Details for: VAPB

Gene ID: 9217

Symbol: VAPB

Ensembl ID: ENSG00000124164

Description: VAMP associated protein B and C

Associated with

Other Information

Genular Protein ID: 3206570346

Symbol: VAPB_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 9920726

Title: Molecular cloning and characterization of mammalian homologues of vesicle-associated membrane protein-associated (VAMP-associated) proteins.

PubMed ID: 9920726

DOI: 10.1006/bbrc.1998.9876

PubMed ID: 10931946

Title: Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning.

PubMed ID: 10931946

DOI: 10.1073/pnas.160270997

PubMed ID: 12975309

Title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

PubMed ID: 12975309

DOI: 10.1101/gr.1293003

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12665801

Title: Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.

PubMed ID: 12665801

DOI: 10.1038/nbt810

PubMed ID: 16227268

Title: Human VAP-B is involved in hepatitis C virus replication through interaction with NS5A and NS5B.

PubMed ID: 16227268

DOI: 10.1128/jvi.79.21.13473-13482.2005

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16891305

Title: Characterization of amyotrophic lateral sclerosis-linked P56S mutation of vesicle-associated membrane protein-associated protein B (VAPB/ALS8).

PubMed ID: 16891305

DOI: 10.1074/jbc.m605049200

PubMed ID: 16895911

Title: Efficient trafficking of ceramide from the endoplasmic reticulum to the Golgi apparatus requires a VAMP-associated protein-interacting FFAT motif of CERT.

PubMed ID: 16895911

DOI: 10.1074/jbc.m605032200

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19289470

Title: Promotion of neurite extension by protrudin requires its interaction with vesicle-associated membrane protein-associated protein.

PubMed ID: 19289470

DOI: 10.1074/jbc.m807938200

PubMed ID: 20940299

Title: Characterization of the properties of a novel mutation in VAPB in familial amyotrophic lateral sclerosis.

PubMed ID: 20940299

DOI: 10.1074/jbc.m110.161398

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21976701

Title: Protrudin serves as an adaptor molecule that connects KIF5 and its cargoes in vesicular transport during process formation.

PubMed ID: 21976701

DOI: 10.1091/mbc.e11-01-0068

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22131369

Title: VAPB interacts with the mitochondrial protein PTPIP51 to regulate calcium homeostasis.

PubMed ID: 22131369

DOI: 10.1093/hmg/ddr559

PubMed ID: 22720086

Title: Intrinsically unstructured domain 3 of hepatitis C Virus NS5A forms a 'fuzzy complex' with VAPB-MSP domain which carries ALS-causing mutations.

PubMed ID: 22720086

DOI: 10.1371/journal.pone.0039261

PubMed ID: 24105263

Title: STARD3 or STARD3NL and VAP form a novel molecular tether between late endosomes and the ER.

PubMed ID: 24105263

DOI: 10.1242/jcs.139295

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25114211

Title: Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli.

PubMed ID: 25114211

DOI: 10.1073/pnas.1413825111

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 29858488

Title: Identification of MOSPD2, a novel scaffold for endoplasmic reticulum membrane contact sites.

PubMed ID: 29858488

DOI: 10.15252/embr.201745453

PubMed ID: 30741634

Title: Human VPS13A is associated with multiple organelles and influences mitochondrial morphology and lipid droplet motility.

PubMed ID: 30741634

DOI: 10.7554/elife.43561

PubMed ID: 33124732

Title: FFAT motif phosphorylation controls formation and lipid transfer function of inter-organelle contacts.

PubMed ID: 33124732

DOI: 10.15252/embj.2019104369

PubMed ID: 30659099

Title: The activity of Sac1 across ER-TGN contact sites requires the four-phosphate-adaptor-protein-1.

PubMed ID: 30659099

DOI: 10.1083/jcb.201812021

PubMed ID: 32344433

Title: GRAF2, WDR44, and MICAL1 mediate Rab8/10/11-dependent export of E-cadherin, MMP14, and CFTR DeltaF508.

PubMed ID: 32344433

DOI: 10.1083/jcb.201811014

PubMed ID: 15372378

Title: A mutation in the vesicle-trafficking protein VAPB causes late-onset spinal muscular atrophy and amyotrophic lateral sclerosis.

PubMed ID: 15372378

DOI: 10.1086/425287

Sequence Information:

  • Length: 243
  • Mass: 27228
  • Checksum: 22AEEF9EC7FC0B3F
  • Sequence:
  • MAKVEQVLSL EPQHELKFRG PFTDVVTTNL KLGNPTDRNV CFKVKTTAPR RYCVRPNSGI 
    IDAGASINVS VMLQPFDYDP NEKSKHKFMV QSMFAPTDTS DMEAVWKEAK PEDLMDSKLR 
    CVFELPAEND KPHDVEINKI ISTTASKTET PIVSKSLSSS LDDTEVKKVM EECKRLQGEV 
    QRLREENKQF KEEDGLRMRK TVQSNSPISA LAPTGKEEGL STRLLALVVL FFIVGVIIGK 
    IAL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.