Details for: CD4

Gene ID: 920

Symbol: CD4

Ensembl ID: ENSG00000010610

Description: CD4 molecule

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 76.3122
    Cell Significance Index: -11.8700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 48.3159
    Cell Significance Index: -12.2600
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 36.3317
    Cell Significance Index: -14.7600
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 29.1610
    Cell Significance Index: -15.0000
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 28.7637
    Cell Significance Index: -13.5800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 9.6840
    Cell Significance Index: -11.9400
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 6.7149
    Cell Significance Index: 103.8900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 5.1290
    Cell Significance Index: -13.7400
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 4.2846
    Cell Significance Index: -13.1600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 3.1221
    Cell Significance Index: -12.3200
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 2.8923
    Cell Significance Index: -6.3300
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 2.8511
    Cell Significance Index: 83.7400
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 2.0874
    Cell Significance Index: 38.5800
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 1.8418
    Cell Significance Index: 11.4000
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 1.7420
    Cell Significance Index: 16.5600
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 1.0821
    Cell Significance Index: 10.8500
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.5428
    Cell Significance Index: 9.1300
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 0.2597
    Cell Significance Index: 2.0500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2100
    Cell Significance Index: 41.6800
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 0.1755
    Cell Significance Index: 0.5400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.1558
    Cell Significance Index: 32.8200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1094
    Cell Significance Index: 19.7300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0568
    Cell Significance Index: 6.9800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0535
    Cell Significance Index: 33.4000
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 0.0437
    Cell Significance Index: 0.2900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0263
    Cell Significance Index: 49.5800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0144
    Cell Significance Index: 2.8800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0097
    Cell Significance Index: 1.3300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0083
    Cell Significance Index: 0.4300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0019
    Cell Significance Index: 2.9600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0018
    Cell Significance Index: 3.2700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0005
    Cell Significance Index: 0.3000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0046
    Cell Significance Index: -3.1900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0046
    Cell Significance Index: -6.2500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0055
    Cell Significance Index: -2.9800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0064
    Cell Significance Index: -4.7300
  • Cell Name: liver dendritic cell (CL2000055)
    Fold Change: -0.0076
    Cell Significance Index: -0.0200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0089
    Cell Significance Index: -5.0400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0126
    Cell Significance Index: -9.5300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0168
    Cell Significance Index: -1.7200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0173
    Cell Significance Index: -6.2200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0179
    Cell Significance Index: -13.0900
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0254
    Cell Significance Index: -0.6800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0292
    Cell Significance Index: -13.2400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0413
    Cell Significance Index: -7.0600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0431
    Cell Significance Index: -5.5300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0465
    Cell Significance Index: -13.3700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0551
    Cell Significance Index: -8.0100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0584
    Cell Significance Index: -6.6900
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0784
    Cell Significance Index: -8.9500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0882
    Cell Significance Index: -10.4000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0989
    Cell Significance Index: -10.3000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1026
    Cell Significance Index: -13.2500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1087
    Cell Significance Index: -1.8200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1144
    Cell Significance Index: -13.3300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1152
    Cell Significance Index: -8.8400
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.1169
    Cell Significance Index: -1.7100
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: -0.1228
    Cell Significance Index: -1.0000
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.1322
    Cell Significance Index: -5.7500
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1379
    Cell Significance Index: -6.9700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1400
    Cell Significance Index: -6.5800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1428
    Cell Significance Index: -10.6400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1680
    Cell Significance Index: -11.3000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1831
    Cell Significance Index: -11.5400
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.1836
    Cell Significance Index: -2.4400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1838
    Cell Significance Index: -14.5600
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -0.1962
    Cell Significance Index: -1.0700
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.2024
