CD3D | ENSG00000167286 | NCBI 915

Details for: CD3D

Gene ID: 915

Symbol: CD3D

Ensembl ID: ENSG00000167286

Description: CD3 delta subunit of T-cell receptor complex

Associated with

Adaptive immune system
(R-HSA-1280218)
Cargo recognition for clathrin-mediated endocytosis
(R-HSA-8856825)
Clathrin-mediated endocytosis
(R-HSA-8856828)
Costimulation by the cd28 family
(R-HSA-388841)
Downstream tcr signaling
(R-HSA-202424)
Generation of second messenger molecules
(R-HSA-202433)
Immune system
(R-HSA-168256)
Immunoregulatory interactions between a lymphoid and a non-lymphoid cell
(R-HSA-198933)
Membrane trafficking
(R-HSA-199991)
Pd-1 signaling
(R-HSA-389948)
Phosphorylation of cd3 and tcr zeta chains
(R-HSA-202427)
Tcr signaling
(R-HSA-202403)
Translocation of zap-70 to immunological synapse
(R-HSA-202430)
Vesicle-mediated transport
(R-HSA-5653656)
Adaptive immune response
(GO:0002250)
Alpha-beta t cell activation
(GO:0046631)
Alpha-beta t cell receptor complex
(GO:0042105)
Cell surface receptor signaling pathway
(GO:0007166)
Clathrin-coated endocytic vesicle membrane
(GO:0030669)
Cytoplasm
(GO:0005737)
External side of plasma membrane
(GO:0009897)
Identical protein binding
(GO:0042802)
Plasma membrane
(GO:0005886)
Positive thymic t cell selection
(GO:0045059)
Protein binding
(GO:0005515)
T cell receptor complex
(GO:0042101)
T cell receptor signaling pathway
(GO:0050852)
Transmembrane signaling receptor activity
(GO:0004888)

Other Information

Proteins

T-cell surface glycoprotein CD3 delta chain

Genular Protein ID: 960396967

Symbol: CD3D_HUMAN

Name: T-cell surface glycoprotein CD3 delta chain

UniProtKB Accession Codes:

P04234 A8MVP6

Database IDs:

Citations:

PubMed ID: 2939461

Title: Exon/intron organization of the genes coding for the delta chains of the human and murine T-cell receptor/T3 complex.

PubMed ID: 2939461

DOI: 10.1073/pnas.83.9.2944

PubMed ID: 6095101

Title: Isolation of cDNA clones encoding the 20K T3 glycoprotein of human T-cell receptor complex.

PubMed ID: 6095101

DOI: 10.1038/312413a0

PubMed ID: 3488209

Title: T3 delta pre-mRNA is transcribed from a non-TATA promoter and is alternatively spliced in human T cells.

PubMed ID: 3488209

DOI: 10.1002/j.1460-2075.1986.tb04353.x

PubMed ID: 15028279

Title: PCR isolation and cloning of novel splice variant mRNAs from known drug target genes.

PubMed ID: 15028279

DOI: 10.1016/j.ygeno.2003.09.023

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2540970

Title: Dephosphorylation of the human T lymphocyte CD3 antigen.

PubMed ID: 2540970

DOI: 10.1111/j.1432-1033.1989.tb14693.x

PubMed ID: 2470098

Title: The CD4 and CD8 antigens are coupled to a protein-tyrosine kinase (p56lck) that phosphorylates the CD3 complex.

PubMed ID: 2470098

DOI: 10.1073/pnas.86.9.3277

PubMed ID: 1828760

Title: Pairwise, cooperative and inhibitory interactions describe the assembly and probable structure of the T-cell antigen receptor.

PubMed ID: 1828760

DOI: 10.1002/j.1460-2075.1991.tb07687.x

PubMed ID: 1396954

Title: Biochemical evidence of the physical association of the majority of CD3 delta chains with the accessory/co-receptor molecules CD4 and CD8 on nonactivated T lymphocytes.

PubMed ID: 1396954

DOI: 10.1002/eji.1830221002

PubMed ID: 1372642

Title: Ontogeny of human natural killer (NK) cells: fetal NK cells mediate cytolytic function and express cytoplasmic CD3 epsilon,delta proteins.

PubMed ID: 1372642

DOI: 10.1084/jem.175.4.1055

PubMed ID: 12507424

Title: The organizing principle in the formation of the T cell receptor-CD3 complex.

