Details for: PCSK7

Gene ID: 9159

Symbol: PCSK7

Ensembl ID: ENSG00000160613

Description: proprotein convertase subtilisin/kexin type 7

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 2.28
    Marker Score: 1,376
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 2.18
    Marker Score: 772
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 2.06
    Marker Score: 890
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 2.05
    Marker Score: 2,024
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 2.01
    Marker Score: 1,879
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 1.89
    Marker Score: 5,220
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 1.79
    Marker Score: 1,929
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 1.72
    Marker Score: 1,446
  • Cell Name: CD56-positive, CD161-positive immature natural killer cell, human (CL0002338)
    Fold Change: 1.71
    Marker Score: 563
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 1.68
    Marker Score: 428
  • Cell Name: memory regulatory T cell (CL0002678)
    Fold Change: 1.68
    Marker Score: 586
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 1.64
    Marker Score: 5,841
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.61
    Marker Score: 98,981
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 1.61
    Marker Score: 3,528
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 1.59
    Marker Score: 4,652
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 1.59
    Marker Score: 10,134
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 1.55
    Marker Score: 4,349
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.54
    Marker Score: 6,651
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 1.54
    Marker Score: 4,865
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.54
    Marker Score: 14,606
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 1.54
    Marker Score: 4,824
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 1.52
    Marker Score: 738
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.52
    Marker Score: 14,263
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 1.51
    Marker Score: 818
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.51
    Marker Score: 55,616
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.51
    Marker Score: 15,567
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 1.5
    Marker Score: 79,539
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.5
    Marker Score: 12,868
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 1.49
    Marker Score: 1,132
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 1.49
    Marker Score: 7,161
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 1.47
    Marker Score: 514
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 1.47
    Marker Score: 732
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 1.46
    Marker Score: 855
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 1.46
    Marker Score: 553
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 1.46
    Marker Score: 2,500
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 1.45
    Marker Score: 14,349
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.44
    Marker Score: 5,883
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 1.43
    Marker Score: 406
  • Cell Name: CD8-alpha alpha positive, gamma-delta intraepithelial T cell (CL0000802)
    Fold Change: 1.43
    Marker Score: 466
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 1.43
    Marker Score: 443
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 1.41
    Marker Score: 414
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.41
    Marker Score: 2,177
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 1.4
    Marker Score: 1,016
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 1.4
    Marker Score: 31,283
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.38
    Marker Score: 29,404
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.38
    Marker Score: 1,520
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 1.37
    Marker Score: 693
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.37
    Marker Score: 327
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 1.35
    Marker Score: 1,021
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 1.34
    Marker Score: 1,462
  • Cell Name: CD4-positive, CD25-positive, alpha-beta regulatory T cell (CL0000792)
    Fold Change: 1.34
    Marker Score: 355
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 1.34
    Marker Score: 545
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 1.34
    Marker Score: 3,145
  • Cell Name: mesenchymal lymphangioblast (CL0005021)
    Fold Change: 1.33
    Marker Score: 298
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 1.33
    Marker Score: 502
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.32
    Marker Score: 50,181
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 1.31
    Marker Score: 2,205
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 1.3
    Marker Score: 814
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 1.3
    Marker Score: 2,329
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.3
    Marker Score: 5,036
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 1.3
    Marker Score: 1,161
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: 1.3
    Marker Score: 666
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.29
    Marker Score: 25,656
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 1.29
    Marker Score: 848
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.28
    Marker Score: 19,106
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 1.27
    Marker Score: 382
  • Cell Name: blood vessel smooth muscle cell (CL0019018)
    Fold Change: 1.25
    Marker Score: 328
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 1.25
    Marker Score: 1,145
  • Cell Name: Schwann cell precursor (CL0002375)
    Fold Change: 1.24
    Marker Score: 309
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 1.24
    Marker Score: 1,608
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 1.24
    Marker Score: 2,612
  • Cell Name: progenitor cell of endocrine pancreas (CL0002351)
    Fold Change: 1.23
    Marker Score: 268
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 1.23
    Marker Score: 3,079
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.22
    Marker Score: 7,825
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.22
    Marker Score: 12,388
  • Cell Name: pre-B-I cell (CL0000956)
    Fold Change: 1.21
    Marker Score: 309
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 1.21
    Marker Score: 277
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 1.21
    Marker Score: 417
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.21
    Marker Score: 1,778
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 1.2
    Marker Score: 4,976
  • Cell Name: basal cell (CL0000646)
    Fold Change: 1.2
    Marker Score: 1,546
  • Cell Name: cardiac mesenchymal cell (CL0000569)
    Fold Change: 1.19
    Marker Score: 294
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.19
    Marker Score: 9,138
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.19
    Marker Score: 66,295
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 1.18
    Marker Score: 409
  • Cell Name: interneuron (CL0000099)
    Fold Change: 1.18
    Marker Score: 540
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 1.18
    Marker Score: 1,021
  • Cell Name: NKp44-negative group 3 innate lymphoid cell, human (CL0001080)
    Fold Change: 1.17
    Marker Score: 258
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 1.17
    Marker Score: 229
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.17
    Marker Score: 1,342
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 1.16
    Marker Score: 368
  • Cell Name: fat cell (CL0000136)
    Fold Change: 1.16
    Marker Score: 650
  • Cell Name: endothelial cell of sinusoid (CL0002262)
    Fold Change: 1.16
    Marker Score: 282
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 1.16
    Marker Score: 484
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 1.15
    Marker Score: 1,107
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.15
    Marker Score: 1,151
  • Cell Name: NKp44-positive group 3 innate lymphoid cell, human (CL0001079)
    Fold Change: 1.15
    Marker Score: 261
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 1.15
    Marker Score: 5,323
  • Cell Name: type I enteroendocrine cell (CL0002277)
    Fold Change: 1.15
    Marker Score: 286
  • Cell Name: oocyte (CL0000023)
    Fold Change: 1.14
    Marker Score: 283

