Details for: CD3G

Gene ID: 917

Symbol: CD3G

Ensembl ID: ENSG00000160654

Description: CD3 gamma subunit of T-cell receptor complex

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 57.9682
    Cell Significance Index: -23.5500
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 33.7836
    Cell Significance Index: -15.9500
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 24.8549
    Cell Significance Index: -23.7300
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 5.2635
    Cell Significance Index: 81.4400
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 5.0291
    Cell Significance Index: 147.7000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 4.3575
    Cell Significance Index: 108.9300
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 4.1162
    Cell Significance Index: 12.5500
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 4.0535
    Cell Significance Index: -12.4500
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 3.9673
    Cell Significance Index: 39.7800
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 1.6384
    Cell Significance Index: 14.3300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.6064
    Cell Significance Index: 72.8200
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 1.2017
    Cell Significance Index: 12.4600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.0882
    Cell Significance Index: 207.0900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.0182
    Cell Significance Index: 22.0600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.8600
    Cell Significance Index: 85.0700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.7296
    Cell Significance Index: 658.7900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3629
    Cell Significance Index: 59.0300
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.2549
    Cell Significance Index: 1.3900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2137
    Cell Significance Index: 23.2400
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 0.1987
    Cell Significance Index: 1.4300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.1864
    Cell Significance Index: 4.9900
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 0.1587
    Cell Significance Index: 1.2400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0623
    Cell Significance Index: 4.3100
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 0.0450
    Cell Significance Index: 0.3800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0242
    Cell Significance Index: 0.5100
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0013
    Cell Significance Index: -0.0200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0043
    Cell Significance Index: -0.1500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0075
    Cell Significance Index: -14.1100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0097
    Cell Significance Index: -0.2800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0125
    Cell Significance Index: -23.0000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0150
    Cell Significance Index: -23.0700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0172
    Cell Significance Index: -23.3600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0180
    Cell Significance Index: -13.6000
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: -0.0215
    Cell Significance Index: -0.1600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0245
    Cell Significance Index: -15.3200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0249
    Cell Significance Index: -18.4600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0261
    Cell Significance Index: -11.5200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0295
    Cell Significance Index: -16.1000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0297
    Cell Significance Index: -16.7700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0309
    Cell Significance Index: -3.6000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0356
    Cell Significance Index: -26.1200
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0390
    Cell Significance Index: -0.3700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0392
    Cell Significance Index: -14.0500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0405
    Cell Significance Index: -25.7000
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0437
    Cell Significance Index: -1.9000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0532
    Cell Significance Index: -24.1500
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0532
    Cell Significance Index: -2.6900
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0561
    Cell Significance Index: -0.8200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0626
    Cell Significance Index: -12.4300
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0653
    Cell Significance Index: -2.6700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0661
    Cell Significance Index: -19.0300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0689
    Cell Significance Index: -13.8200
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0718
    Cell Significance Index: -1.2200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0744
    Cell Significance Index: -4.5600
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0759
    Cell Significance Index: -0.7100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0801
    Cell Significance Index: -16.8700
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0812
    Cell Significance Index: -1.4000
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0952
    Cell Significance Index: -1.3000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1059
    Cell Significance Index: -18.0800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.1080
    Cell Significance Index: -19.4700
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.1092
    Cell Significance Index: -1.0500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1113
    Cell Significance Index: -13.1300
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1147
    Cell Significance Index: -2.9300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.1161
    Cell Significance Index: -14.8800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.1183
    Cell Significance Index: -16.2400
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.1254
    Cell Significance Index: -1.4800
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: -0.1373
    Cell Significance Index: -1.1700
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.1446
    Cell Significance Index: -1.5000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1447
    Cell Significance Index: -15.0700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1530
    Cell Significance Index: -17.5300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1594
    Cell Significance Index: -7.4900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1635
    Cell Significance Index: -11.5600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.1639
    Cell Significance Index: -20.1500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1665
    Cell Significance Index: -21.5100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1774
    Cell Significance Index: -25.7900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.2096
    Cell Significance Index: -21.4100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2157
    Cell Significance Index: -6.9100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.2165
    Cell Significance Index: -13.0000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2293
    Cell Significance Index: -15.4200
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.2497
    Cell Significance Index: -5.1800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2524
    Cell Significance Index: -19.3700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2882
    Cell Significance Index: -21.4800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.3002
    Cell Significance Index: -8.3900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.3342
    Cell Significance Index: -20.5400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.3533
    Cell Significance Index: -22.7900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.3602
    Cell Significance Index: -20.2200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.3681
    Cell Significance Index: -23.2000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.3805
    Cell Significance Index: -19.9800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.3939
    Cell Significance Index: -20.4600
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: -0.4210
    Cell Significance Index: -3.8000
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: -0.4267
    Cell Significance Index: -3.4100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.4302
    Cell Significance Index: -20.0600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.4439
    Cell Significance Index: -15.5500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.4479
    Cell Significance Index: -23.3300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.4587
    Cell Significance Index: -20.2900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.4682
    Cell Significance Index: -15.3300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.4828
    Cell Significance Index: -12.4100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.4832
    Cell Significance Index: -15.3900
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.5095
    Cell Significance Index: -5.1700
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: -0.5118
    Cell Significance Index: -2.1300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Structure:** The CD3G gene encodes for a 20-kDa protein, which is part of the TCR complex. 2. **Expression:** CD3G is highly expressed in mature gamma-delta T cells, alpha-beta T cells, and regulatory T cells. 3. **Function:** CD3G is essential for T cell activation, signaling, and regulation, including the phosphorylation of TCR zeta chains and the activation of downstream signaling pathways. 4. **Signaling Pathways:** CD3G is involved in various signaling pathways, including the activation of Zap-70, the translocation of Zap-70 to the immunological synapse, and the regulation of actin dynamics for phagocytic cup formation. **Pathways and Functions:** 1. **Adaptive Immune Response:** CD3G is essential for the activation and regulation of alpha-beta T cells, which play a critical role in the adaptive immune response. 2. **Gamma-Delta T Cell Activation:** CD3G is crucial for the activation and signaling of gamma-delta T cells, which are involved in the recognition of pathogens and the regulation of the immune response. 3. **Regulation of Lymphocyte Apoptosis:** CD3G is involved in the regulation of lymphocyte apoptosis, which is essential for the maintenance of immune homeostasis. 4. **Phagocytosis:** CD3G is involved in the regulation of phagocytic activity, including the recognition of pathogens and the activation of phagocytic cells. 5. **Innate Immune Response:** CD3G is also involved in the innate immune response, including the recognition of pathogens and the activation of innate immune cells. **Clinical Significance:** 1. **Autoimmune Diseases:** Dysregulation of CD3G has been implicated in various autoimmune diseases, including multiple sclerosis, type 1 diabetes, and rheumatoid arthritis. 2. **Cancer:** CD3G is overexpressed in certain types of cancer, including leukemia and lymphoma, and its dysregulation has been implicated in tumorigenesis. 3. **Infectious Diseases:** CD3G is involved in the recognition and clearance of pathogens, including Leishmania parasites, and its dysregulation has been implicated in the pathogenesis of infectious diseases. 4. **Immunotherapy:** CD3G is a potential target for immunotherapy, including checkpoint inhibitors and T cell activators, which aim to modulate the immune response and treat various diseases. In conclusion, the CD3G gene plays a critical role in the regulation of T cell function and the immune response. Its dysregulation has been implicated in various immune-related disorders, and its potential as a therapeutic target is an area of active research.