PubMed ID: 12507424

DOI: 10.1016/s0092-8674(02)01194-7

PubMed ID: 12215456

Title: CD3 delta establishes a functional link between the T cell receptor and CD8.

PubMed ID: 12215456

DOI: 10.1074/jbc.m208119200

PubMed ID: 14602880

Title: Effect of CD3delta deficiency on maturation of alpha/beta and gamma/delta T-cell lineages in severe combined immunodeficiency.

PubMed ID: 14602880

DOI: 10.1056/nejmoa031178

PubMed ID: 12522270

Title: Profiling of tyrosine phosphorylation pathways in human cells using mass spectrometry.

PubMed ID: 12522270

DOI: 10.1073/pnas.2436191100

PubMed ID: 15144186

Title: Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry.

PubMed ID: 15144186

DOI: 10.1021/ac035352d

PubMed ID: 15546002

Title: Severe combined immunodeficiency caused by deficiency in either the delta or the epsilon subunit of CD3.

PubMed ID: 15546002

DOI: 10.1172/jci22588

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 21883749

Title: Genotype, phenotype, and outcomes of nine patients with T-B+NK+ SCID.

PubMed ID: 21883749

DOI: 10.1111/j.1399-3046.2011.01563.x

PubMed ID: 15534202

Title: Crystal structure of a human CD3-epsilon/delta dimer in complex with a UCHT1 single-chain antibody fragment.

PubMed ID: 15534202

DOI: 10.1073/pnas.0407359101

Sequence Information:

Length: 171
Mass: 18930
Checksum: 6C1F248150186D21
Sequence:

MEHSTFLSGL VLATLLSQVS PFKIPIEELE DRVFVNCNTS ITWVEGTVGT LLSDITRLDL 
GKRILDPRGI YRCNGTDIYK DKESTVQVHY RMCQSCVELD PATVAGIIVT DVIATLLLAL 
GVFCFAGHET GRLSGAADTQ ALLRNDQVYQ PLRDRDDAQY SHLGGNWARN K

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: CD3D

Associated with

Other Information

Exon/intron organization of the genes coding for the delta chains of the human and murine T-cell receptor/T3 complex. PubMed ID: 2939461

Isolation of cDNA clones encoding the 20K T3 glycoprotein of human T-cell receptor complex. PubMed ID: 6095101

T3 delta pre-mRNA is transcribed from a non-TATA promoter and is alternatively spliced in human T cells. PubMed ID: 3488209

PCR isolation and cloning of novel splice variant mRNAs from known drug target genes. PubMed ID: 15028279

Human chromosome 11 DNA sequence and analysis including novel gene identification. PubMed ID: 16554811

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Dephosphorylation of the human T lymphocyte CD3 antigen. PubMed ID: 2540970

The CD4 and CD8 antigens are coupled to a protein-tyrosine kinase (p56lck) that phosphorylates the CD3 complex. PubMed ID: 2470098

Pairwise, cooperative and inhibitory interactions describe the assembly and probable structure of the T-cell antigen receptor. PubMed ID: 1828760

Biochemical evidence of the physical association of the majority of CD3 delta chains with the accessory/co-receptor molecules CD4 and CD8 on nonactivated T lymphocytes. PubMed ID: 1396954

Ontogeny of human natural killer (NK) cells: fetal NK cells mediate cytolytic function and express cytoplasmic CD3 epsilon,delta proteins. PubMed ID: 1372642

The organizing principle in the formation of the T cell receptor-CD3 complex. PubMed ID: 12507424

CD3 delta establishes a functional link between the T cell receptor and CD8. PubMed ID: 12215456

Effect of CD3delta deficiency on maturation of alpha/beta and gamma/delta T-cell lineages in severe combined immunodeficiency. PubMed ID: 14602880

Profiling of tyrosine phosphorylation pathways in human cells using mass spectrometry. PubMed ID: 12522270

Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry. PubMed ID: 15144186

Severe combined immunodeficiency caused by deficiency in either the delta or the epsilon subunit of CD3. PubMed ID: 15546002

Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. PubMed ID: 19690332

Genotype, phenotype, and outcomes of nine patients with T-B+NK+ SCID. PubMed ID: 21883749

Crystal structure of a human CD3-epsilon/delta dimer in complex with a UCHT1 single-chain antibody fragment. PubMed ID: 15534202