Details for: CD3D

Gene ID: 915

Symbol: CD3D

Ensembl ID: ENSG00000167286

Description: CD3 delta subunit of T-cell receptor complex

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 181.7478
    Cell Significance Index: -28.2700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 123.8747
    Cell Significance Index: -31.4200
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 97.1726
    Cell Significance Index: -40.0300
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 81.9036
    Cell Significance Index: -42.1300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 22.3609
    Cell Significance Index: -27.5700
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 8.7753
    Cell Significance Index: 257.7200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 8.3965
    Cell Significance Index: 295.0400
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 7.9801
    Cell Significance Index: -31.4900
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 7.7748
    Cell Significance Index: -23.8800
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 3.8160
    Cell Significance Index: 11.6300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 3.4912
    Cell Significance Index: 87.2700
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 3.1944
    Cell Significance Index: 32.0300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 3.0552
    Cell Significance Index: 88.0300
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 2.9199
    Cell Significance Index: 45.1800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.3450
    Cell Significance Index: 60.9700
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 1.2801
    Cell Significance Index: 6.9800
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.1507
    Cell Significance Index: 23.8700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.6569
    Cell Significance Index: 64.9900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6281
    Cell Significance Index: 567.1500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.2978
    Cell Significance Index: 34.7100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2690
    Cell Significance Index: 43.7600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1063
    Cell Significance Index: 20.2300
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 0.0983
    Cell Significance Index: 0.8600
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 0.0264
    Cell Significance Index: 0.2100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.0202
    Cell Significance Index: 2.1900
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: -0.0029
    Cell Significance Index: -0.0300
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0141
    Cell Significance Index: -0.3600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0160
    Cell Significance Index: -0.8100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0172
    Cell Significance Index: -32.4400
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0191
    Cell Significance Index: -0.3300
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0275
    Cell Significance Index: -1.1200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0304
    Cell Significance Index: -23.0300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0412
    Cell Significance Index: -30.5300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0482
    Cell Significance Index: -21.3000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0541
    Cell Significance Index: -30.5100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0574
    Cell Significance Index: -42.0900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0900
    Cell Significance Index: -40.8700
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.1005
    Cell Significance Index: -4.3700
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.1371
    Cell Significance Index: -1.3000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.1466
    Cell Significance Index: -29.1000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1519
    Cell Significance Index: -17.9100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.1613
    Cell Significance Index: -32.3500
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.1700
    Cell Significance Index: -1.5900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.1706
    Cell Significance Index: -11.8000
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1708
    Cell Significance Index: -2.9300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1740
    Cell Significance Index: -10.6700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1890
    Cell Significance Index: -32.2800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.1990
    Cell Significance Index: -35.8800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.2084
    Cell Significance Index: -26.7200
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.2133
    Cell Significance Index: -3.1200
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.2157
    Cell Significance Index: -1.8200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.2527
    Cell Significance Index: -34.7000
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.2558
    Cell Significance Index: -4.3500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2710
    Cell Significance Index: -31.0500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.2789
    Cell Significance Index: -34.2900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2817
    Cell Significance Index: -40.9500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2950
    Cell Significance Index: -13.8700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.2954
    Cell Significance Index: -38.1600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.3019
    Cell Significance Index: -21.3500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.3302
    Cell Significance Index: -33.7300
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.3735
    Cell Significance Index: -4.4100
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.3793
    Cell Significance Index: -5.1600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.4376
    Cell Significance Index: -9.4800
  • Cell Name: mature T cell (CL0002419)
    Fold Change: -0.4433
