AURKB | ENSG00000178999 | NCBI 9212

Details for: AURKB

Gene ID: 9212

Symbol: AURKB

Ensembl ID: ENSG00000178999

Description: aurora kinase B

Associated with

Amplification of signal from the kinetochores
(R-HSA-141424)
Amplification of signal from unattached kinetochores via a mad2 inhibitory signal
(R-HSA-141444)
Apc/c-mediated degradation of cell cycle proteins
(R-HSA-174143)
Apc/c:cdh1 mediated degradation of cdc20 and other apc/c:cdh1 targeted proteins in late mitosis/early g1
(R-HSA-174178)
Cell cycle
(R-HSA-1640170)
Cell cycle, mitotic
(R-HSA-69278)
Cell cycle checkpoints
(R-HSA-69620)
Eml4 and nudc in mitotic spindle formation
(R-HSA-9648025)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Metabolism of proteins
(R-HSA-392499)
Mitotic anaphase
(R-HSA-68882)
Mitotic metaphase and anaphase
(R-HSA-2555396)
Mitotic prometaphase
(R-HSA-68877)
Mitotic spindle checkpoint
(R-HSA-69618)
M phase
(R-HSA-68886)
Regulation of mecp2 expression and activity
(R-HSA-9022692)
Regulation of mitotic cell cycle
(R-HSA-453276)
Regulation of tp53 activity
(R-HSA-5633007)
Regulation of tp53 activity through phosphorylation
(R-HSA-6804756)
Resolution of sister chromatid cohesion
(R-HSA-2500257)
Rho gtpase effectors
(R-HSA-195258)
Rho gtpases activate formins
(R-HSA-5663220)
Rna polymerase ii transcription
(R-HSA-73857)
Separation of sister chromatids
(R-HSA-2467813)
Signaling by rho gtpases
(R-HSA-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-HSA-9716542)
Signal transduction
(R-HSA-162582)
Sumo e3 ligases sumoylate target proteins
(R-HSA-3108232)
Sumoylation
(R-HSA-2990846)
Sumoylation of dna replication proteins
(R-HSA-4615885)
Transcriptional regulation by mecp2
(R-HSA-8986944)
Transcriptional regulation by tp53
(R-HSA-3700989)
Abscission
(GO:0009838)
Atp binding
(GO:0005524)
Attachment of spindle microtubules to kinetochore
(GO:0008608)
Cell cycle g2/m phase transition
(GO:0044839)
Cellular response to uv
(GO:0034644)
Chromocenter
(GO:0010369)
Chromosome passenger complex
(GO:0032133)
Cleavage furrow formation
(GO:0036089)
Condensed chromosome, centromeric region
(GO:0000779)
Cytosol
(GO:0005829)
Kinase binding
(GO:0019900)
Kinetochore
(GO:0000776)
Microtubule cytoskeleton
(GO:0015630)
Midbody
(GO:0030496)
Mitotic cell cycle
(GO:0000278)
Mitotic cytokinesis
(GO:0000281)
Mitotic cytokinesis checkpoint signaling
(GO:0044878)
Mitotic spindle assembly
(GO:0090307)
Mitotic spindle midzone assembly
(GO:0051256)
Mitotic spindle organization
(GO:0007052)
Mitotic spindle pole
(GO:0097431)
Negative regulation of b cell apoptotic process
(GO:0002903)
Negative regulation of cgas/sting signaling pathway
(GO:0160049)
Negative regulation of cytokinesis
(GO:0032466)
Negative regulation of innate immune response
(GO:0045824)
Negative regulation of protein binding
(GO:0032091)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Positive regulation of attachment of mitotic spindle microtubules to kinetochore
(GO:1902425)
Positive regulation of cytokinesis
(GO:0032467)
Positive regulation of lateral attachment of mitotic spindle microtubules to kinetochore
(GO:1905116)
Positive regulation of mitotic cell cycle spindle assembly checkpoint
(GO:0090267)
Positive regulation of mitotic cytokinesis
(GO:1903490)
Positive regulation of mitotic sister chromatid segregation
(GO:0062033)
Positive regulation of mitotic sister chromatid separation
(GO:1901970)
Positive regulation of telomerase activity
(GO:0051973)
Positive regulation of telomere capping
(GO:1904355)
Positive regulation of telomere maintenance via telomerase
(GO:0032212)
Post-translational protein modification
(GO:0043687)
Protein autophosphorylation
(GO:0046777)
Protein binding
(GO:0005515)
Protein localization to kinetochore
(GO:0034501)
Protein phosphorylation
(GO:0006468)
Protein serine/threonine/tyrosine kinase activity
(GO:0004712)
Protein serine/threonine kinase activity
(GO:0004674)
Protein serine kinase activity
(GO:0106310)
Regulation of chromosome segregation
(GO:0051983)
Regulation of cytokinesis
(GO:0032465)
Regulation of signal transduction by p53 class mediator
(GO:1901796)
Spindle
(GO:0005819)
Spindle microtubule
(GO:0005876)
Spindle midzone
(GO:0051233)
Spindle organization
(GO:0007051)
Spindle pole centrosome
(GO:0031616)

