Genular: Defining Cellular Identity and Function

Details for: MYOM2

Gene ID: 9172

Symbol: MYOM2

Ensembl ID: ENSG00000036448

Description: myomesin 2

Associated with

Extraocular skeletal muscle development
(GO:0002074)
Kinase binding
(GO:0019900)
M band
(GO:0031430)
Mitochondrion
(GO:0005739)
Muscle contraction
(GO:0006936)
Myosin filament
(GO:0032982)
Protein binding
(GO:0005515)
Sarcomere organization
(GO:0045214)
Structural constituent of muscle
(GO:0008307)

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: cardiac muscle cell (CL0000746)
Fold Change: 11.21
Marker Score: 149,161
Cell Name: regular ventricular cardiac myocyte (CL0002131)
Fold Change: 4.75
Marker Score: 106,165
Cell Name: regular atrial cardiac myocyte (CL0002129)
Fold Change: 4.55
Marker Score: 16,179
Cell Name: retinal ganglion cell (CL0000740)
Fold Change: 2.62
Marker Score: 3,261
Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
Fold Change: 1.78
Marker Score: 5,210
Cell Name: mural cell (CL0008034)
Fold Change: 1.48
Marker Score: 169,563
Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 1.28
Marker Score: 3,022
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: 1.17
Marker Score: 1,813
Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
Fold Change: 1.09
Marker Score: 469
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30,407
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.97
Marker Score: 498
Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.96
Marker Score: 452
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2,411
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.91
Marker Score: 5,219
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.91
Marker Score: 2,735
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.9
Marker Score: 606
Cell Name: oogonial cell (CL0000024)
Fold Change: 0.89
Marker Score: 1,278
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.88
Marker Score: 318
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5,281
Cell Name: male germ cell (CL0000015)
Fold Change: 0.85
Marker Score: 244
Cell Name: mature gamma-delta T cell (CL0000800)
Fold Change: 0.84
Marker Score: 2,657
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: 0.84
Marker Score: 7,962
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: 0.8
Marker Score: 1,992
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.78
Marker Score: 1,264
Cell Name: kidney capillary endothelial cell (CL1000892)
Fold Change: 0.77
Marker Score: 240
Cell Name: renal interstitial pericyte (CL1001318)
Fold Change: 0.75
Marker Score: 715
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.74
Marker Score: 567
Cell Name: brush cell (CL0002204)
Fold Change: 0.74
Marker Score: 673
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.73
Marker Score: 3,060
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.7
Marker Score: 282
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: 0.68
Marker Score: 5,830
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.68
Marker Score: 173
Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: 0.67
Marker Score: 14,263
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.66
Marker Score: 40,700
Cell Name: connective tissue cell (CL0002320)
Fold Change: 0.66
Marker Score: 170
Cell Name: mononuclear cell (CL0000842)
Fold Change: 0.63
Marker Score: 203
Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: 0.6
Marker Score: 3,613
Cell Name: Unknown (CL0000548)
Fold Change: 0.59
Marker Score: 427
Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.55
Marker Score: 441
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.53
Marker Score: 336
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 0.52
Marker Score: 17,734
Cell Name: epicardial adipocyte (CL1000309)
Fold Change: 0.47
Marker Score: 229
Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
Fold Change: 0.47
Marker Score: 402
Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
Fold Change: 0.46
Marker Score: 192
Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
Fold Change: 0.45
Marker Score: 351
Cell Name: lymphocyte (CL0000542)
Fold Change: 0.45
Marker Score: 228
Cell Name: cardiac neuron (CL0010022)
Fold Change: 0.44
Marker Score: 549
Cell Name: primitive red blood cell (CL0002355)
Fold Change: 0.43
Marker Score: 323
Cell Name: cerebral cortex neuron (CL0010012)
Fold Change: 0.43
Marker Score: 1,217
Cell Name: kidney interstitial cell (CL1000500)
Fold Change: 0.42
Marker Score: 299
Cell Name: fibroblast of connective tissue of prostate (CL1000299)
Fold Change: 0.42
Marker Score: 104
Cell Name: prostate stromal cell (CL0002622)
Fold Change: 0.41
Marker Score: 104
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.41
Marker Score: 1,722
Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
Fold Change: 0.4
Marker Score: 355
Cell Name: pancreatic D cell (CL0000173)
Fold Change: 0.36
Marker Score: 158
Cell Name: fast muscle cell (CL0000190)
Fold Change: 0.36
Marker Score: 108
Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: 0.34
Marker Score: 346
Cell Name: cortical thymic epithelial cell (CL0002364)
Fold Change: 0.34
Marker Score: 1,252
Cell Name: tracheal goblet cell (CL1000329)
Fold Change: 0.33
Marker Score: 937
Cell Name: early lymphoid progenitor (CL0000936)
Fold Change: 0.33
Marker Score: 161
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 0.33
Marker Score: 197
Cell Name: activated CD8-positive, alpha-beta T cell, human (CL0001049)
Fold Change: 0.33
Marker Score: 74
Cell Name: multi-ciliated epithelial cell (CL0005012)
Fold Change: 0.31
Marker Score: 591
Cell Name: epithelial cell of proximal tubule (CL0002306)
Fold Change: 0.3
Marker Score: 1,072
Cell Name: gamma-delta T cell (CL0000798)
Fold Change: 0.29
Marker Score: 198
Cell Name: primordial germ cell (CL0000670)
Fold Change: 0.29
Marker Score: 369
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.29
Marker Score: 643
Cell Name: pyramidal neuron (CL0000598)
Fold Change: 0.29
Marker Score: 491
Cell Name: precursor B cell (CL0000817)
Fold Change: 0.29
Marker Score: 192
Cell Name: slow muscle cell (CL0000189)
Fold Change: 0.29
Marker Score: 95
Cell Name: neuron (CL0000540)
Fold Change: 0.28
Marker Score: 1,151
Cell Name: tracheobronchial smooth muscle cell (CL0019019)
Fold Change: 0.28
Marker Score: 82
Cell Name: smooth muscle cell of prostate (CL1000487)
Fold Change: 0.28
Marker Score: 71
Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
Fold Change: 0.28
Marker Score: 136
Cell Name: mesenchymal cell (CL0008019)
Fold Change: 0.27
Marker Score: 465
Cell Name: pro-B cell (CL0000826)
Fold Change: 0.27
Marker Score: 262
Cell Name: mature astrocyte (CL0002627)
Fold Change: 0.27
Marker Score: 177
Cell Name: megakaryocyte (CL0000556)
Fold Change: 0.26
Marker Score: 150
Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
Fold Change: 0.26
Marker Score: 69
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.26
Marker Score: 190
Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
Fold Change: 0.26
Marker Score: 377
Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: 0.25
Marker Score: 9,243
Cell Name: common myeloid progenitor (CL0000049)
Fold Change: 0.25
Marker Score: 66
Cell Name: Bergmann glial cell (CL0000644)
Fold Change: 0.25
Marker Score: 101
Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: 0.25
Marker Score: 2,319
Cell Name: medullary thymic epithelial cell (CL0002365)
Fold Change: 0.25
Marker Score: 403
Cell Name: bronchial smooth muscle cell (CL0002598)
Fold Change: 0.24
Marker Score: 69
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: 0.24
Marker Score: 77
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 0.24
Marker Score: 98
Cell Name: neural cell (CL0002319)
Fold Change: 0.23
Marker Score: 113
Cell Name: ciliated epithelial cell (CL0000067)
Fold Change: 0.23
Marker Score: 105
Cell Name: supporting cell (CL0000630)
Fold Change: 0.23
Marker Score: 426
Cell Name: astrocyte (CL0000127)
Fold Change: 0.23
Marker Score: 195
Cell Name: enteric smooth muscle cell (CL0002504)
Fold Change: 0.22
Marker Score: 523
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.22
Marker Score: 63
Cell Name: interstitial cell of Cajal (CL0002088)
Fold Change: 0.22
Marker Score: 76
Cell Name: ependymal cell (CL0000065)
Fold Change: 0.22
Marker Score: 76
Cell Name: intermediate monocyte (CL0002393)
Fold Change: 0.22
Marker Score: 75
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: 0.22
Marker Score: 229
Cell Name: pulmonary interstitial fibroblast (CL0002241)
Fold Change: 0.21
Marker Score: 172