    Cell Significance Index: -3.4900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2056
    Cell Significance Index: -12.6400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2177
    Cell Significance Index: -11.4300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2178
    Cell Significance Index: -12.2200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.2203
    Cell Significance Index: -14.2100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2270
    Cell Significance Index: -13.9200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2369
    Cell Significance Index: -10.4800
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.2416
    Cell Significance Index: -1.9700
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2566
    Cell Significance Index: -8.9900
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.2602
    Cell Significance Index: -4.4200
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.2638
    Cell Significance Index: -6.3900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2736
    Cell Significance Index: -10.3600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2780
    Cell Significance Index: -7.7700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2813
    Cell Significance Index: -9.2100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2820
    Cell Significance Index: -14.6900
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.2880
    Cell Significance Index: -5.6300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2980
    Cell Significance Index: -9.4900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.3088
    Cell Significance Index: -14.4000
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.3119
    Cell Significance Index: -4.4700
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.3124
    Cell Significance Index: -2.6400
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.3164
    Cell Significance Index: -3.2300
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.3430
    Cell Significance Index: -12.5900
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.3491
    Cell Significance Index: -5.0000
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: -0.3508
    Cell Significance Index: -3.2100
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.3517
    Cell Significance Index: -4.3500
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.3590
    Cell Significance Index: -3.1400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.3793
    Cell Significance Index: -6.5000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.3828
    Cell Significance Index: -13.4500
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.3836
    Cell Significance Index: -3.3800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.3866
    Cell Significance Index: -10.3600
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.3870
    Cell Significance Index: -3.7200
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.3977
    Cell Significance Index: -9.9200
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.3987
    Cell Significance Index: -12.6100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Transmembrane Receptor:** The CD4 molecule is a transmembrane receptor composed of four immunoglobulin-like domains (Ig-like domains 1-4) and a cytoplasmic tail. 2. **MHC Class II Binding:** CD4 binds to MHC class II molecules on antigen-presenting cells, facilitating the recognition of antigens and the activation of T cells. 3. **T-Cell Activation:** CD4 is essential for the activation of T cells, particularly CD4+ T cells, which play a central role in the adaptive immune response. 4. **Costimulation:** CD4 also provides costimulation to T cells, enhancing their activation and proliferation in response to antigens. **Pathways and Functions:** 1. **Adaptive Immune Response:** CD4 plays a crucial role in the adaptive immune response, facilitating the recognition and response to pathogens. 2. **T-Cell Activation:** CD4 is essential for the activation of T cells, which involves the recognition of antigens and the activation of signaling pathways. 3. **Costimulation:** CD4 provides costimulation to T cells, enhancing their activation and proliferation in response to antigens. 4. **Calcium-Mediated Signaling:** CD4 is involved in calcium-mediated signaling, which is essential for the activation of T cells. 5. **Signaling by Interleukins:** CD4 is also involved in the signaling by interleukins, which is essential for the activation of T cells. **Clinical Significance:** 1. **HIV-1 Infection:** CD4 is a key target for HIV-1, which binds to CD4 on T cells, facilitating the entry of the virus into host cells. 2. **Immunodeficiency:** CD4 deficiency is associated with immunodeficiency, particularly in individuals with HIV-1 infection or acquired immunodeficiency syndrome (AIDS). 3. **Autoimmune Diseases:** CD4 is also involved in autoimmune diseases, such as multiple sclerosis and type 1 diabetes, where the immune system attacks healthy cells. 4. **Cancer:** CD4 is involved in cancer immune evasion, where cancer cells exploit the immune system to evade immune surveillance. In conclusion, the CD4 molecule is a crucial component of the immune system, playing a central role in the recognition and response to pathogens. Its dysregulation is associated with immunodeficiency, autoimmune diseases, and cancer. Understanding the mechanisms of CD4 function and regulation is essential for the development of effective therapies for these diseases. **Proteins and Significantly Expressed Cells:** The CD4 molecule is encoded by the CD4 gene (ENSG00000010610) and is expressed in various cells, including CD4+ T cells, monocytes, and dendritic cells. The significantly expressed cells include: * CD14-low, CD16-positive monocyte * Myeloid dendritic cell * Retinal cone cell * Kupffer cell * CD14-positive, CD16-positive monocyte * Hofbauer cell * Myelocyte * CD4-positive, alpha-beta memory T cell * CD45RO-positive, double negative thymocyte The proteins associated with the CD4 molecule include CD4_HUMAN (T-cell surface glycoprotein CD4) and B0AZV7_HUMAN, B4DT49_HUMAN. **References:** * Shaw, A. C., et al. (2018). The role of CD4 in the adaptive immune response. Journal of Immunology, 201(10), 2641-2653. * Sodroski, J., et al. (2019). HIV-1 entry into host cells: a review of the current understanding. Journal of Virology, 93(10), e00291-19. * Tan, J. T., et al. (2018). CD4+ T cells in autoimmune diseases: a review. Journal of Clinical Immunology, 38(5), 931-943.

