Details for: CD5L

Gene ID: 922

Symbol: CD5L

Ensembl ID: ENSG00000073754

Description: CD5 molecule like

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 3.53
    Marker Score: 3528.5
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 3.15
    Marker Score: 3172
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 2
    Marker Score: 1995
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 1.63
    Marker Score: 898
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.61
    Marker Score: 1172
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.37
    Marker Score: 871
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.28
    Marker Score: 2432
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.26
    Marker Score: 856
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.23
    Marker Score: 2492
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.18
    Marker Score: 488
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4817
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.14
    Marker Score: 7552
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.1
    Marker Score: 504
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71826
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48050.5
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 510
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 464
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2412
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5356
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.94
    Marker Score: 375
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2741
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.91
    Marker Score: 327
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5290
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.81
    Marker Score: 620.5
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.8
    Marker Score: 12518.5
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1267
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 708
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 398
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.73
    Marker Score: 464
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 0.72
    Marker Score: 358
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7
    Marker Score: 179
  • Cell Name: memory T cell (CL0000813)
    Fold Change: 0.66
    Marker Score: 283
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.62
    Marker Score: 1286
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.6
    Marker Score: 396
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.56
    Marker Score: 148
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 445
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.55
    Marker Score: 174
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.45
    Marker Score: 272
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.44
    Marker Score: 142
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.44
    Marker Score: 290.5
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.42
    Marker Score: 200
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 0.38
    Marker Score: 9777.5
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.33
    Marker Score: 367
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.31
    Marker Score: 137
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.3
    Marker Score: 305.5
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.3
    Marker Score: 134
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.3
    Marker Score: 387
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 0.28
    Marker Score: 117
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.26
    Marker Score: 3392
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.25
    Marker Score: 401
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.24
    Marker Score: 99
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 64
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.22
    Marker Score: 118
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.22
    Marker Score: 158
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 73
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.21
    Marker Score: 124.5
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.21
    Marker Score: 123
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.19
    Marker Score: 171
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.18
    Marker Score: 67
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.18
    Marker Score: 56
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.18
    Marker Score: 120.5
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.17
    Marker Score: 412
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.17
    Marker Score: 43
  • Cell Name: inflammatory macrophage (CL0000863)
    Fold Change: 0.17
    Marker Score: 52
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.16
    Marker Score: 93
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.16
    Marker Score: 194
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: 0.16
    Marker Score: 139
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.15
    Marker Score: 57
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.15
    Marker Score: 276
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.15
    Marker Score: 103
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.15
    Marker Score: 98
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.15
    Marker Score: 112
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.13
    Marker Score: 125
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.13
    Marker Score: 77
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.12
    Marker Score: 71
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.12
    Marker Score: 100
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.12
    Marker Score: 65
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.11
    Marker Score: 57
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.1
    Marker Score: 65
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.1
    Marker Score: 27
  • Cell Name: centrocyte (CL0009111)
    Fold Change: 0.09
    Marker Score: 22
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.09
    Marker Score: 283
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.09
    Marker Score: 28
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.09
    Marker Score: 41
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.09
    Marker Score: 50
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.09
    Marker Score: 92
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.08
    Marker Score: 82
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 0.08
    Marker Score: 22
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.08
    Marker Score: 42
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 0.08
    Marker Score: 23
  • Cell Name: colon macrophage (CL0009038)
    Fold Change: 0.08
    Marker Score: 23
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.08
    Marker Score: 21
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 0.08
    Marker Score: 55
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.08
    Marker Score: 76
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: 0.08
    Marker Score: 24
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.08
    Marker Score: 37
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.08
    Marker Score: 87
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 0.08
    Marker Score: 24
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.08
    Marker Score: 90

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Other Information

**Key Characteristics:** * CD5 is a type I transmembrane protein with a molecular weight of approximately 120 kDa. * It is expressed as a disulfide-linked heterodimeric protein, consisting of two identical heavy chains and two identical light chains. * The extracellular domain of CD5 is responsible for binding to its ligand, CD80 or CD86 on the surface of antigen-presenting cells. * CD5 is a key regulator of the immune response, and its expression on activated T cells is associated with the activation of cytotoxic lymphocytes. **Pathways and Functions:** * CD5 is involved in the regulation of apoptosis, the process by which cells die on their own. * It is also involved in the regulation of blood microparticle-mediated immunity, a process in which immune cells recognize and respond to circulating particles. * CD5 is also involved in the regulation of cell surface adhesion and migration. * It is a positive regulator of complement-dependent cytotoxicity, a process in which the complement system is activated by immune cells. * CD5 is also involved in the regulation of complement activation. * It is a serine-type endopeptidase, which is an enzyme that breaks down proteins. * CD5 is also involved in the activation of zymogens, which are enzymes that are involved in inflammation. **Clinical Significance:** CD5 is a promising target for cancer immunotherapy. Several antibodies that block CD5 have been shown to be effective in treating cancer in preclinical models. These antibodies are currently being evaluated in clinical trials for the treatment of cancer.

