Details for: HGS
Associated with
Other Information
Genular Protein ID: 182618730
Symbol: HGS_HUMAN
Name: Hepatocyte growth factor-regulated tyrosine kinase substrate
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 9407053
Title: Hrs is associated with STAM, a signal-transducing adaptor molecule. Its suppressive effect on cytokine-induced cell growth.
PubMed ID: 9407053
PubMed ID: 9630564
Title: Human Hrs, a tyrosine kinase substrate in growth factor-stimulated cells: cDNA cloning and mapping of the gene to chromosome 17.
PubMed ID: 9630564
PubMed ID: 10861283
Title: The neurofibromatosis 2 tumor suppressor protein interacts with hepatocyte growth factor-regulated tyrosine kinase substrate.
PubMed ID: 10861283
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 9252367
Title: Hrs, a tyrosine kinase substrate with a conserved double zinc finger domain, is localized to the cytoplasmic surface of early endosomes.
PubMed ID: 9252367
PubMed ID: 14602072
Title: The E3 ubiquitin ligase AIP4 mediates ubiquitination and sorting of the G protein-coupled receptor CXCR4.
PubMed ID: 14602072
PubMed ID: 12551915
Title: STAM and Hrs are subunits of a multivalent ubiquitin-binding complex on early endosomes.
PubMed ID: 12551915
PubMed ID: 12900394
Title: HIV Gag mimics the Tsg101-recruiting activity of the human Hrs protein.
PubMed ID: 12900394
PubMed ID: 15509564
Title: Identification of human VPS37C, a component of endosomal sorting complex required for transport-I important for viral budding.
PubMed ID: 15509564
PubMed ID: 16159959
Title: Ubiquilin recruits Eps15 into ubiquitin-rich cytoplasmic aggregates via a UIM-UBL interaction.
PubMed ID: 16159959
DOI: 10.1242/jcs.02571
PubMed ID: 15592455
Title: Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.
PubMed ID: 15592455
DOI: 10.1038/nbt1046
PubMed ID: 16964243
Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.
PubMed ID: 16964243
DOI: 10.1038/nbt1240
PubMed ID: 18675823
Title: Hypertonia-associated protein Trak1 is a novel regulator of endosome-to-lysosome trafficking.
PubMed ID: 18675823
PubMed ID: 15772161
Title: CART: an Hrs/actinin-4/BERP/myosin V protein complex required for efficient receptor recycling.
PubMed ID: 15772161
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 19413330
Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
PubMed ID: 19413330
DOI: 10.1021/ac9004309
PubMed ID: 19296456
Title: Membrane insertion of the FYVE domain is modulated by pH.
PubMed ID: 19296456
DOI: 10.1002/prot.22392
PubMed ID: 19608861
Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.
PubMed ID: 19608861
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 23166352
Title: Charcot-Marie-Tooth disease-linked protein SIMPLE functions with the ESCRT machinery in endosomal trafficking.
PubMed ID: 23166352
PubMed ID: 23236378
Title: Mammalian alpha arrestins link activated seven transmembrane receptors to Nedd4 family e3 ubiquitin ligases and interact with beta arrestins.
PubMed ID: 23236378
PubMed ID: 23208550
Title: Distinct roles for beta-arrestin2 and arrestin-domain-containing proteins in beta2 adrenergic receptor trafficking.
PubMed ID: 23208550
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 24790097
Title: The ubiquitin ligase deltex-3l regulates endosomal sorting of the G protein-coupled receptor CXCR4.
PubMed ID: 24790097
PubMed ID: 25588945
Title: LAPTM4B is a PtdIns(4,5)P2 effector that regulates EGFR signaling, lysosomal sorting, and degradation.
PubMed ID: 25588945
PubMed ID: 16462748
Title: Double-sided ubiquitin binding of Hrs-UIM in endosomal protein sorting.
PubMed ID: 16462748
DOI: 10.1038/nsmb1051
PubMed ID: 19278655
Title: Hybrid structural model of the complete human ESCRT-0 complex.
PubMed ID: 19278655
PubMed ID: 21070952
Title: Crystallographic and functional analysis of the ESCRT-I /HIV-1 Gag PTAP interaction.
PubMed ID: 21070952
PubMed ID: 18987736
Title: DNA sequencing of a cytogenetically normal acute myeloid leukaemia genome.
PubMed ID: 18987736
DOI: 10.1038/nature07485
Sequence Information:
- Length: 777
- Mass: 86192
- Checksum: DD64167A19DCF030
- Sequence:
MGRGSGTFER LLDKATSQLL LETDWESILQ ICDLIRQGDT QAKYAVNSIK KKVNDKNPHV ALYALEVMES VVKNCGQTVH DEVANKQTME ELKDLLKRQV EVNVRNKILY LIQAWAHAFR NEPKYKVVQD TYQIMKVEGH VFPEFKESDA MFAAERAPDW VDAEECHRCR VQFGVMTRKH HCRACGQIFC GKCSSKYSTI PKFGIEKEVR VCEPCYEQLN RKAEGKATST TELPPEYLTS PLSQQSQLPP KRDETALQEE EELQLALALS QSEAEEKERL RQKSTYTSYP KAEPMPSASS APPASSLYSS PVNSSAPLAE DIDPELARYL NRNYWEKKQE EARKSPTPSA PVPLTEPAAQ PGEGHAAPTN VVENPLPETD SQPIPPSGGP FSEPQFHNGE SEESHEQFLK ALQNAVTTFV NRMKSNHMRG RSITNDSAVL SLFQSINGMH PQLLELLNQL DERRLYYEGL QDKLAQIRDA RGALSALREE HREKLRRAAE EAERQRQIQL AQKLEIMRQK KQEYLEVQRQ LAIQRLQEQE KERQMRLEQQ KQTVQMRAQM PAFPLPYAQL QAMPAAGGVL YQPSGPASFP STFSPAGSVE GSPMHGVYMS QPAPAAGPYP SMPSTAADPS MVSAYMYPAG ATGAQAAPQA QAGPTASPAY SSYQPTPTAG YQNVASQAPQ SLPAISQPPQ SSTMGYMGSQ SVSMGYQPYN MQNLMTTLPS QDASLPPQQP YIAGQQPMYQ QMAPSGGPPQ QQPPVAQQPQ AQGPPAQGSE AQLISFD
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.