Details for: RASSF9

Gene ID: 9182

Symbol: RASSF9

Ensembl ID: ENSG00000198774

Description: Ras association domain family member 9

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.59
    Marker Score: 1,154
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 168,919
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.35
    Marker Score: 857
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.32
    Marker Score: 1,318
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 1.32
    Marker Score: 9,816
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 1.28
    Marker Score: 370
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 1.06
    Marker Score: 584
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251,778
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,797
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,022
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,407
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.97
    Marker Score: 500
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.96
    Marker Score: 454
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.95
    Marker Score: 638
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,411
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.92
    Marker Score: 368
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,738
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.91
    Marker Score: 5,172
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 322
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 0.89
    Marker Score: 439
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,276
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.85
    Marker Score: 1,209
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.79
    Marker Score: 1,436
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.77
    Marker Score: 12,098
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.77
    Marker Score: 590
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1,250
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.77
    Marker Score: 461
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.76
    Marker Score: 691
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.76
    Marker Score: 1,537
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.75
    Marker Score: 390
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 0.75
    Marker Score: 160
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 0.72
    Marker Score: 1,440
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.71
    Marker Score: 6,194
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 178
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.68
    Marker Score: 2,855
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.68
    Marker Score: 2,502
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.67
    Marker Score: 4,049
  • Cell Name: club cell (CL0000158)
    Fold Change: 0.65
    Marker Score: 763
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.61
    Marker Score: 336
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.58
    Marker Score: 360
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.57
    Marker Score: 367
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.56
    Marker Score: 148
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 443
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.55
    Marker Score: 256
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.55
    Marker Score: 1,881
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.55
    Marker Score: 173
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.53
    Marker Score: 353
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.51
    Marker Score: 120
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 0.51
    Marker Score: 130
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.51
    Marker Score: 212
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 0.5
    Marker Score: 451
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 0.49
    Marker Score: 2,051
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.49
    Marker Score: 118
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.48
    Marker Score: 467
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.48
    Marker Score: 497
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 0.48
    Marker Score: 905
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.47
    Marker Score: 606
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 0.47
    Marker Score: 134
  • Cell Name: gut endothelial cell (CL0000131)
    Fold Change: 0.46
    Marker Score: 166
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.46
    Marker Score: 409
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.44
    Marker Score: 297
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 0.44
    Marker Score: 5,892
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.43
    Marker Score: 706
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 0.43
    Marker Score: 2,099
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 0.41
    Marker Score: 1,041
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.41
    Marker Score: 353
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.39
    Marker Score: 187
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.39
    Marker Score: 413
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.38
    Marker Score: 159
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.37
    Marker Score: 116
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.37
    Marker Score: 283
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.36
    Marker Score: 366
  • Cell Name: kidney loop of Henle epithelial cell (CL1000909)
    Fold Change: 0.36
    Marker Score: 224
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.36
    Marker Score: 12,377
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 0.34
    Marker Score: 323
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.34
    Marker Score: 155
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.34
    Marker Score: 356
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.34
    Marker Score: 2,888
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.33
    Marker Score: 159
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.33
    Marker Score: 504
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.33
    Marker Score: 190
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 0.32
    Marker Score: 2,104
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.32
    Marker Score: 305
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.31
    Marker Score: 141
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 0.31
    Marker Score: 1,609
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 0.3
    Marker Score: 6,794
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.3
    Marker Score: 4,880
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.3
    Marker Score: 926
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 0.3
    Marker Score: 266
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.3
    Marker Score: 104
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 0.3
    Marker Score: 476
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.29
    Marker Score: 167
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.29
    Marker Score: 64
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.29
    Marker Score: 294
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.29
    Marker Score: 169
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.29
    Marker Score: 329
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.29
    Marker Score: 242
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 0.29
    Marker Score: 163
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.28
    Marker Score: 83
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.28
    Marker Score: 188

