BUB3 | ENSG00000154473 | NCBI 9184

Details for: BUB3

Gene ID: 9184

Symbol: BUB3

Ensembl ID: ENSG00000154473

Description: BUB3 mitotic checkpoint protein

Associated with

Activation of apc/c and apc/c:cdc20 mediated degradation of mitotic proteins
(R-HSA-176814)
Amplification of signal from the kinetochores
(R-HSA-141424)
Amplification of signal from unattached kinetochores via a mad2 inhibitory signal
(R-HSA-141444)
Apc-cdc20 mediated degradation of nek2a
(R-HSA-179409)
Apc/c-mediated degradation of cell cycle proteins
(R-HSA-174143)
Apc/c:cdc20 mediated degradation of mitotic proteins
(R-HSA-176409)
Apc:cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint
(R-HSA-179419)
Cdc20:phospho-apc/c mediated degradation of cyclin a
(R-HSA-174184)
Cell cycle
(R-HSA-1640170)
Cell cycle, mitotic
(R-HSA-69278)
Cell cycle checkpoints
(R-HSA-69620)
Eml4 and nudc in mitotic spindle formation
(R-HSA-9648025)
Inactivation of apc/c via direct inhibition of the apc/c complex
(R-HSA-141430)
Inhibition of the proteolytic activity of apc/c required for the onset of anaphase by mitotic spindle checkpoint components
(R-HSA-141405)
Mitotic anaphase
(R-HSA-68882)
Mitotic metaphase and anaphase
(R-HSA-2555396)
Mitotic prometaphase
(R-HSA-68877)
Mitotic spindle checkpoint
(R-HSA-69618)
M phase
(R-HSA-68886)
Regulation of apc/c activators between g1/s and early anaphase
(R-HSA-176408)
Regulation of mitotic cell cycle
(R-HSA-453276)
Resolution of sister chromatid cohesion
(R-HSA-2500257)
Rho gtpase effectors
(R-HSA-195258)
Rho gtpases activate formins
(R-HSA-5663220)
Separation of sister chromatids
(R-HSA-2467813)
Signaling by rho gtpases
(R-HSA-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-HSA-9716542)
Signal transduction
(R-HSA-162582)
Attachment of spindle microtubules to kinetochore
(GO:0008608)
Bub1-bub3 complex
(GO:1990298)
Cell division
(GO:0051301)
Cytosol
(GO:0005829)
Kinetochore
(GO:0000776)
Meiotic cell cycle
(GO:0051321)
Mitotic checkpoint complex
(GO:0033597)
Mitotic spindle assembly checkpoint signaling
(GO:0007094)
Nucleoplasm
(GO:0005654)
Protein binding
(GO:0005515)
Protein localization to kinetochore
(GO:0034501)
Ubiquitin binding
(GO:0043130)

Other Information

Proteins

Mitotic checkpoint protein BUB3
A0A140VJF3_HUMAN

Genular Protein ID: 3715844611

Symbol: BUB3_HUMAN

Name: Mitotic checkpoint protein BUB3

UniProtKB Accession Codes:

O43684 A6NJ42 B2R6E7 D3DRE9 O43685

Database IDs:

Citations:

PubMed ID: 10198256

Title: Phosphorylation of human MAD1 by the BUB1 kinase in vitro.

PubMed ID: 10198256

DOI: 10.1006/bbrc.1999.0514

PubMed ID: 9660858

Title: The human homologue of Bub3 is required for kinetochore localization of Bub1 and a Mad3/Bub1-related protein kinase.

PubMed ID: 9660858

DOI: 10.1083/jcb.142.1.1

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15525512

Title: Phosphorylation of Cdc20 by Bub1 provides a catalytic mechanism for APC/C inhibition by the spindle checkpoint.

PubMed ID: 15525512

DOI: 10.1016/j.molcel.2004.09.031

PubMed ID: 18199686

Title: The human spindle assembly checkpoint protein Bub3 is required for the establishment of efficient kinetochore-microtubule attachments.

PubMed ID: 18199686

DOI: 10.1091/mbc.e07-07-0633

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24462186

Title: A microtubule-associated zinc finger protein, BuGZ, regulates mitotic chromosome alignment by ensuring Bub3 stability and kinetochore targeting.

PubMed ID: 24462186

DOI: 10.1016/j.devcel.2013.12.013

PubMed ID: 24462187

Title: BuGZ is required for Bub3 stability, Bub1 kinetochore function, and chromosome alignment.

PubMed ID: 24462187

DOI: 10.1016/j.devcel.2013.12.014

Sequence Information:

Length: 328
Mass: 37155
Checksum: 2915572A57368E5A
Sequence:

MTGSNEFKLN QPPEDGISSV KFSPNTSQFL LVSSWDTSVR LYDVPANSMR LKYQHTGAVL 
DCAFYDPTHA WSGGLDHQLK MHDLNTDQEN LVGTHDAPIR CVEYCPEVNV MVTGSWDQTV 
KLWDPRTPCN AGTFSQPEKV YTLSVSGDRL IVGTAGRRVL VWDLRNMGYV QQRRESSLKY 
QTRCIRAFPN KQGYVLSSIE GRVAVEYLDP SPEVQKKKYA FKCHRLKENN IEQIYPVNAI 
SFHNIHNTFA TGGSDGFVNI WDPFNKKRLC QFHRYPTSIA SLAFSNDGTT LAIASSYMYE 
MDDTEHPEDG IFIRQVTDAE TKPKSPCT

Genular Protein ID: 2328871093

Symbol: A0A140VJF3_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A140VJF3

Database IDs:

Sequence Information:

Length: 326
Mass: 36955
Checksum: F1EA57368E5A6345
Sequence:

MTGSNEFKLN QPPEDGISSV KFSPNTSQFL LVSSWDTSVR LYDVPANSMR LKYQHTGAVL 
DCAFYDPTHA WSGGLDHQLK MHDLNTDQEN LVGTHDAPIR CVEYCPEVNV MVTGSWDQTV 
KLWDPRTPCN AGTFSQPEKV YTLSVSGDRL IVGTAGRRVL VWDLRNMGYV QQRRESSLKY 
QTRCIRAFPN KQGYVLSSIE GRVAVEYLDP SPEVQKKKYA FKCHRLKENN IEQIYPVNAI 
SFHNIHNTFA TGGSDGFVNI WDPFNKKRLC QFHRYPTSIA SLAFSNDGTT LAIASSYMYE 
MDDTEHPEDG IFIRQVTDAE TKPKST

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: BUB3

Associated with

Other Information

Phosphorylation of human MAD1 by the BUB1 kinase in vitro. PubMed ID: 10198256

The human homologue of Bub3 is required for kinetochore localization of Bub1 and a Mad3/Bub1-related protein kinase. PubMed ID: 9660858

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence and comparative analysis of human chromosome 10. PubMed ID: 15164054

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Phosphorylation of Cdc20 by Bub1 provides a catalytic mechanism for APC/C inhibition by the spindle checkpoint. PubMed ID: 15525512

The human spindle assembly checkpoint protein Bub3 is required for the establishment of efficient kinetochore-microtubule attachments. PubMed ID: 18199686

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Lysine acetylation targets protein complexes and co-regulates major cellular functions. PubMed ID: 19608861

Initial characterization of the human central proteome. PubMed ID: 21269460

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

A microtubule-associated zinc finger protein, BuGZ, regulates mitotic chromosome alignment by ensuring Bub3 stability and kinetochore targeting. PubMed ID: 24462186

BuGZ is required for Bub3 stability, Bub1 kinetochore function, and chromosome alignment. PubMed ID: 24462187