Genular Protein ID: 3412171745

Symbol: CD3G_HUMAN

Name: T-cell surface glycoprotein CD3 gamma chain

UniProtKB Accession Codes:

P09693 Q2HIZ6

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 ComplexPortal 4 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 6 DrugCentral 1 ELM 1 EMBL 8 EMDB 14 Ensembl 1 ExpressionAtlas 1 GO 21 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 16 PDBsum 16 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 13 RefSeq 2 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2944745

Title: Primary structure of the T3 gamma subunit of the T3/T cell antigen receptor complex deduced from cDNA sequences: evolution of the T3 gamma and delta subunits.

PubMed ID: 2944745

DOI: 10.1002/j.1460-2075.1986.tb04429.x

PubMed ID: 2826124

Title: Physical linkage of three CD3 genes on human chromosome 11.

PubMed ID: 2826124

DOI: 10.1002/j.1460-2075.1987.tb02600.x

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2540970

Title: Dephosphorylation of the human T lymphocyte CD3 antigen.

PubMed ID: 2540970

DOI: 10.1111/j.1432-1033.1989.tb14693.x

PubMed ID: 3112151

Title: The human T3 gamma chain is phosphorylated at serine 126 in response to T lymphocyte activation.

PubMed ID: 3112151

DOI: 10.1016/s0021-9258(18)60903-2

PubMed ID: 2470098

Title: The CD4 and CD8 antigens are coupled to a protein-tyrosine kinase (p56lck) that phosphorylates the CD3 complex.

PubMed ID: 2470098

DOI: 10.1073/pnas.86.9.3277

PubMed ID: 1535555

Title: A novel di-leucine motif and a tyrosine-based motif independently mediate lysosomal targeting and endocytosis of CD3 chains.

PubMed ID: 1535555

DOI: 10.1016/0092-8674(92)90636-q

PubMed ID: 1635567

Title: Brief report: primary immunodeficiency caused by mutations in the gene encoding the CD3-gamma subunit of the T-lymphocyte receptor.

PubMed ID: 1635567

DOI: 10.1056/nejm199208203270805

PubMed ID: 8187769

Title: CD3 gamma contains a phosphoserine-dependent di-leucine motif involved in down-regulation of the T cell receptor.

PubMed ID: 8187769

DOI: 10.1002/j.1460-2075.1994.tb06492.x

PubMed ID: 8636209

Title: Role of CD3 gamma in T cell receptor assembly.

PubMed ID: 8636209

DOI: 10.1083/jcb.132.3.299

PubMed ID: 14995914

Title: TCR trafficking in resting and stimulated T cells.

PubMed ID: 14995914

DOI: 10.1615/critrevimmunol.v24.i1.30

PubMed ID: 17277165

Title: Differential biological role of CD3 chains revealed by human immunodeficiencies.

PubMed ID: 17277165

DOI: 10.4049/jimmunol.178.4.2556

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 15136729

Title: Crystal structure of the human T cell receptor CD3 epsilon gamma heterodimer complexed to the therapeutic mAb OKT3.

PubMed ID: 15136729

DOI: 10.1073/pnas.0402295101

Sequence Information:

  • Length: 182
  • Mass: 20469
  • Checksum: EE65C0186FB9872B
  • Sequence:
    • MEQGKGLAVL ILAIILLQGT LAQSIKGNHL VKVYDYQEDG SVLLTCDAEA KNITWFKDGK 
MIGFLTEDKK KWNLGSNAKD PRGMYQCKGS QNKSKPLQVY YRMCQNCIEL NAATISGFLF 
AEIVSIFVLA VGVYFIAGQD GVRQSRASDK QTLLPNDQLY QPLKDREDDQ YSHLQGNQLR 
RN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.