Details for: CD247
Associated with
Cells (max top 100)
(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
Fold Change: 4.73
Marker Score: 13809 - Cell Name: intraepithelial lymphocyte (CL0002496)
Fold Change: 4.29
Marker Score: 4769 - Cell Name: mature gamma-delta T cell (CL0000800)
Fold Change: 3.92
Marker Score: 12376 - Cell Name: retinal bipolar neuron (CL0000748)
Fold Change: 3.5
Marker Score: 29618 - Cell Name: decidual natural killer cell, human (CL0002343)
Fold Change: 3.46
Marker Score: 9560.5 - Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
Fold Change: 2.87
Marker Score: 1238 - Cell Name: mature T cell (CL0002419)
Fold Change: 2.81
Marker Score: 27797 - Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
Fold Change: 2.75
Marker Score: 4054 - Cell Name: retinal cone cell (CL0000573)
Fold Change: 2.62
Marker Score: 7507 - Cell Name: mature alpha-beta T cell (CL0000791)
Fold Change: 2.6
Marker Score: 137730 - Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 2.49
Marker Score: 15931 - Cell Name: ILC1, human (CL0001077)
Fold Change: 2.47
Marker Score: 625.5 - Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
Fold Change: 2.45
Marker Score: 2061 - Cell Name: thymocyte (CL0000893)
Fold Change: 2.43
Marker Score: 2546 - Cell Name: CD56-positive, CD161-positive immature natural killer cell, human (CL0002338)
Fold Change: 2.35
Marker Score: 775 - Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
Fold Change: 2.34
Marker Score: 3307 - Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
Fold Change: 2.28
Marker Score: 6409.5 - Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
Fold Change: 2.25
Marker Score: 4014 - Cell Name: T-helper 22 cell (CL0001042)
Fold Change: 2.24
Marker Score: 9584.5 - Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
Fold Change: 2.24
Marker Score: 1963 - Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
Fold Change: 2.23
Marker Score: 5439.5 - Cell Name: DN3 thymocyte (CL0000807)
Fold Change: 2.21
Marker Score: 1106 - Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
Fold Change: 2.21
Marker Score: 1598 - Cell Name: double negative thymocyte (CL0002489)
Fold Change: 2.18
Marker Score: 3007 - Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
Fold Change: 2.14
Marker Score: 2001 - Cell Name: CD8-alpha alpha positive, gamma-delta intraepithelial T cell (CL0000802)
Fold Change: 2.05
Marker Score: 665 - Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
Fold Change: 2.02
Marker Score: 1112 - Cell Name: memory regulatory T cell (CL0002678)
Fold Change: 1.96
Marker Score: 684 - Cell Name: exhausted T cell (CL0011025)
Fold Change: 1.94
Marker Score: 1116 - Cell Name: NKp44-negative group 3 innate lymphoid cell, human (CL0001080)
Fold Change: 1.9
Marker Score: 418 - Cell Name: alpha-beta T cell (CL0000789)
Fold Change: 1.88
Marker Score: 1421.5 - Cell Name: DN1 thymic pro-T cell (CL0000894)
Fold Change: 1.85
Marker Score: 573 - Cell Name: regulatory T cell (CL0000815)
Fold Change: 1.84
Marker Score: 2037.5 - Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
Fold Change: 1.82
Marker Score: 1336 - Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
Fold Change: 1.82
Marker Score: 1066 - Cell Name: CD4-positive, CD25-positive, alpha-beta regulatory T cell (CL0000792)
Fold Change: 1.81
Marker Score: 481 - Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
Fold Change: 1.76
Marker Score: 3018 - Cell Name: naive regulatory T cell (CL0002677)
Fold Change: 1.76
Marker Score: 534 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: 1.75
Marker Score: 1739.5 - Cell Name: NKp44-positive group 3 innate lymphoid cell, human (CL0001079)
Fold Change: 1.75
Marker Score: 396 - Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
Fold Change: 1.68
Marker Score: 1300 - Cell Name: type I NK T cell (CL0000921)
Fold Change: 1.67
Marker Score: 1313 - Cell Name: naive T cell (CL0000898)
Fold Change: 1.66
Marker Score: 1071 - Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
Fold Change: 1.66
Marker Score: 1787 - Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
Fold Change: 1.64
Marker Score: 1192 - Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
Fold Change: 1.61
Marker Score: 991 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 1.59
Marker Score: 1152 - Cell Name: double negative T regulatory cell (CL0011024)
Fold Change: 1.58
Marker Score: 1531.5 - Cell Name: natural T-regulatory cell (CL0000903)
Fold Change: 1.55
Marker Score: 799 - Cell Name: mucosal invariant T cell (CL0000940)
Fold Change: 1.55
Marker Score: 1379 - Cell Name: activated CD8-positive, alpha-beta T cell, human (CL0001049)
Fold Change: 1.54
Marker Score: 350 - Cell Name: Unknown (CL0000548)
Fold Change: 1.52
Marker Score: 1110.5 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 1.51
Marker Score: 1509 - Cell Name: natural killer cell (CL0000623)
Fold Change: 1.46
Marker Score: 1894 - Cell Name: mural cell (CL0008034)
Fold Change: 1.46
Marker Score: 167484 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 1.38
Marker Score: 426 - Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
Fold Change: 1.38
Marker Score: 3102 - Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
