Details for: AP4M1

Gene ID: 9179

Symbol: AP4M1

Ensembl ID: ENSG00000221838

Description: adaptor related protein complex 4 subunit mu 1

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 168,866
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,755
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47,979
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.98
    Marker Score: 8,554
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,404
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.93
    Marker Score: 481
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.93
    Marker Score: 437
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,716
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.87
    Marker Score: 13,623
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.87
    Marker Score: 4,957
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,253
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.85
    Marker Score: 307
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.83
    Marker Score: 928
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.8
    Marker Score: 1,152
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.8
    Marker Score: 1,629
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.79
    Marker Score: 1,858
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,266
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 0.77
    Marker Score: 1,467
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.75
    Marker Score: 234
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.73
    Marker Score: 920
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.73
    Marker Score: 1,131
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.73
    Marker Score: 293
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.73
    Marker Score: 559
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.72
    Marker Score: 375
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.71
    Marker Score: 2,443
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.69
    Marker Score: 2,908
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.68
    Marker Score: 1,151
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.67
    Marker Score: 611
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.67
    Marker Score: 1,396
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.66
    Marker Score: 169
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.65
    Marker Score: 358
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.63
    Marker Score: 204
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 0.62
    Marker Score: 209
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 0.62
    Marker Score: 1,689
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.61
    Marker Score: 366
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.6
    Marker Score: 3,606
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.6
    Marker Score: 1,629
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.6
    Marker Score: 1,059
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.6
    Marker Score: 5,133
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.59
    Marker Score: 446
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 0.59
    Marker Score: 350
  • Cell Name: Unknown (CL0002371)
    Fold Change: 0.58
    Marker Score: 620
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.57
    Marker Score: 2,473
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 0.57
    Marker Score: 823
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.57
    Marker Score: 169
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.56
    Marker Score: 161
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.56
    Marker Score: 562
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 0.55
    Marker Score: 7,317
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.55
    Marker Score: 11,794
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.53
    Marker Score: 18,513
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.53
    Marker Score: 426
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.53
    Marker Score: 352
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.53
    Marker Score: 5,437
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.52
    Marker Score: 2,014
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.52
    Marker Score: 5,235
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.52
    Marker Score: 2,103
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.52
    Marker Score: 216
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.51
    Marker Score: 246
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.51
    Marker Score: 1,211
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.51
    Marker Score: 248
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.51
    Marker Score: 337
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.51
    Marker Score: 528
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.5
    Marker Score: 176
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.5
    Marker Score: 1,423
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.5
    Marker Score: 4,711
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.49
    Marker Score: 116
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.49
    Marker Score: 424
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.49
    Marker Score: 232
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.49
    Marker Score: 2,001
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.48
    Marker Score: 4,865
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.48
    Marker Score: 5,401
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.48
    Marker Score: 1,847
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 0.48
    Marker Score: 449
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.48
    Marker Score: 194
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.47
    Marker Score: 511
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.47
    Marker Score: 3,082
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.46
    Marker Score: 315
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.46
    Marker Score: 120
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 0.46
    Marker Score: 1,643
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.46
    Marker Score: 1,134
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 0.46
    Marker Score: 10,286
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.46
    Marker Score: 1,083
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 0.45
    Marker Score: 146
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 0.45
    Marker Score: 485
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.45
    Marker Score: 124
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.45
    Marker Score: 290
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.45
    Marker Score: 207
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.45
    Marker Score: 27,579
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.45
    Marker Score: 473
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.45
    Marker Score: 1,757
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.45
    Marker Score: 539
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.44
    Marker Score: 572
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.44
    Marker Score: 203
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.44
    Marker Score: 404
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.44
    Marker Score: 124
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.44
    Marker Score: 3,754
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.43
    Marker Score: 180
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.43
    Marker Score: 381
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 0.42
    Marker Score: 151

