Details for: CD247

Gene ID: 919

Symbol: CD247

Ensembl ID: ENSG00000198821

Description: CD247 molecule

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 4.73
    Marker Score: 13809
  • Cell Name: intraepithelial lymphocyte (CL0002496)
    Fold Change: 4.29
    Marker Score: 4769
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 3.92
    Marker Score: 12376
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 3.5
    Marker Score: 29618
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 3.46
    Marker Score: 9560.5
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 2.87
    Marker Score: 1238
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 2.81
    Marker Score: 27797
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 2.75
    Marker Score: 4054
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: 2.62
    Marker Score: 7507
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 2.6
    Marker Score: 137730
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 2.49
    Marker Score: 15931
  • Cell Name: ILC1, human (CL0001077)
    Fold Change: 2.47
    Marker Score: 625.5
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 2.45
    Marker Score: 2061
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 2.43
    Marker Score: 2546
  • Cell Name: CD56-positive, CD161-positive immature natural killer cell, human (CL0002338)
    Fold Change: 2.35
    Marker Score: 775
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 2.34
    Marker Score: 3307
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 2.28
    Marker Score: 6409.5
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 2.25
    Marker Score: 4014
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 2.24
    Marker Score: 9584.5
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 2.24
    Marker Score: 1963
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 2.23
    Marker Score: 5439.5
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 2.21
    Marker Score: 1106
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: 2.21
    Marker Score: 1598
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 2.18
    Marker Score: 3007
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 2.14
    Marker Score: 2001
  • Cell Name: CD8-alpha alpha positive, gamma-delta intraepithelial T cell (CL0000802)
    Fold Change: 2.05
    Marker Score: 665
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: 2.02
    Marker Score: 1112
  • Cell Name: memory regulatory T cell (CL0002678)
    Fold Change: 1.96
    Marker Score: 684
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 1.94
    Marker Score: 1116
  • Cell Name: NKp44-negative group 3 innate lymphoid cell, human (CL0001080)
    Fold Change: 1.9
    Marker Score: 418
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 1.88
    Marker Score: 1421.5
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 1.85
    Marker Score: 573
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: 1.84
    Marker Score: 2037.5
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 1.82
    Marker Score: 1336
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 1.82
    Marker Score: 1066
  • Cell Name: CD4-positive, CD25-positive, alpha-beta regulatory T cell (CL0000792)
    Fold Change: 1.81
    Marker Score: 481
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 1.76
    Marker Score: 3018
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: 1.76
    Marker Score: 534
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 1.75
    Marker Score: 1739.5
  • Cell Name: NKp44-positive group 3 innate lymphoid cell, human (CL0001079)
    Fold Change: 1.75
    Marker Score: 396
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: 1.68
    Marker Score: 1300
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 1.67
    Marker Score: 1313
  • Cell Name: naive T cell (CL0000898)
    Fold Change: 1.66
    Marker Score: 1071
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 1.66
    Marker Score: 1787
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 1.64
    Marker Score: 1192
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 1.61
    Marker Score: 991
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.59
    Marker Score: 1152
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 1.58
    Marker Score: 1531.5
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: 1.55
    Marker Score: 799
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 1.55
    Marker Score: 1379
  • Cell Name: activated CD8-positive, alpha-beta T cell, human (CL0001049)
    Fold Change: 1.54
    Marker Score: 350
  • Cell Name: Unknown (CL0000548)
    Fold Change: 1.52
    Marker Score: 1110.5
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.51
    Marker Score: 1509
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 1.46
    Marker Score: 1894
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.46
    Marker Score: 167484
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 1.38
    Marker Score: 426
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: 1.38
    Marker Score: 3102
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 1.36
    Marker Score: 1117
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.31
    Marker Score: 789
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 1.31
    Marker Score: 472
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 1.27
    Marker Score: 2484
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 1.26
    Marker Score: 848
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.24
    Marker Score: 840
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: 1.17
    Marker Score: 974
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.14
    Marker Score: 4778
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: 1.14
    Marker Score: 1002
  • Cell Name: memory T cell (CL0000813)
    Fold Change: 1.11
    Marker Score: 476
  • Cell Name: blood cell (CL0000081)
    Fold Change: 1.08
    Marker Score: 12610
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 1.08
    Marker Score: 373
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 1.06
    Marker Score: 1722
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 1.06
    Marker Score: 898.5
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251750
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 1.03
    Marker Score: 518
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71769
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47993
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30402
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.97
    Marker Score: 500
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.97
    Marker Score: 1830
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.96
    Marker Score: 454
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.95
    Marker Score: 58606
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2410
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 0.94
    Marker Score: 1023
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.94
    Marker Score: 7177.5
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.92
    Marker Score: 367
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.91
    Marker Score: 13653
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.91
    Marker Score: 14274
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2730
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.9
    Marker Score: 284
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.89
    Marker Score: 319
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.89
    Marker Score: 5060
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5281
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.87
    Marker Score: 665
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 0.87
    Marker Score: 483
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.85
    Marker Score: 7994.5
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.84
    Marker Score: 389
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.82
    Marker Score: 31215
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1252
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.77
    Marker Score: 15330
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.77
    Marker Score: 318
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.76
    Marker Score: 2955

