IL1RL1 | ENSG00000115602 | NCBI 9173

Details for: IL1RL1

Gene ID: 9173

Symbol: IL1RL1

Ensembl ID: ENSG00000115602

Description: interleukin 1 receptor like 1

Associated with

Cytokine signaling in immune system
(R-HSA-1280215)
Immune system
(R-HSA-168256)
Interleukin-1 family signaling
(R-HSA-446652)
Interleukin-33 signaling
(R-HSA-9014843)
Intracellular signaling by second messengers
(R-HSA-9006925)
Negative regulation of the pi3k/akt network
(R-HSA-199418)
Pi5p, pp2a and ier3 regulate pi3k/akt signaling
(R-HSA-6811558)
Pip3 activates akt signaling
(R-HSA-1257604)
Signaling by interleukins
(R-HSA-449147)
Cytokine receptor activity
(GO:0004896)
Cytosol
(GO:0005829)
External side of plasma membrane
(GO:0009897)
Extracellular region
(GO:0005576)
Focal adhesion
(GO:0005925)
Immune response
(GO:0006955)
Inflammatory response
(GO:0006954)
Interleukin-1 receptor activity
(GO:0004908)
Interleukin-33 binding
(GO:0002113)
Interleukin-33 receptor activity
(GO:0002114)
Interleukin-33-mediated signaling pathway
(GO:0038172)
Macrophage differentiation
(GO:0030225)
Nad+ nucleotidase, cyclic adp-ribose generating
(GO:0061809)
Nadp+ nucleosidase activity
(GO:0050135)
Negative regulation of t-helper 1 type immune response
(GO:0002826)
Negative regulation of type ii interferon production
(GO:0032689)
Plasma membrane
(GO:0005886)
Positive regulation of chemokine production
(GO:0032722)
Positive regulation of inflammatory response
(GO:0050729)
Positive regulation of interleukin-5 production
(GO:0032754)
Positive regulation of macrophage activation
(GO:0043032)
Protein binding
(GO:0005515)
Signal transduction
(GO:0007165)

Other Information

Proteins

Interleukin-1 receptor-like 1

Genular Protein ID: 633222079

Symbol: ILRL1_HUMAN

Name: Interleukin-1 receptor-like 1

UniProtKB Accession Codes:

Q01638 A8K6B3 B4E0I3 Q53TU7 Q8NEJ3 Q9ULV7 Q9UQ44

Database IDs:

Citations:

PubMed ID: 1482686

Title: Nucleotide sequence of a complementary DNA for human ST2.

PubMed ID: 1482686

DOI: 10.1016/0167-4781(92)90125-j

PubMed ID: 10527832

Title: Presence and expression of a novel variant form of ST2 gene product in human leukemic cell line UT-7/GM.

PubMed ID: 10527832

DOI: 10.1006/bbrc.1999.1469

PubMed ID: 10936050

Title: The cloning and nucleotide sequence of human ST2L cDNA.

PubMed ID: 10936050

DOI: 10.1006/geno.2000.6269

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15340161

Title: Signal peptide prediction based on analysis of experimentally verified cleavage sites.

PubMed ID: 15340161

DOI: 10.1110/ps.04682504

PubMed ID: 11478810

Title: Tissue distribution and subcellular localization of a variant form of the human ST2 gene product, ST2V.

PubMed ID: 11478810

DOI: 10.1006/bbrc.2001.5306

PubMed ID: 16286016

Title: IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST 2 and induces T helper type 2-associated cytokines.

PubMed ID: 16286016

DOI: 10.1016/j.immuni.2005.09.015

PubMed ID: 14759258

Title: An unappreciated role for RNA surveillance.

PubMed ID: 14759258

DOI: 10.1186/gb-2004-5-2-r8

PubMed ID: 19836339

Title: Structure of IL-33 and its interaction with the ST2 and IL-1RAcP receptors--insight into heterotrimeric IL-1 signaling complexes.