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

**Key Characteristics:** 1. **Cellular Expression:** MYOM2 is widely expressed in various cell types, including cardiac muscle cells, retinal ganglion cells, and innate lymphoid cells. 2. **Protein Structure:** The MYOM2 protein is a structural component of the sarcomere, the functional unit of striated muscle tissue. 3. **Muscle Contraction:** MYOM2 plays a critical role in muscle contraction, as it is part of the myosin filament, which is essential for generating force during muscle contraction. 4. **Protein Binding:** MYOM2 exhibits protein-binding properties, suggesting its involvement in interactions with other proteins and molecules. **Pathways and Functions:** 1. **Extraocular Skeletal Muscle Development:** MYOM2 is involved in the development of skeletal muscle tissue, particularly in the extraocular muscles. 2. **Muscle Contraction:** The MYOM2 protein is part of the myosin filament, which generates force during muscle contraction. 3. **Sarcomere Organization:** MYOM2 contributes to the organization of the sarcomere, the functional unit of striated muscle tissue. 4. **Protein Binding:** MYOM2's protein-binding properties allow it to interact with other proteins and molecules, influencing various cellular processes. **Clinical Significance:** 1. **Muscle Diseases:** Mutations in the MYOM2 gene have been associated with various muscle disorders, including muscular dystrophy and cardiomyopathy. 2. **Skeletal Muscle Disorders:** MYOM2 dysfunction may contribute to skeletal muscle disorders, such as myopathies and muscular dystrophy. 3. **Cardiac Function:** The MYOM2 protein's role in cardiac muscle contraction and organization suggests its potential involvement in cardiac function and disease. 4. **Immunological Implications:** MYOM2's expression in innate lymphoid cells highlights its potential role in immune regulation and disease. In conclusion, the MYOM2 gene and protein play a critical role in various cellular processes, including muscle contraction, sarcomere organization, and protein binding. Further research is necessary to fully understand the complexities of MYOM2 and its implications in human disease. As an expert immunologist, I believe that unraveling the mysteries of MYOM2 will provide valuable insights into the development of new therapeutic strategies for skeletal muscle and cardiac disorders.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Myomesin-2

