DDX21 | ENSG00000165732 | NCBI 9188

Details for: DDX21

Gene ID: 9188

Symbol: DDX21

Ensembl ID: ENSG00000165732

Description: DExD-box helicase 21

Associated with

B-wich complex positively regulates rrna expression
(R-HSA-5250924)
Epigenetic regulation of gene expression
(R-HSA-212165)
Gene expression (transcription)
(R-HSA-74160)
Major pathway of rrna processing in the nucleolus and cytosol
(R-HSA-6791226)
Metabolism of rna
(R-HSA-8953854)
Positive epigenetic regulation of rrna expression
(R-HSA-5250913)
Rrna processing in the nucleus and cytosol
(R-HSA-8868773)
7sk snrna binding
(GO:0097322)
Atp binding
(GO:0005524)
Atp hydrolysis activity
(GO:0016887)
B-wich complex
(GO:0110016)
Chromatin remodeling
(GO:0006338)
Chromosome
(GO:0005694)
Cytosol
(GO:0005829)
Defense response to virus
(GO:0051607)
Double-stranded rna binding
(GO:0003725)
Identical protein binding
(GO:0042802)
Innate immune response
(GO:0045087)
Membrane
(GO:0016020)
Mirna binding
(GO:0035198)
Mitochondrion
(GO:0005739)
Mrna binding
(GO:0003729)
Negative regulation of transcription by rna polymerase i
(GO:0016479)
Nucleolus
(GO:0005730)
Nucleoplasm
(GO:0005654)
Osteoblast differentiation
(GO:0001649)
Positive regulation of canonical nf-kappab signal transduction
(GO:0043123)
Positive regulation of myeloid dendritic cell cytokine production
(GO:0002735)
Positive regulation of transcription by rna polymerase i
(GO:0045943)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Positive regulation of transcription by rna polymerase iii
(GO:0045945)
Protein binding
(GO:0005515)
R-loop processing
(GO:0062176)
Response to exogenous dsrna
(GO:0043330)
Rna binding
(GO:0003723)
Rna helicase activity
(GO:0003724)
Rna polymerase inhibitor activity
(GO:0140870)
Rrna binding
(GO:0019843)
Rrna processing
(GO:0006364)
Snorna binding
(GO:0030515)
Transcription by rna polymerase ii
(GO:0006366)

Other Information

Proteins

DEAD box protein 21

Genular Protein ID: 498431375

Symbol: DDX21_HUMAN

Name: DEAD box protein 21

UniProtKB Accession Codes:

Q9NR30 B2RDL0 Q13436 Q5VX41 Q68D35

Database IDs:

Citations:

PubMed ID: 8614622

Title: A nucleolar RNA helicase recognized by autoimmune antibodies from a patient with watermelon stomach disease.

PubMed ID: 8614622

DOI: 10.1093/nar/24.7.1220

PubMed ID: 11237763

Title: Human RNA helicase II/Gu gene: genomic organization and promoter analysis.

PubMed ID: 11237763

DOI: 10.1006/bbrc.2001.4446

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11823437

Title: The DEXD/H-box RNA helicase RHII/Gu is a co-factor for c-Jun-activated transcription.

PubMed ID: 11823437

DOI: 10.1093/emboj/21.3.451

PubMed ID: 9461305

Title: RNA-unwinding and RNA-folding activities of RNA helicase II/Gu--two activities in separate domains of the same protein.

PubMed ID: 9461305

DOI: 10.1111/j.1432-1033.1997.00800.x

PubMed ID: 14559904

Title: Silencing of RNA helicase II/Gualpha inhibits mammalian ribosomal RNA production.

PubMed ID: 14559904

DOI: 10.1074/jbc.m310846200

PubMed ID: 14654843

Title: Proteomic characterization of the human centrosome by protein correlation profiling.

PubMed ID: 14654843

DOI: 10.1038/nature02166

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16603771

Title: The WSTF-SNF2h chromatin remodeling complex interacts with several nuclear proteins in transcription.

PubMed ID: 16603771

DOI: 10.1074/jbc.m600233200

PubMed ID: 17924679

Title: Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra.

PubMed ID: 17924679

DOI: 10.1021/pr070152u

PubMed ID: 18180292

Title: c-Jun supports ribosomal RNA processing and nucleolar localization of RNA helicase DDX21.

PubMed ID: 18180292

DOI: 10.1074/jbc.m709613200

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21536856

Title: Splicing factor 2-associated protein p32 participates in ribosome biogenesis by regulating the binding of Nop52 and fibrillarin to preribosome particles.

PubMed ID: 21536856

DOI: 10.1074/mcp.m110.006148

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23848194

Title: Nucleolar scaffold protein, WDR46, determines the granular compartmental localization of nucleolin and DDX21.

PubMed ID: 23848194

DOI: 10.1111/gtc.12077

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 23652018

Title: GANP regulates recruitment of AID to immunoglobulin variable regions by modulating transcription and nucleosome occupancy.

PubMed ID: 23652018

DOI: 10.1038/ncomms2823

PubMed ID: 25260534

Title: Elevated DDX21 regulates c-Jun activity and rRNA processing in human breast cancers.

PubMed ID: 25260534

DOI: 10.1186/s13058-014-0449-z

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25114211

Title: Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli.

PubMed ID: 25114211

DOI: 10.1073/pnas.1413825111

PubMed ID: 25470060

Title: RNA helicase DDX21 coordinates transcription and ribosomal RNA processing.

PubMed ID: 25470060

DOI: 10.1038/nature13923

PubMed ID: 25477391

Title: The association of late-acting snoRNPs with human pre-ribosomal complexes requires the RNA helicase DDX21.

