ZW10 | ENSG00000086827 | NCBI 9183

Details for: ZW10

Gene ID: 9183

Symbol: ZW10

Ensembl ID: ENSG00000086827

Description: zw10 kinetochore protein

Associated with

Amplification of signal from the kinetochores
(R-HSA-141424)
Amplification of signal from unattached kinetochores via a mad2 inhibitory signal
(R-HSA-141444)
Cell cycle
(R-HSA-1640170)
Cell cycle, mitotic
(R-HSA-69278)
Cell cycle checkpoints
(R-HSA-69620)
Copi-dependent golgi-to-er retrograde traffic
(R-HSA-6811434)
Eml4 and nudc in mitotic spindle formation
(R-HSA-9648025)
Golgi-to-er retrograde transport
(R-HSA-8856688)
Intra-golgi and retrograde golgi-to-er traffic
(R-HSA-6811442)
Membrane trafficking
(R-HSA-199991)
Mitotic anaphase
(R-HSA-68882)
Mitotic metaphase and anaphase
(R-HSA-2555396)
Mitotic prometaphase
(R-HSA-68877)
Mitotic spindle checkpoint
(R-HSA-69618)
M phase
(R-HSA-68886)
Resolution of sister chromatid cohesion
(R-HSA-2500257)
Rho gtpase effectors
(R-HSA-195258)
Rho gtpases activate formins
(R-HSA-5663220)
Separation of sister chromatids
(R-HSA-2467813)
Signaling by rho gtpases
(R-HSA-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-HSA-9716542)
Signal transduction
(R-HSA-162582)
Vesicle-mediated transport
(R-HSA-5653656)
Cell division
(GO:0051301)
Centromeric dna binding
(GO:0019237)
Cytosol
(GO:0005829)
Dsl1/nzr complex
(GO:0070939)
Endoplasmic reticulum
(GO:0005783)
Endoplasmic reticulum membrane
(GO:0005789)
Endoplasmic reticulum to golgi vesicle-mediated transport
(GO:0006888)
Establishment of mitotic spindle orientation
(GO:0000132)
Golgi organization
(GO:0007030)
Kinetochore
(GO:0000776)
Kinetochore microtubule
(GO:0005828)
Lipid droplet
(GO:0005811)
Meiotic cell cycle
(GO:0051321)
Membrane
(GO:0016020)
Mitotic metaphase chromosome alignment
(GO:0007080)
Mitotic sister chromatid segregation
(GO:0000070)
Mitotic spindle assembly checkpoint signaling
(GO:0007094)
Nucleus
(GO:0005634)
Protein-containing complex assembly
(GO:0065003)
Protein binding
(GO:0005515)
Protein localization to kinetochore
(GO:0034501)
Protein transport
(GO:0015031)
Regulation of attachment of spindle microtubules to kinetochore
(GO:0051988)
Regulation of exit from mitosis
(GO:0007096)
Retrograde vesicle-mediated transport, golgi to endoplasmic reticulum
(GO:0006890)
Rzz complex
(GO:1990423)
Spindle pole
(GO:0000922)

Other Information

Proteins

Centromere/kinetochore protein zw10 homolog

Genular Protein ID: 662196291

Symbol: ZW10_HUMAN

Name: Centromere/kinetochore protein zw10 homolog

UniProtKB Accession Codes:

O43264 A1A528

Database IDs:

Citations:

PubMed ID: 9298984

Title: Conservation of the centromere/kinetochore protein ZW10.

PubMed ID: 9298984

DOI: 10.1083/jcb.138.6.1289

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12665801

Title: Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.

PubMed ID: 12665801

DOI: 10.1038/nbt810

PubMed ID: 11590237

Title: The ZW10 and Rough Deal checkpoint proteins function together in a large, evolutionarily conserved complex targeted to the kinetochore.

PubMed ID: 11590237

DOI: 10.1242/jcs.114.17.3103

PubMed ID: 12686595

Title: Zwilch, a new component of the ZW10/ROD complex required for kinetochore functions.

PubMed ID: 12686595

DOI: 10.1091/mbc.e02-09-0624

PubMed ID: 15029241

Title: Implication of ZW10 in membrane trafficking between the endoplasmic reticulum and Golgi.

PubMed ID: 15029241

DOI: 10.1038/sj.emboj.7600135

PubMed ID: 15272311

Title: Involvement of BNIP1 in apoptosis and endoplasmic reticulum membrane fusion.

PubMed ID: 15272311

DOI: 10.1038/sj.emboj.7600333

PubMed ID: 15094189

Title: Recapitulation of the Roberts syndrome cellular phenotype by inhibition of INCENP, ZWINT-1 and ZW10 genes.

PubMed ID: 15094189

DOI: 10.1016/j.gene.2004.01.028

PubMed ID: 15485811

Title: Human Zwint-1 specifies localization of Zeste White 10 to kinetochores and is essential for mitotic checkpoint signaling.

PubMed ID: 15485811

DOI: 10.1074/jbc.m407588200

PubMed ID: 15824131

Title: ZW10 links mitotic checkpoint signaling to the structural kinetochore.