Genular Protein ID: 3199099628

Symbol: CD5L_HUMAN

Name: CD5 antigen-like

UniProtKB Accession Codes:

O43866 A8K7M5 Q6UX63

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CPTAC 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 7 Ensembl 1 GO 14 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 2 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9045627

Title: Molecular cloning, mapping to human chromosome 1 q21-q23, and cell binding characteristics of Spalpha, a new member of the scavenger receptor cysteine-rich (SRCR) family of proteins.

PubMed ID: 9045627

DOI: 10.1074/jbc.272.10.6151

PubMed ID: 12975309

Title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

PubMed ID: 12975309

DOI: 10.1101/gr.1293003

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8034987

Title: Two-dimensional polyacrylamide gel electrophoresis analysis of cryoglobulins and identification of an IgM-associated peptide.

PubMed ID: 8034987

DOI: 10.1016/0022-1759(94)90284-4

PubMed ID: 11981870

Title: IgM are associated to Spalpha (CD5 antigen-like).

PubMed ID: 11981870

DOI: 10.1002/1522-2683(200204)23:7/8<1203::aid-elps1203>3.0.co;2-1

PubMed ID: 15340161

Title: Signal peptide prediction based on analysis of experimentally verified cleavage sites.

PubMed ID: 15340161

DOI: 10.1110/ps.04682504

PubMed ID: 16030018

Title: A role for human Sp alpha as a pattern recognition receptor.

PubMed ID: 16030018

DOI: 10.1074/jbc.m505042200

PubMed ID: 23236605

Title: Modification of N-glycosylation modulates the secretion and lipolytic function of apoptosis inhibitor of macrophage (AIM).

PubMed ID: 23236605

DOI: 10.1016/j.febslet.2012.08.017

PubMed ID: 24223991

Title: The scavenger protein apoptosis inhibitor of macrophages (AIM) potentiates the antimicrobial response against Mycobacterium tuberculosis by enhancing autophagy.

PubMed ID: 24223991

DOI: 10.1371/journal.pone.0079670

PubMed ID: 24583716

Title: The macrophage soluble receptor AIM/Api6/CD5L displays a broad pathogen recognition spectrum and is involved in early response to microbial aggression.

PubMed ID: 24583716

DOI: 10.1038/cmi.2014.12

PubMed ID: 24295828

Title: Human scavenger protein AIM increases foam cell formation and CD36-mediated oxLDL uptake.

PubMed ID: 24295828

DOI: 10.1189/jlb.1212660

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24804991

Title: Stabilization and augmentation of circulating AIM in mice by synthesized IgM-Fc.

PubMed ID: 24804991

DOI: 10.1371/journal.pone.0097037

PubMed ID: 25713983

Title: The human CD5L/AIM-CD36 axis: A novel autophagy inducer in macrophages that modulates inflammatory responses.

PubMed ID: 25713983

DOI: 10.1080/15548627.2015.1017183

Sequence Information:

  • Length: 347
  • Mass: 38088
  • Checksum: 40A8BE08F9495D83
  • Sequence:
    • MALLFSLILA ICTRPGFLAS PSGVRLVGGL HRCEGRVEVE QKGQWGTVCD DGWDIKDVAV 
LCRELGCGAA SGTPSGILYE PPAEKEQKVL IQSVSCTGTE DTLAQCEQEE VYDCSHDEDA 
GASCENPESS FSPVPEGVRL ADGPGHCKGR VEVKHQNQWY TVCQTGWSLR AAKVVCRQLG 
CGRAVLTQKR CNKHAYGRKP IWLSQMSCSG REATLQDCPS GPWGKNTCNH DEDTWVECED 
PFDLRLVGGD NLCSGRLEVL HKGVWGSVCD DNWGEKEDQV VCKQLGCGKS LSPSFRDRKC 
YGPGVGRIWL DNVRCSGEEQ SLEQCQHRFW GFHDCTHQED VAVICSG

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.