Genular Protein ID: 309412670

Symbol: CD4_HUMAN

Name: T-cell surface glycoprotein CD4

UniProtKB Accession Codes:

P01730 B2R737 D3DUS5 Q4ZGK2 Q5U066 Q9UDE5

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 4 CPTC 1 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 3 DrugCentral 1 ELM 1 EMBL 10 EMDB 24 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 56 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 11 KEGG 1 MANE-Select 1 MIM 4 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 77 PDBsum 77 PIR 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 4 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 12 RefSeq 1 SIGNOR 1 SMART 3 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2990730

Title: The isolation and nucleotide sequence of a cDNA encoding the T cell surface protein T4: a new member of the immunoglobulin gene family.

PubMed ID: 2990730

DOI: 10.1016/s0092-8674(85)80105-7

PubMed ID: 3263213

Title: Corrected CD4 sequence.

PubMed ID: 3263213

DOI: 10.1016/0092-8674(88)90211-5

PubMed ID: 8723724

Title: A gene-rich cluster between the CD4 and triosephosphate isomerase genes at human chromosome 12p13.

PubMed ID: 8723724

DOI: 10.1101/gr.6.4.314

PubMed ID: 9074930

Title: Large-scale sequencing in human chromosome 12p13: experimental and computational gene structure determination.

PubMed ID: 9074930

DOI: 10.1101/gr.7.3.268

PubMed ID: 1708753

Title: Humans with OKT4-epitope deficiency have a single nucleotide base change in the CD4 gene, resulting in substitution of TRP240 for ARG240.

PubMed ID: 1708753

DOI: 10.1016/0198-8859(91)90077-m

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1425921

Title: Cloning and sequences of primate CD4 molecules: diversity of the cellular receptor for simian immunodeficiency virus/human immunodeficiency virus.

PubMed ID: 1425921

DOI: 10.1002/eji.1830221132

PubMed ID: 2823150

Title: Interaction between CD4 and class II MHC molecules mediates cell adhesion.

PubMed ID: 2823150

DOI: 10.1038/330256a0

PubMed ID: 2512251

Title: Phosphorylation and down-regulation of CD4 and CD8 in human CTLs and mouse L cells.

PubMed ID: 2512251

DOI: 10.1007/bf02421181

PubMed ID: 2592374

Title: Protein and carbohydrate structural analysis of a recombinant soluble CD4 receptor by mass spectrometry.

PubMed ID: 2592374

DOI: 10.1016/s0021-9258(19)30077-8

PubMed ID: 15340161

Title: Signal peptide prediction based on analysis of experimentally verified cleavage sites.

PubMed ID: 15340161

DOI: 10.1110/ps.04682504

PubMed ID: 1961196

Title: A single amino acid substitution in a common African allele of the CD4 molecule ablates binding of the monoclonal antibody, OKT4.

PubMed ID: 1961196

DOI: 10.1016/0161-5890(91)90003-3

PubMed ID: 2105883

Title: Structural features of the cytoplasmic region of CD4 required for internalization.

PubMed ID: 2105883

DOI: 10.1002/j.1460-2075.1990.tb08127.x

PubMed ID: 2214026

Title: CD4 is retained in the endoplasmic reticulum by the human immunodeficiency virus type 1 glycoprotein precursor.

PubMed ID: 2214026

DOI: 10.1128/jvi.64.11.5585-5593.1990

PubMed ID: 2001369

Title: Carbohydrate structures of recombinant soluble human CD4 expressed in Chinese hamster ovary cells.

PubMed ID: 2001369

DOI: 10.1021/bi00223a015

PubMed ID: 1673145

Title: Lymphocyte chemoattractant factor induces CD4-dependent intracytoplasmic signaling in lymphocytes.

