Details for: CD247

Gene ID: 919

Symbol: CD247

Ensembl ID: ENSG00000198821

Description: CD247 molecule

Associated with

Other Information

Genular Protein ID: 3548340032

Symbol: CD3Z_HUMAN

Name: T-cell surface glycoprotein CD3 zeta chain

UniProtKB Accession Codes:

P20963 B1AK49 Q5VX13 Q8TAX4

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 4 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 DrugBank 3 ELM 1 EMBL 7 EMDB 5 Ensembl 2 EvolutionaryTrace 1 GO 21 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 3 OrthoDB 1 PANTHER 2 PDB 19 PDBsum 15 PIR 1 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 12 RefSeq 2 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2974162

Title: Molecular cloning and chromosomal localization of the human T-cell receptor zeta chain: distinction from the molecular CD3 complex.

PubMed ID: 2974162

DOI: 10.1073/pnas.85.24.9709

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2532305

Title: Co-association of CD3 zeta with a receptor (CD16) for IgG Fc on human natural killer cells.

PubMed ID: 2532305

DOI: 10.1038/342803a0

PubMed ID: 2470098

Title: The CD4 and CD8 antigens are coupled to a protein-tyrosine kinase (p56lck) that phosphorylates the CD3 complex.

PubMed ID: 2470098

DOI: 10.1073/pnas.86.9.3277

PubMed ID: 1825220

Title: Analysis of Fc gamma RIII (CD16) membrane expression and association with CD3 zeta and Fc epsilon RI-gamma by site-directed mutation.

PubMed ID: 1825220

PubMed ID: 7509083

Title: Sequential interactions of the TCR with two distinct cytoplasmic tyrosine kinases.

PubMed ID: 7509083

DOI: 10.1126/science.7509083

PubMed ID: 9811718

Title: Zeta chain of the T-cell receptor interacts with nef of simian immunodeficiency virus and human immunodeficiency virus type 2.

PubMed ID: 9811718

DOI: 10.1128/jvi.72.12.9827-9834.1998

PubMed ID: 9484780

Title: Stimulation through the T cell receptor leads to interactions between SHB and several signaling proteins.

PubMed ID: 9484780

DOI: 10.1038/sj.onc.1201607

PubMed ID: 10224289

Title: Induction of Fas ligand expression by HIV involves the interaction of Nef with the T cell receptor zeta chain.

PubMed ID: 10224289

DOI: 10.1084/jem.189.9.1489

PubMed ID: 10449770

Title: SLAP, a dimeric adapter protein, plays a functional role in T cell receptor signaling.

PubMed ID: 10449770

DOI: 10.1073/pnas.96.17.9775

PubMed ID: 11722641

Title: Reduced T-cell receptor CD3zeta-chain protein and sustained CD3epsilon expression at the site of mycobacterial infection.

PubMed ID: 11722641

DOI: 10.1046/j.1365-2567.2001.01323.x

PubMed ID: 11390434

Title: The transmembrane adaptor protein TRIM regulates T-cell receptor (TCR) expression and TCR-mediated signaling via an association with the TCR zeta chain.

PubMed ID: 11390434

DOI: 10.1084/jem.193.11.1269

PubMed ID: 12176041

Title: DOCK2 mediates T cell receptor-induced activation of Rac2 and IL-2 transcription.

PubMed ID: 12176041

DOI: 10.1016/s0006-291x(02)00931-2

PubMed ID: 11978774

Title: BY55/CD160 acts as a co-receptor in TCR signal transduction of a human circulating cytotoxic effector T lymphocyte subset lacking CD28 expression.

PubMed ID: 11978774

DOI: 10.1093/intimm/14.5.445

PubMed ID: 12522270

Title: Profiling of tyrosine phosphorylation pathways in human cells using mass spectrometry.

PubMed ID: 12522270

DOI: 10.1073/pnas.2436191100

PubMed ID: 15144186

Title: Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry.

PubMed ID: 15144186

DOI: 10.1021/ac035352d

PubMed ID: 16027224

Title: Src-like adaptor protein down-regulates T cell receptor (TCR)-CD3 expression by targeting TCRzeta for degradation.

