Details for: CD5L

Gene ID: 922

Symbol: CD5L

Ensembl ID: ENSG00000073754

Description: CD5 molecule like

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 10.0935
    Cell Significance Index: -1.5700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 1.2734
    Cell Significance Index: -1.5700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.6861
    Cell Significance Index: 17.1500
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.6556
    Cell Significance Index: 9.5600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.5837
    Cell Significance Index: 12.6500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.5584
    Cell Significance Index: 17.8900
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.5152
    Cell Significance Index: 8.6700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.3717
    Cell Significance Index: 22.7900
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: 0.3696
    Cell Significance Index: 0.9900
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 0.2975
    Cell Significance Index: -0.6500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.2937
    Cell Significance Index: 7.8600
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 0.2867
    Cell Significance Index: 1.3200
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.2526
    Cell Significance Index: 2.0600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1659
    Cell Significance Index: 31.5800
  • Cell Name: intrahepatic cholangiocyte (CL0002538)
    Fold Change: 0.1606
    Cell Significance Index: 0.6100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1426
    Cell Significance Index: 6.4700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.1216
    Cell Significance Index: 7.3000
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 0.1110
    Cell Significance Index: 1.0300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.0702
    Cell Significance Index: 7.6400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0582
    Cell Significance Index: 4.4700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0438
    Cell Significance Index: 0.7500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0437
    Cell Significance Index: 0.9300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0434
    Cell Significance Index: 4.3000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0419
    Cell Significance Index: 37.8200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0283
    Cell Significance Index: 1.9600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0256
    Cell Significance Index: 4.1700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0220
    Cell Significance Index: 4.3700
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.0154
    Cell Significance Index: 0.1900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0124
    Cell Significance Index: 1.4600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0063
    Cell Significance Index: 0.1700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.0018
    Cell Significance Index: 0.0500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0013
    Cell Significance Index: 0.4800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0006
    Cell Significance Index: 0.0200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0005
    Cell Significance Index: 0.0900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0002
    Cell Significance Index: 0.2700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0001
    Cell Significance Index: 0.1900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0002
    Cell Significance Index: -0.3300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0003
    Cell Significance Index: -0.0100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0004
    Cell Significance Index: -0.5900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0020
    Cell Significance Index: -1.4800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0024
    Cell Significance Index: -1.8100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0027
    Cell Significance Index: -1.7300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0032
    Cell Significance Index: -1.7900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0033
    Cell Significance Index: -1.5200
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: -0.0033
    Cell Significance Index: -0.0300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0036
    Cell Significance Index: -0.7200
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0039
    Cell Significance Index: -0.0500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0043
    Cell Significance Index: -1.2500
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0053
    Cell Significance Index: -0.1100
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0063
    Cell Significance Index: -0.0900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0086
    Cell Significance Index: -1.8100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0095
    Cell Significance Index: -1.7200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0095
    Cell Significance Index: -1.3800
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0106
    Cell Significance Index: -0.1600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0111
    Cell Significance Index: -1.2700
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.0122
    Cell Significance Index: -0.1800
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.0124
    Cell Significance Index: -0.1800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0128
    Cell Significance Index: -1.3100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0142
    Cell Significance Index: -1.7400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0156
    Cell Significance Index: -1.6200
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0164
    Cell Significance Index: -0.5200
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0170
    Cell Significance Index: -0.2200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0202
    Cell Significance Index: -1.3600
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0210
    Cell Significance Index: -0.4100
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0224
    Cell Significance Index: -0.3300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0224
    Cell Significance Index: -0.6300
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.0230
    Cell Significance Index: -0.3300
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: -0.0236
    Cell Significance Index: -0.2400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0257
    Cell Significance Index: -1.5800
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0269
    Cell Significance Index: -0.6700
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.0284
    Cell Significance Index: -0.2500
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0300
    Cell Significance Index: -1.2300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0335
    Cell Significance Index: -1.8800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0355
    Cell Significance Index: -1.5700
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0356
    Cell Significance Index: -0.6000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0391
    Cell Significance Index: -1.9800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0404
    Cell Significance Index: -1.9000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0425
    Cell Significance Index: -1.6100
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.0432
    Cell Significance Index: -0.6000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0434
    Cell Significance Index: -1.5200
  • Cell Name: inflammatory macrophage (CL0000863)
    Fold Change: -0.0442
    Cell Significance Index: -0.3400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0442
    Cell Significance Index: -1.1800
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: -0.0450
    Cell Significance Index: -0.3600
  • Cell Name: L5/6 near-projecting glutamatergic neuron (CL4030067)
    Fold Change: -0.0461
    Cell Significance Index: -0.2400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0473
    Cell Significance Index: -1.5500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0474
    Cell Significance Index: -1.5100
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0492
    Cell Significance Index: -0.7200
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.0504
    Cell Significance Index: -1.2300
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.0518
    Cell Significance Index: -0.6100
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0520
    Cell Significance Index: -1.9100
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.0523
    Cell Significance Index: -0.8300
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.0526
    Cell Significance Index: -0.7300
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0534
    Cell Significance Index: -1.5300
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0548
    Cell Significance Index: -0.7300
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0549
    Cell Significance Index: -1.3700
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0563
    Cell Significance Index: -1.0400
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: -0.0570
    Cell Significance Index: -0.7300
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0579
    Cell Significance Index: -0.7700
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0605
    Cell Significance Index: -1.5100
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0627
    Cell Significance Index: -0.6400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Structural Homology**: The CD5L protein shares a high degree of sequence similarity with the CD5 molecule, suggesting a conserved evolutionary origin. 2. **Tissue Distribution**: CD5L is expressed in a wide range of cell types, including immune cells, endothelial cells, and epithelial cells, highlighting its potential role in various physiological and pathological processes. 3. **Cellular Functions**: CD5L has been implicated in apoptosis, regulation of complement activation, and immune system response, indicating its importance in maintaining immune homeostasis. 4. **Protein-Protein Interactions**: The CD5L protein interacts with other molecules, such as CD5, complement components, and serine-type endopeptidases, suggesting complex regulatory mechanisms. **Pathways and Functions:** 1. **Apoptotic Process**: CD5L has been shown to regulate apoptosis in various cell types, including immune cells and endothelial cells. 2. **Regulation of Complement Activation**: CD5L interacts with complement components, modulating the activation of the complement system and preventing excessive inflammation. 3. **Immune System Process**: CD5L plays a role in immune system regulation, influencing the activity of immune cells and the response to pathogens. 4. **Zymogen Activation**: CD5L has been implicated in the activation of serine-type endopeptidases, suggesting a role in protein processing and regulation. **Clinical Significance:** 1. **Immune System Disorders**: Dysregulation of the CD5L gene has been linked to various immune system disorders, including autoimmune diseases and inflammatory conditions. 2. **Cancer**: CD5L expression has been found in certain types of cancer, including leukemia and lymphoma, suggesting its potential role in tumorigenesis. 3. **Cardiovascular Disease**: CD5L has been implicated in cardiovascular disease, influencing endothelial cell function and inflammation. 4. **Infectious Diseases**: CD5L expression has been found in response to certain pathogens, highlighting its role in immune system regulation and defense. In conclusion, the CD5L gene has been found to play a complex and multifaceted role in immune regulation, cellular defense, and tissue homeostasis. Further research is needed to fully elucidate the functions and clinical significance of this gene, but its potential implications for the diagnosis and treatment of various diseases make it an important area of investigation.