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Other Information

**Key characteristics:** - CD247 is a cell surface glycoprotein that is expressed on NKp46-positive innate lymphoid cells, human, intraepithelial lymphocytes, mature gamma-delta T cells, retinal bipolar neurons, decidual natural killer cells, human, CD8-positive, alpha-beta cytokine secreting effector T cells, mature T cells, effector memory CD8-positive, alpha-beta T cell, terminally differentiated, and retinal cone cells. - It is a member of the immunoglobulin superfamily and is expressed on the surface of professional antigen-presenting cells (APCs). - CD247 is a key regulator of the adaptive immune system and is involved in the regulation of innate immunity. **Pathways and functions:** - CD247 is involved in the regulation of the adaptive immune system by interacting with the CD28 family of cell surface proteins. - It is involved in the costimulation of T cells by activating the CD28 family of cell surface proteins. - CD247 is involved in the downstream signaling pathways of the T cell receptor (TCR) and the Fcgamma receptor (fcgr). - It is involved in the generation of second messenger molecules, including IL-2, IL-4, and IFN-gamma. - CD247 is involved in the regulation of innate immunity by interacting with the MHC class I pathway. - It is involved in the regulation of parasitic infection pathways by interacting with parasitic antigens. **Clinical significance:** - Mutations in CD247 have been linked to several human diseases, including cancer, autoimmune disorders, and inflammatory diseases. - Targeting CD247 has been investigated as a therapeutic strategy for cancer and autoimmune disorders.

Genular Protein ID: 3548340032

Symbol: CD3Z_HUMAN

Name: T-cell surface glycoprotein CD3 zeta chain

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 2974162

Title: Molecular cloning and chromosomal localization of the human T-cell receptor zeta chain: distinction from the molecular CD3 complex.

PubMed ID: 2974162

DOI: 10.1073/pnas.85.24.9709

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2532305

Title: Co-association of CD3 zeta with a receptor (CD16) for IgG Fc on human natural killer cells.

PubMed ID: 2532305

DOI: 10.1038/342803a0

PubMed ID: 2470098

Title: The CD4 and CD8 antigens are coupled to a protein-tyrosine kinase (p56lck) that phosphorylates the CD3 complex.

PubMed ID: 2470098

DOI: 10.1073/pnas.86.9.3277

PubMed ID: 1825220

Title: Analysis of Fc gamma RIII (CD16) membrane expression and association with CD3 zeta and Fc epsilon RI-gamma by site-directed mutation.

PubMed ID: 1825220

PubMed ID: 7509083

Title: Sequential interactions of the TCR with two distinct cytoplasmic tyrosine kinases.

PubMed ID: 7509083

DOI: 10.1126/science.7509083

PubMed ID: 9811718

Title: Zeta chain of the T-cell receptor interacts with nef of simian immunodeficiency virus and human immunodeficiency virus type 2.

PubMed ID: 9811718

DOI: 10.1128/jvi.72.12.9827-9834.1998

PubMed ID: 9484780

Title: Stimulation through the T cell receptor leads to interactions between SHB and several signaling proteins.

PubMed ID: 9484780

DOI: 10.1038/sj.onc.1201607

PubMed ID: 10224289

Title: Induction of Fas ligand expression by HIV involves the interaction of Nef with the T cell receptor zeta chain.

PubMed ID: 10224289

DOI: 10.1084/jem.189.9.1489

PubMed ID: 10449770

Title: SLAP, a dimeric adapter protein, plays a functional role in T cell receptor signaling.

PubMed ID: 10449770

DOI: 10.1073/pnas.96.17.9775

PubMed ID: 11722641

Title: Reduced T-cell receptor CD3zeta-chain protein and sustained CD3epsilon expression at the site of mycobacterial infection.

PubMed ID: 11722641

DOI: 10.1046/j.1365-2567.2001.01323.x

PubMed ID: 11390434

Title: The transmembrane adaptor protein TRIM regulates T-cell receptor (TCR) expression and TCR-mediated signaling via an association with the TCR zeta chain.

PubMed ID: 11390434

DOI: 10.1084/jem.193.11.1269

PubMed ID: 12176041

Title: DOCK2 mediates T cell receptor-induced activation of Rac2 and IL-2 transcription.

