Details for: ACVR2A

Gene ID: 92

Symbol: ACVR2A

Ensembl ID: ENSG00000121989

Description: activin A receptor type 2A

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 232.1511
    Cell Significance Index: -36.1100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 141.5373
    Cell Significance Index: -35.9000
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 73.1803
    Cell Significance Index: -29.7300
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 31.1602
    Cell Significance Index: -29.7500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 29.2955
    Cell Significance Index: -36.1200
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 9.1840
    Cell Significance Index: -20.1000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 9.1433
    Cell Significance Index: -36.0800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 2.4137
    Cell Significance Index: 459.3400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 2.1722
    Cell Significance Index: 55.8400
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 2.0467
    Cell Significance Index: 39.9500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.8255
    Cell Significance Index: 366.2000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.5670
    Cell Significance Index: 21.3800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.4284
    Cell Significance Index: 39.9200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 1.3731
    Cell Significance Index: 84.4000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 1.3667
    Cell Significance Index: 76.6900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 1.2577
    Cell Significance Index: 84.5700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.2575
    Cell Significance Index: 249.5500
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 1.0731
    Cell Significance Index: 13.3100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.0672
    Cell Significance Index: 382.7800
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 1.0599
    Cell Significance Index: 25.4200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.9017
    Cell Significance Index: 19.7500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.8013
    Cell Significance Index: 93.3800
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.6491
    Cell Significance Index: 448.9700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.6253
    Cell Significance Index: 101.7000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.5913
    Cell Significance Index: 35.5000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.5285
    Cell Significance Index: 11.4500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.5258
    Cell Significance Index: 40.3500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.3800
    Cell Significance Index: 19.7400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3742
    Cell Significance Index: 37.0200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3646
    Cell Significance Index: 10.5100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3642
    Cell Significance Index: 25.1900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.3168
    Cell Significance Index: 57.1100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.3121
    Cell Significance Index: 11.8200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.2780
    Cell Significance Index: 17.5200
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.2772
    Cell Significance Index: 7.9100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2622
    Cell Significance Index: 11.8900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2165
    Cell Significance Index: 95.7300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.2152
    Cell Significance Index: 9.5200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1855
    Cell Significance Index: 22.8100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0794
    Cell Significance Index: 3.7000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0784
    Cell Significance Index: 42.8100
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0764
    Cell Significance Index: 1.3100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0706
    Cell Significance Index: 2.4800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0442
    Cell Significance Index: 20.0400
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.0432
    Cell Significance Index: 0.4700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0388
    Cell Significance Index: 52.7800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0379
    Cell Significance Index: 2.6800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0363
    Cell Significance Index: 68.2800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0303
    Cell Significance Index: 19.2400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0233
    Cell Significance Index: 35.8700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0124
    Cell Significance Index: 22.8000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0062
    Cell Significance Index: 5.6000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0336
    Cell Significance Index: -4.6200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0345
    Cell Significance Index: -25.2800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0370
    Cell Significance Index: -5.3800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0415
    Cell Significance Index: -30.7700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0456
    Cell Significance Index: -34.4800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0463
    Cell Significance Index: -5.9300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0639
    Cell Significance Index: -36.0100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0648
    Cell Significance Index: -40.4800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1042
    Cell Significance Index: -29.9900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1054
    Cell Significance Index: -18.0000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1197
    Cell Significance Index: -2.5500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1742
    Cell Significance Index: -19.9600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1845
    Cell Significance Index: -38.8700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.2284
    Cell Significance Index: -23.3300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2379
    Cell Significance Index: -7.7900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.2385
    Cell Significance Index: -30.8100
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.2420
    Cell Significance Index: -5.0200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2633
    Cell Significance Index: -16.1400
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: -0.2738
    Cell Significance Index: -2.4300
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.2739
    Cell Significance Index: -3.9400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.2925
    Cell Significance Index: -34.5000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2996
    Cell Significance Index: -31.2000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.3457
    Cell Significance Index: -9.2300
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.3576
    Cell Significance Index: -7.0700
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.3584
    Cell Significance Index: -3.3000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.3843
    Cell Significance Index: -18.0600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.4086
    Cell Significance Index: -13.0100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4151
    Cell Significance Index: -32.8800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.4198
    Cell Significance Index: -31.2900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.4335
    Cell Significance Index: -22.7600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.4395
    Cell Significance Index: -14.0800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.5308
    Cell Significance Index: -27.6500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.5387
    Cell Significance Index: -34.7600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.5643
    Cell Significance Index: -15.3600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.5677
    Cell Significance Index: -14.1900
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.5852
    Cell Significance Index: -12.4200
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.6015
    Cell Significance Index: -8.8800
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.6147
    Cell Significance Index: -8.7500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.6439
    Cell Significance Index: -22.3800
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.6510
    Cell Significance Index: -13.0700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.6984
    Cell Significance Index: -20.0200
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.7219
    Cell Significance Index: -25.2900
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.7264
    Cell Significance Index: -18.1200
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.7591
    Cell Significance Index: -8.2700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.7612
    Cell Significance Index: -12.7400
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.7636
    Cell Significance Index: -24.1500
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.7812
    Cell Significance Index: -6.3700
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.7900
    Cell Significance Index: -23.2700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** ACVR2A is a single-pass transmembrane receptor that belongs to the TGF-β superfamily of receptors. It is characterized by the presence of a serine/threonine kinase domain, a cysteine-rich extracellular domain, and a cytoplasmic domain that interacts with Smad proteins. ACVR2A is highly expressed in various tissues, including the cornea, brain, and testes, and is involved in the regulation of cell proliferation, differentiation, and survival. **Pathways and Functions:** ACVR2A is involved in several signaling pathways, including: 1. **Activin signaling pathway:** ACVR2A is a coreceptor for activin, a member of the TGF-β superfamily, and is involved in the regulation of activin-induced cell proliferation, differentiation, and survival. 2. **BMP signaling pathway:** ACVR2A is also involved in the regulation of BMP-induced cell proliferation, differentiation, and survival. 3. **Nodal signaling pathway:** ACVR2A is involved in the regulation of nodal-induced cell proliferation, differentiation, and survival. 4. **Smad protein signaling pathway:** ACVR2A interacts with Smad proteins, which are transcriptional coactivators that regulate gene expression in response to TGF-β superfamily signals. ACVR2A is involved in various cellular processes, including: 1. **Cell proliferation:** ACVR2A regulates cell proliferation in response to activin, BMP, and nodal signals. 2. **Cell differentiation:** ACVR2A regulates cell differentiation in response to activin, BMP, and nodal signals. 3. **Cell survival:** ACVR2A regulates cell survival in response to activin, BMP, and nodal signals. 4. **Tissue homeostasis:** ACVR2A regulates tissue homeostasis by regulating cell proliferation, differentiation, and survival in response to activin, BMP, and nodal signals. **Clinical Significance:** Dysregulation of ACVR2A has been implicated in various diseases, including: 1. **Bone disorders:** ACVR2A is involved in the regulation of bone mineralization and osteoblast differentiation, and dysregulation of ACVR2A has been implicated in bone disorders such as osteoporosis and bone cancer. 2. **Neurological disorders:** ACVR2A is involved in the regulation of neuronal development and function, and dysregulation of ACVR2A has been implicated in neurological disorders such as autism and schizophrenia. 3. **Reproductive disorders:** ACVR2A is involved in the regulation of spermatogenesis and sperm function, and dysregulation of ACVR2A has been implicated in reproductive disorders such as infertility and erectile dysfunction. 4. **Cancer:** ACVR2A is involved in the regulation of cell proliferation, differentiation, and survival, and dysregulation of ACVR2A has been implicated in various cancers, including breast, lung, and colon cancer. In conclusion, the ACVR2A gene plays a crucial role in various biological processes, including embryonic development, cell signaling, and tissue homeostasis. Dysregulation of ACVR2A has been implicated in various diseases, including bone disorders, neurological disorders, reproductive disorders, and cancer. Further research is needed to elucidate the mechanisms by which ACVR2A regulates cellular processes and to develop therapeutic strategies for the treatment of diseases associated with ACVR2A dysregulation.

