Details for: LGI1

Gene ID: 9211

Symbol: LGI1

Ensembl ID: ENSG00000108231

Description: leucine rich glioma inactivated 1

Associated with

Other Information

Genular Protein ID: 1716769069

Symbol: LGI1_HUMAN

Name: Leucine-rich glioma-inactivated protein 1

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 9879993

Title: A novel gene, LGI1, from 10q24 is rearranged and downregulated in malignant brain tumors.

PubMed ID: 9879993

DOI: 10.1038/sj.onc.1202481

PubMed ID: 11978770

Title: Mutations in the LGI1/Epitempin gene on 10q24 cause autosomal dominant lateral temporal epilepsy.

PubMed ID: 11978770

DOI: 10.1093/hmg/11.9.1119

PubMed ID: 12975309

Title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

PubMed ID: 12975309

DOI: 10.1101/gr.1293003

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15047712

Title: LGI1, a putative tumor metastasis suppressor gene, controls in vitro invasiveness and expression of matrix metalloproteinases in glioma cells through the ERK1/2 pathway.

PubMed ID: 15047712

DOI: 10.1074/jbc.m314192200

PubMed ID: 17067999

Title: The epilepsy gene LGI1 encodes a secreted glycoprotein that binds to the cell surface.

PubMed ID: 17067999

DOI: 10.1093/hmg/ddl421

PubMed ID: 16518856

Title: Increased expression of LGI1 gene triggers growth inhibition and apoptosis of neuroblastoma cells.

PubMed ID: 16518856

DOI: 10.1002/jcp.20627

PubMed ID: 16787412

Title: The LGI1/epitempin gene encodes two protein isoforms differentially expressed in human brain.

PubMed ID: 16787412

DOI: 10.1111/j.1471-4159.2006.03939.x

PubMed ID: 17296837

Title: Two novel epilepsy-linked mutations leading to a loss of function of LGI1.

PubMed ID: 17296837

DOI: 10.1001/archneur.64.2.217

PubMed ID: 27066583

Title: Dysfunctional ADAM22 implicated in progressive encephalopathy with cortical atrophy and epilepsy.

PubMed ID: 27066583

DOI: 10.1212/nxg.0000000000000046

PubMed ID: 19191227

Title: LGI1 mutations in autosomal dominant and sporadic lateral temporal epilepsy.

PubMed ID: 19191227

DOI: 10.1002/humu.20925

PubMed ID: 11810107

Title: Mutations in LGI1 cause autosomal-dominant partial epilepsy with auditory features.

PubMed ID: 11810107

DOI: 10.1038/ng832

PubMed ID: 12205652

Title: LGI1 is mutated in familial temporal lobe epilepsy characterized by aphasic seizures.

PubMed ID: 12205652

DOI: 10.1002/ana.10280

PubMed ID: 12601709

Title: Epilepsy with auditory features: a LGI1 gene mutation suggests a loss-of-function mechanism.

PubMed ID: 12601709

DOI: 10.1002/ana.10492

PubMed ID: 12771268

Title: Novel LGI1 mutation in a family with autosomal dominant partial epilepsy with auditory features.

PubMed ID: 12771268

DOI: 10.1212/01.wnl.0000063324.39980.4a

PubMed ID: 15079010

Title: LGI1 mutations in temporal lobe epilepsies.

PubMed ID: 15079010

DOI: 10.1212/01.wnl.0000118213.94650.81

PubMed ID: 17562837

Title: A de novo LGI1 mutation causing idiopathic partial epilepsy with telephone-induced seizures.

PubMed ID: 17562837

DOI: 10.1212/01.wnl.0000264932.44153.3c

PubMed ID: 18625862

Title: A novel loss-of-function LGI1 mutation linked to autosomal dominant lateral temporal epilepsy.

PubMed ID: 18625862

DOI: 10.1001/archneur.65.7.939

PubMed ID: 19552651

Title: Drug resistant ADLTE and recurrent partial status epilepticus with dysphasic features in a family with a novel LGI1mutation: electroclinical, genetic, and EEG/fMRI findings.

