NEURL1 | ENSG00000107954 | NCBI 9148

Details for: NEURL1

Gene ID: 9148

Symbol: NEURL1

Ensembl ID: ENSG00000107954

Description: neuralized E3 ubiquitin protein ligase 1

Associated with

Activated notch1 transmits signal to the nucleus
(R-HSA-2122948)
Constitutive signaling by notch1 hd+pest domain mutants
(R-HSA-2894862)
Constitutive signaling by notch1 hd domain mutants
(R-HSA-2691232)
Constitutive signaling by notch1 pest domain mutants
(R-HSA-2644606)
Disease
(R-HSA-1643685)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
Notch2 activation and transmission of signal to the nucleus
(R-HSA-2979096)
Notch3 activation and transmission of signal to the nucleus
(R-HSA-9013507)
Signaling by notch
(R-HSA-157118)
Signaling by notch1
(R-HSA-1980143)
Signaling by notch1 hd+pest domain mutants in cancer
(R-HSA-2894858)
Signaling by notch1 hd domain mutants in cancer
(R-HSA-2691230)
Signaling by notch1 in cancer
(R-HSA-2644603)
Signaling by notch1 pest domain mutants in cancer
(R-HSA-2644602)
Signaling by notch2
(R-HSA-1980145)
Signaling by notch3
(R-HSA-9012852)
Signal transduction
(R-HSA-162582)
Apical dendrite
(GO:0097440)
Cellular response to amino acid stimulus
(GO:0071230)
Dendritic spine
(GO:0043197)
Lactation
(GO:0007595)
Metal ion binding
(GO:0046872)
Negative regulation of cell population proliferation
(GO:0008285)
Negative regulation of notch signaling pathway
(GO:0045746)
Nervous system development
(GO:0007399)
Notch signaling pathway
(GO:0007219)
Perikaryon
(GO:0043204)
Perinuclear region of cytoplasm
(GO:0048471)
Plasma membrane
(GO:0005886)
Positive regulation of apoptotic process
(GO:0043065)
Positive regulation of dendritic spine development
(GO:0060999)
Positive regulation of filopodium assembly
(GO:0051491)
Positive regulation of long-term neuronal synaptic plasticity
(GO:0048170)
Positive regulation of synapse maturation
(GO:0090129)
Postsynaptic density
(GO:0014069)
Protein binding
(GO:0005515)
Protein monoubiquitination
(GO:0006513)
Regulation of translation
(GO:0006417)
Skeletal muscle tissue development
(GO:0007519)
Sperm axoneme assembly
(GO:0007288)
Translation factor activity, non-nucleic acid binding
(GO:0045183)
Ubiquitin-protein transferase activity
(GO:0004842)
Ubiquitin protein ligase activity
(GO:0061630)

Other Information

Proteins

E3 ubiquitin-protein ligase NEURL1
B4DS86_HUMAN

Genular Protein ID: 360152338

Symbol: NEUL1_HUMAN

Name: E3 ubiquitin-protein ligase NEURL1

UniProtKB Accession Codes:

O76050 Q5TDR2 Q5TDR3 Q8TAN0 Q9H463

Database IDs:

Citations:

PubMed ID: 9519875

Title: Identification of a human homolog of the Drosophila neuralized gene within the 10q25.1 malignant astrocytoma deletion region.

PubMed ID: 9519875

DOI: 10.1038/sj.onc.1201618

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11585928

Title: Isolation of a murine homologue of the Drosophila neuralized gene, a gene required for axonemal integrity in spermatozoa and terminal maturation of the mammary gland.

PubMed ID: 11585928

DOI: 10.1128/mcb.21.21.7481-7494.2001

PubMed ID: 20847082

Title: Neuralized1 causes apoptosis and downregulates Notch target genes in medulloblastoma.

PubMed ID: 20847082

DOI: 10.1093/neuonc/noq091

Sequence Information:

Length: 574
Mass: 61860
Checksum: D9699F08F7443EBB
Sequence:

MGNNFSSIPS LPRGNPSRAP RGHPQNLKDS IGGPFPVTSH RCHHKQKHCP AVLPSGGLPA 
TPLLFHPHTK GSQILMDLSH KAVKRQASFC NAITFSNRPV LIYEQVRLKI TKKQCCWSGA 
LRLGFTSKDP SRIHPDSLPK YACPDLVSQS GFWAKALPEE FANEGNIIAF WVDKKGRVFH 
RINDSAVMLF FSGVRTADPL WALVDVYGLT RGVQLLDSEL VLPDCLRPRS FTALRRPSLR 
READDARLSV SLCDLNVPGA DGDEAAPAAG CPIPQNSLNS QHSRALPAQL DGDLRFHALR 
AGAHVRILDE QTVARVEHGR DERALVFTSR PVRVAETIFV KVTRSGGARP GALSFGVTTC 
DPGTLRPADL PFSPEALVDR KEFWAVCRVP GPLHSGDILG LVVNADGELH LSHNGAAAGM 
QLCVDASQPL WMLFGLHGTI TQIRILGSTI LAERGIPSLP CSPASTPTSP SALGSRLSDP 
LLSTCSSGPL GSSAGGTAPN SPVSLPESPV TPGLGQWSDE CTICYEHAVD TVIYTCGHMC 
LCYACGLRLK KALHACCPIC RRPIKDIIKT YRSS

Genular Protein ID: 160677883

Symbol: B4DS86_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DS86

Database IDs:

Sequence Information:

Length: 155
Mass: 16336
Checksum: A929260DE2C63E7C
Sequence:

MQLCVDASQP LWMLFGLHGT ITQIRILGST ILAERGIPSL PCSPASTPTS PSALGSRLSD 
PLLSTCSSGP LGSSAGGTAP NSPVSLPESP VTPGLGQWSD ECTICYEHAV DTVIYTCGHM 
CLCYACGLRL KKALHACCPI CRRPIKDIIK TYRSS

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: NEURL1

Associated with

Other Information

Identification of a human homolog of the Drosophila neuralized gene within the 10q25.1 malignant astrocytoma deletion region. PubMed ID: 9519875

The DNA sequence and comparative analysis of human chromosome 10. PubMed ID: 15164054

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334