMed ID: 7994575

DOI: 10.1016/s0969-2126(94)00076-x

PubMed ID: 7915183

Title: Structure of the glycosylated adhesion domain of human T lymphocyte glycoprotein CD2.

PubMed ID: 7915183

DOI: 10.1016/0969-2126(93)90009-6

PubMed ID: 7544493

Title: Conformation and function of the N-linked glycan in the adhesion domain of human CD2.

PubMed ID: 7544493

DOI: 10.1126/science.7544493

PubMed ID: 10380930

Title: Structure of a heterophilic adhesion complex between the human CD2 and CD58 (LFA-3) counterreceptors.

PubMed ID: 10380930

DOI: 10.1016/s0092-8674(00)80790-4

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

Length: 351
Mass: 39448
Checksum: A03D853C3B618917
Sequence:

MSFPCKFVAS FLLIFNVSSK GAVSKEITNA LETWGALGQD INLDIPSFQM SDDIDDIKWE 
KTSDKKKIAQ FRKEKETFKE KDTYKLFKNG TLKIKHLKTD DQDIYKVSIY DTKGKNVLEK 
IFDLKIQERV SKPKISWTCI NTTLTCEVMN GTDPELNLYQ DGKHLKLSQR VITHKWTTSL 
SAKFKCTAGN KVSKESSVEP VSCPEKGLDI YLIIGICGGG SLLMVFVALL VFYITKRKKQ 
RSRRNDEELE TRAHRVATEE RGRKPHQIPA STPQNPATSQ HPPPPPGHRS QAPSHRPPPP 
GHRVQHQPQK RPPAPSGTQV HQQKGPPLPR PRVQPKPPHG AAENSLSPSS N

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: CD2

Associated with

Other Information

Exon-intron organization and sequence comparison of human and murine T11 (CD2) genes. PubMed ID: 2894031

Molecular cloning of the CD2 antigen, the T-cell erythrocyte receptor, by a rapid immunoselection procedure. PubMed ID: 2437578

Molecular cloning of the human T-lymphocyte surface CD2 (T11) antigen. PubMed ID: 3490670

Molecular cloning and expression of T11 cDNAs reveal a receptor-like structure on human T lymphocytes. PubMed ID: 2883656

The structure of the human CD2 gene and its expression in transgenic mice. PubMed ID: 2901953

The DNA sequence and biological annotation of human chromosome 1. PubMed ID: 16710414

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Monoclonal antibody and ligand binding sites of the T cell erythrocyte receptor (CD2). PubMed ID: 2444890

Overlapping but nonidentical binding sites on CD2 for CD58 and a second ligand CD59. PubMed ID: 1377404

A cdc15-like adaptor protein (CD2BP1) interacts with the CD2 cytoplasmic domain and regulates CD2-triggered adhesion. PubMed ID: 9857189

Human immunodeficiency-causing mutation defines CD16 in spontaneous NK cell cytotoxicity. PubMed ID: 23006327

Crystal structure of the extracellular region of the human cell adhesion molecule CD2 at 2.5 A resolution. PubMed ID: 7994575

Structure of the glycosylated adhesion domain of human T lymphocyte glycoprotein CD2. PubMed ID: 7915183

Conformation and function of the N-linked glycan in the adhesion domain of human CD2. PubMed ID: 7544493

Structure of a heterophilic adhesion complex between the human CD2 and CD58 (LFA-3) counterreceptors. PubMed ID: 10380930

The consensus coding sequences of human breast and colorectal cancers. PubMed ID: 16959974