Details for: CD5

Gene ID: 921

Symbol: CD5

Ensembl ID: ENSG00000110448

Description: CD5 molecule

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 28.4162
    Cell Significance Index: -4.4200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 18.7271
    Cell Significance Index: -4.7500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 3.6417
    Cell Significance Index: -4.4900
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 2.9482
    Cell Significance Index: 86.5900
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 2.7922
    Cell Significance Index: 8.5100
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 2.1243
    Cell Significance Index: 21.3000
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 1.3121
    Cell Significance Index: -4.0300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 0.9967
    Cell Significance Index: -2.6700
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 0.8613
    Cell Significance Index: 8.9300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.6771
    Cell Significance Index: 21.6900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.5606
    Cell Significance Index: 25.4100
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 0.4470
    Cell Significance Index: 3.9100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.4307
    Cell Significance Index: 81.9600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3523
    Cell Significance Index: 34.8600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2398
    Cell Significance Index: 216.4900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.2327
    Cell Significance Index: 4.9600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1737
    Cell Significance Index: 28.2500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.1420
    Cell Significance Index: 15.4500
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.1114
    Cell Significance Index: 1.6000
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 0.1096
    Cell Significance Index: 1.8900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0966
    Cell Significance Index: 6.0900
  • Cell Name: monocyte-derived dendritic cell (CL0011031)
    Fold Change: 0.0960
    Cell Significance Index: 1.6500
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.0939
    Cell Significance Index: 2.4000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.0693
    Cell Significance Index: 4.1600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0538
    Cell Significance Index: 3.7200
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.0266
    Cell Significance Index: 0.1500
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 0.0225
    Cell Significance Index: 0.1800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0188
    Cell Significance Index: 3.7700
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 0.0174
    Cell Significance Index: 0.1800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0076
    Cell Significance Index: 0.2200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0061
    Cell Significance Index: 11.4300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0059
    Cell Significance Index: 9.1100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0043
    Cell Significance Index: 7.8900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.0018
    Cell Significance Index: 0.1100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0008
    Cell Significance Index: 1.0200
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0011
    Cell Significance Index: -0.0100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0024
    Cell Significance Index: -0.8600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0029
    Cell Significance Index: -0.5700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0031
    Cell Significance Index: -0.1100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0032
    Cell Significance Index: -0.0800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0059
    Cell Significance Index: -4.4600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0066
    Cell Significance Index: -4.9100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0070
    Cell Significance Index: -3.1100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0073
    Cell Significance Index: -4.1100
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0075
    Cell Significance Index: -0.3800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0088
    Cell Significance Index: -4.8200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0100
    Cell Significance Index: -6.3400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0106
    Cell Significance Index: -0.2300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0108
    Cell Significance Index: -4.9200
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0121
    Cell Significance Index: -0.2500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0125
    Cell Significance Index: -3.6000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0144
    Cell Significance Index: -1.7000
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0186
    Cell Significance Index: -0.2800
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.0187
    Cell Significance Index: -0.1800
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: -0.0211
    Cell Significance Index: -0.1800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0226
    Cell Significance Index: -3.8600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0230
    Cell Significance Index: -4.8500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0250
    Cell Significance Index: -1.6800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0265
    Cell Significance Index: -3.8500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0284
    Cell Significance Index: -3.6400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0324
    Cell Significance Index: -5.8400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0336
    Cell Significance Index: -3.9100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0341
    Cell Significance Index: -4.6900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0382
    Cell Significance Index: -3.9800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0399
    Cell Significance Index: -4.5700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0402
    Cell Significance Index: -1.7800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0416
    Cell Significance Index: -1.0700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0449
    Cell Significance Index: -1.7000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0492
    Cell Significance Index: -6.0500
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0492
    Cell Significance Index: -2.1400
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0495
    Cell Significance Index: -2.0300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0504
    Cell Significance Index: -6.5100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0538
    Cell Significance Index: -4.1300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0580
    Cell Significance Index: -5.9200
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0593
    Cell Significance Index: -0.7000
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0632
    Cell Significance Index: -0.8600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0633
    Cell Significance Index: -2.9500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0635
    Cell Significance Index: -2.9900
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: -0.0643
    Cell Significance Index: -0.5800
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.0758
    Cell Significance Index: -0.6400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0781
    Cell Significance Index: -4.3800
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0786
    Cell Significance Index: -1.1500
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0807
    Cell Significance Index: -1.3700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0888
    Cell Significance Index: -6.6200
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0913
    Cell Significance Index: -3.2000
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.0926
    Cell Significance Index: -0.9400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0929
    Cell Significance Index: -5.7100
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.0935
    Cell Significance Index: -1.3400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0938
    Cell Significance Index: -2.5100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0959
    Cell Significance Index: -2.6800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0960
    Cell Significance Index: -5.0400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0974
    Cell Significance Index: -5.0600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0994
    Cell Significance Index: -6.4100
  • Cell Name: mature T cell (CL0002419)
    Fold Change: -0.1001
    Cell Significance Index: -0.7200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1009
    Cell Significance Index: -3.2200
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.1147
    Cell Significance Index: -0.9900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1179
    Cell Significance Index: -3.8600
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.1181
    Cell Significance Index: -1.1200
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.1249
    Cell Significance Index: -3.9500
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.1293
    Cell Significance Index: -2.6300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** CD5 is a type II transmembrane glycoprotein, consisting of an extracellular domain, a transmembrane domain, and an intracellular domain. The extracellular domain contains immunoglobulin-like domains, which are involved in cell-cell interactions and binding to other molecules. The intracellular domain contains a tyrosine kinase domain, which is essential for signaling and cell proliferation. CD5 is highly conserved across species, suggesting its importance in immune function. **Pathways and Functions** CD5 is involved in several signaling pathways, including: 1. **Apoptotic signaling pathway**: CD5 can regulate apoptosis (programmed cell death) in T cells, thereby influencing the development and maintenance of immune tolerance. 2. **Cell recognition**: CD5 interacts with other molecules, such as CD4 and CD8, to facilitate T cell recognition and interaction with antigen-presenting cells. 3. **External side of plasma membrane**: CD5 is located on the surface of T cells, where it can interact with extracellular molecules and influence cell signaling. 4. **Protein binding**: CD5 can bind to various proteins, including CD4, CD8, and the tyrosine kinase domain, to regulate signaling and cell function. 5. **Signaling receptor activity**: CD5 acts as a signaling receptor, transmitting signals from the extracellular environment to the intracellular signaling pathways. **Clinical Significance** Dysregulation of CD5 has been implicated in several immune-related disorders, including: 1. **Autoimmune diseases**: CD5 has been linked to autoimmune diseases, such as multiple sclerosis and type 1 diabetes, where T cell dysregulation is a key feature. 2. **Cancers**: CD5 is overexpressed in certain types of cancer, including leukemia and lymphoma, where it can contribute to tumor growth and survival. 3. **Immunodeficiency disorders**: CD5 deficiency has been associated with immunodeficiency disorders, such as X-linked lymphoproliferative disease, where T cell dysfunction is a hallmark. 4. **Allergic diseases**: CD5 has been implicated in allergic diseases, such as atopic dermatitis and asthma, where T cell dysregulation is a key feature. In summary, CD5 is a critical component of the immune system, playing a key role in T cell development, function, and survival. Its dysregulation has been implicated in several immune-related disorders, highlighting the importance of this gene in human health and disease.