Genular Protein ID: 3199099628

Symbol: CD5L_HUMAN

Name: CD5 antigen-like

UniProtKB Accession Codes:

O43866 A8K7M5 Q6UX63

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CPTAC 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 7 Ensembl 1 GO 14 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 2 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9045627

Title: Molecular cloning, mapping to human chromosome 1 q21-q23, and cell binding characteristics of Spalpha, a new member of the scavenger receptor cysteine-rich (SRCR) family of proteins.

PubMed ID: 9045627

DOI: 10.1074/jbc.272.10.6151

PubMed ID: 12975309

Title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

PubMed ID: 12975309

DOI: 10.1101/gr.1293003

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8034987

Title: Two-dimensional polyacrylamide gel electrophoresis analysis of cryoglobulins and identification of an IgM-associated peptide.

PubMed ID: 8034987

DOI: 10.1016/0022-1759(94)90284-4

PubMed ID: 11981870

Title: IgM are associated to Spalpha (CD5 antigen-like).

PubMed ID: 11981870

DOI: 10.1002/1522-2683(200204)23:7/8<1203::aid-elps1203>3.0.co;2-1

PubMed ID: 15340161

Title: Signal peptide prediction based on analysis of experimentally verified cleavage sites.

PubMed ID: 15340161

DOI: 10.1110/ps.04682504

PubMed ID: 16030018

Title: A role for human Sp alpha as a pattern recognition receptor.

PubMed ID: 16030018

DOI: 10.1074/jbc.m505042200

PubMed ID: 23236605

Title: Modification of N-glycosylation modulates the secretion and lipolytic function of apoptosis inhibitor of macrophage (AIM).

PubMed ID: 23236605

DOI: 10.1016/j.febslet.2012.08.017

PubMed ID: 24223991

Title: The scavenger protein apoptosis inhibitor of macrophages (AIM) potentiates the antimicrobial response against Mycobacterium tuberculosis by enhancing autophagy.

PubMed ID: 24223991

DOI: 10.1371/journal.pone.0079670

PubMed ID: 24583716

Title: The macrophage soluble receptor AIM/Api6/CD5L displays a broad pathogen recognition spectrum and is involved in early response to microbial aggression.

PubMed ID: 24583716

DOI: 10.1038/cmi.2014.12

PubMed ID: 24295828

Title: Human scavenger protein AIM increases foam cell formation and CD36-mediated oxLDL uptake.

PubMed ID: 24295828

DOI: 10.1189/jlb.1212660

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24804991

Title: Stabilization and augmentation of circulating AIM in mice by synthesized IgM-Fc.

PubMed ID: 24804991

DOI: 10.1371/journal.pone.0097037

PubMed ID: 25713983

Title: The human CD5L/AIM-CD36 axis: A novel autophagy inducer in macrophages that modulates inflammatory responses.

PubMed ID: 25713983

DOI: 10.1080/15548627.2015.1017183

Sequence Information:

  • Length: 347
  • Mass: 38088
  • Checksum: 40A8BE08F9495D83
  • Sequence:
    • MALLFSLILA ICTRPGFLAS PSGVRLVGGL HRCEGRVEVE QKGQWGTVCD DGWDIKDVAV 
LCRELGCGAA SGTPSGILYE PPAEKEQKVL IQSVSCTGTE DTLAQCEQEE VYDCSHDEDA 
GASCENPESS FSPVPEGVRL ADGPGHCKGR VEVKHQNQWY TVCQTGWSLR AAKVVCRQLG 
CGRAVLTQKR CNKHAYGRKP IWLSQMSCSG REATLQDCPS GPWGKNTCNH DEDTWVECED 
PFDLRLVGGD NLCSGRLEVL HKGVWGSVCD DNWGEKEDQV VCKQLGCGKS LSPSFRDRKC 
YGPGVGRIWL DNVRCSGEEQ SLEQCQHRFW GFHDCTHQED VAVICSG

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.