Details for: CD247

Gene ID: 919

Symbol: CD247

Ensembl ID: ENSG00000198821

Description: CD247 molecule

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 111.4788
    Cell Significance Index: -17.3400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 71.0052
    Cell Significance Index: -18.0100
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 61.6851
    Cell Significance Index: -25.0600
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 51.7317
    Cell Significance Index: -26.6100
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 44.3317
    Cell Significance Index: -20.9300
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: 23.5415
    Cell Significance Index: 63.0700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 13.9867
    Cell Significance Index: -17.2500
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 4.8853
    Cell Significance Index: 143.4800
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 4.5581
    Cell Significance Index: -14.0000
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 4.0099
    Cell Significance Index: 62.0400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.8927
    Cell Significance Index: 41.0100
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 1.5568
    Cell Significance Index: 15.6100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.4284
    Cell Significance Index: 64.7500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.0735
    Cell Significance Index: 204.2900
  • Cell Name: activated type II NK T cell (CL0000931)
    Fold Change: 0.9960
    Cell Significance Index: 2.5500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.9895
    Cell Significance Index: 97.8800
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 0.8393
    Cell Significance Index: 8.9300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.7163
    Cell Significance Index: 646.7900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.5459
    Cell Significance Index: 109.5100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4781
    Cell Significance Index: 77.7500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.4311
    Cell Significance Index: 154.6300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.3059
    Cell Significance Index: 13.5300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.3042
    Cell Significance Index: 11.5200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2765
    Cell Significance Index: 30.0700
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 0.2264
    Cell Significance Index: 0.6900
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.1687
    Cell Significance Index: 0.9200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0811
    Cell Significance Index: 56.1000
  • Cell Name: immature NK T cell (CL0000914)
    Fold Change: 0.0508
    Cell Significance Index: 0.6500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0446
    Cell Significance Index: 0.9500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0265
    Cell Significance Index: 1.8300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0066
    Cell Significance Index: 0.1900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0011
    Cell Significance Index: 2.1500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0002
    Cell Significance Index: 0.3700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0003
    Cell Significance Index: -0.0100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0027
    Cell Significance Index: -4.9300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0036
    Cell Significance Index: -0.2200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0039
    Cell Significance Index: -5.2400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0185
    Cell Significance Index: -14.0300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0246
    Cell Significance Index: -18.2400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0276
    Cell Significance Index: -12.2000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0304
    Cell Significance Index: -0.7600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0309
    Cell Significance Index: -19.3100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0315
    Cell Significance Index: -17.1900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0324
    Cell Significance Index: -18.2700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0364
    Cell Significance Index: -23.1400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0430
    Cell Significance Index: -19.5100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0494
    Cell Significance Index: -14.2200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0551
    Cell Significance Index: -10.9400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0745
    Cell Significance Index: -8.7800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0805
    Cell Significance Index: -14.5200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0882
    Cell Significance Index: -18.5800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0959
    Cell Significance Index: -13.9400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1051
    Cell Significance Index: -17.9500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.1060
    Cell Significance Index: -13.5900
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.1088
    Cell Significance Index: -4.7300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.1238
    Cell Significance Index: -17.0000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1352
    Cell Significance Index: -9.0900
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.1404
    Cell Significance Index: -2.4200
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1485
    Cell Significance Index: -3.0800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.1601
    Cell Significance Index: -19.6900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1673
    Cell Significance Index: -17.4200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.1737
    Cell Significance Index: -10.4300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1750
    Cell Significance Index: -20.3900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1757