    Cell Significance Index: -3.1900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.4726
    Cell Significance Index: -30.4900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.4803
    Cell Significance Index: -36.8600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.4942
    Cell Significance Index: -29.6700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.4953
    Cell Significance Index: -31.2200
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.4991
    Cell Significance Index: -7.0100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.5179
    Cell Significance Index: -38.6000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.5317
    Cell Significance Index: -42.1100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.5715
    Cell Significance Index: -18.3100
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: -0.6371
    Cell Significance Index: -4.7400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.6394
    Cell Significance Index: -17.8700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.6465
    Cell Significance Index: -39.7400
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: -0.6526
    Cell Significance Index: -6.0400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.6710
    Cell Significance Index: -14.2900
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: -0.6985
    Cell Significance Index: -5.9500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.7196
    Cell Significance Index: -37.3800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.7468
    Cell Significance Index: -34.8200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.8213
    Cell Significance Index: -21.9700
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.8295
    Cell Significance Index: -12.5000
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.8340
    Cell Significance Index: -8.6500
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.8361
    Cell Significance Index: -11.8800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.8817
    Cell Significance Index: -39.0000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.9749
    Cell Significance Index: -31.0500
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.9874
    Cell Significance Index: -9.4900
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.9886
    Cell Significance Index: -36.2900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -1.0299
    Cell Significance Index: -39.0000
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -1.0305
    Cell Significance Index: -10.4100
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: -1.0690
    Cell Significance Index: -10.4700
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: -1.0989
    Cell Significance Index: -9.9200
  • Cell Name: monocyte-derived dendritic cell (CL0011031)
    Fold Change: -1.1176
    Cell Significance Index: -19.2000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -1.1241
    Cell Significance Index: -30.1200
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -1.1329
    Cell Significance Index: -32.3300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -1.1333
    Cell Significance Index: -30.2600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -1.2308
    Cell Significance Index: -42.7700
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -1.2464
    Cell Significance Index: -31.0900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -1.2520
    Cell Significance Index: -32.9200
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: -1.3234
    Cell Significance Index: -10.7900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** CD3D exhibits several key characteristics that are essential for its function. These include: * **Transmembrane localization**: CD3D is a transmembrane glycoprotein, meaning that it spans the cell membrane and has both extracellular and intracellular domains. * **Heterodimerization**: CD3D can form heterodimers with other CD3 subunits, which is necessary for the proper functioning of the TCR complex. * **Phosphorylation**: CD3D undergoes phosphorylation upon T-cell activation, which is essential for the activation of downstream signaling pathways. * **Cell surface expression**: CD3D is expressed on the surface of mature T cells, where it plays a crucial role in T-cell activation and proliferation. **Pathways and Functions** CD3D is involved in several key signaling pathways that are essential for T-cell function. These include: * **T-cell receptor signaling pathway**: CD3D plays a crucial role in the TCR signaling pathway, which involves the activation of downstream signaling molecules such as Zap-70 and NF-AT. * **Costimulation by the CD28 family**: CD3D interacts with the CD28 family of costimulatory molecules, which provides additional signals necessary for T-cell activation and proliferation. * **Phosphorylation of CD3 and TCR zeta chains**: CD3D undergoes phosphorylation upon T-cell activation, which activates downstream signaling pathways and promotes T-cell proliferation. * **Generation of second messenger molecules**: CD3D generates second messenger molecules such as calcium and inositol trisphosphate, which are essential for T-cell activation and proliferation. **Clinical Significance** CD3D has significant clinical implications, particularly in the context of T-cell-related disorders. Some of the key clinical implications of CD3D include: * **T-cell leukemia**: Mutations in the CD3D gene have been implicated in T-cell leukemia, a type of blood cancer that arises from malignant T cells. * **Autoimmune disorders**: CD3D has been implicated in autoimmune disorders such as multiple sclerosis and type 1 diabetes, where T-cell dysfunction and dysregulation play a key role. * **Immunotherapy**: CD3D has been explored as a target for immunotherapy, where it can be targeted to selectively kill malignant T cells. In conclusion, CD3D is a critical component of the T-cell receptor complex, playing a pivotal role in T-cell activation and proliferation. Its dysregulation can have significant clinical implications, particularly in the context of T-cell-related disorders. Further research is necessary to fully elucidate the complex functions of CD3D and its role in the adaptive immune response.

