MAP3K13 | ENSG00000073803 | NCBI 9175

Details for: MAP3K13

Gene ID: 9175

Symbol: MAP3K13

Ensembl ID: ENSG00000073803

Description: mitogen-activated protein kinase kinase kinase 13

Associated with

Atp binding
(GO:0005524)
Cytoplasm
(GO:0005737)
Enzyme binding
(GO:0019899)
Identical protein binding
(GO:0042802)
Ikappab kinase complex binding
(GO:0106137)
Jnk cascade
(GO:0007254)
Jun kinase kinase kinase activity
(GO:0004706)
Map kinase kinase kinase activity
(GO:0004709)
Membrane
(GO:0016020)
Metal ion binding
(GO:0046872)
Peptidyl-serine phosphorylation
(GO:0018105)
Positive regulation of axon extension
(GO:0045773)
Positive regulation of branching morphogenesis of a nerve
(GO:1905492)
Positive regulation of jun kinase activity
(GO:0043507)
Positive regulation of neuron maturation
(GO:0014042)
Positive regulation of neuron projection arborization
(GO:0150012)
Positive regulation of nf-kappab transcription factor activity
(GO:0051092)
Protein autophosphorylation
(GO:0046777)
Protein binding
(GO:0005515)
Protein homodimerization activity
(GO:0042803)
Protein kinase binding
(GO:0019901)
Protein phosphorylation
(GO:0006468)
Protein serine/threonine kinase activator activity
(GO:0043539)
Protein serine/threonine kinase activity
(GO:0004674)
Protein serine kinase activity
(GO:0106310)
Stress-activated mapk cascade
(GO:0051403)

Other Information

Proteins

Mitogen-activated protein kinase kinase kinase 13

Genular Protein ID: 3882655614

Symbol: M3K13_HUMAN

Name: Mitogen-activated protein kinase kinase kinase 13

UniProtKB Accession Codes:

O43283 B2R6U2 B4DLE3 B4DMV2 B4DZJ4 D3DNU1 Q05BY6 Q15450 Q2NKN3

Database IDs:

Citations:

PubMed ID: 9353328

Title: Molecular cloning and functional expression of a cDNA encoding a new member of mixed lineage protein kinase from human brain.

PubMed ID: 9353328

DOI: 10.1074/jbc.272.45.28622

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8274451

Title: Identification of 21 novel human protein kinases, including 3 members of a family related to the cell cycle regulator nimA of Aspergillus nidulans.

PubMed ID: 8274451

PubMed ID: 11163770

Title: Identification and characterization of functional domains in a mixed lineage kinase LZK.

PubMed ID: 11163770

DOI: 10.1016/s0014-5793(00)02432-7

PubMed ID: 11726277

Title: Mixed lineage kinase LZK forms a functional signaling complex with JIP-1, a scaffold protein of the c-Jun NH(2)-terminal kinase pathway.

PubMed ID: 11726277

DOI: 10.1093/oxfordjournals.jbchem.a003048

PubMed ID: 12492477

Title: Mixed lineage kinase LZK and antioxidant protein-1 activate NF-kappaB synergistically.

PubMed ID: 12492477

DOI: 10.1046/j.1432-1033.2003.03363.x

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

Sequence Information:

Length: 966
Mass: 108296
Checksum: 9687F38C8AB20AB1
Sequence:

MANFQEHLSC SSSPHLPFSE SKTFNGLQDE LTAMGNHPSP KLLEDQQEKG MVRTELIESV 
HSPVTTTVLT SVSEDSRDQF ENSVLQLREH DESETAVSQG NSNTVDGEST SGTEDIKIQF 
SRSGSGSGGF LEGLFGCLRP VWNIIGKAYS TDYKLQQQDT WEVPFEEISE LQWLGSGAQG 
AVFLGKFRAE EVAIKKVREQ NETDIKHLRK LKHPNIIAFK GVCTQAPCYC IIMEYCAHGQ 
LYEVLRAGRK ITPRLLVDWS TGIASGMNYL HLHKIIHRDL KSPNVLVTHT DAVKISDFGT 
SKELSDKSTK MSFAGTVAWM APEVIRNEPV SEKVDIWSFG VVLWELLTGE IPYKDVDSSA 
IIWGVGSNSL HLPVPSTCPD GFKILMKQTW QSKPRNRPSF RQTLMHLDIA SADVLATPQE 
TYFKSQAEWR EEVKKHFEKI KSEGTCIHRL DEELIRRRRE ELRHALDIRE HYERKLERAN 
NLYMELSAIM LQLEMREKEL IKREQAVEKK YPGTYKRHPV RPIIHPNAME KLMKRKGVPH 
KSGMQTKRPD LLRSEGIPTT EVAPTASPLS GSPKMSTSSS KSRYRSKPRH RRGNSRGSHS 
DFAAILKNQP AQENSPHPTY LHQAQSQYPS LHHHNSLQQQ YQQPPPAMSQ SHHPRLNMHG 
QDIATCANNL RYFGPAAALR SPLSNHAQRQ LPGSSPDLIS TAMAADCWRS SEPDKGQAGP 
WGCCQADAYD PCLQCRPEQY GSLDIPSAEP VGRSPDLSKS PAHNPLLENA QSSEKTEENE 
FSGCRSESSL GTSHLGTPPA LPRKTRPLQK SGDDSSEEEE GEVDSEVEFP RRQRPHRCIS 
SCQSYSTFSS ENFSVSDGEE GNTSDHSNSP DELADKLEDR LAEKLDDLLS QTPEIPIDIS 
SHSDGLSDKE CAVRRVKTQM SLGKLCVEER GYENPMQFEE SDCDSSDGEC SDATVRTNKH 
YSSATW

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: MAP3K13

Associated with

Other Information

Molecular cloning and functional expression of a cDNA encoding a new member of mixed lineage protein kinase from human brain. PubMed ID: 9353328

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence, annotation and analysis of human chromosome 3. PubMed ID: 16641997

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Identification of 21 novel human protein kinases, including 3 members of a family related to the cell cycle regulator nimA of Aspergillus nidulans. PubMed ID: 8274451

Identification and characterization of functional domains in a mixed lineage kinase LZK. PubMed ID: 11163770

Mixed lineage kinase LZK forms a functional signaling complex with JIP-1, a scaffold protein of the c-Jun NH(2)-terminal kinase pathway. PubMed ID: 11726277

Mixed lineage kinase LZK and antioxidant protein-1 activate NF-kappaB synergistically. PubMed ID: 12492477

Patterns of somatic mutation in human cancer genomes. PubMed ID: 17344846