Fold Change: 1.36
Marker Score: 1117 - Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 1.31
Marker Score: 789 - Cell Name: innate lymphoid cell (CL0001065)
Fold Change: 1.31
Marker Score: 472 - Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
Fold Change: 1.27
Marker Score: 2484 - Cell Name: gamma-delta T cell (CL0000798)
Fold Change: 1.26
Marker Score: 848 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 1.24
Marker Score: 840 - Cell Name: T follicular helper cell (CL0002038)
Fold Change: 1.17
Marker Score: 974 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 1.14
Marker Score: 4778 - Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
Fold Change: 1.14
Marker Score: 1002 - Cell Name: memory T cell (CL0000813)
Fold Change: 1.11
Marker Score: 476 - Cell Name: blood cell (CL0000081)
Fold Change: 1.08
Marker Score: 12610 - Cell Name: intermediate monocyte (CL0002393)
Fold Change: 1.08
Marker Score: 373 - Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
Fold Change: 1.06
Marker Score: 1722 - Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
Fold Change: 1.06
Marker Score: 898.5 - Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: 1.04
Marker Score: 251750 - Cell Name: lymphocyte (CL0000542)
Fold Change: 1.03
Marker Score: 518 - Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71769 - Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 47993 - Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30402 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.97
Marker Score: 500 - Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 0.97
Marker Score: 1830 - Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.96
Marker Score: 454 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.95
Marker Score: 58606 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2410 - Cell Name: CD4-positive helper T cell (CL0000492)
Fold Change: 0.94
Marker Score: 1023 - Cell Name: sncg GABAergic cortical interneuron (CL4023015)
Fold Change: 0.94
Marker Score: 7177.5 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.92
Marker Score: 367 - Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: 0.91
Marker Score: 13653 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.91
Marker Score: 14274 - Cell Name: abnormal cell (CL0001061)
Fold Change: 0.91
Marker Score: 2730 - Cell Name: renal beta-intercalated cell (CL0002201)
Fold Change: 0.9
Marker Score: 284 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.89
Marker Score: 319 - Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.89
Marker Score: 5060 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5281 - Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.87
Marker Score: 665 - Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
Fold Change: 0.87
Marker Score: 483 - Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: 0.85
Marker Score: 7994.5 - Cell Name: mature NK T cell (CL0000814)
Fold Change: 0.84
Marker Score: 389 - Cell Name: vip GABAergic cortical interneuron (CL4023016)
Fold Change: 0.82
Marker Score: 31215 - Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.77
Marker Score: 1252 - Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: 0.77
Marker Score: 15330 - Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 0.77
Marker Score: 318 - Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.76
Marker Score: 2955
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Other Information
Genular Protein ID: 3548340032
Symbol: CD3Z_HUMAN
Name: T-cell surface glycoprotein CD3 zeta chain
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 2974162
Title: Molecular cloning and chromosomal localization of the human T-cell receptor zeta chain: distinction from the molecular CD3 complex.
PubMed ID: 2974162
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 16710414
Title: The DNA sequence and biological annotation of human chromosome 1.
PubMed ID: 16710414
DOI: 10.1038/nature04727
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 2532305
Title: Co-association of CD3 zeta with a receptor (CD16) for IgG Fc on human natural killer cells.
PubMed ID: 2532305
DOI: 10.1038/342803a0
PubMed ID: 2470098
Title: The CD4 and CD8 antigens are coupled to a protein-tyrosine kinase (p56lck) that phosphorylates the CD3 complex.
PubMed ID: 2470098
PubMed ID: 1825220
Title: Analysis of Fc gamma RIII (CD16) membrane expression and association with CD3 zeta and Fc epsilon RI-gamma by site-directed mutation.
PubMed ID: 1825220
PubMed ID: 7509083
Title: Sequential interactions of the TCR with two distinct cytoplasmic tyrosine kinases.
PubMed ID: 7509083
PubMed ID: 9811718
Title: Zeta chain of the T-cell receptor interacts with nef of simian immunodeficiency virus and human immunodeficiency virus type 2.
PubMed ID: 9811718
PubMed ID: 9484780
Title: Stimulation through the T cell receptor leads to interactions between SHB and several signaling proteins.
PubMed ID: 9484780
PubMed ID: 10224289
Title: Induction of Fas ligand expression by HIV involves the interaction of Nef with the T cell receptor zeta chain.
PubMed ID: 10224289
PubMed ID: 10449770
Title: SLAP, a dimeric adapter protein, plays a functional role in T cell receptor signaling.