    Cell Significance Index: -20.1300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1759
    Cell Significance Index: -13.5000
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1812
    Cell Significance Index: -4.6300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1846
    Cell Significance Index: -23.8500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1902
    Cell Significance Index: -13.4500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1915
    Cell Significance Index: -9.0000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2063
    Cell Significance Index: -12.6800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.2273
    Cell Significance Index: -23.2200
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.2442
    Cell Significance Index: -2.3800
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.2462
    Cell Significance Index: -3.3500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2509
    Cell Significance Index: -8.0400
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: -0.2643
    Cell Significance Index: -2.7400
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.2737
    Cell Significance Index: -3.9200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.3075
    Cell Significance Index: -22.9200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.3183
    Cell Significance Index: -8.9000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.3233
    Cell Significance Index: -18.1400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.3307
    Cell Significance Index: -20.8400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.3415
    Cell Significance Index: -17.9300
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.3485
    Cell Significance Index: -7.5300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.3643
    Cell Significance Index: -9.7500
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.3651
    Cell Significance Index: -18.4500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3652
    Cell Significance Index: -11.6300
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: -0.3662
    Cell Significance Index: -3.2600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.3662
    Cell Significance Index: -19.0200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.3688
    Cell Significance Index: -9.4800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.3705
    Cell Significance Index: -23.9100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.3919
    Cell Significance Index: -13.7300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3928
    Cell Significance Index: -12.8600
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.4010
    Cell Significance Index: -6.8100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.4260
    Cell Significance Index: -19.8600
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.4271
    Cell Significance Index: -7.3200
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.4293
    Cell Significance Index: -12.2500
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.4563
    Cell Significance Index: -3.5500
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.4607
    Cell Significance Index: -9.1100
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.4667
    Cell Significance Index: -9.3700
  • Cell Name: mature T cell (CL0002419)
    Fold Change: -0.4794
    Cell Significance Index: -3.4500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.4817
    Cell Significance Index: -25.0900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Expression**: CD247 is expressed on various immune cells, including T cells, NK cells, and some innate lymphoid cells. 2. **Structure**: CD247 is a transmembrane receptor that interacts with other components of the TCR complex to facilitate signal transduction. 3. **Function**: CD247 plays a crucial role in T-cell activation, proliferation, and differentiation, and is involved in regulating immune responses, including anti-inflammatory responses and phagocytosis. 4. **Interactions**: CD247 interacts with other components of the TCR complex, including CD3ε, CD3γ, and CD3δ, as well as with other signaling molecules, such as CD28 and PD-1. **Pathways and Functions** 1. **Adaptive Immune Response**: CD247 is involved in the adaptive immune response, where it plays a crucial role in T-cell activation, proliferation, and differentiation. 2. **Alpha-Beta T Cell Activation**: CD247 is essential for the activation of alpha-beta T cells, which are a key subset of T cells involved in the adaptive immune response. 3. **Costimulation by the CD28 Family**: CD247 interacts with CD28, a co-stimulatory molecule, to facilitate T-cell activation and proliferation. 4. **Anti-Inflammatory Response Favouring Leishmania Parasite Infection**: CD247 is involved in regulating immune responses to Leishmania parasites, and its expression is upregulated in response to parasite infection. 5. **Signal Transduction**: CD247 is involved in signal transduction pathways that regulate T-cell activation, proliferation, and differentiation. **Clinical Significance** 1. **Immunodeficiency Diseases**: Mutations in the CD247 gene have been associated with immunodeficiency diseases, such as severe combined immunodeficiency (SCID). 2. **Cancer**: CD247 is overexpressed in some types of cancer, including leukemia and lymphoma, and is involved in tumor progression and immune evasion. 3. **Viral Infections**: CD247 is involved in the regulation of immune responses to viral infections, including HIV-1 and HCV. 4. **Parasite Infections**: CD247 is involved in the regulation of immune responses to parasitic infections, including Leishmania and malaria. In conclusion, the CD247 gene encodes for a crucial component of the TCR complex, which plays a central role in the adaptive immune response. CD247 is involved in regulating immune responses, including anti-inflammatory responses and phagocytosis, and its expression is upregulated in response to parasite infection. The clinical significance of CD247 is evident in its association with immunodeficiency diseases, cancer, viral infections, and parasite infections.