PubMed ID: 12176041

DOI: 10.1016/s0006-291x(02)00931-2

PubMed ID: 11978774

Title: BY55/CD160 acts as a co-receptor in TCR signal transduction of a human circulating cytotoxic effector T lymphocyte subset lacking CD28 expression.

PubMed ID: 11978774

DOI: 10.1093/intimm/14.5.445

PubMed ID: 12522270

Title: Profiling of tyrosine phosphorylation pathways in human cells using mass spectrometry.

PubMed ID: 12522270

DOI: 10.1073/pnas.2436191100

PubMed ID: 15144186

Title: Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry.

PubMed ID: 15144186

DOI: 10.1021/ac035352d

PubMed ID: 16027224

Title: Src-like adaptor protein down-regulates T cell receptor (TCR)-CD3 expression by targeting TCRzeta for degradation.

PubMed ID: 16027224

DOI: 10.1083/jcb.200501164

PubMed ID: 16051847

Title: Primary sooty mangabey simian immunodeficiency virus and human immunodeficiency virus type 2 nef alleles modulate cell surface expression of various human receptors and enhance viral infectivity and replication.

PubMed ID: 16051847

DOI: 10.1128/jvi.79.16.10547-10560.2005

PubMed ID: 15592455

Title: Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.

PubMed ID: 15592455

DOI: 10.1038/nbt1046

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 23858057

Title: CD81 controls sustained T cell activation signaling and defines the maturation stages of cognate immunological synapses.

PubMed ID: 23858057

DOI: 10.1128/mcb.00302-13

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 26783323

Title: A novel human autoimmune syndrome caused by combined hypomorphic and activating mutations in ZAP-70.

PubMed ID: 26783323

DOI: 10.1084/jem.20150888

PubMed ID: 28465009

Title: Crk adaptor proteins regulate CD3zeta chain phosphorylation and TCR/CD3 down-modulation in activated T cells.

PubMed ID: 28465009

DOI: 10.1016/j.cellsig.2017.04.022

PubMed ID: 28652325

Title: Transmembrane features governing Fc receptor CD16A assembly with CD16A signaling adaptor molecules.

PubMed ID: 28652325

DOI: 10.1073/pnas.1706483114

PubMed ID: 7680960

Title: Binding of a high affinity phosphotyrosyl peptide to the Src SH2 domain: crystal structures of the complexed and peptide-free forms.

PubMed ID: 7680960

DOI: 10.1016/0092-8674(93)90405-f

PubMed ID: 16672702

Title: Inherited and somatic CD3zeta mutations in a patient with T-cell deficiency.

PubMed ID: 16672702

DOI: 10.1056/nejmoa053750

PubMed ID: 7659156

Title: Molecular basis for interaction of the protein tyrosine kinase ZAP-70 with the T-cell receptor.

PubMed ID: 7659156

DOI: 10.1038/377032a0

PubMed ID: 7544002

Title: Solution structure of the Shc SH2 domain complexed with a tyrosine-phosphorylated peptide from the T-cell receptor.

PubMed ID: 7544002

DOI: 10.1073/pnas.92.17.7784

PubMed ID: 15684325

Title: Structural basis for the function and regulation of the receptor protein tyrosine phosphatase CD45.

PubMed ID: 15684325

DOI: 10.1084/jem.20041890

PubMed ID: 17055436

Title: The structure of the zetazeta transmembrane dimer reveals features essential for its assembly with the T cell receptor.

PubMed ID: 17055436

DOI: 10.1016/j.cell.2006.08.044

Sequence Information:

  • Length: 164
  • Mass: 18696
  • Checksum: 9408260374856EE9
  • Sequence:
  • MKWKALFTAA ILQAQLPITE AQSFGLLDPK LCYLLDGILF IYGVILTALF LRVKFSRSAD 
    APAYQQGQNQ LYNELNLGRR EEYDVLDKRR GRDPEMGGKP QRRKNPQEGL YNELQKDKMA 
    EAYSEIGMKG ERRRGKGHDG LYQGLSTATK DTYDALHMQA LPPR

Genular Protein ID: 3686725291

Symbol: A0A8V8TPP4_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

Sequence Information:

  • Length: 172
  • Mass: 19726
  • Checksum: 0BDEBC8EDE340DC7
  • Sequence:
  • MVRSWEKGLH SLVRTPLTTS EDQQVFEEAQ SFGLLDPKLC YLLDGILFIY GVILTALFLR 
    VKFSRSADAP AYQQGQNQLY NELNLGRREE YDVLDKRRGR DPEMGGKPQR RKNPQEGLYN 
    ELQKDKMAEA YSEIGMKGER RRGKGHDGLY QGLSTATKDT YDALHMQALP PR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.