Details for: BMP15

Gene ID: 9210

Symbol: BMP15

Ensembl ID: ENSG00000130385

Description: bone morphogenetic protein 15

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: Unknown (CL0000003)
    Fold Change: 33.49
    Marker Score: 103,522
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 15.95
    Marker Score: 161,658
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 4.7
    Marker Score: 30,312
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 3.72
    Marker Score: 6,775
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 3.16
    Marker Score: 3,177
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 2.96
    Marker Score: 1,640
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 2.08
    Marker Score: 2,574
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.16
    Marker Score: 7,692
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.07
    Marker Score: 2,035
  • Cell Name: oocyte (CL0000023)
    Fold Change: 1.05
    Marker Score: 259
  • Cell Name: pericyte (CL0000669)
    Fold Change: 1.03
    Marker Score: 603
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 0.99
    Marker Score: 71,504
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 0.99
    Marker Score: 47,831
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,397
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.96
    Marker Score: 439
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,413
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.94
    Marker Score: 1,534
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5,344
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2,743
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,288
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.82
    Marker Score: 465
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.8
    Marker Score: 732
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.79
    Marker Score: 249
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.78
    Marker Score: 406
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.76
    Marker Score: 238
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.71
    Marker Score: 259
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.69
    Marker Score: 256
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.69
    Marker Score: 551
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.67
    Marker Score: 930
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.58
    Marker Score: 1,173
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.57
    Marker Score: 257
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.52
    Marker Score: 246
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.49
    Marker Score: 258
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.49
    Marker Score: 7,595
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.48
    Marker Score: 253
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.48
    Marker Score: 286
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.47
    Marker Score: 252
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.45
    Marker Score: 2,683
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.42
    Marker Score: 246
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.41
    Marker Score: 256
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.41
    Marker Score: 244
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.4
    Marker Score: 166
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.36
    Marker Score: 238
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.32
    Marker Score: 250
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.32
    Marker Score: 154
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.32
    Marker Score: 142
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.32
    Marker Score: 241
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.32
    Marker Score: 273
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.29
    Marker Score: 259
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.27
    Marker Score: 259
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.26
    Marker Score: 250
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.24
    Marker Score: 245
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.23
    Marker Score: 252
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.22
    Marker Score: 147
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.2
    Marker Score: 210
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.2
    Marker Score: 230
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.2
    Marker Score: 254
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.18
    Marker Score: 250
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.15
    Marker Score: 258
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.15
    Marker Score: 260
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 0.14
    Marker Score: 259
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.13
    Marker Score: 536
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.13
    Marker Score: 436
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.12
    Marker Score: 249
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.12
    Marker Score: 255
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.11
    Marker Score: 205
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.11
    Marker Score: 256
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.09
    Marker Score: 327
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.09
    Marker Score: 209
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.09
    Marker Score: 244
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.07
    Marker Score: 183
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.06
    Marker Score: 256
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 0.03
    Marker Score: 258
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.03
    Marker Score: 259
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.03
    Marker Score: 246
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.03
    Marker Score: 258
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.03
    Marker Score: 255
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.02
    Marker Score: 253
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.02
    Marker Score: 255
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.01
    Marker Score: 256
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.01
    Marker Score: 259
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.01
    Marker Score: 251
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.01
    Marker Score: 255
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.01
    Marker Score: 246
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0
    Marker Score: 218

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Reproductive Function:** BMP15 is specifically expressed in the ovaries and plays a critical role in the development and maturation of oocytes. It regulates follicular growth, ovulation, and the maintenance of female fertility. 2. **Immunological Significance:** BMP15 is involved in various immunological processes, including cytokine activity, signal transduction, and regulation of IGF transport. Its expression is found in immune cells, such as microglial cells and endothelial cells, highlighting its potential role in immune regulation. 3. **Cellular Expression:** BMP15 is expressed in a wide range of cell types, including neurons, progenitor cells, endothelial cells, and erythrocytes, suggesting its multifaceted roles in various biological processes. 4. **Signaling Pathways:** BMP15 is involved in multiple signaling pathways, including the TGF-β, Wnt, and PI3K/AKT pathways, which regulate cell growth, differentiation, and survival. **Pathways and Functions:** 1. **Follicular Growth and Oocyte Maturation:** BMP15 regulates follicular growth, ovulation, and oocyte maturation by modulating the expression of other genes involved in these processes. 2. **Cytokine Activity:** BMP15 induces the production of cytokines, such as IL-6 and TNF-α, which regulate immune responses and inflammation. 3. **Signal Transduction:** BMP15 activates various signaling pathways, including the PI3K/AKT and MAPK/ERK pathways, which regulate cell growth, differentiation, and survival. 4. **Regulation of IGF Transport:** BMP15 regulates the transport and uptake of IGFs by IGF-binding proteins (IGFBPs), which modulate IGF activity and signaling. 5. **Endoplasmic Reticulum Lumen and Extracellular Space:** BMP15 is involved in the regulation of protein transport and processing in the endoplasmic reticulum lumen and extracellular space. **Clinical Significance:** 1. **Reproductive Disorders:** Mutations in the BMP15 gene are associated with polycystic ovary syndrome (PCOS), sterile infertility, and premature ovarian failure. 2. **Immunological Disorders:** Abnormalities in BMP15 expression and function may contribute to the development of autoimmune diseases, such as rheumatoid arthritis and lupus. 3. **Cancer:** BMP15 is involved in tumor growth, invasion, and metastasis, suggesting its potential role in cancer development and progression. 4. **Neurological Disorders:** BMP15 is expressed in neurons and has been implicated in neurological disorders, such as Alzheimer's disease and Parkinson's disease. In conclusion, BMP15 is a critical gene involved in reproductive biology and immunology, with a wide range of functions and implications for human health. Further research is needed to fully elucidate the mechanisms by which BMP15 regulates various biological processes and to explore its potential therapeutic applications.