Genular Protein ID: 960396967

Symbol: CD3D_HUMAN

Name: T-cell surface glycoprotein CD3 delta chain

UniProtKB Accession Codes:

P04234 A8MVP6

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 ComplexPortal 2 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 DrugBank 7 DrugCentral 1 ELM 1 EMBL 8 EMDB 14 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 13 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 15 PDBsum 15 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 8 RefSeq 3 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2939461

Title: Exon/intron organization of the genes coding for the delta chains of the human and murine T-cell receptor/T3 complex.

PubMed ID: 2939461

DOI: 10.1073/pnas.83.9.2944

PubMed ID: 6095101

Title: Isolation of cDNA clones encoding the 20K T3 glycoprotein of human T-cell receptor complex.

PubMed ID: 6095101

DOI: 10.1038/312413a0

PubMed ID: 3488209

Title: T3 delta pre-mRNA is transcribed from a non-TATA promoter and is alternatively spliced in human T cells.

PubMed ID: 3488209

DOI: 10.1002/j.1460-2075.1986.tb04353.x

PubMed ID: 15028279

Title: PCR isolation and cloning of novel splice variant mRNAs from known drug target genes.

PubMed ID: 15028279

DOI: 10.1016/j.ygeno.2003.09.023

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2540970

Title: Dephosphorylation of the human T lymphocyte CD3 antigen.

PubMed ID: 2540970

DOI: 10.1111/j.1432-1033.1989.tb14693.x

PubMed ID: 2470098

Title: The CD4 and CD8 antigens are coupled to a protein-tyrosine kinase (p56lck) that phosphorylates the CD3 complex.

PubMed ID: 2470098

DOI: 10.1073/pnas.86.9.3277

PubMed ID: 1828760

Title: Pairwise, cooperative and inhibitory interactions describe the assembly and probable structure of the T-cell antigen receptor.

PubMed ID: 1828760

DOI: 10.1002/j.1460-2075.1991.tb07687.x

PubMed ID: 1396954

Title: Biochemical evidence of the physical association of the majority of CD3 delta chains with the accessory/co-receptor molecules CD4 and CD8 on nonactivated T lymphocytes.

PubMed ID: 1396954

DOI: 10.1002/eji.1830221002

PubMed ID: 1372642

Title: Ontogeny of human natural killer (NK) cells: fetal NK cells mediate cytolytic function and express cytoplasmic CD3 epsilon,delta proteins.

PubMed ID: 1372642

DOI: 10.1084/jem.175.4.1055

PubMed ID: 12507424

Title: The organizing principle in the formation of the T cell receptor-CD3 complex.

PubMed ID: 12507424

DOI: 10.1016/s0092-8674(02)01194-7

PubMed ID: 12215456

Title: CD3 delta establishes a functional link between the T cell receptor and CD8.

PubMed ID: 12215456

DOI: 10.1074/jbc.m208119200

PubMed ID: 14602880

Title: Effect of CD3delta deficiency on maturation of alpha/beta and gamma/delta T-cell lineages in severe combined immunodeficiency.

PubMed ID: 14602880

DOI: 10.1056/nejmoa031178

PubMed ID: 12522270

Title: Profiling of tyrosine phosphorylation pathways in human cells using mass spectrometry.

PubMed ID: 12522270

DOI: 10.1073/pnas.2436191100

PubMed ID: 15144186

Title: Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry.

PubMed ID: 15144186

DOI: 10.1021/ac035352d

PubMed ID: 15546002

Title: Severe combined immunodeficiency caused by deficiency in either the delta or the epsilon subunit of CD3.

PubMed ID: 15546002

DOI: 10.1172/jci22588

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 21883749

Title: Genotype, phenotype, and outcomes of nine patients with T-B+NK+ SCID.

PubMed ID: 21883749

DOI: 10.1111/j.1399-3046.2011.01563.x

PubMed ID: 15534202

Title: Crystal structure of a human CD3-epsilon/delta dimer in complex with a UCHT1 single-chain antibody fragment.

PubMed ID: 15534202

DOI: 10.1073/pnas.0407359101

Sequence Information:

  • Length: 171
  • Mass: 18930
  • Checksum: 6C1F248150186D21
  • Sequence:
    • MEHSTFLSGL VLATLLSQVS PFKIPIEELE DRVFVNCNTS ITWVEGTVGT LLSDITRLDL 
GKRILDPRGI YRCNGTDIYK DKESTVQVHY RMCQSCVELD PATVAGIIVT DVIATLLLAL 
GVFCFAGHET GRLSGAADTQ ALLRNDQVYQ PLRDRDDAQY SHLGGNWARN K

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.