Details for: DCLK1

Gene ID: 9201

Symbol: DCLK1

Ensembl ID: ENSG00000133083

Description: doublecortin like kinase 1

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 5.99
    Marker Score: 202,346
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 5.38
    Marker Score: 18,047
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 4.49
    Marker Score: 24,099
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 4.28
    Marker Score: 22,463
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 4.03
    Marker Score: 2,655
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 3.86
    Marker Score: 17,870
  • Cell Name: granule cell (CL0000120)
    Fold Change: 3.7
    Marker Score: 27,886
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 3.62
    Marker Score: 2,105
  • Cell Name: CNS interneuron (CL0000402)
    Fold Change: 3.52
    Marker Score: 1,692
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 3.52
    Marker Score: 4,954
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 3.38
    Marker Score: 7,768
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: 3.27
    Marker Score: 2,485
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 2.95
    Marker Score: 4,959
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 2.92
    Marker Score: 8,342
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 2.86
    Marker Score: 56,942
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 2.78
    Marker Score: 3,467
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 2.73
    Marker Score: 40,803
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 2.72
    Marker Score: 20,859
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 2.72
    Marker Score: 103,252
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 2.65
    Marker Score: 1,019
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 2.56
    Marker Score: 5,628
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 2.51
    Marker Score: 1,406
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 2.49
    Marker Score: 10,367
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 2.43
    Marker Score: 89,550
  • Cell Name: ganglion interneuron (CL0000397)
    Fold Change: 2.3
    Marker Score: 697
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 2.29
    Marker Score: 8,841
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 2.2
    Marker Score: 20,672
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.08
    Marker Score: 127,859
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 2.04
    Marker Score: 21,058
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.99
    Marker Score: 8,092
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.93
    Marker Score: 18,326
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 1.89
    Marker Score: 33,606
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.88
    Marker Score: 16,153
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 1.84
    Marker Score: 477
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 1.72
    Marker Score: 1,702
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 1.66
    Marker Score: 697
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.65
    Marker Score: 2,550
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 1.62
    Marker Score: 969
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.6
    Marker Score: 1,161
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 1.56
    Marker Score: 6,036
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 1.55
    Marker Score: 384
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.55
    Marker Score: 1,549
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 1.53
    Marker Score: 6,351
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 1.51
    Marker Score: 993
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.46
    Marker Score: 167,567
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 1.44
    Marker Score: 394
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 1.4
    Marker Score: 323
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 1.38
    Marker Score: 1,912
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.36
    Marker Score: 863
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.36
    Marker Score: 3,196
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.35
    Marker Score: 2,740
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 1.33
    Marker Score: 2,552
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.32
    Marker Score: 28,082
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.29
    Marker Score: 20,139
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 1.27
    Marker Score: 1,103
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.25
    Marker Score: 848
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 1.25
    Marker Score: 5,211
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 1.24
    Marker Score: 417
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 1.19
    Marker Score: 2,418
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 1.18
    Marker Score: 655
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.16
    Marker Score: 482
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.14
    Marker Score: 4,791
  • Cell Name: sympathetic neuron (CL0011103)
    Fold Change: 1.13
    Marker Score: 374
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.1
    Marker Score: 37,520
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.1
    Marker Score: 658
  • Cell Name: fat cell (CL0000136)
    Fold Change: 1.09
    Marker Score: 609
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 1.08
    Marker Score: 6,520
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.06
    Marker Score: 1,224
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 1.05
    Marker Score: 1,174
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 1.04
    Marker Score: 781
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.03
    Marker Score: 789
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 1.02
    Marker Score: 439
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,782
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,007
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,405
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 504
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 457
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,412
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.95
    Marker Score: 435
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5,303
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.92
    Marker Score: 370
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,735
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 0.9
    Marker Score: 2,354
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 323
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 0.89
    Marker Score: 326
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.87
    Marker Score: 431
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,279
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 0.83
    Marker Score: 394
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.8
    Marker Score: 383
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.78
    Marker Score: 917
  • Cell Name: meningeal macrophage (CL0000879)
    Fold Change: 0.78
    Marker Score: 219
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1,257
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 0.77
    Marker Score: 7,815
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 703
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 392
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.75
    Marker Score: 190
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.74
    Marker Score: 1,292
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.74
    Marker Score: 1,134
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 0.73
    Marker Score: 510
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 0.73
    Marker Score: 435