Other Information

Proteins

Aurora 1

Genular Protein ID: 530625459

Symbol: AURKB_HUMAN

Name: Aurora 1

UniProtKB Accession Codes:

Q96GD4 B4DNM4 C7G533 C7G534 C7G535 D3DTR4 J9JID1 O14630 O60446 O95083 Q96DV5 Q9UQ46

Database IDs:

Citations:

PubMed ID: 9514916

Title: cDNA cloning, expression, subcellular localization, and chromosomal assignment of mammalian aurora homologues, aurora-related kinase (ARK) 1 and 2.

PubMed ID: 9514916

DOI: 10.1006/bbrc.1998.8250

PubMed ID: 9809983

Title: Multinuclearity and increased ploidy caused by overexpression of the aurora- and Ipl1-like midbody-associated protein mitotic kinase in human cancer cells.

PubMed ID: 9809983

PubMed ID: 9858806

Title: Identification and characterization of STK12/Aik2: a human gene related to aurora of Drosophila and yeast IPL1.

PubMed ID: 9858806

DOI: 10.1159/000015089

PubMed ID: 11471245

Title: In silico cloning of a new protein kinase, Aik2, related to Drosophila aurora using the new tool: EST Blast.

PubMed ID: 11471245

PubMed ID: 19134008

Title: Expression of Aurora B and alternative variant forms in hepatocellular carcinoma and adjacent tissue.

PubMed ID: 19134008

DOI: 10.1111/j.1349-7006.2008.01068.x

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11516652

Title: INCENP is required for proper targeting of Survivin to the centromeres and the anaphase spindle during mitosis.

PubMed ID: 11516652

DOI: 10.1016/s0960-9822(01)00238-x

PubMed ID: 11756469

Title: CENP-A is phosphorylated by Aurora B kinase and plays an unexpected role in completion of cytokinesis.

PubMed ID: 11756469

DOI: 10.1083/jcb.200108125

PubMed ID: 11413462

Title: Mitotic kinases as regulators of cell division and its checkpoints.

PubMed ID: 11413462

DOI: 10.1038/35048096

PubMed ID: 11856369

Title: Aurora-B phosphorylates Histone H3 at serine28 with regard to the mitotic chromosome condensation.

PubMed ID: 11856369

DOI: 10.1046/j.1356-9597.2001.00498.x

PubMed ID: 11784863

Title: Mitotic phosphorylation of histone H3: spatio-temporal regulation by mammalian Aurora kinases.

PubMed ID: 11784863

DOI: 10.1128/mcb.22.3.874-885.2002

PubMed ID: 12689593

Title: Phosphorylation by aurora B converts MgcRacGAP to a RhoGAP during cytokinesis.

PubMed ID: 12689593

DOI: 10.1016/s1534-5807(03)00089-3

PubMed ID: 12458200

Title: Aurora-B regulates the cleavage furrow-specific vimentin phosphorylation in the cytokinetic process.

PubMed ID: 12458200

DOI: 10.1074/jbc.m210892200

PubMed ID: 12686604

Title: Functional significance of the specific sites phosphorylated in desmin at cleavage furrow: Aurora-B may phosphorylate and regulate type III intermediate filaments during cytokinesis coordinatedly with Rho-kinase.

PubMed ID: 12686604

DOI: 10.1091/mbc.e02-09-0612

PubMed ID: 12925766

Title: Exploring the functional interactions between Aurora B, INCENP, and survivin in mitosis.

PubMed ID: 12925766

DOI: 10.1091/mbc.e02-11-0769

PubMed ID: 14674694

Title: Human Aurora-B binds to a proteasome alpha-subunit HC8 and undergoes degradation in a proteasome-dependent manner.