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** PCSK7 is a member of the proprotein convertase subtilisin/kexin family, which is characterized by their ability to cleave and activate proproteins. PCSK7 is primarily localized to the Golgi membrane and trans-Golgi network, where it processes and activates various proteins, including peptide hormones and growth factors. Its substrate specificity is broad, and it has been shown to cleave a wide range of proteins, including those involved in immune responses. **Pathways and Functions:** PCSK7 is involved in several key pathways, including: 1. **Protein Processing:** PCSK7 processes and activates proproteins, which are essential for various cellular functions, including immune responses. 2. **Peptide Hormone Processing:** PCSK7 cleaves and activates peptide hormones, such as growth factors and cytokines, which regulate immune cell function and inflammation. 3. **Golgi Membrane Trafficking:** PCSK7 is involved in the trafficking of proteins within the Golgi membrane, regulating their secretion and localization. 4. **Immune Cell Function:** PCSK7 has been shown to regulate the function of various immune cells, including T cells, B cells, and natural killer cells, through the processing and activation of proproteins. **Clinical Significance:** PCSK7 has been implicated in several immune-related disorders, including: 1. **Autoimmune Diseases:** PCSK7 has been shown to play a role in the development of autoimmune diseases, such as rheumatoid arthritis and lupus, through its regulation of proproteins involved in inflammation and immune responses. 2. **Cancer:** PCSK7 has been implicated in the progression of various cancers, including breast and lung cancer, through its regulation of growth factors and cytokines. 3. **Infectious Diseases:** PCSK7 has been shown to play a role in the regulation of immune responses to infections, including viral and bacterial infections. In conclusion, PCSK7 is a critical enzyme involved in the processing and regulation of various proteins in the immune system. Its dysregulation has been implicated in several immune-related disorders, highlighting the importance of PCSK7 in maintaining immune homeostasis. **Recommendations:** 1. Further research is necessary to fully understand the role of PCSK7 in immune regulation and its implications in disease. 2. PCSK7 inhibitors may be developed as therapeutic agents for the treatment of autoimmune and cancer-related disorders. 3. PCSK7 may serve as a biomarker for immune-related disorders, allowing for early detection and monitoring of disease progression. **Future Directions:** 1. Investigate the substrate specificity of PCSK7 and its role in regulating protein processing in different cell types. 2. Examine the role of PCSK7 in regulating immune responses to infections and vaccines. 3. Develop PCSK7 inhibitors as therapeutic agents for the treatment of immune-related disorders. By continuing to explore the role of PCSK7 in immune regulation, we can gain a deeper understanding of its importance in maintaining immune homeostasis and developing novel therapeutic strategies for immune-related disorders.