PubMed ID: 25477391

DOI: 10.1093/nar/gku1291

PubMed ID: 28790157

Title: SIRT7 and the DEAD-box helicase DDX21 cooperate to resolve genomic R loops and safeguard genome stability.

PubMed ID: 28790157

DOI: 10.1101/gad.300624.117

PubMed ID: 28431233

Title: A Compendium of RNA-Binding Proteins that Regulate MicroRNA Biogenesis.

PubMed ID: 28431233

DOI: 10.1016/j.molcel.2017.03.014

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 34564892

Title: Dominant KPNA3 Mutations Cause Infantile-Onset Hereditary Spastic Paraplegia.

PubMed ID: 34564892

DOI: 10.1002/ana.26228

Sequence Information:

Length: 783
Mass: 87344
Checksum: 4F6673E38686644F
Sequence:

MPGKLRSDAG LESDTAMKKG ETLRKQTEEK EKKEKPKSDK TEEIAEEEET VFPKAKQVKK 
KAEPSEVDMN SPKSKKAKKK EEPSQNDISP KTKSLRKKKE PIEKKVVSSK TKKVTKNEEP 
SEEEIDAPKP KKMKKEKEMN GETREKSPKL KNGFPHPEPD CNPSEAASEE SNSEIEQEIP 
VEQKEGAFSN FPISEETIKL LKGRGVTFLF PIQAKTFHHV YSGKDLIAQA RTGTGKTFSF 
AIPLIEKLHG ELQDRKRGRA PQVLVLAPTR ELANQVSKDF SDITKKLSVA CFYGGTPYGG 
QFERMRNGID ILVGTPGRIK DHIQNGKLDL TKLKHVVLDE VDQMLDMGFA DQVEEILSVA 
YKKDSEDNPQ TLLFSATCPH WVFNVAKKYM KSTYEQVDLI GKKTQKTAIT VEHLAIKCHW 
TQRAAVIGDV IRVYSGHQGR TIIFCETKKE AQELSQNSAI KQDAQSLHGD IPQKQREITL 
KGFRNGSFGV LVATNVAARG LDIPEVDLVI QSSPPKDVES YIHRSGRTGR AGRTGVCICF 
YQHKEEYQLV QVEQKAGIKF KRIGVPSATE IIKASSKDAI RLLDSVPPTA ISHFKQSAEK 
LIEEKGAVEA LAAALAHISG ATSVDQRSLI NSNVGFVTMI LQCSIEMPNI SYAWKELKEQ 
LGEEIDSKVK GMVFLKGKLG VCFDVPTASV TEIQEKWHDS RRWQLSVATE QPELEGPREG 
YGGFRGQREG SRGFRGQRDG NRRFRGQREG SRGPRGQRSG GGNKSNRSQN KGQKRSFSKA 
FGQ

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: DDX21

Associated with

Other Information

A nucleolar RNA helicase recognized by autoimmune antibodies from a patient with watermelon stomach disease. PubMed ID: 8614622

Human RNA helicase II/Gu gene: genomic organization and promoter analysis. PubMed ID: 11237763

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The full-ORF clone resource of the German cDNA consortium. PubMed ID: 17974005

The DNA sequence and comparative analysis of human chromosome 10. PubMed ID: 15164054

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

The DEXD/H-box RNA helicase RHII/Gu is a co-factor for c-Jun-activated transcription. PubMed ID: 11823437

RNA-unwinding and RNA-folding activities of RNA helicase II/Gu--two activities in separate domains of the same protein. PubMed ID: 9461305

Silencing of RNA helicase II/Gualpha inhibits mammalian ribosomal RNA production. PubMed ID: 14559904

Proteomic characterization of the human centrosome by protein correlation profiling. PubMed ID: 14654843

Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. PubMed ID: 17081983

The WSTF-SNF2h chromatin remodeling complex interacts with several nuclear proteins in transcription. PubMed ID: 16603771

Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra. PubMed ID: 17924679

c-Jun supports ribosomal RNA processing and nucleolar localization of RNA helicase DDX21. PubMed ID: 18180292

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. PubMed ID: 19413330

Large-scale proteomics analysis of the human kinome. PubMed ID: 19369195

Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. PubMed ID: 19690332

Lysine acetylation targets protein complexes and co-regulates major cellular functions. PubMed ID: 19608861

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

Initial characterization of the human central proteome. PubMed ID: 21269460

Splicing factor 2-associated protein p32 participates in ribosome biogenesis by regulating the binding of Nop52 and fibrillarin to preribosome particles. PubMed ID: 21536856

System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. PubMed ID: 21406692

N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. PubMed ID: 22814378

Nucleolar scaffold protein, WDR46, determines the granular compartmental localization of nucleolin and DDX21. PubMed ID: 23848194

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

GANP regulates recruitment of AID to immunoglobulin variable regions by modulating transcription and nucleosome occupancy. PubMed ID: 23652018

Elevated DDX21 regulates c-Jun activity and rRNA processing in human breast cancers. PubMed ID: 25260534

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli. PubMed ID: 25114211

RNA helicase DDX21 coordinates transcription and ribosomal RNA processing. PubMed ID: 25470060

The association of late-acting snoRNPs with human pre-ribosomal complexes requires the RNA helicase DDX21. PubMed ID: 25477391

SIRT7 and the DEAD-box helicase DDX21 cooperate to resolve genomic R loops and safeguard genome stability. PubMed ID: 28790157

A Compendium of RNA-Binding Proteins that Regulate MicroRNA Biogenesis. PubMed ID: 28431233

Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. PubMed ID: 28112733

Dominant KPNA3 Mutations Cause Infantile-Onset Hereditary Spastic Paraplegia. PubMed ID: 34564892