PubMed ID: 14674694

DOI: 10.1023/a:1027317014159

PubMed ID: 14610074

Title: Aurora-B phosphorylation in vitro identifies a residue of survivin that is essential for its localization and binding to inner centromere protein (INCENP) in vivo.

PubMed ID: 14610074

DOI: 10.1074/jbc.m311299200

PubMed ID: 14722118

Title: Autophosphorylation of a newly identified site of Aurora-B is indispensable for cytokinesis.

PubMed ID: 14722118

DOI: 10.1074/jbc.m311128200

PubMed ID: 15020684

Title: Bub1 is required for kinetochore localization of BubR1, Cenp-E, Cenp-F and Mad2, and chromosome congression.

PubMed ID: 15020684

DOI: 10.1242/jcs.01006

PubMed ID: 15249581

Title: Borealin: a novel chromosomal passenger required for stability of the bipolar mitotic spindle.

PubMed ID: 15249581

DOI: 10.1083/jcb.200404001

PubMed ID: 14602875

Title: Identification of the substrates and interaction proteins of aurora kinases from a protein-protein interaction model.

PubMed ID: 14602875

DOI: 10.1074/mcp.m300072-mcp200

PubMed ID: 15064709

Title: Aurora B -TACC1 protein complex in cytokinesis.

PubMed ID: 15064709

DOI: 10.1038/sj.onc.1207593

PubMed ID: 16179162

Title: Septin1, a new interaction partner for human serine/threonine kinase aurora-B.

PubMed ID: 16179162

DOI: 10.1016/j.bbrc.2005.06.212

PubMed ID: 16103226

Title: An ECT2-centralspindlin complex regulates the localization and function of RhoA.

PubMed ID: 16103226

DOI: 10.1083/jcb.200501097

PubMed ID: 16764853

Title: EVI5 protein associates with the INCENP-aurora B kinase-survivin chromosomal passenger complex and is involved in the completion of cytokinesis.

PubMed ID: 16764853

DOI: 10.1016/j.yexcr.2006.03.032

PubMed ID: 17617734

Title: Shugoshin 1 plays a central role in kinetochore assembly and is required for kinetochore targeting of Plk1.

PubMed ID: 17617734

DOI: 10.4161/cc.6.13.4442

PubMed ID: 17543862

Title: A Cul3-based E3 ligase removes Aurora B from mitotic chromosomes, regulating mitotic progression and completion of cytokinesis in human cells.

PubMed ID: 17543862

DOI: 10.1016/j.devcel.2007.03.019

PubMed ID: 17726514

Title: Interphase nucleo-cytoplasmic shuttling and localization of SIRT2 during mitosis.

PubMed ID: 17726514

DOI: 10.1371/journal.pone.0000784

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18591255

Title: A survivin-ran complex regulates spindle formation in tumor cells.

PubMed ID: 18591255

DOI: 10.1128/mcb.02039-07

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19995937

Title: The Cul3-KLHL21 E3 ubiquitin ligase targets aurora B to midzone microtubules in anaphase and is required for cytokinesis.

PubMed ID: 19995937

DOI: 10.1083/jcb.200906117

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 20605920

Title: RINGO C is required to sustain the spindle-assembly checkpoint.

PubMed ID: 20605920

DOI: 10.1242/jcs.059964

PubMed ID: 20562864

Title: Human POGZ modulates dissociation of HP1alpha from mitotic chromosome arms through Aurora B activation.

PubMed ID: 20562864

DOI: 10.1038/ncb2075

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 20929775

Title: Two histone marks establish the inner centromere and chromosome bi-orientation.

PubMed ID: 20929775

DOI: 10.1126/science.1194498

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21658950

Title: A positive feedback loop involving Haspin and Aurora B promotes CPC accumulation at centromeres in mitosis.

PubMed ID: 21658950

DOI: 10.1016/j.cub.2011.05.016

PubMed ID: 20959462

Title: Aurora B interacts with NIR-p53, leading to p53 phosphorylation in its DNA-binding domain and subsequent functional suppression.

PubMed ID: 20959462

DOI: 10.1074/jbc.m110.174755

PubMed ID: 21225229

Title: PAR, a protein involved in the cell cycle, is functionally related to chromosomal passenger proteins.