Genular Protein ID: 3413777323

Symbol: PCSK7_HUMAN

Name: Proprotein convertase subtilisin/kexin type 7

UniProtKB Accession Codes:

Q16549 B0YJ60 Q3C1X1 Q53GM4 Q96FK8 Q9UL57

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugCentral 1 EC 1 EMBL 11 EPD 1 Ensembl 3 ExpressionAtlas 1 GO 7 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 10 KEGG 1 MANE-Select 1 MEROPS 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PROSITE 4 PROSITE-ProRule 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SAM 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8615762

Title: PC8, a new member of the convertase family.

PubMed ID: 8615762

DOI: 10.1042/bj3140727

PubMed ID: 8564950

Title: A new member of the proprotein convertase gene family (LPC) is located at a chromosome translocation breakpoint in lymphomas.

PubMed ID: 8564950

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10362256

Title: Molecular analysis of an unstable genomic region at chromosome band 11q23 reveals a disruption of the gene encoding the alpha2 subunit of platelet-activating factor acetylhydrolase (Pafah1a2) in human lymphoma.

PubMed ID: 10362256

DOI: 10.1038/sj.onc.1202645

PubMed ID: 9341152

Title: Biosynthesis, distinct post-translational modifications, and functional characterization of lymphoma proprotein convertase.

PubMed ID: 9341152

DOI: 10.1074/jbc.272.43.27116

Sequence Information:

  • Length: 785
  • Mass: 86247
  • Checksum: 4A268754766C32DA
  • Sequence:
    • MPKGRQKVPH LDAPLGLPTC LWLELAGLFL LVPWVMGLAG TGGPDGQGTG GPSWAVHLES 
LEGDGEEETL EQQADALAQA AGLVNAGRIG ELQGHYLFVQ PAGHRPALEV EAIRQQVEAV 
LAGHEAVRWH SEQRLLRRAK RSVHFNDPKY PQQWHLNNRR SPGRDINVTG VWERNVTGRG 
VTVVVVDDGV EHTIQDIAPN YSPEGSYDLN SNDPDPMPHP DVENGNHHGT RCAGEIAAVP 
NNSFCAVGVA YGSRIAGIRV LDGPLTDSME AVAFNKHYQI NDIYSCSWGP DDDGKTVDGP 
HQLGKAALQH GVIAGRQGFG SIFVVASGNG GQHNDNCNYD GYANSIYTVT IGAVDEEGRM 
PFYAEECASM LAVTFSGGDK MLRSIVTTDW DLQKGTGCTE GHTGTSAAAP LAAGMIALML 
QVRPCLTWRD VQHIIVFTAT RYEDRRAEWV TNEAGFSHSH QHGFGLLNAW RLVNAAKIWT 
SVPYLASYVS PVLKENKAIP QSPRSLEVLW NVSRMDLEMS GLKTLEHVAV TVSITHPRRG 
SLELKLFCPS GMMSLIGAPR SMDSDPNGFN DWTFSTVRCW GERARGTYRL VIRDVGDESF 
QVGILRQWQL TLYGSVWSAV DIRDRQRLLE SAMSGKYLHD DFALPCPPGL KIPEEDGYTI 
TPNTLKTLVL VGCFTVFWTV YYMLEVYLSQ RNVASNQVCR SGPCHWPHRS RKAKEEGTEL 
ESVPLCSSKD PDEVETESRG PPTTSDLLAP DLLEQGDWSL SQNKSALDCP HQHLDVPHGK 
EEQIC

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.