CD3G | ENSG00000160654 | NCBI 917

Details for: CD3G

Gene ID: 917

Symbol: CD3G

Ensembl ID: ENSG00000160654

Description: CD3 gamma subunit of T-cell receptor complex

Associated with

Adaptive immune system
(R-HSA-1280218)
Anti-inflammatory response favouring leishmania parasite infection
(R-HSA-9662851)
Cargo recognition for clathrin-mediated endocytosis
(R-HSA-8856825)
Clathrin-mediated endocytosis
(R-HSA-8856828)
Costimulation by the cd28 family
(R-HSA-388841)
Disease
(R-HSA-1643685)
Downstream tcr signaling
(R-HSA-202424)
Fcgamma receptor (fcgr) dependent phagocytosis
(R-HSA-2029480)
Fcgr3a-mediated il10 synthesis
(R-HSA-9664323)
Fcgr3a-mediated phagocytosis
(R-HSA-9664422)
Fcgr activation
(R-HSA-2029481)
Generation of second messenger molecules
(R-HSA-202433)
Immune system
(R-HSA-168256)
Immunoregulatory interactions between a lymphoid and a non-lymphoid cell
(R-HSA-198933)
Infectious disease
(R-HSA-5663205)
Innate immune system
(R-HSA-168249)
Leishmania infection
(R-HSA-9658195)
Leishmania parasite growth and survival
(R-HSA-9664433)
Leishmania phagocytosis
(R-HSA-9664417)
Membrane trafficking
(R-HSA-199991)
Parasite infection
(R-HSA-9664407)
Parasitic infection pathways
(R-HSA-9824443)
Pd-1 signaling
(R-HSA-389948)
Phosphorylation of cd3 and tcr zeta chains
(R-HSA-202427)
Regulation of actin dynamics for phagocytic cup formation
(R-HSA-2029482)
Role of phospholipids in phagocytosis
(R-HSA-2029485)
Tcr signaling
(R-HSA-202403)
Translocation of zap-70 to immunological synapse
(R-HSA-202430)
Vesicle-mediated transport
(R-HSA-5653656)
Adaptive immune response
(GO:0002250)
Alpha-beta t cell activation
(GO:0046631)
Alpha-beta t cell receptor complex
(GO:0042105)
Cell surface receptor signaling pathway
(GO:0007166)
Clathrin-coated endocytic vesicle membrane
(GO:0030669)
Cytosol
(GO:0005829)
Establishment or maintenance of cell polarity
(GO:0007163)
External side of plasma membrane
(GO:0009897)
Gamma-delta t cell activation
(GO:0046629)
Gamma-delta t cell receptor complex
(GO:0042106)
Identical protein binding
(GO:0042802)
Plasma membrane
(GO:0005886)
Positive thymic t cell selection
(GO:0045059)
Protein-containing complex assembly
(GO:0065003)
Protein binding
(GO:0005515)
Protein transport
(GO:0015031)
Regulation of lymphocyte apoptotic process
(GO:0070228)
Signaling receptor complex adaptor activity
(GO:0030159)
T cell activation
(GO:0042110)
T cell receptor binding
(GO:0042608)
T cell receptor signaling pathway
(GO:0050852)
Transmembrane signaling receptor activity
(GO:0004888)

Other Information

Proteins

T-cell surface glycoprotein CD3 gamma chain

Genular Protein ID: 3412171745

Symbol: CD3G_HUMAN

Name: T-cell surface glycoprotein CD3 gamma chain

UniProtKB Accession Codes:

P09693 Q2HIZ6

Database IDs:

Citations:

PubMed ID: 2944745

Title: Primary structure of the T3 gamma subunit of the T3/T cell antigen receptor complex deduced from cDNA sequences: evolution of the T3 gamma and delta subunits.

PubMed ID: 2944745

DOI: 10.1002/j.1460-2075.1986.tb04429.x

PubMed ID: 2826124

Title: Physical linkage of three CD3 genes on human chromosome 11.

PubMed ID: 2826124

DOI: 10.1002/j.1460-2075.1987.tb02600.x

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2540970

Title: Dephosphorylation of the human T lymphocyte CD3 antigen.

