ACVR2A | ENSG00000121989 | NCBI 92

Details for: ACVR2A

Gene ID: 92

Symbol: ACVR2A

Ensembl ID: ENSG00000121989

Description: activin A receptor type 2A

Associated with

Developmental biology
(R-HSA-1266738)
Regulation of signaling by nodal
(R-HSA-1433617)
Signaling by activin
(R-HSA-1502540)
Signaling by bmp
(R-HSA-201451)
Signaling by nodal
(R-HSA-1181150)
Signaling by tgfb family members
(R-HSA-9006936)
Signal transduction
(R-HSA-162582)
Activin binding
(GO:0048185)
Activin receptor activity
(GO:0017002)
Activin receptor complex
(GO:0048179)
Activin receptor signaling pathway
(GO:0032924)
Anterior/posterior pattern specification
(GO:0009952)
Atp binding
(GO:0005524)
Bmp receptor activity
(GO:0098821)
Bmp signaling pathway
(GO:0030509)
Cell surface
(GO:0009986)
Cellular response to bmp stimulus
(GO:0071773)
Cellular response to growth factor stimulus
(GO:0071363)
Coreceptor activity
(GO:0015026)
Cytoplasm
(GO:0005737)
Determination of left/right symmetry
(GO:0007368)
Embryonic skeletal system development
(GO:0048706)
Gastrulation with mouth forming second
(GO:0001702)
Growth factor binding
(GO:0019838)
Inhibin-betaglycan-actrii complex
(GO:0034673)
Inhibin binding
(GO:0034711)
Mesoderm development
(GO:0007498)
Metal ion binding
(GO:0046872)
Odontogenesis of dentin-containing tooth
(GO:0042475)
Pdz domain binding
(GO:0030165)
Penile erection
(GO:0043084)
Phosphorylation
(GO:0016310)
Plasma membrane
(GO:0005886)
Positive regulation of activin receptor signaling pathway
(GO:0032927)
Positive regulation of bone mineralization
(GO:0030501)
Positive regulation of erythrocyte differentiation
(GO:0045648)
Positive regulation of osteoblast differentiation
(GO:0045669)
Positive regulation of protein phosphorylation
(GO:0001934)
Positive regulation of smad protein signal transduction
(GO:0060391)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Protein binding
(GO:0005515)
Protein phosphorylation
(GO:0006468)
Protein self-association
(GO:0043621)
Protein serine/threonine kinase activity
(GO:0004674)
Receptor complex
(GO:0043235)
Regulation of nitric oxide biosynthetic process
(GO:0045428)
Sertoli cell proliferation
(GO:0060011)
Spermatogenesis
(GO:0007283)
Sperm ejaculation
(GO:0042713)
Transmembrane receptor protein serine/threonine kinase activity
(GO:0004675)
Transmembrane receptor protein serine/threonine kinase signaling pathway
(GO:0007178)

Other Information

Proteins

Activin receptor type IIA

Genular Protein ID: 492134488

Symbol: AVR2A_HUMAN

Name: Activin receptor type IIA

UniProtKB Accession Codes:

P27037 B2RAB8 B4DWQ2 D3DP85 Q53TH4 Q6NWV2 Q92474

Database IDs:

Citations:

PubMed ID: 1311955

Title: Cloning of the human activin receptor cDNA reveals high evolutionary conservation.

PubMed ID: 1311955

DOI: 10.1016/0167-4781(92)90472-c

PubMed ID: 1314589

Title: Molecular cloning and binding properties of the human type II activin receptor.

PubMed ID: 1314589

DOI: 10.1016/0006-291x(92)91194-u

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12667445

Title: The BMP7/ActRII extracellular domain complex provides new insights into the cooperative nature of receptor assembly.

PubMed ID: 12667445

DOI: 10.1016/s1097-2765(03)00094-7

PubMed ID: 17911401

Title: Activin receptor-like kinase-2 inhibits activin signaling by blocking the binding of activin to its type II receptor.

PubMed ID: 17911401

DOI: 10.1677/joe-07-0281

PubMed ID: 21791611

Title: TSC-22 promotes transforming growth factor beta-mediated cardiac myofibroblast differentiation by antagonizing Smad7 activity.

PubMed ID: 21791611

DOI: 10.1128/mcb.05448-11

PubMed ID: 25368322

Title: Small molecules dorsomorphin and LDN-193189 inhibit myostatin/GDF8 signaling and promote functional myoblast differentiation.

PubMed ID: 25368322

DOI: 10.1074/jbc.m114.604397

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

PubMed ID: 21248752

Title: Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma.

PubMed ID: 21248752

DOI: 10.1038/nature09639

Sequence Information:

Length: 513
Mass: 57848
Checksum: A89822E880979618
Sequence:

MGAAAKLAFA VFLISCSSGA ILGRSETQEC LFFNANWEKD RTNQTGVEPC YGDKDKRRHC 
FATWKNISGS IEIVKQGCWL DDINCYDRTD CVEKKDSPEV YFCCCEGNMC NEKFSYFPEM 
EVTQPTSNPV TPKPPYYNIL LYSLVPLMLI AGIVICAFWV YRHHKMAYPP VLVPTQDPGP 
PPPSPLLGLK PLQLLEVKAR GRFGCVWKAQ LLNEYVAVKI FPIQDKQSWQ NEYEVYSLPG 
MKHENILQFI GAEKRGTSVD VDLWLITAFH EKGSLSDFLK ANVVSWNELC HIAETMARGL 
AYLHEDIPGL KDGHKPAISH RDIKSKNVLL KNNLTACIAD FGLALKFEAG KSAGDTHGQV 
GTRRYMAPEV LEGAINFQRD AFLRIDMYAM GLVLWELASR CTAADGPVDE YMLPFEEEIG 
QHPSLEDMQE VVVHKKKRPV LRDYWQKHAG MAMLCETIEE CWDHDAEARL SAGCVGERIT 
QMQRLTNIIT TEDIVTVVTM VTNVDFPPKE SSL

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: ACVR2A

Associated with

Other Information

Cloning of the human activin receptor cDNA reveals high evolutionary conservation. PubMed ID: 1311955

Molecular cloning and binding properties of the human type II activin receptor. PubMed ID: 1314589

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

Generation and annotation of the DNA sequences of human chromosomes 2 and 4. PubMed ID: 15815621

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

The BMP7/ActRII extracellular domain complex provides new insights into the cooperative nature of receptor assembly. PubMed ID: 12667445

Activin receptor-like kinase-2 inhibits activin signaling by blocking the binding of activin to its type II receptor. PubMed ID: 17911401

TSC-22 promotes transforming growth factor beta-mediated cardiac myofibroblast differentiation by antagonizing Smad7 activity. PubMed ID: 21791611

Small molecules dorsomorphin and LDN-193189 inhibit myostatin/GDF8 signaling and promote functional myoblast differentiation. PubMed ID: 25368322

Patterns of somatic mutation in human cancer genomes. PubMed ID: 17344846

Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma. PubMed ID: 21248752