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** DCLK1 is a member of the doublecortin-like kinase family, characterized by its ability to phosphorylate and regulate various proteins involved in immune responses, neuronal development, and cancer progression. Its expression is widely observed in various cell types, including immune cells, neurons, and muscle cells. The kinase's activity is regulated by specific phosphorylation sites, allowing it to modulate its interactions with downstream targets. **Pathways and Functions:** DCLK1 is involved in multiple signaling pathways that regulate immune responses, including: 1. **Intracellular signal transduction**: DCLK1 phosphorylates and activates key components of the MAPK/ERK and PI3K/AKT signaling pathways, modulating immune cell function and cytokine production. 2. **Protein localization to nucleus**: DCLK1 regulates the subcellular localization of transcription factors, influencing gene expression and immune response modulation. 3. **Axon extension and neuron migration**: DCLK1 is essential for the development and maturation of neurons, influencing axon extension and neuronal migration. 4. **Endosomal transport**: DCLK1 regulates the trafficking of endosomes, influencing the degradation and recycling of proteins involved in immune responses. **Clinical Significance:** DCLK1's involvement in immune regulation and disease progression highlights its potential as a therapeutic target in various clinical settings, including: 1. **Autoimmune disorders**: DCLK1's role in regulating immune responses suggests its potential as a therapeutic target in autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis. 2. **Cancer**: DCLK1's expression in cancer cells and its involvement in tumor progression and metastasis make it a promising target for cancer therapy. 3. **Neurological disorders**: DCLK1's role in neuronal development and function suggests its potential as a therapeutic target in neurological disorders, such as Alzheimer's disease and Parkinson's disease. **Conclusion:** In conclusion, DCLK1's complex roles in immune regulation, neuronal development, and cancer progression highlight its potential as a therapeutic target in various clinical settings. Further research is necessary to fully elucidate the molecular mechanisms underlying DCLK1's functions and to develop effective therapeutic strategies targeting this kinase. **Recommendations:** 1. **Immunological studies**: Investigate the role of DCLK1 in immune cell function and cytokine production to elucidate its potential as a therapeutic target in autoimmune disorders. 2. **Cancer research**: Explore the expression and function of DCLK1 in cancer cells to identify potential therapeutic targets for cancer therapy. 3. **Neurological studies**: Investigate the role of DCLK1 in neuronal development and function to elucidate its potential as a therapeutic target in neurological disorders. By advancing our understanding of DCLK1's molecular pathways and clinical implications, we can develop effective therapeutic strategies to target this kinase and improve treatment outcomes for patients with immune-related disorders and cancer.

Genular Protein ID: 4109336855

Symbol: DCLK1_HUMAN

Name: Serine/threonine-protein kinase DCLK1

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 9747029

Title: Expression and chromosomal localization of KIAA0369, a putative kinase structurally related to Doublecortin.

PubMed ID: 9747029

DOI: 10.1007/s100380050063

PubMed ID: 10036192

Title: DCAMKL1, a brain-specific transmembrane protein on 13q12.3 that is similar to doublecortin (DCX).

PubMed ID: 10036192

DOI: 10.1006/geno.1998.5718

PubMed ID: 9205841

Title: Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.

PubMed ID: 9205841

DOI: 10.1093/dnares/4.2.141

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15057823

Title: The DNA sequence and analysis of human chromosome 13.

PubMed ID: 15057823

DOI: 10.1038/nature02379

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10051403

Title: Genomic structure, chromosomal mapping, and expression pattern of human DCAMKL1 (KIAA0369), a homologue of DCX (XLIS).

PubMed ID: 10051403

DOI: 10.1006/geno.1998.5673

PubMed ID: 16548883

Title: Transcriptomic and proteomic analyses of rhabdomyosarcoma cells reveal differential cellular gene expression in response to enterovirus 71 infection.

PubMed ID: 16548883

DOI: 10.1111/j.1462-5822.2005.00644.x

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

Sequence Information:

  • Length: 740
  • Mass: 82224
  • Checksum: D7B6D855099A315C
  • Sequence:
  • MSFGRDMELE HFDERDKAQR YSRGSRVNGL PSPTHSAHCS FYRTRTLQTL SSEKKAKKVR 
    FYRNGDRYFK GIVYAISPDR FRSFEALLAD LTRTLSDNVN LPQGVRTIYT IDGLKKISSL 
    DQLVEGESYV CGSIEPFKKL EYTKNVNPNW SVNVKTTSAS RAVSSLATAK GSPSEVRENK 
    DFIRPKLVTI IRSGVKPRKA VRILLNKKTA HSFEQVLTDI TDAIKLDSGV VKRLYTLDGK 
    QVMCLQDFFG DDDIFIACGP EKFRYQDDFL LDESECRVVK STSYTKIASS SRRSTTKSPG 
    PSRRSKSPAS TSSVNGTPGS QLSTPRSGKS PSPSPTSPGS LRKQRSSQHG GSSTSLASTK 
    VCSSMDENDG PGEEVSEEGF QIPATITERY KVGRTIGDGN FAVVKECVER STAREYALKI 
    IKKSKCRGKE HMIQNEVSIL RRVKHPNIVL LIEEMDVPTE LYLVMELVKG GDLFDAITST 
    NKYTERDASG MLYNLASAIK YLHSLNIVHR DIKPENLLVY EHQDGSKSLK LGDFGLATIV 
    DGPLYTVCGT PTYVAPEIIA ETGYGLKVDI WAAGVITYIL LCGFPPFRGS GDDQEVLFDQ 
    ILMGQVDFPS PYWDNVSDSA KELITMMLLV DVDQRFSAVQ VLEHPWVNDD GLPENEHQLS 
    VAGKIKKHFN TGPKPNSTAA GVSVIATTAL DKERQVFRRR RNQDVRSRYK AQPAPPELNS 
    ESEDYSPSSS ETVRSPNSPF

Genular Protein ID: 988657426

Symbol: A0A9L9PXT2_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 15057823

Title: The DNA sequence and analysis of human chromosome 13.

PubMed ID: 15057823

DOI: 10.1038/nature02379

Sequence Information:

  • Length: 56
  • Mass: 5914
  • Checksum: D76B15FF91376B9F
  • Sequence:
  • MLELIEVNGT PGSQLSTPRS GKSPSPSPTS PGSLRKQRDL YRPLSSDDLD SVGDSV

Genular Protein ID: 3082070064

Symbol: B7Z5K4_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 433
  • Mass: 47623
  • Checksum: D1A1B5E6AAACE398
  • Sequence:
  • MLELIEVNGT PGSQLSTPRS GKSPSPSPTS PGSLRKQRSS QHGGSSTSLA STKVCSSMDE 
    NDGPGEEVSE EGFQIPATIT ERYKVGRTIG DGNFAVVKEC VERSTAREYA LKIIKKSKCR 
    GKEHMIQNEV SILRRVKHPN IVLLIEEMDV PTELYLVMEL VKGGDLFDAI TSTNKYTERD 
    ASGMLYNLAS AIKYLHSLNI VHRDIKPENL LVYEHQDGSK SLKLGDFGLA TIVDGPLYTV 
    CGTPTYVAPE IIAETGYGLK VDIWAAGVIT YILLCGFPPF RGSGDDQEVL FDQILMGQVG 
    FPSPYWDNVS DSAKELITMM LLVDVDQRFS AVQVLEHPWV NDDGLPENEH QLSVAGKIKK 
    HFNTGPKPNS TAAGVSVIAT TALDKERQVF RRRRNQDVRS RYKAQPAPPE LNSESEDYSP 
    SSSETVRSPN SPF

Genular Protein ID: 3895882934

Symbol: Q5VZY9_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 15057823

Title: The DNA sequence and analysis of human chromosome 13.

PubMed ID: 15057823

DOI: 10.1038/nature02379

Sequence Information:

  • Length: 363
  • Mass: 40457
  • Checksum: DE6323CEF652839A
  • Sequence:
  • MSFGRDMELE HFDERDKAQR YSRGSRVNGL PSPTHSAHCS FYRTRTLQTL SSEKKAKKVR 
    FYRNGDRYFK GIVYAISPDR FRSFEALLAD LTRTLSDNVN LPQGVRTIYT IDGLKKISSL 
    DQLVEGESYV CGSIEPFKKL EYTKNVNPNW SVNVKTTSAS RAVSSLATAK GSPSEVRENK 
    DFIRPKLVTI IRSGVKPRKA VRILLNKKTA HSFEQVLTDI TDAIKLDSGV VKRLYTLDGK 
    QVMCLQDFFG DDDIFIACGP EKFRYQDDFL LDESECRVVK STSYTKIASS SRRSTTKSPG 
    PSRRSKSPAS TSSVNGTPGS QLSTPRSGKS PSPSPTSPGS LRKQRDLYRP LSSDDLDSVG 
    DSV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.