PubMed ID: 19836339

DOI: 10.1016/j.str.2009.08.009

PubMed ID: 19508382

Title: Interleukin-33 overexpression is associated with liver fibrosis in mice and humans.

PubMed ID: 19508382

DOI: 10.1111/j.1582-4934.2009.00801.x

PubMed ID: 23319592

Title: The GOLD domain-containing protein TMED1 is involved in interleukin-33 signaling.

PubMed ID: 23319592

DOI: 10.1074/jbc.m112.403899

PubMed ID: 35238669

Title: Reciprocal regulation of IL-33 receptor-mediated inflammatory response and pulmonary fibrosis by TRAF6 and USP38.

PubMed ID: 35238669

DOI: 10.1073/pnas.2116279119

PubMed ID: 23980170

Title: Structural insights into the interaction of IL-33 with its receptors.

PubMed ID: 23980170

DOI: 10.1073/pnas.1308651110

Sequence Information:

Length: 556
Mass: 63358
Checksum: CB3E444A2DD477B5
Sequence:

MGFWILAILT ILMYSTAAKF SKQSWGLENE ALIVRCPRQG KPSYTVDWYY SQTNKSIPTQ 
ERNRVFASGQ LLKFLPAAVA DSGIYTCIVR SPTFNRTGYA NVTIYKKQSD CNVPDYLMYS 
TVSGSEKNSK IYCPTIDLYN WTAPLEWFKN CQALQGSRYR AHKSFLVIDN VMTEDAGDYT 
CKFIHNENGA NYSVTATRSF TVKDEQGFSL FPVIGAPAQN EIKEVEIGKN ANLTCSACFG 
KGTQFLAAVL WQLNGTKITD FGEPRIQQEE GQNQSFSNGL ACLDMVLRIA DVKEEDLLLQ 
YDCLALNLHG LRRHTVRLSR KNPIDHHSIY CIIAVCSVFL MLINVLVIIL KMFWIEATLL 
WRDIAKPYKT RNDGKLYDAY VVYPRNYKSS TDGASRVEHF VHQILPDVLE NKCGYTLCIY 
GRDMLPGEDV VTAVETNIRK SRRHIFILTP QITHNKEFAY EQEVALHCAL IQNDAKVILI 
EMEALSELDM LQAEALQDSL QHLMKVQGTI KWREDHIANK RSLNSKFWKH VRYQMPVPSK 
IPRKASSLTP LAAQKQ

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: IL1RL1

Associated with

Other Information

Nucleotide sequence of a complementary DNA for human ST2. PubMed ID: 1482686

Presence and expression of a novel variant form of ST2 gene product in human leukemic cell line UT-7/GM. PubMed ID: 10527832

The cloning and nucleotide sequence of human ST2L cDNA. PubMed ID: 10936050

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

Generation and annotation of the DNA sequences of human chromosomes 2 and 4. PubMed ID: 15815621

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Signal peptide prediction based on analysis of experimentally verified cleavage sites. PubMed ID: 15340161

Tissue distribution and subcellular localization of a variant form of the human ST2 gene product, ST2V. PubMed ID: 11478810

IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST 2 and induces T helper type 2-associated cytokines. PubMed ID: 16286016

An unappreciated role for RNA surveillance. PubMed ID: 14759258

Structure of IL-33 and its interaction with the ST2 and IL-1RAcP receptors--insight into heterotrimeric IL-1 signaling complexes. PubMed ID: 19836339

Interleukin-33 overexpression is associated with liver fibrosis in mice and humans. PubMed ID: 19508382

The GOLD domain-containing protein TMED1 is involved in interleukin-33 signaling. PubMed ID: 23319592

Reciprocal regulation of IL-33 receptor-mediated inflammatory response and pulmonary fibrosis by TRAF6 and USP38. PubMed ID: 35238669

Structural insights into the interaction of IL-33 with its receptors. PubMed ID: 23980170