Details for: CD3E

Gene ID: 916

Symbol: CD3E

Ensembl ID: ENSG00000198851

Description: CD3 epsilon subunit of T-cell receptor complex

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 4.9
    Marker Score: 15448
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 4.89
    Marker Score: 48438
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 4.49
    Marker Score: 237282
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 4.35
    Marker Score: 4201
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 4.26
    Marker Score: 11947
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 4.12
    Marker Score: 17670
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 4.02
    Marker Score: 5921
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 3.88
    Marker Score: 2276
  • Cell Name: intraepithelial lymphocyte (CL0002496)
    Fold Change: 3.84
    Marker Score: 4266
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 3.78
    Marker Score: 2742
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 3.66
    Marker Score: 3080
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: 3.57
    Marker Score: 2582
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 3.46
    Marker Score: 3079
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: 3.46
    Marker Score: 1779
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 3.4
    Marker Score: 1696
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 3.39
    Marker Score: 3173
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 3.38
    Marker Score: 2653
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 3.37
    Marker Score: 1453
  • Cell Name: CD8-alpha alpha positive, gamma-delta intraepithelial T cell (CL0000802)
    Fold Change: 3.29
    Marker Score: 1071
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 3.29
    Marker Score: 4536
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 3.27
    Marker Score: 9044
  • Cell Name: naive T cell (CL0000898)
    Fold Change: 3.25
    Marker Score: 2096
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 3.25
    Marker Score: 6365
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 3.25
    Marker Score: 1997
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 3.24
    Marker Score: 4586
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 3.11
    Marker Score: 2280
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: 3.07
    Marker Score: 1696
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 3.01
    Marker Score: 1729
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 3
    Marker Score: 19165
  • Cell Name: memory regulatory T cell (CL0002678)
    Fold Change: 2.99
    Marker Score: 1042
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 2.95
    Marker Score: 916
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 2.95
    Marker Score: 5057
  • Cell Name: CD4-positive, CD25-positive, alpha-beta regulatory T cell (CL0000792)
    Fold Change: 2.71
    Marker Score: 719
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 2.69
    Marker Score: 2899
  • Cell Name: blood cell (CL0000081)
    Fold Change: 2.66
    Marker Score: 30968.5
  • Cell Name: NKp44-negative group 3 innate lymphoid cell, human (CL0001080)
    Fold Change: 2.65
    Marker Score: 583
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 2.65
    Marker Score: 2007
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 2.63
    Marker Score: 811
  • Cell Name: memory T cell (CL0000813)
    Fold Change: 2.53
    Marker Score: 1088
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: 2.46
    Marker Score: 746
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 2.42
    Marker Score: 4316
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: 2.34
    Marker Score: 2584
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: 2.32
    Marker Score: 5214
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: 2.24
    Marker Score: 1861
  • Cell Name: ILC1, human (CL0001077)
    Fold Change: 2.06
    Marker Score: 522
  • Cell Name: CD56-positive, CD161-positive immature natural killer cell, human (CL0002338)
    Fold Change: 2.03
    Marker Score: 669
  • Cell Name: NKp44-positive group 3 innate lymphoid cell, human (CL0001079)
    Fold Change: 2.01
    Marker Score: 455
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 2
    Marker Score: 3261
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.98
    Marker Score: 1973
  • Cell Name: activated CD8-positive, alpha-beta T cell, human (CL0001049)
    Fold Change: 1.82
    Marker Score: 412
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 1.73
    Marker Score: 1466
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 1.65
    Marker Score: 1107
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 1.62
    Marker Score: 906
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.59
    Marker Score: 1154
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 1.53
    Marker Score: 6282
  • Cell Name: Unknown (CL0000548)
    Fold Change: 1.45
    Marker Score: 1055
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 1.38
    Marker Score: 1444
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 1.3
    Marker Score: 1144
  • Cell Name: T follicular regulatory cell (CL0009113)
    Fold Change: 1.3
    Marker Score: 352
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.24
    Marker Score: 842
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: 1.19
    Marker Score: 1052
  • Cell Name: T-helper 1 cell (CL0000545)
    Fold Change: 1.15
    Marker Score: 449
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.14
    Marker Score: 4784
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 1.11
    Marker Score: 559
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 1
    Marker Score: 1089
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1
    Marker Score: 1894
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71778
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48006
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30402
  • Cell Name: activated CD4-positive, alpha-beta T cell, human (CL0001043)
    Fold Change: 0.98
    Marker Score: 445
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.97
    Marker Score: 500
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.96
    Marker Score: 454
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2411
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5318
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.93
    Marker Score: 1204
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 0.93
    Marker Score: 2708
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.92
    Marker Score: 367
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2729
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.89
    Marker Score: 319
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5280
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.86
    Marker Score: 658
  • Cell Name: group 3 innate lymphoid cell (CL0001071)
    Fold Change: 0.83
    Marker Score: 349
  • Cell Name: CD34-positive, CD56-positive, CD117-positive common innate lymphoid precursor, human (CL0001074)
    Fold Change: 0.79
    Marker Score: 219
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1254
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: 0.76
    Marker Score: 496
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.75
    Marker Score: 390
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.75
    Marker Score: 682
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 0.73
    Marker Score: 600
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.73
    Marker Score: 337
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.71
    Marker Score: 293
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.7
    Marker Score: 420
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 0.7
    Marker Score: 1704
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 176
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 0.67
    Marker Score: 329
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: 0.66
    Marker Score: 514
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 0.66
    Marker Score: 668
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.63
    Marker Score: 289
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.63
    Marker Score: 401
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.62
    Marker Score: 204
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.58
    Marker Score: 461

Hover over a box to see details here...

