Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 28.4162
Cell Significance Index: -4.4200 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 18.7271
Cell Significance Index: -4.7500 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 3.6417
Cell Significance Index: -4.4900 - Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 2.9482
Cell Significance Index: 86.5900 - Cell Name: T-helper 22 cell (CL0001042)
Fold Change: 2.7922
Cell Significance Index: 8.5100 - Cell Name: DN3 thymocyte (CL0000807)
Fold Change: 2.1243
Cell Significance Index: 21.3000 - Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 1.3121
Cell Significance Index: -4.0300 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 0.9967
Cell Significance Index: -2.6700 - Cell Name: DN1 thymic pro-T cell (CL0000894)
Fold Change: 0.8613
Cell Significance Index: 8.9300 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 0.6771
Cell Significance Index: 21.6900 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.5606
Cell Significance Index: 25.4100 - Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
Fold Change: 0.4470
Cell Significance Index: 3.9100 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.4307
Cell Significance Index: 81.9600 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.3523
Cell Significance Index: 34.8600 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.2398
Cell Significance Index: 216.4900 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.2327
Cell Significance Index: 4.9600 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.1737
Cell Significance Index: 28.2500 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.1420
Cell Significance Index: 15.4500 - Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: 0.1114
Cell Significance Index: 1.6000 - Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
Fold Change: 0.1096
Cell Significance Index: 1.8900 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 0.0966
Cell Significance Index: 6.0900 - Cell Name: monocyte-derived dendritic cell (CL0011031)
Fold Change: 0.0960
Cell Significance Index: 1.6500 - Cell Name: pro-T cell (CL0000827)
Fold Change: 0.0939
Cell Significance Index: 2.4000 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.0693
Cell Significance Index: 4.1600 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.0538
Cell Significance Index: 3.7200 - Cell Name: mature alpha-beta T cell (CL0000791)
Fold Change: 0.0266
Cell Significance Index: 0.1500 - Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
Fold Change: 0.0225
Cell Significance Index: 0.1800 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.0188
Cell Significance Index: 3.7700 - Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
Fold Change: 0.0174
Cell Significance Index: 0.1800 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.0076
Cell Significance Index: 0.2200 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0061
Cell Significance Index: 11.4300 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.0059
Cell Significance Index: 9.1100 - Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.0043
Cell Significance Index: 7.8900 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: 0.0018
Cell Significance Index: 0.1100 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.0008
Cell Significance Index: 1.0200 - Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
Fold Change: -0.0011
Cell Significance Index: -0.0100 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: -0.0024
Cell Significance Index: -0.8600 - Cell Name: neoplastic cell (CL0001063)
Fold Change: -0.0029
Cell Significance Index: -0.5700 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.0031
Cell Significance Index: -0.1100 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.0032
Cell Significance Index: -0.0800 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0059
Cell Significance Index: -4.4600 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0066
Cell Significance Index: -4.9100 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: -0.0070
Cell Significance Index: -3.1100 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0073
Cell Significance Index: -4.1100 - Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.0075
Cell Significance Index: -0.3800 - Cell Name: cell in vitro (CL0001034)
Fold Change: -0.0088
Cell Significance Index: -4.8200 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0100
Cell Significance Index: -6.3400 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -0.0106
Cell Significance Index: -0.2300 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0108
Cell Significance Index: -4.9200 - Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -0.0121
Cell Significance Index: -0.2500 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0125
Cell Significance Index: -3.6000 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.0144
Cell Significance Index: -1.7000 - Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: -0.0186
Cell Significance Index: -0.2800 - Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
Fold Change: -0.0187
Cell Significance Index: -0.1800 - Cell Name: alpha-beta T cell (CL0000789)
Fold Change: -0.0211
Cell Significance Index: -0.1800 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0226
Cell Significance Index: -3.8600 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0230
Cell Significance Index: -4.8500 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.0250
Cell Significance Index: -1.6800 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0265
Cell Significance Index: -3.8500 - Cell Name: odontoblast (CL0000060)
Fold Change: -0.0284
Cell Significance Index: -3.6400 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: -0.0324
Cell Significance Index: -5.8400 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.0336
Cell Significance Index: -3.9100 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.0341
Cell Significance Index: -4.6900 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.0382
Cell Significance Index: -3.9800 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0399
Cell Significance Index: -4.5700 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.0402