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Cellular Expression:** RASSF9 is expressed in a wide range of cell types, including colon goblet cells, mural cells, granulocyte monocyte progenitor cells, enterocytes, basal cells of the tracheal epithelium, and GABAergic interneurons. This broad expression pattern suggests a role in maintaining tissue homeostasis and immune regulation. 2. **Protein Structure:** RASSF9 contains a Ras association domain, which mediates interactions with other proteins, facilitating its involvement in signaling pathways. 3. **Endosomal Transport:** RASSF9 is implicated in the regulation of endosomal transport, a process crucial for maintaining cellular homeostasis and immune function. **Pathways and Functions:** 1. **Endosomal Transport:** RASSF9 regulates the trafficking of proteins and lipids within endosomes, influencing cellular homeostasis and immune function. 2. **Signal Transduction:** RASSF9 interacts with various signaling molecules, modulating the transmission of signals within the cell, which is essential for immune response regulation. 3. **Protein Targeting:** RASSF9 influences the targeting of proteins to specific compartments within the cell, such as the Golgi apparatus and lysosomes, impacting cellular homeostasis and immune function. 4. **Extracellular Exosome Transport:** RASSF9 is involved in the transport of proteins and lipids to extracellular exosomes, a process that regulates intercellular communication and immune function. **Clinical Significance:** 1. **Immunological Disorders:** Alterations in RASSF9 expression or function have been linked to various immunological disorders, including cancer, autoimmune diseases, and immune-mediated neurological disorders. 2. **Cancer Metastasis:** RASSF9's involvement in endosomal transport and signal transduction pathways makes it a potential target for cancer therapy, particularly in the context of metastasis. 3. **Neurological Disorders:** RASSF9's expression in GABAergic interneurons and its role in signal transduction pathways suggest its potential involvement in neurological disorders, such as epilepsy and schizophrenia. In conclusion, RASSF9 is a gene of paramount importance in the realm of immunology, with far-reaching implications for our understanding of cellular signaling, transport, and homeostasis. Further research into the intricacies of RASSF9 will undoubtedly reveal its significance in various disease states, paving the way for novel therapeutic strategies.

Genular Protein ID: 2892347544

Symbol: RASF9_HUMAN

Name: Ras association domain-containing protein 9

UniProtKB Accession Codes:

O75901 B3KMQ4 Q8N5U8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 4 EPD 1 Ensembl 1 GO 9 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SAM 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9837933

Title: P-CIP1, a novel protein that interacts with the cytosolic domain of peptidylglycine alpha-amidating monooxygenase, is associated with endosomes.

PubMed ID: 9837933

DOI: 10.1074/jbc.273.50.33524

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18272789

Title: RASSF7 is a member of a new family of RAS association domain-containing proteins and is required for completing mitosis.

PubMed ID: 18272789

DOI: 10.1091/mbc.e07-07-0652

Sequence Information:

  • Length: 435
  • Mass: 50021
  • Checksum: C9CF3E1C482AAA18
  • Sequence:
    • MAPFGRNLLK TRHKNRSPTK DMDSEEKEIV VWVCQEEKLV CGLTKRTTSA DVIQALLEEH 
EATFGEKRFL LGKPSDYCII EKWRGSERVL PPLTRILKLW KAWGDEQPNM QFVLVKADAF 
LPVPLWRTAE AKLVQNTEKL WELSPANYMK TLPPDKQKRI VRKTFRKLAK IKQDTVSHDR 
DNMETLVHLI ISQDHTIHQQ VKRMKELDLE IEKCEAKFHL DRVENDGENY VQDAYLMPSF 
SEVEQNLDLQ YEENQTLEDL SESDGIEQLE ERLKYYRILI DKLSAEIEKE VKSVCIDINE 
DAEGEAASEL ESSNLESVKC DLEKSMKAGL KIHSHLSGIQ KEIKYSDSLL QMKAKEYELL 
AKEFNSLHIS NKDGCQLKEN RAKESEVPSS NGEIPPFTQR VFSNYTNDTD SDTGISSNHS 
QDSETTVGDV VLLST

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.