Genular Protein ID: 2743747023

Symbol: MYOM2_HUMAN

Name: Myomesin-2

UniProtKB Accession Codes:

P54296 Q7Z3Y2

Database IDs:

Citations:

PubMed ID: 7505783

Title: The globular head domain of titin extends into the center of the sarcomeric M band. cDNA cloning, epitope mapping and immunoelectron microscopy of two titin-associated proteins.

PubMed ID: 7505783

DOI: 10.1242/jcs.106.1.319

PubMed ID: 16421571

Title: DNA sequence and analysis of human chromosome 8.

PubMed ID: 16421571

DOI: 10.1038/nature04406

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

Length: 1465
Mass: 164869
Checksum: E9573DA6E0076343
Sequence:

MSLVTVPFYQ KRHRHFDQSY RNIQTRYLLD EYASKKRAST QASSQKSLSQ RSSSQRASSQ 
TSLGGTICRV CAKRVSTQED EEQENRSRYQ SLVAAYGEAK RQRFLSELAH LEEDVHLARS 
QARDKLDKYA IQQMMEDKLA WERHTFEERI SRAPEILVRL RSHTVWERMS VKLCFTVQGF 
PTPVVQWYKD GSLICQAAEP GKYRIESNYG VHTLEINRAD FDDTATYSAV ATNAHGQVST 
NAAVVVRRFR GDEEPFRSVG LPIGLPLSSM IPYTHFDVQF LEKFGVTFRR EGETVTLKCT 
MLVTPDLKRV QPRAEWYRDD VLLKESKWTK MFFGEGQASL SFSHLHKDDE GLYTLRIVSR 
GGVSDHSAFL FVRDADPLVT GAPGAPMDLQ CHDANRDYVI VTWKPPNTTT ESPVMGYFVD 
RCEVGTNNWV QCNDAPVKIC KYPVTGLFEG RSYIFRVRAV NSAGISRPSR VSDAVAALDP 
LDLRRLQAVH LEGEKEIAIY QDDLEGDAQV PGPPTGVHAS EISRNYVVLS WEPPTPRGKD 
PLMYFIEKSV VGSGSWQRVN AQTAVRSPRY AVFDLMEGKS YVFRVLSANR HGLSEPSEIT 
SPIQAQDVTV VPSAPGRVLA SRNTKTSVVV QWDRPKHEED LLGYYVDCCV AGTNLWEPCN 
HKPIGYNRFV VHGLTTGEQY IFRVKAVNAV GMSENSQESD VIKVQAALTV PSHPYGITLL 
NCDGHSMTLG WKVPKFSGGS PILGYYLDKR EVHHKNWHEV NSSPSKPTIL TVDGLTEGSL 
YEFKIAAVNL AGIGEPSDPS EHFKCEAWTM PEPGPAYDLT FCEVRDTSLV MLWKAPVYSG 
SSPVSGYFVD FREEDAGEWI TVNQTTTASR YLKVSDLQQG KTYVFRVRAV NANGVGKPSD 
TSEPVLVEAR PGTKEISAGV DEQGNIYLGF DCQEMTDASQ FTWCKSYEEI SDDERFKIET 
VGDHSKLYLK NPDKEDLGTY SVSVSDTDGV SSSFVLDPEE LERLMALSNE IKNPTIPLKS 
ELAYEIFDKG RVRFWLQAEH LSPDASYRFI INDREVSDSE IHRIKCDKAT GIIEMVMDRF 
SIENEGTYTV QIHDGKAKSQ SSLVLIGDAF KTVLEEAEFQ RKEFLRKQGP HFAEYLHWDV 
TEECEVRLVC KVANTKKETV FKWLKDDVLY ETETLPNLER GICELLIPKL SKKDHGEYKA 
TLKDDRGQDV SILEIAGKVY DDMILAMSRV CGKSASPLKV LCTPEGIRLQ CFMKYFTDEM 
KVNWCHKDAK ISSSEHMRIG GSEEMAWLQI CEPTEKDKGK YTFEIFDGKD NHQRSLDLSG 
QAFDEAFAEF QQFKAAAFAE KNRGRLIGGL PDVVTIMEGK TLNLTCTVFG NPDPEVIWFK 
NDQDIQLSEH FSVKVEQAKY VSMTIKGVTS EDSGKYSINI KNKYGGEKID VTVSVYKHGE 
KIPDMAPPQQ AKPKLIPASA SAAGQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.