Genular Protein ID: 3548340032

Symbol: CD3Z_HUMAN

Name: T-cell surface glycoprotein CD3 zeta chain

UniProtKB Accession Codes:

P20963 B1AK49 Q5VX13 Q8TAX4

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 4 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 DrugBank 6 ELM 1 EMBL 7 EMDB 14 Ensembl 2 EvolutionaryTrace 1 GO 21 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 3 OrthoDB 1 PANTHER 2 PDB 22 PDBsum 22 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 12 RefSeq 2 SIGNOR 1 SMART 1 SMR 1 STRING 1 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2974162

Title: Molecular cloning and chromosomal localization of the human T-cell receptor zeta chain: distinction from the molecular CD3 complex.

PubMed ID: 2974162

DOI: 10.1073/pnas.85.24.9709

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2532305

Title: Co-association of CD3 zeta with a receptor (CD16) for IgG Fc on human natural killer cells.

PubMed ID: 2532305

DOI: 10.1038/342803a0

PubMed ID: 2470098

Title: The CD4 and CD8 antigens are coupled to a protein-tyrosine kinase (p56lck) that phosphorylates the CD3 complex.

PubMed ID: 2470098

DOI: 10.1073/pnas.86.9.3277

PubMed ID: 1825220

Title: Analysis of Fc gamma RIII (CD16) membrane expression and association with CD3 zeta and Fc epsilon RI-gamma by site-directed mutation.

PubMed ID: 1825220

PubMed ID: 1385158

Title: Evidence for an association between the T cell receptor/CD3 antigen complex and the CD5 antigen in human T lymphocytes.

PubMed ID: 1385158

DOI: 10.1002/eji.1830221135

PubMed ID: 1384049

Title: CD5 acts as a tyrosine kinase substrate within a receptor complex comprising T-cell receptor zeta chain/CD3 and protein-tyrosine kinases p56lck and p59fyn.

PubMed ID: 1384049

DOI: 10.1073/pnas.89.19.9311

PubMed ID: 7509083

Title: Sequential interactions of the TCR with two distinct cytoplasmic tyrosine kinases.

PubMed ID: 7509083

DOI: 10.1126/science.7509083

PubMed ID: 9811718

Title: Zeta chain of the T-cell receptor interacts with nef of simian immunodeficiency virus and human immunodeficiency virus type 2.

PubMed ID: 9811718

DOI: 10.1128/jvi.72.12.9827-9834.1998

PubMed ID: 9484780

Title: Stimulation through the T cell receptor leads to interactions between SHB and several signaling proteins.

PubMed ID: 9484780

DOI: 10.1038/sj.onc.1201607

PubMed ID: 10224289

Title: Induction of Fas ligand expression by HIV involves the interaction of Nef with the T cell receptor zeta chain.

PubMed ID: 10224289

DOI: 10.1084/jem.189.9.1489

PubMed ID: 10449770

Title: SLAP, a dimeric adapter protein, plays a functional role in T cell receptor signaling.

PubMed ID: 10449770

DOI: 10.1073/pnas.96.17.9775

PubMed ID: 11722641

Title: Reduced T-cell receptor CD3zeta-chain protein and sustained CD3epsilon expression at the site of mycobacterial infection.

PubMed ID: 11722641

DOI: 10.1046/j.1365-2567.2001.01323.x

PubMed ID: 11390434

Title: The transmembrane adaptor protein TRIM regulates T-cell receptor (TCR) expression and TCR-mediated signaling via an association with the TCR zeta chain.

PubMed ID: 11390434

DOI: 10.1084/jem.193.11.1269

PubMed ID: 12176041

Title: DOCK2 mediates T cell receptor-induced activation of Rac2 and IL-2 transcription.

PubMed ID: 12176041

DOI: 10.1016/s0006-291x(02)00931-2

PubMed ID: 11978774

Title: BY55/CD160 acts as a co-receptor in TCR signal transduction of a human circulating cytotoxic effector T lymphocyte subset lacking CD28 expression.

PubMed ID: 11978774

DOI: 10.1093/intimm/14.5.445

PubMed ID: 12522270

Title: Profiling of tyrosine phosphorylation pathways in human cells using mass spectrometry.

PubMed ID: 12522270

DOI: 10.1073/pnas.2436191100

PubMed ID: 15144186

Title: Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry.

PubMed ID: 15144186

DOI: 10.1021/ac035352d

PubMed ID: 16027224

Title: Src-like adaptor protein down-regulates T cell receptor (TCR)-CD3 expression by targeting TCRzeta for degradation.