Cell Significance Index: -1.7800 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.0416
Cell Significance Index: -1.0700 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.0449
Cell Significance Index: -1.7000 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.0492
Cell Significance Index: -6.0500 - Cell Name: eukaryotic cell (CL0000255)
Fold Change: -0.0492
Cell Significance Index: -2.1400 - Cell Name: neuron associated cell (CL0000095)
Fold Change: -0.0495
Cell Significance Index: -2.0300 - Cell Name: lactocyte (CL0002325)
Fold Change: -0.0504
Cell Significance Index: -6.5100 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.0538
Cell Significance Index: -4.1300 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0580
Cell Significance Index: -5.9200 - Cell Name: T cell (CL0000084)
Fold Change: -0.0593
Cell Significance Index: -0.7000 - Cell Name: lymphocyte (CL0000542)
Fold Change: -0.0632
Cell Significance Index: -0.8600 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.0633
Cell Significance Index: -2.9500 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.0635
Cell Significance Index: -2.9900 - Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
Fold Change: -0.0643
Cell Significance Index: -0.5800 - Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
Fold Change: -0.0758
Cell Significance Index: -0.6400 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.0781
Cell Significance Index: -4.3800 - Cell Name: hematopoietic cell (CL0000988)
Fold Change: -0.0786
Cell Significance Index: -1.1500 - Cell Name: leukocyte (CL0000738)
Fold Change: -0.0807
Cell Significance Index: -1.3700 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.0888
Cell Significance Index: -6.6200 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.0913
Cell Significance Index: -3.2000 - Cell Name: CD4-positive helper T cell (CL0000492)
Fold Change: -0.0926
Cell Significance Index: -0.9400 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.0929
Cell Significance Index: -5.7100 - Cell Name: proerythroblast (CL0000547)
Fold Change: -0.0935
Cell Significance Index: -1.3400 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.0938
Cell Significance Index: -2.5100 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.0959
Cell Significance Index: -2.6800 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.0960
Cell Significance Index: -5.0400 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.0974
Cell Significance Index: -5.0600 - Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.0994
Cell Significance Index: -6.4100 - Cell Name: mature T cell (CL0002419)
Fold Change: -0.1001
Cell Significance Index: -0.7200 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.1009
Cell Significance Index: -3.2200 - Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
Fold Change: -0.1147
Cell Significance Index: -0.9900 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.1179
Cell Significance Index: -3.8600 - Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
Fold Change: -0.1181
Cell Significance Index: -1.1200 - Cell Name: lens fiber cell (CL0011004)
Fold Change: -0.1249
Cell Significance Index: -3.9500 - Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: -0.1293
Cell Significance Index: -2.6300
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 760088228
Symbol: CD5_HUMAN
Name: T-cell surface glycoprotein CD5
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 3093892
Title: Isolation of complementary DNA clones encoding the human lymphocyte glycoprotein T1/Leu-1.
PubMed ID: 3093892
DOI: 10.1038/323346a0
PubMed ID: 8740779
Title: Evolutionarily conserved transcription regulatory elements within the 5'-flanking region of the human CD5 gene.
PubMed ID: 8740779
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 16554811
Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.
PubMed ID: 16554811
DOI: 10.1038/nature04632
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 1711157
Title: The B-cell surface protein CD72/Lyb-2 is the ligand for CD5.
PubMed ID: 1711157
DOI: 10.1038/351662a0
PubMed ID: 1385158
Title: Evidence for an association between the T cell receptor/CD3 antigen complex and the CD5 antigen in human T lymphocytes.
PubMed ID: 1385158
PubMed ID: 1384049
Title: CD5 acts as a tyrosine kinase substrate within a receptor complex comprising T-cell receptor zeta chain/CD3 and protein-tyrosine kinases p56lck and p59fyn.
PubMed ID: 1384049
PubMed ID: 12522270
Title: Profiling of tyrosine phosphorylation pathways in human cells using mass spectrometry.
PubMed ID: 12522270
PubMed ID: 15144186
Title: Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry.
PubMed ID: 15144186
DOI: 10.1021/ac035352d
PubMed ID: 19690332
Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
PubMed ID: 19690332
PubMed ID: 23376399
Title: The carboxy-terminal region of CD5 is required for c-CBL mediated TCR signaling downmodulation in thymocytes.
PubMed ID: 23376399
PubMed ID: 27499044
Title: CD5 expression promotes IL-10 production through activation of the MAPK/Erk pathway and upregulation of TRPC1 channels in B lymphocytes.
PubMed ID: 27499044
DOI: 10.1038/cmi.2016.42
PubMed ID: 17322294
Title: Crystal structure of the third extracellular domain of CD5 reveals the fold of a group B scavenger cysteine-rich receptor domain.
PubMed ID: 17322294
PubMed ID: 18339402
Title: Three-dimensional solution structure and conformational plasticity of the N-terminal scavenger receptor cysteine-rich domain of human CD5.
PubMed ID: 18339402
Sequence Information:
- Length: 495
- Mass: 54578
- Checksum: 9131AEC9683EE1D3
- Sequence:
MPMGSLQPLA TLYLLGMLVA SCLGRLSWYD PDFQARLTRS NSKCQGQLEV YLKDGWHMVC SQSWGRSSKQ WEDPSQASKV CQRLNCGVPL SLGPFLVTYT PQSSIICYGQ LGSFSNCSHS RNDMCHSLGL TCLEPQKTTP PTTRPPPTTT PEPTAPPRLQ LVAQSGGQHC AGVVEFYSGS LGGTISYEAQ DKTQDLENFL CNNLQCGSFL KHLPETEAGR AQDPGEPREH QPLPIQWKIQ NSSCTSLEHC FRKIKPQKSG RVLALLCSGF QPKVQSRLVG GSSICEGTVE VRQGAQWAAL CDSSSARSSL RWEEVCREQQ CGSVNSYRVL DAGDPTSRGL FCPHQKLSQC HELWERNSYC KKVFVTCQDP NPAGLAAGTV ASIILALVLL VVLLVVCGPL AYKKLVKKFR QKKQRQWIGP TGMNQNMSFH RNHTATVRSH AENPTASHVD NEYSQPPRNS HLSAYPALEG ALHRSSMQPD NSSDSDYDLH GAQRL
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.