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** AP4M1 is a member of the AP-4 adaptor complex, which plays a pivotal role in mediating protein interactions and regulating membrane trafficking. The mu 1 subunit of AP-4 is specifically involved in the assembly and disassembly of vesicles, as well as the targeting of proteins to specific compartments within the endomembrane system. AP4M1 exhibits a high degree of specificity in protein binding, interacting with a range of proteins involved in membrane trafficking, protein degradation, and cellular signaling. **Pathways and Functions:** AP4M1 is involved in several key pathways, including: 1. **Autophagosome assembly:** AP4M1 plays a crucial role in the formation and maturation of autophagosomes, which are double-membraned structures responsible for engulfing and degrading cellular waste and damaged organelles. 2. **Clathrin adaptor complex:** AP4M1 interacts with the clathrin adaptor complex to regulate the formation of clathrin-coated vesicles, which are involved in endocytosis and the transport of molecules across the plasma membrane. 3. **Cytoplasmic vesicle formation:** AP4M1 is involved in the assembly and disassembly of cytoplasmic vesicles, which are involved in the transport of proteins and lipids between different compartments within the cell. 4. **Protein targeting:** AP4M1 regulates the targeting of proteins to specific compartments within the endomembrane system, including the Golgi apparatus, lysosomes, and the plasma membrane. **Clinical Significance:** Dysregulation of AP4M1 has been implicated in various diseases, including: 1. **Neurodegenerative disorders:** Mutations in AP4M1 have been associated with neurodegenerative disorders, such as Alzheimer's disease and Parkinson's disease, highlighting the importance of AP4M1 in maintaining neuronal function and integrity. 2. **Cancer:** AP4M1 has been shown to play a role in the regulation of protein degradation and cell growth, making it a potential target for cancer therapy. 3. **Immunological disorders:** AP4M1 has been implicated in the regulation of immune cell function, making it a potential target for the treatment of immunological disorders, such as autoimmune diseases. In conclusion, AP4M1 is a critical regulator of membrane trafficking and cellular homeostasis, playing a key role in maintaining cellular function and integrity. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into the functions and mechanisms of AP4M1.

Genular Protein ID: 4259449004

Symbol: AP4M1_HUMAN

Name: AP-4 adaptor complex mu subunit

UniProtKB Accession Codes:

O00189 D6W5U1 Q8WV65 Q9UHK9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DNASU 1 DisGeNET 1 EMBL 6 EPD 1 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 21 Gene3D 2 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 2 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 2 PIRSF 1 PRINTS 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TCDB 1 TopDownProteomics 1 TreeFam 1 UCSC 1 UniProtKB 3 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9013859

Title: Identification of two new mu-adaptin-related proteins, mu-ARP1 and mu-ARP2.

PubMed ID: 9013859

DOI: 10.1016/s0014-5793(96)01500-1

PubMed ID: 10436028

Title: Characterization of a fourth adaptor-related protein complex.

PubMed ID: 10436028

DOI: 10.1091/mbc.10.8.2787

PubMed ID: 11139587

Title: Signal-binding specificity of the mu4 subunit of the adaptor protein complex, AP-4.

PubMed ID: 11139587

DOI: 10.1074/jbc.m010591200

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10066790

Title: AP-4, a novel protein complex related to clathrin adaptors.

PubMed ID: 10066790

DOI: 10.1074/jbc.274.11.7278

PubMed ID: 19559397

Title: Mutation in the AP4M1 gene provides a model for neuroaxonal injury in cerebral palsy.

PubMed ID: 19559397

DOI: 10.1016/j.ajhg.2009.06.004

PubMed ID: 11802162

Title: AP-4 binds basolateral signals and participates in basolateral sorting in epithelial MDCK cells.

PubMed ID: 11802162

DOI: 10.1038/ncb745

PubMed ID: 26544806

Title: Association between rare variants in AP4E1, a component of intracellular trafficking, and persistent stuttering.

PubMed ID: 26544806

DOI: 10.1016/j.ajhg.2015.10.007

PubMed ID: 29180427

Title: AP-4 mediates export of ATG9A from the trans-Golgi network to promote autophagosome formation.