PubMed ID: 19552651

DOI: 10.1111/j.1528-1167.2009.02181.x

Sequence Information:

  • Length: 557
  • Mass: 63818
  • Checksum: 890EEDA08D95C854
  • Sequence:
  • MESERSKRMG NACIPLKRIA YFLCLLSALL LTEGKKPAKP KCPAVCTCTK DNALCENARS 
    IPRTVPPDVI SLSFVRSGFT EISEGSFLFT PSLQLLLFTS NSFDVISDDA FIGLPHLEYL 
    FIENNNIKSI SRHTFRGLKS LIHLSLANNN LQTLPKDIFK GLDSLTNVDL RGNSFNCDCK 
    LKWLVEWLGH TNATVEDIYC EGPPEYKKRK INSLSSKDFD CIITEFAKSQ DLPYQSLSID 
    TFSYLNDEYV VIAQPFTGKC IFLEWDHVEK TFRNYDNITG TSTVVCKPIV IETQLYVIVA 
    QLFGGSHIYK RDSFANKFIK IQDIEILKIR KPNDIETFKI ENNWYFVVAD SSKAGFTTIY 
    KWNGNGFYSH QSLHAWYRDT DVEYLEIVRT PQTLRTPHLI LSSSSQRPVI YQWNKATQLF 
    TNQTDIPNME DVYAVKHFSV KGDVYICLTR FIGDSKVMKW GGSSFQDIQR MPSRGSMVFQ 
    PLQINNYQYA ILGSDYSFTQ VYNWDAEKAK FVKFQELNVQ APRSFTHVSI NKRNFLFASS 
    FKGNTQIYKH VIVDLSA

Genular Protein ID: 2342218478

Symbol: A0A0S2Z5G1_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 26871637

Title: Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.

PubMed ID: 26871637

DOI: 10.1016/j.cell.2016.01.029

Sequence Information:

  • Length: 243
  • Mass: 27605
  • Checksum: 65761BE3D9E7E625
  • Sequence:
  • MESERSKRMG NACIPLKRIA YFLCLLSALL LTEGKKPAKP KCPAVCTCTK DNALCENARS 
    IPRTVPPDVI SLSFVRSGFT EISEGSFLFT PSLQLLSLAN NNLQTLPKDI FKGLDSLTNV 
    DLRGNSFNCD CKLKWLVEWL GHTNATVEDI YCEGPPEYKK RKINSLSSKD FDCIITEFAK 
    SQDLPYQSLS IDTFSYLNDE YVVIAQPFTG KCIFLEWDHV EKTFRNYDNI TVLREIHRFT 
    NMS

Genular Protein ID: 60262944

Symbol: A0A0S2Z4X3_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 26871637

Title: Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.

PubMed ID: 26871637

DOI: 10.1016/j.cell.2016.01.029

Sequence Information:

  • Length: 291
  • Mass: 33121
  • Checksum: BC10E3E110E016D0
  • Sequence:
  • MESERSKRMG NACIPLKRIA YFLCLLSALL LTEGKKPAKP KCPAVCTCTK DNALCENARS 
    IPRTVPPDVI SLSFVRSGFT EISEGSFLFT PSLQLLLFTS NSFDVISDDA FIGLPHLEYL 
    FIENNNIKSI SRHTFRGLKS LIHLSLANNN LQTLPKDIFK GLDSLTNVDL RGNSFNCDCK 
    LKWLVEWLGH TNATVEDIYC EGPPEYKKRK INSLSSKDFD CIITEFAKSQ DLPYQSLSID 
    TFSYLNDEYV VIAQPFTGKC IFLEWDHVEK TFRNYDNITV LREIHRFTNM S

Genular Protein ID: 3531951123

Symbol: A0A1B0GUD3_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

Sequence Information:

  • Length: 281
  • Mass: 31780
  • Checksum: 96DF2D954C55C3CF
  • Sequence:
  • MESERSKRMG NACIPLKRIA YFLCLLSALL LTEGKKPAKP KCPAVCTCTK DNALCENARS 
    IPRTVPPDVI SLSFVRSGFT EISEGSFLFT PSLQLLLFTS NSFDVISDDA FIGLPHLEYL 
    FIENNNIKSI SRHTFRGLKS LIHLSLANNN LQTLPKDIFK GLDSLTNVDL RGNSFNCDCK 
    LKWLVEWLGH TNATVEDIYC EGPPEYKKRK INSLSSKDFD CIITEFAKSQ DLPYQSLSID 
    TFSYLNDEYV VIAQPFTGKC IFLEWDHVEK TFRNYDNITG S

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.