Genular Protein ID: 4291180405

Symbol: BMP15_HUMAN

Name: Bone morphogenetic protein 15

UniProtKB Accession Codes:

O95972 Q17RM6 Q5JST1 Q9UMS1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 7 Ensembl 1 GO 5 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 4 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 1 SIGNOR 1 SMART 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 9849956

Title: The bone morphogenetic protein 15 gene is X-linked and expressed in oocytes.

PubMed ID: 9849956

DOI: 10.1210/mend.12.12.0206

PubMed ID: 10443672

Title: Human growth differentiation factor 9 (GDF-9) and its novel homolog GDF-9B are expressed in oocytes during early folliculogenesis.

PubMed ID: 10443672

DOI: 10.1210/jcem.84.8.5921

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18227435

Title: Characterization of the post-translational modification of recombinant human BMP-15 mature protein.

PubMed ID: 18227435

DOI: 10.1110/ps.073232608

PubMed ID: 21970812

Title: The ratio of growth differentiation factor 9: bone morphogenetic protein 15 mRNA expression is tightly co-regulated and differs between species over a wide range of ovulation rates.

PubMed ID: 21970812

DOI: 10.1016/j.mce.2011.09.033

PubMed ID: 15136966

Title: Hypergonadotropic ovarian failure associated with an inherited mutation of human bone morphogenetic protein-15 (BMP15) gene.

PubMed ID: 15136966

DOI: 10.1086/422103

PubMed ID: 16645022

Title: Mutations and sequence variants in GDF9 and BMP15 in patients with premature ovarian failure.

PubMed ID: 16645022

DOI: 10.1530/eje.1.02135

PubMed ID: 16508750

Title: Missense mutations in the BMP15 gene are associated with ovarian failure.

PubMed ID: 16508750

DOI: 10.1007/s00439-006-0150-0

PubMed ID: 16464940

Title: Identification of new variants of human BMP15 gene in a large cohort of women with premature ovarian failure.

PubMed ID: 16464940

DOI: 10.1210/jc.2005-2650

PubMed ID: 19263482

Title: BMP15 mutations associated with primary ovarian insufficiency cause a defective production of bioactive protein.

PubMed ID: 19263482

DOI: 10.1002/humu.20961

PubMed ID: 19438907

Title: Analyses of growth differentiation factor 9 (GDF9) and bone morphogenetic protein 15 (BMP15) mutation in Chinese women with premature ovarian failure.

PubMed ID: 19438907

DOI: 10.1111/j.1365-2265.2009.03613.x

PubMed ID: 28585349

Title: CSNK2B splice site mutations in patients cause intellectual disability with or without myoclonic epilepsy.

PubMed ID: 28585349

DOI: 10.1002/humu.23270

Sequence Information:

  • Length: 392
  • Mass: 45055
  • Checksum: A957275EF275A2E8
  • Sequence:
    • MVLLSILRIL FLCELVLFME HRAQMAEGGQ SSIALLAEAP TLPLIEELLE ESPGEQPRKP 
RLLGHSLRYM LELYRRSADS HGHPRENRTI GATMVRLVKP LTNVARPHRG TWHIQILGFP 
LRPNRGLYQL VRATVVYRHH LQLTRFNLSC HVEPWVQKNP TNHFPSSEGD SSKPSLMSNA 
WKEMDITQLV QQRFWNNKGH RILRLRFMCQ QQKDSGGLEL WHGTSSLDIA FLLLYFNDTH 
KSIRKAKFLP RGMEEFMERE SLLRRTRQAD GISAEVTASS SKHSGPENNQ CSLHPFQISF 
RQLGWDHWII APPFYTPNYC KGTCLRVLRD GLNSPNHAII QNLINQLVDQ SVPRPSCVPY 
KYVPISVLMI EANGSILYKE YEGMIAESCT CR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.