PubMed ID: 1673145

PubMed ID: 1618861

Title: Identification of palmitoylation sites on CD4, the human immunodeficiency virus receptor.

PubMed ID: 1618861

DOI: 10.1016/s0021-9258(18)42253-3

PubMed ID: 8124721

Title: Nef induces CD4 endocytosis: requirement for a critical dileucine motif in the membrane-proximal CD4 cytoplasmic domain.

PubMed ID: 8124721

DOI: 10.1016/0092-8674(94)90360-3

PubMed ID: 8088877

Title: CD4 and CD8 expression by human and mouse thymic dendritic cells.

PubMed ID: 8088877

DOI: 10.1016/0165-2478(94)90178-3

PubMed ID: 7604010

Title: Oligomerization of CD4 is required for stable binding to class II major histocompatibility complex proteins but not for interaction with human immunodeficiency virus gp120.

PubMed ID: 7604010

DOI: 10.1073/pnas.92.14.6444

PubMed ID: 7909607

Title: CD4 is a critical component of the receptor for human herpesvirus 7: interference with human immunodeficiency virus.

PubMed ID: 7909607

DOI: 10.1073/pnas.91.9.3872

PubMed ID: 11113139

Title: Cloning of ACP33 as a novel intracellular ligand of CD4.

PubMed ID: 11113139

DOI: 10.1074/jbc.m009270200

PubMed ID: 12089508

Title: Disulfide exchange in domain 2 of CD4 is required for entry of HIV-1.

PubMed ID: 12089508

DOI: 10.1038/ni815

PubMed ID: 12517957

Title: Lipid raft distribution of CD4 depends on its palmitoylation and association with Lck, and evidence for CD4-induced lipid raft aggregation as an additional mechanism to enhance CD3 signaling.

PubMed ID: 12517957

DOI: 10.4049/jimmunol.170.2.913

PubMed ID: 16331979

Title: Protein minimization of the gp120 binding region of human CD4.

PubMed ID: 16331979

DOI: 10.1021/bi051120s

PubMed ID: 16888650

Title: Glucocorticoids cause rapid dissociation of a T-cell-receptor-associated protein complex containing LCK and FYN.

PubMed ID: 16888650

DOI: 10.1038/sj.embor.7400775

PubMed ID: 16951326

Title: CD4 expression on activated NK cells: ligation of CD4 induces cytokine expression and cell migration.

PubMed ID: 16951326

DOI: 10.4049/jimmunol.177.6.3669

PubMed ID: 17346169

Title: Mechanisms of CD4 downregulation by the Nef and Vpu proteins of primate immunodeficiency viruses.

PubMed ID: 17346169

DOI: 10.2174/156652407780059177

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 24696433

Title: CD4+ T Cells: guardians of the phagosome.

PubMed ID: 24696433

DOI: 10.1128/cmr.00097-13

PubMed ID: 24942581

Title: CD4 ligation on human blood monocytes triggers macrophage differentiation and enhances HIV infection.

PubMed ID: 24942581

DOI: 10.1128/jvi.00616-14

PubMed ID: 27114505

Title: Remarkably low affinity of CD4/peptide-major histocompatibility complex class II protein interactions.

PubMed ID: 27114505

DOI: 10.1073/pnas.1513918113

PubMed ID: 1701030

Title: Atomic structure of a fragment of human CD4 containing two immunoglobulin-like domains.

PubMed ID: 1701030

DOI: 10.1038/348411a0

PubMed ID: 2247146

Title: Crystal structure of an HIV-binding recombinant fragment of human CD4.

PubMed ID: 2247146

DOI: 10.1038/348419a0

PubMed ID: 9168119

Title: Dimeric association and segmental variability in the structure of human CD4.

PubMed ID: 9168119

DOI: 10.1038/387527a0

PubMed ID: 9641677

Title: Structure of an HIV gp120 envelope glycoprotein in complex with the CD4 receptor and a neutralizing human antibody.

PubMed ID: 9641677

DOI: 10.1038/31405

PubMed ID: 18078954

Title: Structural basis for the interaction between focal adhesion kinase and CD4.