PubMed ID: 21225229

DOI: 10.3892/ijo.2011.900

PubMed ID: 23036704

Title: A novel big protein TPRBK possessing 25 units of TPR motif is essential for the progress of mitosis and cytokinesis.

PubMed ID: 23036704

DOI: 10.1016/j.gene.2012.09.061

PubMed ID: 22422861

Title: ESCRT-III governs the Aurora B-mediated abscission checkpoint through CHMP4C.

PubMed ID: 22422861

DOI: 10.1126/science.1217180

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24814515

Title: ANCHR mediates Aurora-B-dependent abscission checkpoint control through retention of VPS4.

PubMed ID: 24814515

DOI: 10.1038/ncb2959

PubMed ID: 26829474

Title: Acetylation of Aurora B by TIP60 ensures accurate chromosomal segregation.

PubMed ID: 26829474

DOI: 10.1038/nchembio.2017

PubMed ID: 27332895

Title: Aurora-C interactions with survivin and INCENP reveal shared and distinct features compared with Aurora-B chromosome passenger protein complex.

PubMed ID: 27332895

DOI: 10.1371/journal.pone.0157305

PubMed ID: 29449677

Title: USP35 regulates mitotic progression by modulating the stability of Aurora B.

PubMed ID: 29449677

DOI: 10.1038/s41467-018-03107-0

PubMed ID: 33542149

Title: Phosphorylation and chromatin tethering prevent cGAS activation during mitosis.

PubMed ID: 33542149

DOI: 10.1126/science.abc5386

PubMed ID: 22920039

Title: Crystal structure of human aurora B in complex with INCENP and VX-680.

PubMed ID: 22920039

DOI: 10.1021/jm3008954

PubMed ID: 16762494

Title: Aurora kinases A and B and familial breast cancer risk.

PubMed ID: 16762494

DOI: 10.1016/j.canlet.2006.05.002

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

Sequence Information:

Length: 344
Mass: 39311
Checksum: A5ED13EF5A1FAFBF
Sequence:

MAQKENSYPW PYGRQTAPSG LSTLPQRVLR KEPVTPSALV LMSRSNVQPT AAPGQKVMEN 
SSGTPDILTR HFTIDDFEIG RPLGKGKFGN VYLAREKKSH FIVALKVLFK SQIEKEGVEH 
QLRREIEIQA HLHHPNILRL YNYFYDRRRI YLILEYAPRG ELYKELQKSC TFDEQRTATI 
MEELADALMY CHGKKVIHRD IKPENLLLGL KGELKIADFG WSVHAPSLRR KTMCGTLDYL 
PPEMIEGRMH NEKVDLWCIG VLCYELLVGN PPFESASHNE TYRRIVKVDL KFPASVPMGA 
QDLISKLLRH NPSERLPLAQ VSAHPWVRAN SRRVLPPSAL QSVA

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: AURKB

Associated with

Other Information

cDNA cloning, expression, subcellular localization, and chromosomal assignment of mammalian aurora homologues, aurora-related kinase (ARK) 1 and 2. PubMed ID: 9514916

Multinuclearity and increased ploidy caused by overexpression of the aurora- and Ipl1-like midbody-associated protein mitotic kinase in human cancer cells. PubMed ID: 9809983

Identification and characterization of STK12/Aik2: a human gene related to aurora of Drosophila and yeast IPL1. PubMed ID: 9858806

In silico cloning of a new protein kinase, Aik2, related to Drosophila aurora using the new tool: EST Blast. PubMed ID: 11471245

Expression of Aurora B and alternative variant forms in hepatocellular carcinoma and adjacent tissue. PubMed ID: 19134008

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. PubMed ID: 16625196

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

INCENP is required for proper targeting of Survivin to the centromeres and the anaphase spindle during mitosis. PubMed ID: 11516652

CENP-A is phosphorylated by Aurora B kinase and plays an unexpected role in completion of cytokinesis. PubMed ID: 11756469

Mitotic kinases as regulators of cell division and its checkpoints. PubMed ID: 11413462

Aurora-B phosphorylates Histone H3 at serine28 with regard to the mitotic chromosome condensation. PubMed ID: 11856369

Mitotic phosphorylation of histone H3: spatio-temporal regulation by mammalian Aurora kinases. PubMed ID: 11784863

Phosphorylation by aurora B converts MgcRacGAP to a RhoGAP during cytokinesis. PubMed ID: 12689593

