FCMR | ENSG00000162894 | NCBI 9214

Details for: FCMR

Gene ID: 9214

Symbol: FCMR

Ensembl ID: ENSG00000162894

Description: Fc mu receptor

Associated with

Cellular defense response
(GO:0006968)
Early endosome membrane
(GO:0031901)
Extracellular region
(GO:0005576)
Fc receptor-mediated immune complex endocytosis
(GO:0160006)
Fc receptor signaling pathway
(GO:0038093)
High-affinity igm receptor activity
(GO:0002172)
Humoral immune response mediated by circulating immunoglobulin
(GO:0002455)
Igm binding
(GO:0001791)
Immunoglobulin transcytosis in epithelial cells
(GO:0002414)
Lysosomal membrane
(GO:0005765)
Negative regulation of apoptotic process
(GO:0043066)
Plasma membrane
(GO:0005886)
Polymeric immunoglobulin binding
(GO:0001790)
Protein binding
(GO:0005515)
Regulation of b cell receptor signaling pathway
(GO:0050855)
Trans-golgi network membrane
(GO:0032588)
Transmembrane signaling receptor activity
(GO:0004888)

Other Information

Proteins

FCMR_HUMAN

Genular Protein ID: 3928954933

Symbol: FCMR_HUMAN

Name: N/A

UniProtKB Accession Codes:

O60667 A8K7J2 B7Z6Z0 D9MWM3

Database IDs:

Citations:

PubMed ID: 9586636

Title: Toso, a cell surface, specific regulator of Fas-induced apoptosis in T cells.

PubMed ID: 9586636

DOI: 10.1016/s1074-7613(00)80551-8

PubMed ID: 21908424

Title: Enhanced levels of both the membrane-bound and soluble forms of IgM Fc receptor (Fc?R) in patients with chronic lymphocytic leukemia.

PubMed ID: 21908424

DOI: 10.1182/blood-2011-04-350793

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19858324

Title: Identity of the elusive IgM Fc receptor (FcmuR) in humans.

PubMed ID: 19858324

DOI: 10.1084/jem.20091107

PubMed ID: 21908732

Title: TOSO, the Fcmicro receptor, is highly expressed on chronic lymphocytic leukemia B cells, internalizes upon IgM binding, shuttles to the lysosome, and is downregulated in response to TLR activation.

PubMed ID: 21908732

DOI: 10.4049/jimmunol.1100532

PubMed ID: 22675200

Title: Toso, a functional IgM receptor, is regulated by IL-2 in T and NK cells.

PubMed ID: 22675200

DOI: 10.4049/jimmunol.1200840

PubMed ID: 25601920

Title: Unique ligand-binding property of the human IgM Fc receptor.

PubMed ID: 25601920

DOI: 10.4049/jimmunol.1401866

PubMed ID: 25888699

Title: Nomenclature of Toso, Fas apoptosis inhibitory molecule 3, and IgM FcR.

PubMed ID: 25888699

DOI: 10.4049/jimmunol.1500222

PubMed ID: 28230186

Title: Glycan-independent binding and internalization of human IgM to FCMR, its cognate cellular receptor.

PubMed ID: 28230186

DOI: 10.1038/srep42989

PubMed ID: 30840890

Title: Fcmu receptor as a Costimulatory Molecule for T Cells.

PubMed ID: 30840890

DOI: 10.1016/j.celrep.2019.02.024

PubMed ID: 36949194

Title: Immunoglobulin M perception by FcmuR.

PubMed ID: 36949194

DOI: 10.1038/s41586-023-05835-w

PubMed ID: 37095205

Title: Structural basis for Fc receptor recognition of immunoglobulin M.

PubMed ID: 37095205

DOI: 10.1038/s41594-023-00985-x

Sequence Information:

Length: 390
Mass: 43146
Checksum: FE91D217EECA99C6
Sequence:

MDFWLWPLYF LPVSGALRIL PEVKVEGELG GSVTIKCPLP EMHVRIYLCR EMAGSGTCGT 
VVSTTNFIKA EYKGRVTLKQ YPRKNLFLVE VTQLTESDSG VYACGAGMNT DRGKTQKVTL 
NVHSEYEPSW EEQPMPETPK WFHLPYLFQM PAYASSSKFV TRVTTPAQRG KVPPVHHSSP 
TTQITHRPRV SRASSVAGDK PRTFLPSTTA SKISALEGLL KPQTPSYNHH TRLHRQRALD 
YGSQSGREGQ GFHILIPTIL GLFLLALLGL VVKRAVERRK ALSRRARRLA VRMRALESSQ 
RPRGSPRPRS QNNIYSACPR RARGADAAGT GEAPVPGPGA PLPPAPLQVS ESPWLHAPSL 
KTSCEYVSLY HQPAAMMEDS DSDDYINVPA

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: FCMR

Associated with

Other Information

Toso, a cell surface, specific regulator of Fas-induced apoptosis in T cells. PubMed ID: 9586636

Enhanced levels of both the membrane-bound and soluble forms of IgM Fc receptor (Fc?R) in patients with chronic lymphocytic leukemia. PubMed ID: 21908424

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence and biological annotation of human chromosome 1. PubMed ID: 16710414

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Identity of the elusive IgM Fc receptor (FcmuR) in humans. PubMed ID: 19858324

TOSO, the Fcmicro receptor, is highly expressed on chronic lymphocytic leukemia B cells, internalizes upon IgM binding, shuttles to the lysosome, and is downregulated in response to TLR activation. PubMed ID: 21908732

Toso, a functional IgM receptor, is regulated by IL-2 in T and NK cells. PubMed ID: 22675200

Unique ligand-binding property of the human IgM Fc receptor. PubMed ID: 25601920

Nomenclature of Toso, Fas apoptosis inhibitory molecule 3, and IgM FcR. PubMed ID: 25888699

Glycan-independent binding and internalization of human IgM to FCMR, its cognate cellular receptor. PubMed ID: 28230186

Fcmu receptor as a Costimulatory Molecule for T Cells. PubMed ID: 30840890

Immunoglobulin M perception by FcmuR. PubMed ID: 36949194

Structural basis for Fc receptor recognition of immunoglobulin M. PubMed ID: 37095205