Associated with
Other Information
Genular Protein ID: 309412670
Symbol: CD4_HUMAN
Name: T-cell surface glycoprotein CD4
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 2990730
Title: The isolation and nucleotide sequence of a cDNA encoding the T cell surface protein T4: a new member of the immunoglobulin gene family.
PubMed ID: 2990730
PubMed ID: 3263213
PubMed ID: 8723724
Title: A gene-rich cluster between the CD4 and triosephosphate isomerase genes at human chromosome 12p13.
PubMed ID: 8723724
DOI: 10.1101/gr.6.4.314
PubMed ID: 9074930
Title: Large-scale sequencing in human chromosome 12p13: experimental and computational gene structure determination.
PubMed ID: 9074930
DOI: 10.1101/gr.7.3.268
PubMed ID: 1708753
Title: Humans with OKT4-epitope deficiency have a single nucleotide base change in the CD4 gene, resulting in substitution of TRP240 for ARG240.
PubMed ID: 1708753
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 1425921
Title: Cloning and sequences of primate CD4 molecules: diversity of the cellular receptor for simian immunodeficiency virus/human immunodeficiency virus.
PubMed ID: 1425921
PubMed ID: 2823150
Title: Interaction between CD4 and class II MHC molecules mediates cell adhesion.
PubMed ID: 2823150
DOI: 10.1038/330256a0
PubMed ID: 2512251
Title: Phosphorylation and down-regulation of CD4 and CD8 in human CTLs and mouse L cells.
PubMed ID: 2512251
DOI: 10.1007/bf02421181
PubMed ID: 2592374
Title: Protein and carbohydrate structural analysis of a recombinant soluble CD4 receptor by mass spectrometry.
PubMed ID: 2592374
PubMed ID: 15340161
Title: Signal peptide prediction based on analysis of experimentally verified cleavage sites.
PubMed ID: 15340161
DOI: 10.1110/ps.04682504
PubMed ID: 1961196
Title: A single amino acid substitution in a common African allele of the CD4 molecule ablates binding of the monoclonal antibody, OKT4.
PubMed ID: 1961196
PubMed ID: 2105883
Title: Structural features of the cytoplasmic region of CD4 required for internalization.
PubMed ID: 2105883
PubMed ID: 2214026
Title: CD4 is retained in the endoplasmic reticulum by the human immunodeficiency virus type 1 glycoprotein precursor.
PubMed ID: 2214026
PubMed ID: 2001369
Title: Carbohydrate structures of recombinant soluble human CD4 expressed in Chinese hamster ovary cells.
PubMed ID: 2001369
DOI: 10.1021/bi00223a015
PubMed ID: 1673145
Title: Lymphocyte chemoattractant factor induces CD4-dependent intracytoplasmic signaling in lymphocytes.
PubMed ID: 1673145
PubMed ID: 1618861
Title: Identification of palmitoylation sites on CD4, the human immunodeficiency virus receptor.
PubMed ID: 1618861
PubMed ID: 8124721
Title: Nef induces CD4 endocytosis: requirement for a critical dileucine motif in the membrane-proximal CD4 cytoplasmic domain.
PubMed ID: 8124721
PubMed ID: 8088877
Title: CD4 and CD8 expression by human and mouse thymic dendritic cells.
PubMed ID: 8088877
PubMed ID: 7604010
Title: Oligomerization of CD4 is required for stable binding to class II major histocompatibility complex proteins but not for interaction with human immunodeficiency virus gp120.
PubMed ID: 7604010
PubMed ID: 7909607
Title: CD4 is a critical component of the receptor for human herpesvirus 7: interference with human immunodeficiency virus.
PubMed ID: 7909607
PubMed ID: 11113139
Title: Cloning of ACP33 as a novel intracellular ligand of CD4.
PubMed ID: 11113139
PubMed ID: 12089508
Title: Disulfide exchange in domain 2 of CD4 is required for entry of HIV-1.
PubMed ID: 12089508
DOI: 10.1038/ni815
PubMed ID: 12517957
Title: Lipid raft distribution of CD4 depends on its palmitoylation and association with Lck, and evidence for CD4-induced lipid raft aggregation as an additional mechanism to enhance CD3 signaling.
PubMed ID: 12517957
PubMed ID: 16331979
Title: Protein minimization of the gp120 binding region of human CD4.
PubMed ID: 16331979
DOI: 10.1021/bi051120s
PubMed ID: 16888650
Title: Glucocorticoids cause rapid dissociation of a T-cell-receptor-associated protein complex containing LCK and FYN.
PubMed ID: 16888650
PubMed ID: 16951326
Title: CD4 expression on activated NK cells: ligation of CD4 induces cytokine expression and cell migration.