Genular Protein ID: 492134488

Symbol: AVR2A_HUMAN

Name: Activin receptor type IIA

UniProtKB Accession Codes:

P27037 B2RAB8 B4DWQ2 D3DP85 Q53TH4 Q6NWV2 Q92474

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEBI 14 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 DrugCentral 1 EC 2 EMBL 12 Ensembl 3 EvolutionaryTrace 1 GO 40 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 5 PDBsum 5 PIR 1 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 5 RefSeq 3 Rhea 8 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1311955

Title: Cloning of the human activin receptor cDNA reveals high evolutionary conservation.

PubMed ID: 1311955

DOI: 10.1016/0167-4781(92)90472-c

PubMed ID: 1314589

Title: Molecular cloning and binding properties of the human type II activin receptor.

PubMed ID: 1314589

DOI: 10.1016/0006-291x(92)91194-u

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12667445

Title: The BMP7/ActRII extracellular domain complex provides new insights into the cooperative nature of receptor assembly.

PubMed ID: 12667445

DOI: 10.1016/s1097-2765(03)00094-7

PubMed ID: 17911401

Title: Activin receptor-like kinase-2 inhibits activin signaling by blocking the binding of activin to its type II receptor.

PubMed ID: 17911401

DOI: 10.1677/joe-07-0281

PubMed ID: 21791611

Title: TSC-22 promotes transforming growth factor beta-mediated cardiac myofibroblast differentiation by antagonizing Smad7 activity.

PubMed ID: 21791611

DOI: 10.1128/mcb.05448-11

PubMed ID: 25368322

Title: Small molecules dorsomorphin and LDN-193189 inhibit myostatin/GDF8 signaling and promote functional myoblast differentiation.

PubMed ID: 25368322

DOI: 10.1074/jbc.m114.604397

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

PubMed ID: 21248752

Title: Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma.

PubMed ID: 21248752

DOI: 10.1038/nature09639

Sequence Information:

  • Length: 513
  • Mass: 57848
  • Checksum: A89822E880979618
  • Sequence:
    • MGAAAKLAFA VFLISCSSGA ILGRSETQEC LFFNANWEKD RTNQTGVEPC YGDKDKRRHC 
FATWKNISGS IEIVKQGCWL DDINCYDRTD CVEKKDSPEV YFCCCEGNMC NEKFSYFPEM 
EVTQPTSNPV TPKPPYYNIL LYSLVPLMLI AGIVICAFWV YRHHKMAYPP VLVPTQDPGP 
PPPSPLLGLK PLQLLEVKAR GRFGCVWKAQ LLNEYVAVKI FPIQDKQSWQ NEYEVYSLPG 
MKHENILQFI GAEKRGTSVD VDLWLITAFH EKGSLSDFLK ANVVSWNELC HIAETMARGL 
AYLHEDIPGL KDGHKPAISH RDIKSKNVLL KNNLTACIAD FGLALKFEAG KSAGDTHGQV 
GTRRYMAPEV LEGAINFQRD AFLRIDMYAM GLVLWELASR CTAADGPVDE YMLPFEEEIG 
QHPSLEDMQE VVVHKKKRPV LRDYWQKHAG MAMLCETIEE CWDHDAEARL SAGCVGERIT 
QMQRLTNIIT TEDIVTVVTM VTNVDFPPKE SSL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.