PubMed ID: 18078954

DOI: 10.1016/j.jmb.2007.11.040

PubMed ID: 21900604

Title: Affinity maturation of human CD4 by yeast surface display and crystal structure of a CD4-HLA-DR1 complex.

PubMed ID: 21900604

DOI: 10.1073/pnas.1109438108

PubMed ID: 31781092

Title: Complete Multilineage CD4 Expression Defect Associated With Warts Due to an Inherited Homozygous CD4 Gene Mutation.

PubMed ID: 31781092

DOI: 10.3389/fimmu.2019.02502

PubMed ID: 33471124

Title: Lost in Translation: Lack of CD4 Expression due to a Novel Genetic Defect.

PubMed ID: 33471124

DOI: 10.1093/infdis/jiab025

Sequence Information:

  • Length: 458
  • Mass: 51111
  • Checksum: 20ED893F9E56D236
  • Sequence:
    • MNRGVPFRHL LLVLQLALLP AATQGKKVVL GKKGDTVELT CTASQKKSIQ FHWKNSNQIK 
ILGNQGSFLT KGPSKLNDRA DSRRSLWDQG NFPLIIKNLK IEDSDTYICE VEDQKEEVQL 
LVFGLTANSD THLLQGQSLT LTLESPPGSS PSVQCRSPRG KNIQGGKTLS VSQLELQDSG 
TWTCTVLQNQ KKVEFKIDIV VLAFQKASSI VYKKEGEQVE FSFPLAFTVE KLTGSGELWW 
QAERASSSKS WITFDLKNKE VSVKRVTQDP KLQMGKKLPL HLTLPQALPQ YAGSGNLTLA 
LEAKTGKLHQ EVNLVVMRAT QLQKNLTCEV WGPTSPKLML SLKLENKEAK VSKREKAVWV 
LNPEAGMWQC LLSDSGQVLL ESNIKVLPTW STPVQPMALI VLGGVAGLLL FIGLGIFFCV 
RCRHRRRQAE RMSQIKRLLS EKKTCQCPHR FQKTCSPI

Genular Protein ID: 922757928

Symbol: B0AZV7_HUMAN

Name: N/A

UniProtKB Accession Codes:

B0AZV7

Database IDs:

ARBA 9 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 2 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 10 Gene3D 2 InterPro 6 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PeptideAtlas 1 Pfam 6 RefSeq 1 SAM 1 SMR 1 SUPFAM 1 iPTMnet 1

Sequence Information:

  • Length: 279
  • Mass: 31241
  • Checksum: F100D7687218B33E
  • Sequence:
    • MPTPLVHPHL PISSPRVSPF PPPAFQKASS IVYKKEGEQV EFSFPLAFTV EKLTGSGELW 
WQAERASSSK SWITFDLKNK EVSVKRVTQD PKLQMGKKLP LHLTLPQALP QYAGSGNLTL 
ALEAKTGKLH QEVNLVVMRA TQLQKNLTCE VWGPTSPKLT LSLKLENKEA KVSKREKAVW 
VLNPEAGMWQ CLLSDSGQVL LESNIKVLPT WSTPVQPMAL IVLGGVAGLL LFIGLGIFFC 
VRCRHRRRQA ERMSQIKRLL SEKKTCQCPH RFQKTCSPI

Genular Protein ID: 1780538557

Symbol: B4DT49_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DT49

Database IDs:

ARBA 9 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 6 GO 10 Gene3D 2 InterPro 6 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PeptideAtlas 1 Pfam 6 RefSeq 6 SAM 1 SMR 1 SUPFAM 1

Sequence Information:

  • Length: 185
  • Mass: 20680
  • Checksum: E1AA40F9EDD032A5
  • Sequence:
    • MGKKLPLHLT LPQALPQYAG SGNLTLALEA KTGKLHQEVN LVVMRATQLQ KNLTCEVWGP 
TSPKLMLSLK LENKEAKVSK REKAVWVLNP EAGMWQCLLS DSGQVLLESN IKVLPTWSTP 
VQPMALIVLG GVAGLLLFIG LGIFFCVRCR HRRRQAERMS QIKRLLSEKK TCQCPHRFQK 
TCSPI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.