Genular Protein ID: 760088228

Symbol: CD5_HUMAN

Name: T-cell surface glycoprotein CD5

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 3093892

Title: Isolation of complementary DNA clones encoding the human lymphocyte glycoprotein T1/Leu-1.

PubMed ID: 3093892

DOI: 10.1038/323346a0

PubMed ID: 8740779

Title: Evolutionarily conserved transcription regulatory elements within the 5'-flanking region of the human CD5 gene.

PubMed ID: 8740779

DOI: 10.1111/j.1399-0039.1996.tb02551.x

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1711157

Title: The B-cell surface protein CD72/Lyb-2 is the ligand for CD5.

PubMed ID: 1711157

DOI: 10.1038/351662a0

PubMed ID: 1385158

Title: Evidence for an association between the T cell receptor/CD3 antigen complex and the CD5 antigen in human T lymphocytes.

PubMed ID: 1385158

DOI: 10.1002/eji.1830221135

PubMed ID: 1384049

Title: CD5 acts as a tyrosine kinase substrate within a receptor complex comprising T-cell receptor zeta chain/CD3 and protein-tyrosine kinases p56lck and p59fyn.

PubMed ID: 1384049

DOI: 10.1073/pnas.89.19.9311

PubMed ID: 12522270

Title: Profiling of tyrosine phosphorylation pathways in human cells using mass spectrometry.

PubMed ID: 12522270

DOI: 10.1073/pnas.2436191100

PubMed ID: 15144186

Title: Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry.

PubMed ID: 15144186

DOI: 10.1021/ac035352d

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 23376399

Title: The carboxy-terminal region of CD5 is required for c-CBL mediated TCR signaling downmodulation in thymocytes.

PubMed ID: 23376399

DOI: 10.1016/j.bbrc.2013.01.086

PubMed ID: 27499044

Title: CD5 expression promotes IL-10 production through activation of the MAPK/Erk pathway and upregulation of TRPC1 channels in B lymphocytes.

PubMed ID: 27499044

DOI: 10.1038/cmi.2016.42

PubMed ID: 17322294

Title: Crystal structure of the third extracellular domain of CD5 reveals the fold of a group B scavenger cysteine-rich receptor domain.

PubMed ID: 17322294

DOI: 10.1074/jbc.m611699200

PubMed ID: 18339402

Title: Three-dimensional solution structure and conformational plasticity of the N-terminal scavenger receptor cysteine-rich domain of human CD5.

PubMed ID: 18339402

DOI: 10.1016/j.jmb.2008.02.006

Sequence Information:

  • Length: 495
  • Mass: 54578
  • Checksum: 9131AEC9683EE1D3
  • Sequence:
  • MPMGSLQPLA TLYLLGMLVA SCLGRLSWYD PDFQARLTRS NSKCQGQLEV YLKDGWHMVC 
    SQSWGRSSKQ WEDPSQASKV CQRLNCGVPL SLGPFLVTYT PQSSIICYGQ LGSFSNCSHS 
    RNDMCHSLGL TCLEPQKTTP PTTRPPPTTT PEPTAPPRLQ LVAQSGGQHC AGVVEFYSGS 
    LGGTISYEAQ DKTQDLENFL CNNLQCGSFL KHLPETEAGR AQDPGEPREH QPLPIQWKIQ 
    NSSCTSLEHC FRKIKPQKSG RVLALLCSGF QPKVQSRLVG GSSICEGTVE VRQGAQWAAL 
    CDSSSARSSL RWEEVCREQQ CGSVNSYRVL DAGDPTSRGL FCPHQKLSQC HELWERNSYC 
    KKVFVTCQDP NPAGLAAGTV ASIILALVLL VVLLVVCGPL AYKKLVKKFR QKKQRQWIGP 
    TGMNQNMSFH RNHTATVRSH AENPTASHVD NEYSQPPRNS HLSAYPALEG ALHRSSMQPD 
    NSSDSDYDLH GAQRL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.