PubMed ID: 29180427

DOI: 10.1073/pnas.1717327114

PubMed ID: 32073997

Title: The FTS-Hook-FHIP (FHF) complex interacts with AP-4 to mediate perinuclear distribution of AP-4 and its cargo ATG9A.

PubMed ID: 32073997

DOI: 10.1091/mbc.e19-11-0658

PubMed ID: 20230749

Title: Sorting of the Alzheimer's disease amyloid precursor protein mediated by the AP-4 complex.

PubMed ID: 20230749

DOI: 10.1016/j.devcel.2010.01.015

Sequence Information:

  • Length: 453
  • Mass: 49977
  • Checksum: AE3DCA8C5AED08B7
  • Sequence:
    • MISQFFILSS KGDPLIYKDF RGDSGGRDVA ELFYRKLTGL PGDESPVVMH HHGRHFIHIR 
HSGLYLVVTT SENVSPFSLL ELLSRLATLL GDYCGSLGEG TISRNVALVY ELLDEVLDYG 
YVQTTSTEML RNFIQTEAVV SKPFSLFDLS SVGLFGAETQ QSKVAPSSAA SRPVLSSRSD 
QSQKNEVFLD VVERLSVLIA SNGSLLKVDV QGEIRLKSFL PSGSEMRIGL TEEFCVGKSE 
LRGYGPGIRV DEVSFHSSVN LDEFESHRIL RLQPPQGELT VMRYQLSDDL PSPLPFRLFP 
SVQWDRGSGR LQVYLKLRCD LLSKSQALNV RLHLPLPRGV VSLSQELSSP EQKAELAEGA 
LRWDLPRVQG GSQLSGLFQM DVPGPPGPPS HGLSTSASPL GLGPASLSFE LPRHTCSGLQ 
VRFLRLAFRP CGNANPHKWV RHLSHSDAYV IRI

Genular Protein ID: 420608559

Symbol: C9JC87_HUMAN

Name: N/A

UniProtKB Accession Codes:

C9JC87

Database IDs:

ARBA 10 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 2 CTD 1 ChiTaRS 1 DNASU 1 EMBL 1 EPD 2 Ensembl 2 ExpressionAtlas 1 GO 5 Gene3D 2 GeneTree 1 GenomeRNAi 1 HGNC 1 InterPro 6 MassIVE 1 MaxQB 2 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRNR 1 PIRSF 1 PRINTS 1 PROSITE 3 PeptideAtlas 1 Pfam 2 PhylomeDB 1 Proteomes 2 ProteomicsDB 1 RefSeq 2 SMR 1 SUPFAM 2 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

Sequence Information:

  • Length: 460
  • Mass: 50691
  • Checksum: 86985C5110445050
  • Sequence:
    • MISQFFILSS KGDPLIYKDF RGDSGGRDVA ELFYRKLTGL PGDESPVVMV TSGGRRHHHG 
RHFIHIRHSG LYLVVTTSEN VSPFSLLELL SRLATLLGDY CGSLGEGTIS RNVALVYELL 
DEVLDYGYVQ TTSTEMLRNF IQTEAVVSKP FSLFDLSSVG LFGAETQQSK VAPSSAASRP 
VLSSRSDQSQ KNEVFLDVVE RLSVLIASNG SLLKVDVQGE IRLKSFLPSG SEMRIGLTEE 
FCVGKSELRG YGPGIRVDEV SFHSSVNLDE FESHRILRLQ PPQGELTVMR YQLSDDLPSP 
LPFRLFPSVQ WDRGSGRLQV YLKLRCDLLS KSQALNVRLH LPLPRGVVSL SQELSSPEQK 
AELAEGALRW DLPRVQGGSQ LSGLFQMDVP GPPGPPSHGL STSASPLGLG PASLSFELPR 
HTCSGLQVRF LRLAFRPCGN ANPHKWVRHL SHSDAYVIRI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.