PubMed ID: 16027224

DOI: 10.1083/jcb.200501164

PubMed ID: 16051847

Title: Primary sooty mangabey simian immunodeficiency virus and human immunodeficiency virus type 2 nef alleles modulate cell surface expression of various human receptors and enhance viral infectivity and replication.

PubMed ID: 16051847

DOI: 10.1128/jvi.79.16.10547-10560.2005

PubMed ID: 15592455

Title: Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.

PubMed ID: 15592455

DOI: 10.1038/nbt1046

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 23858057

Title: CD81 controls sustained T cell activation signaling and defines the maturation stages of cognate immunological synapses.

PubMed ID: 23858057

DOI: 10.1128/mcb.00302-13

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 26783323

Title: A novel human autoimmune syndrome caused by combined hypomorphic and activating mutations in ZAP-70.

PubMed ID: 26783323

DOI: 10.1084/jem.20150888

PubMed ID: 28465009

Title: Crk adaptor proteins regulate CD3zeta chain phosphorylation and TCR/CD3 down-modulation in activated T cells.

PubMed ID: 28465009

DOI: 10.1016/j.cellsig.2017.04.022

PubMed ID: 28652325

Title: Transmembrane features governing Fc receptor CD16A assembly with CD16A signaling adaptor molecules.

PubMed ID: 28652325

DOI: 10.1073/pnas.1706483114

PubMed ID: 7680960

Title: Binding of a high affinity phosphotyrosyl peptide to the Src SH2 domain: crystal structures of the complexed and peptide-free forms.

PubMed ID: 7680960

DOI: 10.1016/0092-8674(93)90405-f

PubMed ID: 16672702

Title: Inherited and somatic CD3zeta mutations in a patient with T-cell deficiency.

PubMed ID: 16672702

DOI: 10.1056/nejmoa053750

PubMed ID: 7659156

Title: Molecular basis for interaction of the protein tyrosine kinase ZAP-70 with the T-cell receptor.

PubMed ID: 7659156

DOI: 10.1038/377032a0

PubMed ID: 7544002

Title: Solution structure of the Shc SH2 domain complexed with a tyrosine-phosphorylated peptide from the T-cell receptor.

PubMed ID: 7544002

DOI: 10.1073/pnas.92.17.7784

PubMed ID: 15684325

Title: Structural basis for the function and regulation of the receptor protein tyrosine phosphatase CD45.

PubMed ID: 15684325

DOI: 10.1084/jem.20041890

PubMed ID: 17055436

Title: The structure of the zetazeta transmembrane dimer reveals features essential for its assembly with the T cell receptor.

PubMed ID: 17055436

DOI: 10.1016/j.cell.2006.08.044

Sequence Information:

  • Length: 164
  • Mass: 18696
  • Checksum: 9408260374856EE9
  • Sequence:
    • MKWKALFTAA ILQAQLPITE AQSFGLLDPK LCYLLDGILF IYGVILTALF LRVKFSRSAD 
APAYQQGQNQ LYNELNLGRR EEYDVLDKRR GRDPEMGGKP QRRKNPQEGL YNELQKDKMA 
EAYSEIGMKG ERRRGKGHDG LYQGLSTATK DTYDALHMQA LPPR

Genular Protein ID: 3686725291

Symbol: A0A8V8TPP4_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A8V8TPP4

Database IDs:

ARBA 6 CTD 1 EMBL 2 Ensembl 2 GO 3 GeneTree 1 HGNC 1 InterPro 3 NCBI Taxonomy 1 PANTHER 2 PROSITE 1 PeptideAtlas 2 Pfam 2 Proteomes 2 ProteomicsDB 1 RefSeq 1 SAM 2 SMART 1 SMR 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

Sequence Information:

  • Length: 172
  • Mass: 19726
  • Checksum: 0BDEBC8EDE340DC7
  • Sequence:
    • MVRSWEKGLH SLVRTPLTTS EDQQVFEEAQ SFGLLDPKLC YLLDGILFIY GVILTALFLR 
VKFSRSADAP AYQQGQNQLY NELNLGRREE YDVLDKRRGR DPEMGGKPQR RKNPQEGLYN 
ELQKDKMAEA YSEIGMKGER RRGKGHDGLY QGLSTATKDT YDALHMQALP PR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.