PubMed ID: 2540970

DOI: 10.1111/j.1432-1033.1989.tb14693.x

PubMed ID: 3112151

Title: The human T3 gamma chain is phosphorylated at serine 126 in response to T lymphocyte activation.

PubMed ID: 3112151

DOI: 10.1016/s0021-9258(18)60903-2

PubMed ID: 2470098

Title: The CD4 and CD8 antigens are coupled to a protein-tyrosine kinase (p56lck) that phosphorylates the CD3 complex.

PubMed ID: 2470098

DOI: 10.1073/pnas.86.9.3277

PubMed ID: 1535555

Title: A novel di-leucine motif and a tyrosine-based motif independently mediate lysosomal targeting and endocytosis of CD3 chains.

PubMed ID: 1535555

DOI: 10.1016/0092-8674(92)90636-q

PubMed ID: 1635567

Title: Brief report: primary immunodeficiency caused by mutations in the gene encoding the CD3-gamma subunit of the T-lymphocyte receptor.

PubMed ID: 1635567

DOI: 10.1056/nejm199208203270805

PubMed ID: 8187769

Title: CD3 gamma contains a phosphoserine-dependent di-leucine motif involved in down-regulation of the T cell receptor.

PubMed ID: 8187769

DOI: 10.1002/j.1460-2075.1994.tb06492.x

PubMed ID: 8636209

Title: Role of CD3 gamma in T cell receptor assembly.

PubMed ID: 8636209

DOI: 10.1083/jcb.132.3.299

PubMed ID: 14995914

Title: TCR trafficking in resting and stimulated T cells.

PubMed ID: 14995914

DOI: 10.1615/critrevimmunol.v24.i1.30

PubMed ID: 17277165

Title: Differential biological role of CD3 chains revealed by human immunodeficiencies.

PubMed ID: 17277165

DOI: 10.4049/jimmunol.178.4.2556

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 15136729

Title: Crystal structure of the human T cell receptor CD3 epsilon gamma heterodimer complexed to the therapeutic mAb OKT3.

PubMed ID: 15136729

DOI: 10.1073/pnas.0402295101

Sequence Information:

Length: 182
Mass: 20469
Checksum: EE65C0186FB9872B
Sequence:

MEQGKGLAVL ILAIILLQGT LAQSIKGNHL VKVYDYQEDG SVLLTCDAEA KNITWFKDGK 
MIGFLTEDKK KWNLGSNAKD PRGMYQCKGS QNKSKPLQVY YRMCQNCIEL NAATISGFLF 
AEIVSIFVLA VGVYFIAGQD GVRQSRASDK QTLLPNDQLY QPLKDREDDQ YSHLQGNQLR 
RN

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: CD3G

Associated with

Other Information

Primary structure of the T3 gamma subunit of the T3/T cell antigen receptor complex deduced from cDNA sequences: evolution of the T3 gamma and delta subunits. PubMed ID: 2944745

Physical linkage of three CD3 genes on human chromosome 11. PubMed ID: 2826124

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Dephosphorylation of the human T lymphocyte CD3 antigen. PubMed ID: 2540970

The human T3 gamma chain is phosphorylated at serine 126 in response to T lymphocyte activation. PubMed ID: 3112151

The CD4 and CD8 antigens are coupled to a protein-tyrosine kinase (p56lck) that phosphorylates the CD3 complex. PubMed ID: 2470098

A novel di-leucine motif and a tyrosine-based motif independently mediate lysosomal targeting and endocytosis of CD3 chains. PubMed ID: 1535555

Brief report: primary immunodeficiency caused by mutations in the gene encoding the CD3-gamma subunit of the T-lymphocyte receptor. PubMed ID: 1635567

CD3 gamma contains a phosphoserine-dependent di-leucine motif involved in down-regulation of the T cell receptor. PubMed ID: 8187769

Role of CD3 gamma in T cell receptor assembly. PubMed ID: 8636209

TCR trafficking in resting and stimulated T cells. PubMed ID: 14995914

Differential biological role of CD3 chains revealed by human immunodeficiencies. PubMed ID: 17277165

Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. PubMed ID: 19690332

Crystal structure of the human T cell receptor CD3 epsilon gamma heterodimer complexed to the therapeutic mAb OKT3. PubMed ID: 15136729