PubMed ID: 15824131

DOI: 10.1083/jcb.200411118

PubMed ID: 16732327

Title: Hec1 sequentially recruits Zwint-1 and ZW10 to kinetochores for faithful chromosome segregation and spindle checkpoint control.

PubMed ID: 16732327

DOI: 10.1038/sj.onc.1209687

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19369418

Title: Identification of the neuroblastoma-amplified gene product as a component of the syntaxin 18 complex implicated in Golgi-to-endoplasmic reticulum retrograde transport.

PubMed ID: 19369418

DOI: 10.1091/mbc.e08-11-1104

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20462495

Title: Structural analysis of the RZZ complex reveals common ancestry with multisubunit vesicle tethering machinery.

PubMed ID: 20462495

DOI: 10.1016/j.str.2010.02.014

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 30970241

Title: The ER-Localized Protein DFCP1 Modulates ER-Lipid Droplet Contact Formation.

PubMed ID: 30970241

DOI: 10.1016/j.celrep.2019.03.025

Sequence Information:

Length: 779
Mass: 88829
Checksum: 9C38186153886481
Sequence:

MASFVTEVLA HSGRLEKEDL GTRISRLTRR VEEIKGEVCN MISKKYSEFL PSMQSAQGLI 
TQVDKLSEDI DLLKSRIESE VRRDLHVSTG EFTDLKQQLE RDSVVLSLLK QLQEFSTAIE 
EYNCALTEKK YVTGAQRLEE AQKCLKLLKS RKCFDLKILK SLSMELTIQK QNILYHLGEE 
WQKLIVWKFP PSKDTSSLES YLQTELHLYT EQSHKEEKTP MPPISSVLLA FSVLGELHSK 
LKSFGQMLLK YILRPLASCP SLHAVIESQP NIVIIRFESI MTNLEYPSPS EVFTKIRLVL 
EVLQKQLLDL PLDTDLENEK TSTVPLAEML GDMIWEDLSE CLIKNCLVYS IPTNSSKLQQ 
YEEIIQSTEE FENALKEMRF LKGDTTDLLK YARNINSHFA NKKCQDVIVA ARNLMTSEIH 
NTVKIIPDSK INVPELPTPD EDNKLEVQKV SNTQYHEVMN LEPENTLDQH SFSLPTCRIS 
ESVKKLMELA YQTLLEATTS SDQCAVQLFY SVRNIFHLFH DVVPTYHKEN LQKLPQLAAI 
HHNNCMYIAH HLLTLGHQFR LRLAPILCDG TATFVDLVPG FRRLGTECFL AQMRAQKGEL 
LERLSSARNF SNMDDEENYS AASKAVRQVL HQLKRLGIVW QDVLPVNIYC KAMGTLLNTA 
ISEVIGKITA LEDISTEDGD RLYSLCKTVM DEGPQVFAPL SEESKNKKYQ EEVPVYVPKW 
MPFKELMMML QASLQEIGDR WADGKGPLAA AFSSSEVKAL IRALFQNTER RAAALAKIK

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: ZW10

Associated with

Other Information

Conservation of the centromere/kinetochore protein ZW10. PubMed ID: 9298984

Human chromosome 11 DNA sequence and analysis including novel gene identification. PubMed ID: 16554811

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. PubMed ID: 12665801

The ZW10 and Rough Deal checkpoint proteins function together in a large, evolutionarily conserved complex targeted to the kinetochore. PubMed ID: 11590237

Zwilch, a new component of the ZW10/ROD complex required for kinetochore functions. PubMed ID: 12686595

Implication of ZW10 in membrane trafficking between the endoplasmic reticulum and Golgi. PubMed ID: 15029241

Involvement of BNIP1 in apoptosis and endoplasmic reticulum membrane fusion. PubMed ID: 15272311

Recapitulation of the Roberts syndrome cellular phenotype by inhibition of INCENP, ZWINT-1 and ZW10 genes. PubMed ID: 15094189

Human Zwint-1 specifies localization of Zeste White 10 to kinetochores and is essential for mitotic checkpoint signaling. PubMed ID: 15485811

ZW10 links mitotic checkpoint signaling to the structural kinetochore. PubMed ID: 15824131

Hec1 sequentially recruits Zwint-1 and ZW10 to kinetochores for faithful chromosome segregation and spindle checkpoint control. PubMed ID: 16732327

Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. PubMed ID: 19413330

Identification of the neuroblastoma-amplified gene product as a component of the syntaxin 18 complex implicated in Golgi-to-endoplasmic reticulum retrograde transport. PubMed ID: 19369418

Lysine acetylation targets protein complexes and co-regulates major cellular functions. PubMed ID: 19608861

Structural analysis of the RZZ complex reveals common ancestry with multisubunit vesicle tethering machinery. PubMed ID: 20462495

Initial characterization of the human central proteome. PubMed ID: 21269460

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

N-terminome analysis of the human mitochondrial proteome. PubMed ID: 25944712

The ER-Localized Protein DFCP1 Modulates ER-Lipid Droplet Contact Formation. PubMed ID: 30970241