PubMed ID: 16951326
PubMed ID: 17346169
Title: Mechanisms of CD4 downregulation by the Nef and Vpu proteins of primate immunodeficiency viruses.
PubMed ID: 17346169
PubMed ID: 19159218
Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.
PubMed ID: 19159218
DOI: 10.1021/pr8008012
PubMed ID: 24696433
PubMed ID: 24942581
Title: CD4 ligation on human blood monocytes triggers macrophage differentiation and enhances HIV infection.
PubMed ID: 24942581
DOI: 10.1128/jvi.00616-14
PubMed ID: 27114505
Title: Remarkably low affinity of CD4/peptide-major histocompatibility complex class II protein interactions.
PubMed ID: 27114505
PubMed ID: 1701030
Title: Atomic structure of a fragment of human CD4 containing two immunoglobulin-like domains.
PubMed ID: 1701030
DOI: 10.1038/348411a0
PubMed ID: 2247146
Title: Crystal structure of an HIV-binding recombinant fragment of human CD4.
PubMed ID: 2247146
DOI: 10.1038/348419a0
PubMed ID: 9168119
Title: Dimeric association and segmental variability in the structure of human CD4.
PubMed ID: 9168119
DOI: 10.1038/387527a0
PubMed ID: 9641677
Title: Structure of an HIV gp120 envelope glycoprotein in complex with the CD4 receptor and a neutralizing human antibody.
PubMed ID: 9641677
DOI: 10.1038/31405
PubMed ID: 18078954
Title: Structural basis for the interaction between focal adhesion kinase and CD4.
PubMed ID: 18078954
PubMed ID: 21900604
Title: Affinity maturation of human CD4 by yeast surface display and crystal structure of a CD4-HLA-DR1 complex.
PubMed ID: 21900604
PubMed ID: 31781092
Title: Complete Multilineage CD4 Expression Defect Associated With Warts Due to an Inherited Homozygous CD4 Gene Mutation.
PubMed ID: 31781092
PubMed ID: 33471124
Title: Lost in Translation: Lack of CD4 Expression due to a Novel Genetic Defect.
PubMed ID: 33471124
Sequence Information:
- Length: 458
- Mass: 51111
- Checksum: 20ED893F9E56D236
- Sequence:
MNRGVPFRHL LLVLQLALLP AATQGKKVVL GKKGDTVELT CTASQKKSIQ FHWKNSNQIK ILGNQGSFLT KGPSKLNDRA DSRRSLWDQG NFPLIIKNLK IEDSDTYICE VEDQKEEVQL LVFGLTANSD THLLQGQSLT LTLESPPGSS PSVQCRSPRG KNIQGGKTLS VSQLELQDSG TWTCTVLQNQ KKVEFKIDIV VLAFQKASSI VYKKEGEQVE FSFPLAFTVE KLTGSGELWW QAERASSSKS WITFDLKNKE VSVKRVTQDP KLQMGKKLPL HLTLPQALPQ YAGSGNLTLA LEAKTGKLHQ EVNLVVMRAT QLQKNLTCEV WGPTSPKLML SLKLENKEAK VSKREKAVWV LNPEAGMWQC LLSDSGQVLL ESNIKVLPTW STPVQPMALI VLGGVAGLLL FIGLGIFFCV RCRHRRRQAE RMSQIKRLLS EKKTCQCPHR FQKTCSPI
Genular Protein ID: 922757928
Symbol: B0AZV7_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Sequence Information:
- Length: 279
- Mass: 31241
- Checksum: F100D7687218B33E
- Sequence:
MPTPLVHPHL PISSPRVSPF PPPAFQKASS IVYKKEGEQV EFSFPLAFTV EKLTGSGELW WQAERASSSK SWITFDLKNK EVSVKRVTQD PKLQMGKKLP LHLTLPQALP QYAGSGNLTL ALEAKTGKLH QEVNLVVMRA TQLQKNLTCE VWGPTSPKLT LSLKLENKEA KVSKREKAVW VLNPEAGMWQ CLLSDSGQVL LESNIKVLPT WSTPVQPMAL IVLGGVAGLL LFIGLGIFFC VRCRHRRRQA ERMSQIKRLL SEKKTCQCPH RFQKTCSPI
Genular Protein ID: 1780538557
Symbol: B4DT49_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Sequence Information:
- Length: 185
- Mass: 20680
- Checksum: E1AA40F9EDD032A5
- Sequence:
MGKKLPLHLT LPQALPQYAG SGNLTLALEA KTGKLHQEVN LVVMRATQLQ KNLTCEVWGP TSPKLMLSLK LENKEAKVSK REKAVWVLNP EAGMWQCLLS DSGQVLLESN IKVLPTWSTP VQPMALIVLG GVAGLLLFIG LGIFFCVRCR HRRRQAERMS QIKRLLSEKK TCQCPHRFQK TCSPI
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.