PubMed ID: 16027224

DOI: 10.1083/jcb.200501164

PubMed ID: 16051847

Title: Primary sooty mangabey simian immunodeficiency virus and human immunodeficiency virus type 2 nef alleles modulate cell surface expression of various human receptors and enhance viral infectivity and replication.

PubMed ID: 16051847

DOI: 10.1128/jvi.79.16.10547-10560.2005

PubMed ID: 15592455

Title: Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.

PubMed ID: 15592455

DOI: 10.1038/nbt1046

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 23858057

Title: CD81 controls sustained T cell activation signaling and defines the maturation stages of cognate immunological synapses.

PubMed ID: 23858057

DOI: 10.1128/mcb.00302-13

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 26783323

Title: A novel human autoimmune syndrome caused by combined hypomorphic and activating mutations in ZAP-70.

PubMed ID: 26783323

DOI: 10.1084/jem.20150888

PubMed ID: 28465009

Title: Crk adaptor proteins regulate CD3zeta chain phosphorylation and TCR/CD3 down-modulation in activated T cells.

PubMed ID: 28465009

DOI: 10.1016/j.cellsig.2017.04.022

PubMed ID: 28652325

Title: Transmembrane features governing Fc receptor CD16A assembly with CD16A signaling adaptor molecules.

PubMed ID: 28652325

DOI: 10.1073/pnas.1706483114

PubMed ID: 7680960

Title: Binding of a high affinity phosphotyrosyl peptide to the Src SH2 domain: crystal structures of the complexed and peptide-free forms.

PubMed ID: 7680960

DOI: 10.1016/0092-8674(93)90405-f

PubMed ID: 16672702

Title: Inherited and somatic CD3zeta mutations in a patient with T-cell deficiency.

PubMed ID: 16672702

DOI: 10.1056/nejmoa053750

PubMed ID: 7659156

Title: Molecular basis for interaction of the protein tyrosine kinase ZAP-70 with the T-cell receptor.

PubMed ID: 7659156

DOI: 10.1038/377032a0

PubMed ID: 7544002

Title: Solution structure of the Shc SH2 domain complexed with a tyrosine-phosphorylated peptide from the T-cell receptor.

PubMed ID: 7544002

DOI: 10.1073/pnas.92.17.7784

PubMed ID: 15684325

Title: Structural basis for the function and regulation of the receptor protein tyrosine phosphatase CD45.

PubMed ID: 15684325

DOI: 10.1084/jem.20041890

PubMed ID: 17055436

Title: The structure of the zetazeta transmembrane dimer reveals features essential for its assembly with the T cell receptor.

PubMed ID: 17055436

DOI: 10.1016/j.cell.2006.08.044

Sequence Information:

  • Length: 164
  • Mass: 18696
  • Checksum: 9408260374856EE9
  • Sequence:
    • MKWKALFTAA ILQAQLPITE AQSFGLLDPK LCYLLDGILF IYGVILTALF LRVKFSRSAD 
APAYQQGQNQ LYNELNLGRR EEYDVLDKRR GRDPEMGGKP QRRKNPQEGL YNELQKDKMA 
EAYSEIGMKG ERRRGKGHDG LYQGLSTATK DTYDALHMQA LPPR

Genular Protein ID: 3686725291

Symbol: A0A8V8TPP4_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A8V8TPP4

Database IDs:

ARBA 7 CTD 1 EMBL 2 Ensembl 2 GO 3 GeneTree 1 HGNC 1 InterPro 3 MaxQB 1 NCBI Taxonomy 1 PANTHER 2 PROSITE 1 PeptideAtlas 1 Pfam 2 Proteomes 2 RefSeq 1 SAM 2 SMART 1 SMR 1

Citations:

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

Sequence Information:

  • Length: 172
  • Mass: 19726
  • Checksum: 0BDEBC8EDE340DC7
  • Sequence:
    • MVRSWEKGLH SLVRTPLTTS EDQQVFEEAQ SFGLLDPKLC YLLDGILFIY GVILTALFLR 
VKFSRSADAP AYQQGQNQLY NELNLGRREE YDVLDKRRGR DPEMGGKPQR RKNPQEGLYN 
ELQKDKMAEA YSEIGMKGER RRGKGHDGLY QGLSTATKDT YDALHMQALP PR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.