Hover over a box to see details here...

Hover over a box to see details here...

Other Information

**Key characteristics:** - The CD3E gene is located on chromosome 1, in the T-cell receptor complex locus. - The CD3E gene product is a glycoprotein with a molecular weight of approximately 45 kDa. - The CD3E gene is expressed as a single copy in humans. **Pathways and functions:** - The CD3E gene is involved in the adaptive immune response and the regulation of T cell function. - The CD3E gene is a key component of the TCR complex, which is responsible for recognizing MHC molecules on antigen-presenting cells. - The CD3E gene is also involved in the downstream signaling pathways of the TCR complex, which are responsible for activating T cells. **Clinical significance:** - Mutations in the CD3E gene have been linked to a number of human diseases, including autoimmune disorders, cancer, and neurodegenerative diseases. - The CD3E gene is a promising target for cancer immunotherapy, as it is expressed on many tumor cells and is involved in the activation of T cells. - Targeting the CD3E gene with antibodies or other therapeutic agents is a promising strategy for treating cancer and other diseases that are characterized by T cell dysfunction.

Genular Protein ID: 4230133941

Symbol: CD3E_HUMAN

Name: T-cell surface glycoprotein CD3 epsilon chain

UniProtKB Accession Codes:

P07766 A8K997

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 ComplexPortal 4 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 DrugBank 6 DrugCentral 1 ELM 1 EMBL 12 EMDB 5 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 51 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 18 PDBsum 14 PIR 1 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 6 RefSeq 1 SAM 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3012357

Title: Isolation of cDNA clones encoding the 20K non-glycosylated polypeptide chain of the human T-cell receptor/T3 complex.

PubMed ID: 3012357

DOI: 10.1038/321431a0

PubMed ID: 3267235

Title: Human CD3-epsilon gene contains three miniexons and is transcribed from a non-TATA promoter.

PubMed ID: 3267235

DOI: 10.1073/pnas.85.21.8156

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2470098

Title: The CD4 and CD8 antigens are coupled to a protein-tyrosine kinase (p56lck) that phosphorylates the CD3 complex.

PubMed ID: 2470098

DOI: 10.1073/pnas.86.9.3277

PubMed ID: 1387664

Title: Expression of cytoplasmic CD3 epsilon proteins in activated human adult natural killer (NK) cells and CD3 gamma, delta, epsilon complexes in fetal NK cells. Implications for the relationship of NK and T lymphocytes.

PubMed ID: 1387664

PubMed ID: 8490660

Title: Independent mutations of the human CD3-epsilon gene resulting in a T cell receptor/CD3 complex immunodeficiency.

PubMed ID: 8490660

DOI: 10.1038/ng0193-77

PubMed ID: 10384095

Title: The CD3 epsilon subunit of the TCR contains endocytosis signals.

PubMed ID: 10384095

PubMed ID: 12522270

Title: Profiling of tyrosine phosphorylation pathways in human cells using mass spectrometry.

PubMed ID: 12522270

DOI: 10.1073/pnas.2436191100

PubMed ID: 15144186

Title: Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry.

PubMed ID: 15144186

DOI: 10.1021/ac035352d

PubMed ID: 15546002

Title: Severe combined immunodeficiency caused by deficiency in either the delta or the epsilon subunit of CD3.

PubMed ID: 15546002

DOI: 10.1172/jci22588

PubMed ID: 15294938

Title: Relevance of CD6-mediated interactions in T cell activation and proliferation.

PubMed ID: 15294938

DOI: 10.4049/jimmunol.173.4.2262

PubMed ID: 15972658

Title: The CD3epsilon proline-rich sequence, and its interaction with Nck, is not required for T cell development and function.

PubMed ID: 15972658

DOI: 10.4049/jimmunol.175.1.270

PubMed ID: 15592455

Title: Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.

PubMed ID: 15592455

DOI: 10.1038/nbt1046

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 26507128

Title: CD3epsilon recruits Numb to promote TCR degradation.

PubMed ID: 26507128

DOI: 10.1093/intimm/dxv060

PubMed ID: 9698567

Title: Structural basis for Syk tyrosine kinase ubiquity in signal transduction pathways revealed by the crystal structure of its regulatory SH2 domains bound to a dually phosphorylated ITAM peptide.

PubMed ID: 9698567

DOI: 10.1006/jmbi.1998.1964

PubMed ID: 15136729

Title: Crystal structure of the human T cell receptor CD3 epsilon gamma heterodimer complexed to the therapeutic mAb OKT3.

PubMed ID: 15136729

DOI: 10.1073/pnas.0402295101

PubMed ID: 15534202

Title: Crystal structure of a human CD3-epsilon/delta dimer in complex with a UCHT1 single-chain antibody fragment.

PubMed ID: 15534202

DOI: 10.1073/pnas.0407359101

Sequence Information:

  • Length: 207
  • Mass: 23147
  • Checksum: A1603D01CE9957D7
  • Sequence:
    • MQSGTHWRVL GLCLLSVGVW GQDGNEEMGG ITQTPYKVSI SGTTVILTCP QYPGSEILWQ 
HNDKNIGGDE DDKNIGSDED HLSLKEFSEL EQSGYYVCYP RGSKPEDANF YLYLRARVCE 
NCMEMDVMSV ATIVIVDICI TGGLLLLVYY WSKNRKAKAK PVTRGAGAGG RQRGQNKERP 
PPVPNPDYEP IRKGQRDLYS GLNQRRI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.