PubMed ID: 10449770
PubMed ID: 11722641
Title: Reduced T-cell receptor CD3zeta-chain protein and sustained CD3epsilon expression at the site of mycobacterial infection.
PubMed ID: 11722641
PubMed ID: 11390434
Title: The transmembrane adaptor protein TRIM regulates T-cell receptor (TCR) expression and TCR-mediated signaling via an association with the TCR zeta chain.
PubMed ID: 11390434
PubMed ID: 12176041
Title: DOCK2 mediates T cell receptor-induced activation of Rac2 and IL-2 transcription.
PubMed ID: 12176041
PubMed ID: 11978774
Title: BY55/CD160 acts as a co-receptor in TCR signal transduction of a human circulating cytotoxic effector T lymphocyte subset lacking CD28 expression.
PubMed ID: 11978774
PubMed ID: 12522270
Title: Profiling of tyrosine phosphorylation pathways in human cells using mass spectrometry.
PubMed ID: 12522270
PubMed ID: 15144186
Title: Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry.
PubMed ID: 15144186
DOI: 10.1021/ac035352d
PubMed ID: 16027224
Title: Src-like adaptor protein down-regulates T cell receptor (TCR)-CD3 expression by targeting TCRzeta for degradation.
PubMed ID: 16027224
PubMed ID: 16051847
Title: Primary sooty mangabey simian immunodeficiency virus and human immunodeficiency virus type 2 nef alleles modulate cell surface expression of various human receptors and enhance viral infectivity and replication.
PubMed ID: 16051847
PubMed ID: 15592455
Title: Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.
PubMed ID: 15592455
DOI: 10.1038/nbt1046
PubMed ID: 19690332
Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
PubMed ID: 19690332
PubMed ID: 23858057
Title: CD81 controls sustained T cell activation signaling and defines the maturation stages of cognate immunological synapses.
PubMed ID: 23858057
DOI: 10.1128/mcb.00302-13
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 26783323
Title: A novel human autoimmune syndrome caused by combined hypomorphic and activating mutations in ZAP-70.
PubMed ID: 26783323
DOI: 10.1084/jem.20150888
PubMed ID: 28465009
Title: Crk adaptor proteins regulate CD3zeta chain phosphorylation and TCR/CD3 down-modulation in activated T cells.
PubMed ID: 28465009
PubMed ID: 28652325
Title: Transmembrane features governing Fc receptor CD16A assembly with CD16A signaling adaptor molecules.
PubMed ID: 28652325
PubMed ID: 7680960
Title: Binding of a high affinity phosphotyrosyl peptide to the Src SH2 domain: crystal structures of the complexed and peptide-free forms.
PubMed ID: 7680960
PubMed ID: 16672702
Title: Inherited and somatic CD3zeta mutations in a patient with T-cell deficiency.
PubMed ID: 16672702
DOI: 10.1056/nejmoa053750
PubMed ID: 7659156
Title: Molecular basis for interaction of the protein tyrosine kinase ZAP-70 with the T-cell receptor.
PubMed ID: 7659156
DOI: 10.1038/377032a0
PubMed ID: 7544002
Title: Solution structure of the Shc SH2 domain complexed with a tyrosine-phosphorylated peptide from the T-cell receptor.
PubMed ID: 7544002
PubMed ID: 15684325
Title: Structural basis for the function and regulation of the receptor protein tyrosine phosphatase CD45.
PubMed ID: 15684325
DOI: 10.1084/jem.20041890
PubMed ID: 17055436
Title: The structure of the zetazeta transmembrane dimer reveals features essential for its assembly with the T cell receptor.
PubMed ID: 17055436
Sequence Information:
- Length: 164
- Mass: 18696
- Checksum: 9408260374856EE9
- Sequence:
MKWKALFTAA ILQAQLPITE AQSFGLLDPK LCYLLDGILF IYGVILTALF LRVKFSRSAD APAYQQGQNQ LYNELNLGRR EEYDVLDKRR GRDPEMGGKP QRRKNPQEGL YNELQKDKMA EAYSEIGMKG ERRRGKGHDG LYQGLSTATK DTYDALHMQA LPPR
Genular Protein ID: 3686725291
Symbol: A0A8V8TPP4_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 16710414
Title: The DNA sequence and biological annotation of human chromosome 1.
PubMed ID: 16710414
DOI: 10.1038/nature04727
Sequence Information:
- Length: 172
- Mass: 19726
- Checksum: 0BDEBC8EDE340DC7
- Sequence:
MVRSWEKGLH SLVRTPLTTS EDQQVFEEAQ SFGLLDPKLC YLLDGILFIY GVILTALFLR VKFSRSADAP AYQQGQNQLY NELNLGRREE YDVLDKRRGR DPEMGGKPQR RKNPQEGLYN ELQKDKMAEA YSEIGMKGER RRGKGHDGLY QGLSTATKDT YDALHMQALP PR
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.