Associated with
Other Information
Genular Protein ID: 92780730
Symbol: EXO1_HUMAN
Name: Exonuclease 1
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 9788596
Title: Human exonuclease I interacts with the mismatch repair protein hMSH2.
PubMed ID: 9788596
PubMed ID: 9823303
Title: Identification of a human gene encoding a homologue of Saccharomyces cerevisiae EXO1, an exonuclease implicated in mismatch repair and recombination.
PubMed ID: 9823303
PubMed ID: 9685493
Title: Hex1: a new human Rad2 nuclease family member with homology to yeast exonuclease 1.
PubMed ID: 9685493
PubMed ID: 10364235
Title: Human exonuclease 1 functionally complements its yeast homologues in DNA recombination, RNA primer removal, and mutation avoidance.
PubMed ID: 10364235
PubMed ID: 16710414
Title: The DNA sequence and biological annotation of human chromosome 1.
PubMed ID: 16710414
DOI: 10.1038/nature04727
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 17974005
Title: The full-ORF clone resource of the German cDNA consortium.
PubMed ID: 17974005
PubMed ID: 10608837
Title: The RAD2 domain of human exonuclease 1 exhibits 5' to 3' exonuclease and flap structure-specific endonuclease activities.
PubMed ID: 10608837
PubMed ID: 10856833
Title: Identification of factors interacting with hMSH2 in the fetal liver utilizing the yeast two-hybrid system. In vivo interaction through the C-terminal domains of hEXO1 and hMSH2 and comparative expression analysis.
PubMed ID: 10856833
PubMed ID: 11427529
Title: The interaction of DNA mismatch repair proteins with human exonuclease I.
PubMed ID: 11427529
PubMed ID: 11429708
Title: HNPCC mutations in the human DNA mismatch repair gene hMLH1 influence assembly of hMutLalpha and hMLH1-hEXO1 complexes.
PubMed ID: 11429708
PubMed ID: 12414623
Title: Functional alterations of human exonuclease 1 mutants identified in atypical hereditary nonpolyposis colorectal cancer syndrome.
PubMed ID: 12414623
PubMed ID: 11809771
Title: Human exonuclease I is required for 5' and 3' mismatch repair.
PubMed ID: 11809771
PubMed ID: 11842105
PubMed ID: 14623461
Title: Germline deletions of EXO1 do not cause colorectal tumors and lesions which are null for EXO1 do not have microsatellite instability.
PubMed ID: 14623461
PubMed ID: 12704184
Title: The exonucleolytic and endonucleolytic cleavage activities of human exonuclease 1 are stimulated by an interaction with the carboxyl-terminal region of the Werner syndrome protein.
PubMed ID: 12704184
PubMed ID: 14636568
Title: Mechanism of 5'-directed excision in human mismatch repair.
PubMed ID: 14636568
PubMed ID: 15225546
Title: A defined human system that supports bidirectional mismatch-provoked excision.
PubMed ID: 15225546
PubMed ID: 14676842
Title: Characterization of human exonuclease 1 in complex with mismatch repair proteins, subcellular localization and association with PCNA.
PubMed ID: 14676842
PubMed ID: 16143102
Title: Reconstitution of 5'-directed human mismatch repair in a purified system.
PubMed ID: 16143102
PubMed ID: 15886194
Title: RECQ1 helicase interacts with human mismatch repair factors that regulate genetic recombination.
PubMed ID: 15886194
PubMed ID: 17426132
Title: Nuclear localization of human DNA mismatch repair protein exonuclease 1 (hEXO1).
PubMed ID: 17426132
DOI: 10.1093/nar/gkl1166
PubMed ID: 17525332
Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.
PubMed ID: 17525332
PubMed ID: 18048416
Title: ATR-dependent pathways control hEXO1 stability in response to stalled forks.
PubMed ID: 18048416
DOI: 10.1093/nar/gkm1052
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 19413330
Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
PubMed ID: 19413330
DOI: 10.1021/ac9004309
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 34552057
Title: ZGRF1 promotes end resection of DNA homologous recombination via forming complex with BRCA1/EXO1.
PubMed ID: 34552057
PubMed ID: 36400755
PubMed ID: 11375940
Title: Germline mutations of EXO1 gene in patients with hereditary nonpolyposis colorectal cancer (HNPCC) and atypical HNPCC forms.
PubMed ID: 11375940
PubMed ID: 12517792
Title: EXO1 variants occur commonly in normal population: evidence against a role in hereditary nonpolyposis colorectal cancer.
PubMed ID: 12517792
PubMed ID: 14756672
Title: Hereditary non-polyposis colorectal cancer and the role of hPMS2 and hEXO1 mutations.