Aurora-B regulates the cleavage furrow-specific vimentin phosphorylation in the cytokinetic process. PubMed ID: 12458200

Functional significance of the specific sites phosphorylated in desmin at cleavage furrow: Aurora-B may phosphorylate and regulate type III intermediate filaments during cytokinesis coordinatedly with Rho-kinase. PubMed ID: 12686604

Exploring the functional interactions between Aurora B, INCENP, and survivin in mitosis. PubMed ID: 12925766

Human Aurora-B binds to a proteasome alpha-subunit HC8 and undergoes degradation in a proteasome-dependent manner. PubMed ID: 14674694

Aurora-B phosphorylation in vitro identifies a residue of survivin that is essential for its localization and binding to inner centromere protein (INCENP) in vivo. PubMed ID: 14610074

Autophosphorylation of a newly identified site of Aurora-B is indispensable for cytokinesis. PubMed ID: 14722118

Bub1 is required for kinetochore localization of BubR1, Cenp-E, Cenp-F and Mad2, and chromosome congression. PubMed ID: 15020684

Borealin: a novel chromosomal passenger required for stability of the bipolar mitotic spindle. PubMed ID: 15249581

Identification of the substrates and interaction proteins of aurora kinases from a protein-protein interaction model. PubMed ID: 14602875

Aurora B -TACC1 protein complex in cytokinesis. PubMed ID: 15064709

Septin1, a new interaction partner for human serine/threonine kinase aurora-B. PubMed ID: 16179162

An ECT2-centralspindlin complex regulates the localization and function of RhoA. PubMed ID: 16103226

EVI5 protein associates with the INCENP-aurora B kinase-survivin chromosomal passenger complex and is involved in the completion of cytokinesis. PubMed ID: 16764853

Shugoshin 1 plays a central role in kinetochore assembly and is required for kinetochore targeting of Plk1. PubMed ID: 17617734

A Cul3-based E3 ligase removes Aurora B from mitotic chromosomes, regulating mitotic progression and completion of cytokinesis in human cells. PubMed ID: 17543862

Interphase nucleo-cytoplasmic shuttling and localization of SIRT2 during mitosis. PubMed ID: 17726514

Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. PubMed ID: 18691976

A survivin-ran complex regulates spindle formation in tumor cells. PubMed ID: 18591255

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

The Cul3-KLHL21 E3 ubiquitin ligase targets aurora B to midzone microtubules in anaphase and is required for cytokinesis. PubMed ID: 19995937

Large-scale proteomics analysis of the human kinome. PubMed ID: 19369195

RINGO C is required to sustain the spindle-assembly checkpoint. PubMed ID: 20605920

Human POGZ modulates dissociation of HP1alpha from mitotic chromosome arms through Aurora B activation. PubMed ID: 20562864

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

Two histone marks establish the inner centromere and chromosome bi-orientation. PubMed ID: 20929775

Initial characterization of the human central proteome. PubMed ID: 21269460

A positive feedback loop involving Haspin and Aurora B promotes CPC accumulation at centromeres in mitosis. PubMed ID: 21658950

Aurora B interacts with NIR-p53, leading to p53 phosphorylation in its DNA-binding domain and subsequent functional suppression. PubMed ID: 20959462

PAR, a protein involved in the cell cycle, is functionally related to chromosomal passenger proteins. PubMed ID: 21225229

A novel big protein TPRBK possessing 25 units of TPR motif is essential for the progress of mitosis and cytokinesis. PubMed ID: 23036704

ESCRT-III governs the Aurora B-mediated abscission checkpoint through CHMP4C. PubMed ID: 22422861

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

ANCHR mediates Aurora-B-dependent abscission checkpoint control through retention of VPS4. PubMed ID: 24814515

Acetylation of Aurora B by TIP60 ensures accurate chromosomal segregation. PubMed ID: 26829474

Aurora-C interactions with survivin and INCENP reveal shared and distinct features compared with Aurora-B chromosome passenger protein complex. PubMed ID: 27332895

USP35 regulates mitotic progression by modulating the stability of Aurora B. PubMed ID: 29449677

Phosphorylation and chromatin tethering prevent cGAS activation during mitosis. PubMed ID: 33542149

Crystal structure of human aurora B in complex with INCENP and VX-680. PubMed ID: 22920039

Aurora kinases A and B and familial breast cancer risk. PubMed ID: 16762494

Patterns of somatic mutation in human cancer genomes. PubMed ID: 17344846