PubMed ID: 14756672
PubMed ID: 15550454
Title: Single nucleotide polymorphisms in the EXO1 gene and risk of colorectal cancer in a Japanese population.
PubMed ID: 15550454
PubMed ID: 25860647
Title: A novel POLE mutation associated with cancers of colon, pancreas, ovaries and small intestine.
PubMed ID: 25860647
Sequence Information:
- Length: 846
- Mass: 94103
- Checksum: 850BC21CA9790D08
- Sequence:
MGIQGLLQFI KEASEPIHVR KYKGQVVAVD TYCWLHKGAI ACAEKLAKGE PTDRYVGFCM KFVNMLLSHG IKPILVFDGC TLPSKKEVER SRRERRQANL LKGKQLLREG KVSEARECFT RSINITHAMA HKVIKAARSQ GVDCLVAPYE ADAQLAYLNK AGIVQAIITE DSDLLAFGCK KVILKMDQFG NGLEIDQARL GMCRQLGDVF TEEKFRYMCI LSGCDYLSSL RGIGLAKACK VLRLANNPDI VKVIKKIGHY LKMNITVPED YINGFIRANN TFLYQLVFDP IKRKLIPLNA YEDDVDPETL SYAGQYVDDS IALQIALGNK DINTFEQIDD YNPDTAMPAH SRSHSWDDKT CQKSANVSSI WHRNYSPRPE SGTVSDAPQL KENPSTVGVE RVISTKGLNL PRKSSIVKRP RSAELSEDDL LSQYSLSFTK KTKKNSSEGN KSLSFSEVFV PDLVNGPTNK KSVSTPPRTR NKFATFLQRK NEESGAVVVP GTRSRFFCSS DSTDCVSNKV SIQPLDETAV TDKENNLHES EYGDQEGKRL VDTDVARNSS DDIPNNHIPG DHIPDKATVF TDEESYSFES SKFTRTISPP TLGTLRSCFS WSGGLGDFSR TPSPSPSTAL QQFRRKSDSP TSLPENNMSD VSQLKSEESS DDESHPLREE ACSSQSQESG EFSLQSSNAS KLSQCSSKDS DSEESDCNIK LLDSQSDQTS KLRLSHFSKK DTPLRNKVPG LYKSSSADSL STTKIKPLGP ARASGLSKKP ASIQKRKHHN AENKPGLQIK LNELWKNFGF KKDSEKLPPC KKPLSPVRDN IQLTPEAEED IFNKPECGRV QRAIFQ
Genular Protein ID: 3068586674
Symbol: A8K5H6_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Sequence Information:
- Length: 845
- Mass: 93900
- Checksum: 4A8AE195CD431318
- Sequence:
MGIQGLLQFI KEASEPIHVR KYKGQVVAVD TYCWLHKGAI ACAEKLAKGE PTDRYVGFCM KFVNMLLSHG IKPILVFDGC TLPSKKEVER SRRERRQANL LKGKQLLREG KVSEARECFT RSINITHAMA HKVIKAARSQ GVDCLVAPYE ADAQLAYLNK AGIVQAIITE DSDLLAFGCK KVILKMDQFG NGLEIDQARL GMCRQLGDVF TEEKFRYMCI LSGCDYLSSL RGIGLAKACK VLRLANNPDI VKVIKKIGHY LKMNITVPED YINGFIRANN TFLYQLVFDP IKRKLIPLNA YEDDVDPETL SYAGQYVGDS IALQIALGNK DINTFEQIDD YNPDTAMPAH SRSRSWDDKT CQKSANVSSI WHRNYSPRPE SGTVSDAPQL KENPSTVGVE RVISTKGLNL PRKSSIVKRP RSELSEDDLL SQYSLSFTKK TKKNSSEGNK SLSFSEMFVP DLVNGPTNKK SVSTPPRTRN KFATFLQRKN EESGAVVVPG TRSRFFCSSD STDCVSNKVS IQPLDETAVT DKENNLHESE YGDQEGKRLV DTDVARNSSD DIPNNHIPGD HIPDKATVFT DEESYSFESS KFTRTISPPT LGTLRSCFSW SGGLGDFSRT PSPSPSTALQ QFRRKSDSPT SLPENNMSDV SQLKSEESSD DESHPLREGA CSSQSQESGE FSLQSSNASK LSQCSSKDSD SEESDCNIKL LDSQSDQTSK LCLSHFSKKD TPLRNKVPGL YKSSSADSLS TTKIKPLGPA RASGLSKKPA SIQKRKHHNA ENKPGLQIKL NELWKNFGFK KDSEKLPPCK KPLSPVRDNI QLTPEAEEDI FNKPECGRVQ RAIFQ
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.